Tbl3

Functionⁱ

GO - Molecular functionⁱ

snoRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transducin beta-like protein 3
Gene namesⁱ	Name:Tbl3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:2384863 Tbl3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000362980	2 – 801	Transducin beta-like protein 3Add BLAST		800

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	257	PhosphoserineBy similarity	1
Cross-linkⁱ	407	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8C4J7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8C4J7
PaxDbⁱ	Q8C4J7
PeptideAtlas More...PeptideAtlasⁱ	Q8C4J7
PRIDEⁱ	Q8C4J7

PTM databases

iPTMnetⁱ	Q8C4J7
PhosphoSitePlusⁱ	Q8C4J7
SwissPalmⁱ	Q8C4J7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000040688 Expressed in 247 organ(s), highest expression level in midbrain
ExpressionAtlasⁱ	Q8C4J7 baseline and differential
Genevisibleⁱ	Q8C4J7 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	229469, 4 interactors
IntActⁱ	Q8C4J7, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q8C4J7
STRINGⁱ	10090.ENSMUSP00000120911

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8C4J7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	64 – 105	WD 1Add BLAST	42
Repeatⁱ	107 – 146	WD 2Add BLAST	40
Repeatⁱ	149 – 190	WD 3Add BLAST	42
Repeatⁱ	193 – 232	WD 4Add BLAST	40
Repeatⁱ	245 – 284	WD 5Add BLAST	40
Repeatⁱ	290 – 329	WD 6Add BLAST	40
Repeatⁱ	332 – 372	WD 7Add BLAST	41
Repeatⁱ	374 – 413	WD 8Add BLAST	40
Repeatⁱ	419 – 459	WD 9Add BLAST	41
Repeatⁱ	477 – 516	WD 10Add BLAST	40
Repeatⁱ	519 – 560	WD 11Add BLAST	42
Repeatⁱ	562 – 602	WD 12Add BLAST	41
Repeatⁱ	604 – 642	WD 13Add BLAST	39

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0319 Eukaryota ENOG410XPQD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150935
HOGENOMⁱ	HOG000188765
HOVERGENⁱ	HBG058869
InParanoidⁱ	Q8C4J7
KEGG Orthology (KO) More...KOⁱ	K14555
OMAⁱ	DNHEDRV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G029V
PhylomeDBⁱ	Q8C4J7
TreeFamⁱ	TF314872

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR013934 SSU_processome_Utp13 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08625 Utp13, 1 hit PF00400 WD40, 9 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 13 hits
SUPFAMⁱ	SSF50978 SSF50978, 2 hits
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 9 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8C4J7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAETAAGLCR FKANYAVERK IEPFYKGGKA QLDQTGHYLF CVCGTKVNIL 
        60         70         80         90        100
DVASGALLRS LEQEDQEDIT SFDLSPDDEV LVTASRALLL AQWAWREGTV 
       110        120        130        140        150
TRLWKAIHTA PVASMAFDAT STLLATGGCD GAVRVWDIVQ HYGTHHFRGS 
       160        170        180        190        200
PGVVHLVAFH PDPTRLLLFS SAVDTSIRVW SLQDRSCLAV LTAHYSAVTS 
       210        220        230        240        250
LSFSEGGHTM LSSGRDKICI VWDLQSYQTT RTVPVFESVE ASVLLPEQPA 
       260        270        280        290        300
PALGVKSSGL HFLTAGDQGI LRVWEAASGQ CVYTQPQMPG LRQELTHCTL 
       310        320        330        340        350
ARAADLLLTV TADHNLLLYE AHSLQLQKQF AGYSEEVLDV RFLGPSDSHI 
       360        370        380        390        400
VVASNSPCLK VFELQTLACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSI 
       410        420        430        440        450
RIWKMNKAGQ VACVAQGSGH THSVGTICCS RLKESFLVTG SQDCTVKLWP 
       460        470        480        490        500
LPEALLAKST AADSGPVLLQ AQTTRRCHDK DINSLAVSPN DKLLATGSQD 
       510        520        530        540        550
RTAKLWALPQ CQLLGVFTGH RRGLWNVQFS PTDQVLATAS ADGTIKLWAL 
       560        570        580        590        600
QDFSCLKTFE GHDASVLKVA FVSRGSQLLS SGSDGLLKLW TIKSNECVRT 
       610        620        630        640        650
LDAHEDKVWG LHCSQLDDHA ITGGSDSRII LWKDVTEAEQ AEEQAKREEQ 
       660        670        680        690        700
VIKQQELDNL LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE 
       710        720        730        740        750
ATVLRLRRDQ KEALLRFCVT WNTNSRHCHE AQAVLGVLLR HEAPEELLAY 
       760        770        780        790        800
DGVRGSLEAL LPYTERHFQR LSRTLQAATF LDFLWHNMKL SPCPAAAPPA 

