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Protein

mRNA export factor

Gene

Rae1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.By similarity

GO - Molecular functioni

  • RNA binding Source: MGI
  • ubiquitin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3232142 SUMOylation of ubiquitinylation proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4085377 SUMOylation of SUMOylation proteins
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4570464 SUMOylation of RNA binding proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor
Alternative name(s):
Rae1 protein homolog
mRNA-associated protein mrnp 41
Gene namesi
Name:Rae1
Synonyms:Mrnp41
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913929 Rae1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002375861 – 368mRNA export factorAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C570
MaxQBiQ8C570
PaxDbiQ8C570
PeptideAtlasiQ8C570
PRIDEiQ8C570

PTM databases

iPTMnetiQ8C570
PhosphoSitePlusiQ8C570

Expressioni

Gene expression databases

BgeeiENSMUSG00000027509 Expressed in 286 organ(s), highest expression level in ear vesicle
CleanExiMM_RAE1
ExpressionAtlasiQ8C570 baseline and differential
GenevisibleiQ8C570 MM

Interactioni

Subunit structurei

Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (By similarity). Interacts with NUP98 (PubMed:10209021). Interacts with MYCBP2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211639, 1 interactor
IntActiQ8C570, 2 interactors
MINTiQ8C570
STRINGi10090.ENSMUSP00000029013

Structurei

3D structure databases

ProteinModelPortaliQ8C570
SMRiQ8C570
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 79WD 1Add BLAST43
Repeati84 – 114WD 2Add BLAST31
Repeati125 – 157WD 3Add BLAST33
Repeati168 – 206WD 4Add BLAST39
Repeati215 – 255WD 5Add BLAST41
Repeati271 – 301WD 6Add BLAST31
Repeati310 – 346WD 7Add BLAST37

Sequence similaritiesi

Belongs to the WD repeat rae1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0647 Eukaryota
ENOG410XQ1M LUCA
GeneTreeiENSGT00530000063440
HOGENOMiHOG000208823
HOVERGENiHBG002942
InParanoidiQ8C570
KOiK14298
OMAiHGTFSTC
OrthoDBiEOG091G09GO
PhylomeDBiQ8C570
TreeFamiTF105481

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037631 Gle2/RAE1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10971:SF11 PTHR10971:SF11, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C570-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFGSTSGF GTGGTSMFGS TTTDNHNPMK DIEVTSSPDD SIGCLSFSPP
60 70 80 90 100
TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK
110 120 130 140 150
VFTASCDKTA KMWDLNSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD
160 170 180 190 200
KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ
210 220 230 240 250
PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP
260 270 280 290 300
AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
310 320 330 340 350
DKDARTKLKT SEQLDQPIAA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK
360
NYIFLRNAAE ELKPRNKK
Length:368
Mass (Da):40,965
Last modified:March 1, 2003 - v1
Checksum:i5B1AA677E67F2C85
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ASC6A2ASC6_MOUSE
mRNA export factor
Rae1
203Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232A → T in BAE26867 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079383 mRNA Translation: BAC37627.1
AK146058 mRNA Translation: BAE26867.1
AK156681 mRNA Translation: BAE33805.1
BC059051 mRNA Translation: AAH59051.1
CCDSiCCDS17138.1
RefSeqiNP_780321.1, NM_175112.5
XP_006500086.1, XM_006500023.1
XP_006500087.1, XM_006500024.3
UniGeneiMm.4113

Genome annotation databases

EnsembliENSMUST00000029013; ENSMUSP00000029013; ENSMUSG00000027509
GeneIDi66679
KEGGimmu:66679
UCSCiuc008odg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079383 mRNA Translation: BAC37627.1
AK146058 mRNA Translation: BAE26867.1
AK156681 mRNA Translation: BAE33805.1
BC059051 mRNA Translation: AAH59051.1
CCDSiCCDS17138.1
RefSeqiNP_780321.1, NM_175112.5
XP_006500086.1, XM_006500023.1
XP_006500087.1, XM_006500024.3
UniGeneiMm.4113

3D structure databases

ProteinModelPortaliQ8C570
SMRiQ8C570
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211639, 1 interactor
IntActiQ8C570, 2 interactors
MINTiQ8C570
STRINGi10090.ENSMUSP00000029013

PTM databases

iPTMnetiQ8C570
PhosphoSitePlusiQ8C570

Proteomic databases

EPDiQ8C570
MaxQBiQ8C570
PaxDbiQ8C570
PeptideAtlasiQ8C570
PRIDEiQ8C570

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029013; ENSMUSP00000029013; ENSMUSG00000027509
GeneIDi66679
KEGGimmu:66679
UCSCiuc008odg.2 mouse

Organism-specific databases

CTDi8480
MGIiMGI:1913929 Rae1

Phylogenomic databases

eggNOGiKOG0647 Eukaryota
ENOG410XQ1M LUCA
GeneTreeiENSGT00530000063440
HOGENOMiHOG000208823
HOVERGENiHBG002942
InParanoidiQ8C570
KOiK14298
OMAiHGTFSTC
OrthoDBiEOG091G09GO
PhylomeDBiQ8C570
TreeFamiTF105481

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3232142 SUMOylation of ubiquitinylation proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4085377 SUMOylation of SUMOylation proteins
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4570464 SUMOylation of RNA binding proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs

Miscellaneous databases

PROiPR:Q8C570
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027509 Expressed in 286 organ(s), highest expression level in ear vesicle
CleanExiMM_RAE1
ExpressionAtlasiQ8C570 baseline and differential
GenevisibleiQ8C570 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037631 Gle2/RAE1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10971:SF11 PTHR10971:SF11, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAE1L_MOUSE
AccessioniPrimary (citable) accession number: Q8C570
Secondary accession number(s): Q3UKD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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