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UniProtKB - Q8C5N3 (CWC22_MOUSE)

Entry version 120 (17 Jun 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Pre-mRNA-splicing factor CWC22 homolog

Gene

Cwc22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC22 homolog
Alternative name(s):
Nucampholin homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cwc22
Synonyms:Ncm
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2136773 Cwc22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003020061 – 908Pre-mRNA-splicing factor CWC22 homologAdd BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei38PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei106PhosphoserineCombined sources1
Modified residuei829PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8C5N3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8C5N3

PRoteomics IDEntifications database

More...PRIDEi		Q8C5N3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8C5N3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8C5N3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000027014 Expressed in embryo and 83 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8C5N3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8C5N3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the pre-catalytic spliceosome B and the catalytic spliceosome C complexes.

Interacts with EIF4A3 and PRPF19 in an RNA-independent manner. Direct interaction with EIF4A3 is mediated by the MIF4G domain. Full interaction with EIF4A3 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		219805, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q8C5N3, 1 interactor

Molecular INTeraction database

More...MINTi		Q8C5N3

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000064947

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8C5N3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8C5N3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini161 – 344MIF4GPROSITE-ProRule annotationAdd BLAST184
Domaini453 – 569MIPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 100Arg-richAdd BLAST86
Compositional biasi114 – 117Poly-Lys4
Compositional biasi421 – 436Poly-GluAdd BLAST16
Compositional biasi669 – 712Ser-richAdd BLAST44
Compositional biasi747 – 900Arg-richAdd BLAST154

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CWC22 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2140 Eukaryota
ENOG410XNP2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153458

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006308_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8C5N3

KEGG Orthology (KO)

More...KOi		K13100

Database of Orthologous Groups

More...OrthoDBi		996017at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8C5N3

TreeFam database of animal gene trees

More...TreeFami		TF300510

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51366 MI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C5N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSSVAHMKS SGHNRRETHS SYRRSSSPED RYTEQERSPR DRGYSDYSRS 
        60         70         80         90        100
DYERSRRGYS YDDSMESRSR DREKRRERER DADHRKRSRK SPSPDRSPAR 
       110        120        130        140        150
GGGQSSPQEE PTWKKKKDEL DPLLTRTGGA YIPPAKLRMM QEQITDKSSL 
       160        170        180        190        200
AYQRMSWEAL KKSINGLINK VNISNISIII QELLQENIVR GRGLLSRSVL 
       210        220        230        240        250
QAQSASPIFT HVYAALVAII NSKFPQIGEL ILKRLILNFR KGYRRNDKQL 
       260        270        280        290        300
CLTASKFVAH LINQNVAHEV LCLEMLTLLL ERPTDDSVEV AIGFLKECGL 
       310        320        330        340        350
KLTQVSPRGI NAIFERLRNI LHESEIDKRV QYMIEVMFAV RKDGFKDHPV 
       360        370        380        390        400
ILEGLDLVEE DDQFTHMLPL EDDYNPEDVL NVFKMDPNFM ENEEKYKAIK 
       410        420        430        440        450
KEILDEGDSD SNTDQGAGSS EDEEEEDEEE EGEDEEGGQK VTIHDKTEIN 
       460        470        480        490        500
LVSFRRTIYL AIQSSLDFEE CAHKLLKMEF AESQTKELCN MILDCCAQQR 
       510        520        530        540        550
TYEKFFGLLA GRFCMLKKEY MESFESIFKE QYDTIHRLET NKLRNVAKMF 
       560        570        580        590        600
AHLLYTDSLP WSVLECIKLS EETTTSSSRI FVKIFFQELC EYMGLPKLNA 
       610        620        630        640        650
RLKDETLQPF FEGLLPRDNP RNTRFAINFF TSIGLGGLTD ELREHLKNTP 
       660        670        680        690        700
KVIVAQKPEA EQKKPALTSS SSESSSASDS SDSESDSSES SSESSSDASD 
       710        720        730        740        750
SSSSSSTQSS TSGITAHSAK GTRKKRQGKA RGEEVDKLAR GHQALERRRE 
       760        770        780        790        800
GGREDQRHQE GRTERARSER RRAQNSRDAD WRDPLAKHID DRSHENSHSR 
       810        820        830        840        850
VGNGREQGSH REPEDRHGEP KKRRERRDSF SENEKQRSRN QDSDNVRRKD 
       860        870        880        890        900
RSKSRERSRR HSGHKGDDAR CQNSAERRWE KPGRRPEQSR ESKRSQDRRR 

EKSPTTQK
Length:908
Mass (Da):104,773
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i722C782B3D74643B
GO
Isoform 2 (identifier: Q8C5N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     713-718: Missing.

Show »
Length:902
Mass (Da):104,207
Checksum:iC2A305B558376B90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AYU4B1AYU4_MOUSE
Pre-mRNA-splicing factor CWC22 homo...
Cwc22
723Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AYU8B1AYU8_MOUSE
Pre-mRNA-splicing factor CWC22 homo...
Cwc22
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AYU9B1AYU9_MOUSE
Pre-mRNA-splicing factor CWC22 homo...
Cwc22
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AYU7B1AYU7_MOUSE
Pre-mRNA-splicing factor CWC22 homo...
Cwc22
903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH03993 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9K → KQ in AAH03993 (PubMed:15489334).Curated1
Sequence conflicti493L → P in AAH03993 (PubMed:15489334).Curated1
Sequence conflicti540T → I in AAH03993 (PubMed:15489334).Curated1
Sequence conflicti706S → SS in AAH03993 (PubMed:15489334).Curated1
Sequence conflicti749R → Q in AAH03993 (PubMed:15489334).Curated1
Sequence conflicti847R → K in BAE20931 (PubMed:16141072).Curated1
Sequence conflicti874S → G in AAH03993 (PubMed:15489334).Curated1
Sequence conflicti896Q → R in BAE28941 (PubMed:16141072).Curated1
Sequence conflicti898R → G in BAC32427 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027905713 – 718Missing in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK045589 mRNA Translation: BAC32427.1
AK132001 mRNA Translation: BAE20931.1
AK077961 mRNA Translation: BAC37085.1
AK149528 mRNA Translation: BAE28941.1
BC003993 mRNA Translation: AAH03993.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS16165.1 [Q8C5N3-1]
CCDS57178.1 [Q8C5N3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001277669.1, NM_001290740.1
NP_085037.2, NM_030560.5 [Q8C5N3-1]
NP_766255.1, NM_172667.2 [Q8C5N3-2]
XP_006500499.1, XM_006500436.3
XP_011238158.1, XM_011239856.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000065889; ENSMUSP00000064947; ENSMUSG00000027014 [Q8C5N3-1]
ENSMUST00000111818; ENSMUSP00000107449; ENSMUSG00000027014 [Q8C5N3-2]
ENSMUST00000111821; ENSMUSP00000107452; ENSMUSG00000027014 [Q8C5N3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80744

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:80744

UCSC genome browser

More...UCSCi		uc008kgc.3 mouse [Q8C5N3-1]
uc008kgd.3 mouse [Q8C5N3-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045589 mRNA Translation: BAC32427.1
AK132001 mRNA Translation: BAE20931.1
AK077961 mRNA Translation: BAC37085.1
AK149528 mRNA Translation: BAE28941.1
BC003993 mRNA Translation: AAH03993.1 Different initiation.
CCDSiCCDS16165.1 [Q8C5N3-1]
CCDS57178.1 [Q8C5N3-2]
RefSeqiNP_001277669.1, NM_001290740.1
NP_085037.2, NM_030560.5 [Q8C5N3-1]
NP_766255.1, NM_172667.2 [Q8C5N3-2]
XP_006500499.1, XM_006500436.3
XP_011238158.1, XM_011239856.1

3D structure databases

SMRiQ8C5N3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi219805, 3 interactors
IntActiQ8C5N3, 1 interactor
MINTiQ8C5N3
STRINGi10090.ENSMUSP00000064947

PTM databases

iPTMnetiQ8C5N3
PhosphoSitePlusiQ8C5N3

Proteomic databases

jPOSTiQ8C5N3
PaxDbiQ8C5N3
PRIDEiQ8C5N3

Genome annotation databases

EnsembliENSMUST00000065889; ENSMUSP00000064947; ENSMUSG00000027014 [Q8C5N3-1]
ENSMUST00000111818; ENSMUSP00000107449; ENSMUSG00000027014 [Q8C5N3-2]
ENSMUST00000111821; ENSMUSP00000107452; ENSMUSG00000027014 [Q8C5N3-1]
GeneIDi80744
KEGGimmu:80744
UCSCiuc008kgc.3 mouse [Q8C5N3-1]
uc008kgd.3 mouse [Q8C5N3-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57703
MGIiMGI:2136773 Cwc22

Phylogenomic databases

eggNOGiKOG2140 Eukaryota
ENOG410XNP2 LUCA
GeneTreeiENSGT00940000153458
HOGENOMiCLU_006308_1_0_1
InParanoidiQ8C5N3
KOiK13100
OrthoDBi996017at2759
PhylomeDBiQ8C5N3
TreeFamiTF300510

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80744 9 hits in 11 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cwc22 mouse

Protein Ontology

More...PROi		PR:Q8C5N3
RNActiQ8C5N3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000027014 Expressed in embryo and 83 other tissues
ExpressionAtlasiQ8C5N3 baseline and differential
GenevisibleiQ8C5N3 MM

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
SMARTiView protein in SMART
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCWC22_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C5N3
Secondary accession number(s): Q3UEH0
, Q3V267, Q8BR58, Q99KV6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: June 17, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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