L

Length:801

Mass (Da):88,266

Last modified:March 1, 2003 - v1

Checksum:ⁱ1B5AEE0CCB3D1B3D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F6YAR3	F6YAR3_MOUSE		Transducin beta-like protein 3 Transducin beta-like protein 3	Tbl3	299	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	18	E → G in BAE29182 (PubMed:16141072).Curated	1
Sequence conflictⁱ	457	A → AN in AAH19504 (PubMed:15489334).Curated	1
Sequence conflictⁱ	475	R → Q in AAH19504 (PubMed:15489334).Curated	1
Sequence conflictⁱ	483	N → K in BAE38045 (PubMed:16141072).Curated	1
Sequence conflictⁱ	797	A → V in AAH19504 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK081966 mRNA Translation: BAC38381.1 AK137554 mRNA Translation: BAE23405.1 AK149940 mRNA Translation: BAE29182.1 AK165125 mRNA Translation: BAE38045.1 BC019504 mRNA Translation: AAH19504.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28493.1
NCBI Reference Sequences More...RefSeqⁱ	NP_663371.2, NM_145396.4
UniGeneⁱ	Mm.100353

Genome annotation databases

Ensemblⁱ	ENSMUST00000126319; ENSMUSP00000120911; ENSMUSG00000040688
GeneIDⁱ	213773
KEGGⁱ	mmu:213773
UCSC genome browser More...UCSCⁱ	uc008axv.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8C4J7	Transducin beta-like protein 3		RAT		800	UniRef90_Q8C4J7
Transducin beta-like protein 3		CRIGR		802
transducin beta-like protein 3		MESAU		800
Uncharacterized protein		NEOLE		794
Uncharacterized protein		MOUSE		786
+7

Protein	Similar proteins		Species	Score	Length	Source
Q8C4J7	Transducin beta-like protein 3		RAT		800	UniRef50_Q8C4J7
Transducin beta-like protein 3		CRIGR		802
transducin beta-like protein 3		MESAU		800
Uncharacterized protein		NEOLE		794
Uncharacterized protein		MOUSE		786
+56

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK081966 mRNA Translation: BAC38381.1 AK137554 mRNA Translation: BAE23405.1 AK149940 mRNA Translation: BAE29182.1 AK165125 mRNA Translation: BAE38045.1 BC019504 mRNA Translation: AAH19504.1
CCDSⁱ	CCDS28493.1
RefSeqⁱ	NP_663371.2, NM_145396.4
UniGeneⁱ	Mm.100353

3D structure databases

ProteinModelPortalⁱ	Q8C4J7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229469, 4 interactors
IntActⁱ	Q8C4J7, 1 interactor
MINTⁱ	Q8C4J7
STRINGⁱ	10090.ENSMUSP00000120911

PTM databases

iPTMnetⁱ	Q8C4J7
PhosphoSitePlusⁱ	Q8C4J7
SwissPalmⁱ	Q8C4J7

Proteomic databases

EPDⁱ	Q8C4J7
MaxQBⁱ	Q8C4J7
PaxDbⁱ	Q8C4J7
PeptideAtlasⁱ	Q8C4J7
PRIDEⁱ	Q8C4J7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000126319; ENSMUSP00000120911; ENSMUSG00000040688
GeneIDⁱ	213773
KEGGⁱ	mmu:213773
UCSCⁱ	uc008axv.1 mouse

Organism-specific databases

CTDⁱ	10607
MGIⁱ	MGI:2384863 Tbl3

Phylogenomic databases

eggNOGⁱ	KOG0319 Eukaryota ENOG410XPQD LUCA
GeneTreeⁱ	ENSGT00930000150935
HOGENOMⁱ	HOG000188765
HOVERGENⁱ	HBG058869
InParanoidⁱ	Q8C4J7
KOⁱ	K14555
OMAⁱ	DNHEDRV
OrthoDBⁱ	EOG091G029V
PhylomeDBⁱ	Q8C4J7
TreeFamⁱ	TF314872

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8C4J7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040688 Expressed in 247 organ(s), highest expression level in midbrain
ExpressionAtlasⁱ	Q8C4J7 baseline and differential
Genevisibleⁱ	Q8C4J7 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR013934 SSU_processome_Utp13 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF08625 Utp13, 1 hit PF00400 WD40, 9 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 13 hits
SUPFAMⁱ	SSF50978 SSF50978, 2 hits
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 9 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TBL3_MOUSE
Accessionⁱ	Q8C4J7Primary (citable) accession number: Q8C4J7 Secondary accession number(s): Q3TNP3, Q3UDS9, Q8VE90
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8C4J7 (TBL3_MOUSE)

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Transducin beta-like protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