UniProtKB - Q8C4J7 (TBL3_MOUSE)
Protein
Transducin beta-like protein 3
Gene
Tbl3
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- U3 snoRNA binding Source: GO_Central
GO - Biological processi
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Transducin beta-like protein 3 |
Gene namesi | Name:Tbl3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384863, Tbl3 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
Other locations
- 90S preribosome Source: GO_Central
- small-subunit processome Source: InterPro
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000362980 | 2 – 801 | Transducin beta-like protein 3Add BLAST | 800 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 257 | PhosphoserineBy similarity | 1 | |
Cross-linki | 407 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8C4J7 |
MaxQBi | Q8C4J7 |
PaxDbi | Q8C4J7 |
PeptideAtlasi | Q8C4J7 |
PRIDEi | Q8C4J7 |
PTM databases
iPTMneti | Q8C4J7 |
PhosphoSitePlusi | Q8C4J7 |
SwissPalmi | Q8C4J7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040688, Expressed in epiblast (generic) and 264 other tissues |
ExpressionAtlasi | Q8C4J7, baseline and differential |
Genevisiblei | Q8C4J7, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 229469, 5 interactors |
IntActi | Q8C4J7, 1 interactor |
MINTi | Q8C4J7 |
STRINGi | 10090.ENSMUSP00000120911 |
Miscellaneous databases
RNActi | Q8C4J7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 64 – 105 | WD 1Add BLAST | 42 | |
Repeati | 107 – 146 | WD 2Add BLAST | 40 | |
Repeati | 149 – 190 | WD 3Add BLAST | 42 | |
Repeati | 193 – 232 | WD 4Add BLAST | 40 | |
Repeati | 245 – 284 | WD 5Add BLAST | 40 | |
Repeati | 290 – 329 | WD 6Add BLAST | 40 | |
Repeati | 332 – 372 | WD 7Add BLAST | 41 | |
Repeati | 374 – 413 | WD 8Add BLAST | 40 | |
Repeati | 419 – 459 | WD 9Add BLAST | 41 | |
Repeati | 477 – 516 | WD 10Add BLAST | 40 | |
Repeati | 519 – 560 | WD 11Add BLAST | 42 | |
Repeati | 562 – 602 | WD 12Add BLAST | 41 | |
Repeati | 604 – 642 | WD 13Add BLAST | 39 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0319, Eukaryota |
GeneTreei | ENSGT00940000157651 |
HOGENOMi | CLU_009276_1_0_1 |
InParanoidi | Q8C4J7 |
OMAi | PYVQRHF |
OrthoDBi | 1112002at2759 |
PhylomeDBi | Q8C4J7 |
TreeFami | TF314872 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR013934, SSU_processome_Utp13 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF08625, Utp13, 1 hit PF00400, WD40, 9 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 13 hits |
SUPFAMi | SSF50978, SSF50978, 2 hits |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 9 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8C4J7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAETAAGLCR FKANYAVERK IEPFYKGGKA QLDQTGHYLF CVCGTKVNIL
60 70 80 90 100
DVASGALLRS LEQEDQEDIT SFDLSPDDEV LVTASRALLL AQWAWREGTV
110 120 130 140 150
TRLWKAIHTA PVASMAFDAT STLLATGGCD GAVRVWDIVQ HYGTHHFRGS
160 170 180 190 200
PGVVHLVAFH PDPTRLLLFS SAVDTSIRVW SLQDRSCLAV LTAHYSAVTS
210 220 230 240 250
LSFSEGGHTM LSSGRDKICI VWDLQSYQTT RTVPVFESVE ASVLLPEQPA
260 270 280 290 300
PALGVKSSGL HFLTAGDQGI LRVWEAASGQ CVYTQPQMPG LRQELTHCTL
310 320 330 340 350
ARAADLLLTV TADHNLLLYE AHSLQLQKQF AGYSEEVLDV RFLGPSDSHI
360 370 380 390 400
VVASNSPCLK VFELQTLACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSI
410 420 430 440 450
RIWKMNKAGQ VACVAQGSGH THSVGTICCS RLKESFLVTG SQDCTVKLWP
460 470 480 490 500
LPEALLAKST AADSGPVLLQ AQTTRRCHDK DINSLAVSPN DKLLATGSQD
510 520 530 540 550
RTAKLWALPQ CQLLGVFTGH RRGLWNVQFS PTDQVLATAS ADGTIKLWAL
