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Protein

Protein FAM118B

Gene

Fam118b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in Cajal bodies formation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM118B
Gene namesi
Name:Fam118b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924483 Fam118b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002951052 – 351Protein FAM118BAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9PhosphoserineBy similarity1
Modified residuei11N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8C569
PaxDbiQ8C569
PeptideAtlasiQ8C569
PRIDEiQ8C569

PTM databases

iPTMnetiQ8C569
PhosphoSitePlusiQ8C569

Expressioni

Gene expression databases

BgeeiENSMUSG00000050471 Expressed in 273 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8C569 baseline and differential
GenevisibleiQ8C569 MM

Structurei

3D structure databases

ProteinModelPortaliQ8C569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM118 family.Curated

Phylogenomic databases

eggNOGiENOG410IHIR Eukaryota
ENOG410YDRZ LUCA
GeneTreeiENSGT00390000010215
HOGENOMiHOG000072713
HOVERGENiHBG055230
InParanoidiQ8C569
OMAiCKMEHAG
OrthoDBiEOG091G0ABT
PhylomeDBiQ8C569
TreeFamiTF332439

Family and domain databases

InterProiView protein in InterPro
IPR038916 FAM118
IPR033352 FAM118B
IPR039444 SIR2-like
PANTHERiPTHR28623 PTHR28623, 1 hit
PTHR28623:SF1 PTHR28623:SF1, 1 hit
PfamiView protein in Pfam
PF13289 SIR2_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C569-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTGSQASD KNKIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG
60 70 80 90 100
ISAAVAPQVP ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL
110 120 130 140 150
VHVAHDLIQK LSPRTSNVRS TFFKDCLYEV FDDLESKMED SGKQLLQSVL
160 170 180 190 200
HLMENGALVL TTNFDNLLEL YAADQGKQLE SLDLTDEKKV LEWAQEKRKL
210 220 230 240 250
SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE NKSFLFLGCG
260 270 280 290 300
WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV
310 320 330 340 350
ISYGNDYADL PEYFKRLTCE ISTRGRSAGM AREGQLNGSS AAHGEIRGCS

T
Length:351
Mass (Da):39,508
Last modified:March 1, 2003 - v1
Checksum:i8082AF895A40FE32
GO
Isoform 2 (identifier: Q8C569-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-189: Missing.

Show »
Length:275
Mass (Da):30,822
Checksum:iC25DC8CED9ED8204
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1L4D3Z1L4_MOUSE
Protein FAM118B
Fam118b
268Annotation score:
F6Q255F6Q255_MOUSE
Protein FAM118B
Fam118b
123Annotation score:
A0A1L1SQJ7A0A1L1SQJ7_MOUSE
Protein FAM118B
Fam118b
45Annotation score:
A0A1L1SQ57A0A1L1SQ57_MOUSE
Protein FAM118B
Fam118b
31Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194A → D in BAE40129 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026730114 – 189Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028018 mRNA Translation: BAC25701.1
AK079397 mRNA Translation: BAC37632.1
AK081206 mRNA Translation: BAC38164.1
AK168168 mRNA Translation: BAE40129.1
AK169810 mRNA Translation: BAE41383.1
BC051180 mRNA Translation: AAH51180.1
CCDSiCCDS22960.1 [Q8C569-2]
CCDS22961.1 [Q8C569-1]
RefSeqiNP_001273533.1, NM_001286604.1 [Q8C569-1]
NP_780620.1, NM_175411.5 [Q8C569-2]
NP_919233.1, NM_194257.2 [Q8C569-1]
XP_006510000.1, XM_006509937.3 [Q8C569-1]
XP_011240684.1, XM_011242382.2 [Q8C569-1]
UniGeneiMm.24197

Genome annotation databases

EnsembliENSMUST00000059057; ENSMUSP00000058377; ENSMUSG00000050471 [Q8C569-1]
ENSMUST00000063782; ENSMUSP00000066281; ENSMUSG00000050471 [Q8C569-2]
ENSMUST00000121564; ENSMUSP00000113537; ENSMUSG00000050471 [Q8C569-1]
GeneIDi109229
KEGGimmu:109229
UCSCiuc009ota.2 mouse [Q8C569-1]
uc009otb.2 mouse [Q8C569-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028018 mRNA Translation: BAC25701.1
AK079397 mRNA Translation: BAC37632.1
AK081206 mRNA Translation: BAC38164.1
AK168168 mRNA Translation: BAE40129.1
AK169810 mRNA Translation: BAE41383.1
BC051180 mRNA Translation: AAH51180.1
CCDSiCCDS22960.1 [Q8C569-2]
CCDS22961.1 [Q8C569-1]
RefSeqiNP_001273533.1, NM_001286604.1 [Q8C569-1]
NP_780620.1, NM_175411.5 [Q8C569-2]
NP_919233.1, NM_194257.2 [Q8C569-1]
XP_006510000.1, XM_006509937.3 [Q8C569-1]
XP_011240684.1, XM_011242382.2 [Q8C569-1]
UniGeneiMm.24197

3D structure databases

ProteinModelPortaliQ8C569
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8C569
PhosphoSitePlusiQ8C569

Proteomic databases

EPDiQ8C569
PaxDbiQ8C569
PeptideAtlasiQ8C569
PRIDEiQ8C569

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059057; ENSMUSP00000058377; ENSMUSG00000050471 [Q8C569-1]
ENSMUST00000063782; ENSMUSP00000066281; ENSMUSG00000050471 [Q8C569-2]
ENSMUST00000121564; ENSMUSP00000113537; ENSMUSG00000050471 [Q8C569-1]
GeneIDi109229
KEGGimmu:109229
UCSCiuc009ota.2 mouse [Q8C569-1]
uc009otb.2 mouse [Q8C569-2]

Organism-specific databases

CTDi79607
MGIiMGI:1924483 Fam118b

Phylogenomic databases

eggNOGiENOG410IHIR Eukaryota
ENOG410YDRZ LUCA
GeneTreeiENSGT00390000010215
HOGENOMiHOG000072713
HOVERGENiHBG055230
InParanoidiQ8C569
OMAiCKMEHAG
OrthoDBiEOG091G0ABT
PhylomeDBiQ8C569
TreeFamiTF332439

Miscellaneous databases

ChiTaRSiFam118b mouse
PROiPR:Q8C569
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050471 Expressed in 273 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8C569 baseline and differential
GenevisibleiQ8C569 MM

Family and domain databases

InterProiView protein in InterPro
IPR038916 FAM118
IPR033352 FAM118B
IPR039444 SIR2-like
PANTHERiPTHR28623 PTHR28623, 1 hit
PTHR28623:SF1 PTHR28623:SF1, 1 hit
PfamiView protein in Pfam
PF13289 SIR2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF118B_MOUSE
AccessioniPrimary (citable) accession number: Q8C569
Secondary accession number(s): Q3THR7, Q8BNN4, Q8BT26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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