560 570 580 590 600
QDFSCLKTFE GHDASVLKVA FVSRGSQLLS SGSDGLLKLW TIKSNECVRT
610 620 630 640 650
LDAHEDKVWG LHCSQLDDHA ITGGSDSRII LWKDVTEAEQ AEEQAKREEQ
660 670 680 690 700
VIKQQELDNL LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE
710 720 730 740 750
ATVLRLRRDQ KEALLRFCVT WNTNSRHCHE AQAVLGVLLR HEAPEELLAY
760 770 780 790 800
DGVRGSLEAL LPYTERHFQR LSRTLQAATF LDFLWHNMKL SPCPAAAPPA
L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6YAR3 | F6YAR3_MOUSE | Transducin beta-like protein 3 | Tbl3 | 299 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | E → G in BAE29182 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 457 | A → AN in AAH19504 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 475 | R → Q in AAH19504 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 483 | N → K in BAE38045 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 797 | A → V in AAH19504 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK081966 mRNA Translation: BAC38381.1 AK137554 mRNA Translation: BAE23405.1 AK149940 mRNA Translation: BAE29182.1 AK165125 mRNA Translation: BAE38045.1 BC019504 mRNA Translation: AAH19504.1 |
CCDSi | CCDS28493.1 |
RefSeqi | NP_663371.2, NM_145396.4 |
Genome annotation databases
Ensembli | ENSMUST00000126319; ENSMUSP00000120911; ENSMUSG00000040688 |
GeneIDi | 213773 |
KEGGi | mmu:213773 |
UCSCi | uc008axv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK081966 mRNA Translation: BAC38381.1 AK137554 mRNA Translation: BAE23405.1 AK149940 mRNA Translation: BAE29182.1 AK165125 mRNA Translation: BAE38045.1 BC019504 mRNA Translation: AAH19504.1 |
CCDSi | CCDS28493.1 |
RefSeqi | NP_663371.2, NM_145396.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 229469, 5 interactors |
IntActi | Q8C4J7, 1 interactor |
MINTi | Q8C4J7 |
STRINGi | 10090.ENSMUSP00000120911 |
PTM databases
iPTMneti | Q8C4J7 |
PhosphoSitePlusi | Q8C4J7 |
SwissPalmi | Q8C4J7 |
Proteomic databases
EPDi | Q8C4J7 |
MaxQBi | Q8C4J7 |
PaxDbi | Q8C4J7 |
PeptideAtlasi | Q8C4J7 |
PRIDEi | Q8C4J7 |
Protocols and materials databases
Antibodypediai | 23366, 53 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000126319; ENSMUSP00000120911; ENSMUSG00000040688 |
GeneIDi | 213773 |
KEGGi | mmu:213773 |
UCSCi | uc008axv.1, mouse |
Organism-specific databases
CTDi | 10607 |
MGIi | MGI:2384863, Tbl3 |
Phylogenomic databases
eggNOGi | KOG0319, Eukaryota |
GeneTreei | ENSGT00940000157651 |
HOGENOMi | CLU_009276_1_0_1 |
InParanoidi | Q8C4J7 |
OMAi | PYVQRHF |
OrthoDBi | 1112002at2759 |
PhylomeDBi | Q8C4J7 |
TreeFami | TF314872 |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 213773, 9 hits in 19 CRISPR screens |
ChiTaRSi | Tbl3, mouse |
PROi | PR:Q8C4J7 |
RNActi | Q8C4J7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040688, Expressed in epiblast (generic) and 264 other tissues |
ExpressionAtlasi | Q8C4J7, baseline and differential |
Genevisiblei | Q8C4J7, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR013934, SSU_processome_Utp13 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF08625, Utp13, 1 hit PF00400, WD40, 9 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 13 hits |
SUPFAMi | SSF50978, SSF50978, 2 hits |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 9 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBL3_MOUSE | |
Accessioni | Q8C4J7Primary (citable) accession number: Q8C4J7 Secondary accession number(s): Q3TNP3, Q3UDS9, Q8VE90 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 10, 2009 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot