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Entry version 119 (29 Sep 2021)
Sequence version 3 (26 Feb 2008)
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Protein

Putative Polycomb group protein ASXL3

Gene

Asxl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2221 – 2258PHD-type; atypicalAdd BLAST38

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative Polycomb group protein ASXL3
Alternative name(s):
Additional sex combs-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Asxl3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685175, Asxl3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000045215

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206711 – 2259Putative Polycomb group protein ASXL3Add BLAST2259

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C4A5

PRoteomics IDEntifications database

More...
PRIDEi
Q8C4A5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
281863 [Q8C4A5-1]
281864 [Q8C4A5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C4A5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C4A5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045215, Expressed in superior cervical ganglion and 200 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C4A5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229278, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000095260

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C4A5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C4A5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 83HTH HARE-typePROSITE-ProRule annotationAdd BLAST74
Domaini253 – 362DEUBADPROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni181 – 230DisorderedSequence analysisAdd BLAST50
Regioni364 – 399DisorderedSequence analysisAdd BLAST36
Regioni607 – 643DisorderedSequence analysisAdd BLAST37
Regioni703 – 810DisorderedSequence analysisAdd BLAST108
Regioni857 – 1012DisorderedSequence analysisAdd BLAST156
Regioni1025 – 1049DisorderedSequence analysisAdd BLAST25
Regioni1126 – 1151DisorderedSequence analysisAdd BLAST26
Regioni1433 – 1462DisorderedSequence analysisAdd BLAST30
Regioni1614 – 1643DisorderedSequence analysisAdd BLAST30
Regioni1687 – 1719DisorderedSequence analysisAdd BLAST33
Regioni1993 – 2075DisorderedSequence analysisAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi188 – 203Polar residuesSequence analysisAdd BLAST16
Compositional biasi204 – 218Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi377 – 399Polar residuesSequence analysisAdd BLAST23
Compositional biasi703 – 786Polar residuesSequence analysisAdd BLAST84
Compositional biasi920 – 946Polar residuesSequence analysisAdd BLAST27
Compositional biasi947 – 984Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi1029 – 1049Polar residuesSequence analysisAdd BLAST21
Compositional biasi1126 – 1149Polar residuesSequence analysisAdd BLAST24
Compositional biasi1433 – 1455Polar residuesSequence analysisAdd BLAST23
Compositional biasi1698 – 1719Polar residuesSequence analysisAdd BLAST22
Compositional biasi2020 – 2060Pro residuesSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Asx family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2221 – 2258PHD-type; atypicalAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWPH, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055578

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001823_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C4A5

Database of Orthologous Groups

More...
OrthoDBi
53757at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328464

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026905, ASX-like_PHD
IPR024811, ASX/ASX-like
IPR028020, ASX_DEUBAD_dom
IPR024818, ASXL3
IPR007759, Asxl_HARE-HTH
IPR044867, DEUBAD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13578, PTHR13578, 1 hit
PTHR13578:SF18, PTHR13578:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13919, ASXH, 1 hit
PF05066, HARE-HTH, 1 hit
PF13922, PHD_3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51916, DEUBAD, 1 hit
PS51913, HTH_HARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C4A5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDKRKKKDR TWAEAARLAL EKHPNSPMTA KQILEVIQKE GLKETGTSPL
60 70 80 90 100
ACLNAMLHTN TRVGDGTFFK IPGKSGLYAL RKEESSCPVD GTLDLVVDPD
110 120 130 140 150
LDGAEMAEAS ANGEENRVCT KQVTDEVSST RDCSLTNTAV QSKLVSSFQQ
160 170 180 190 200
HTKKALKQAL RQQQKRRNGV SMMVNKTVPR VVLTPLKVSD EQSDSPSGSE
210 220 230 240 250
SKNGEADSSD KEMKHGQKSP TGKQTSQHLK RLKKSGLGHL KWTKAEDIDI
260 270 280 290 300
ETPGSILVNT NLRALINKHT FASFPQHFQQ YLLLLLPEVD RQMGSDGILR
310 320 330 340 350
LSTSALNNEF FAYAAQGWKQ RLAEGEFTPE MQLRIRQEIE KEKKTEPWKE
360 370 380 390 400
KFFERFYGER SGMSREESIK LTSGPNHEGA EGSSSHGDSG IPGPSAQNAL
410 420 430 440 450
EEQQPKILKS SASLEPDFCT TVCPMLEVPV KDVMTESETE DIFIPEESVI
460 470 480 490 500
QEEVAEEVET SIYECQDEHL KTIPAFSEES ESPATPCEEP QVAAPEDSLE
510 520 530 540 550
SCVVMNDILH TLPHIEVKIV EKLECPQEEM SVVIDQLEIC DSLLPCPSSV
560 570 580 590 600
THILDVEQKE QETTIETSAM ALREGPSSLE SQLPNEGIAV DMELQSDPEE
610 620 630 640 650
QLSENACISE TSFSSESPEG ACASLPSPGG ETQSTSEESC TPASLETTFC
660 670 680 690 700
SEVSSTENTD KYNQRNPTGE SLHASLVSEV SPLATSPEIS EASLMSNLPL
710 720 730 740 750
TSEASPVSNL PLTSEASPMS DLPPTSETSS ESSMPLTSET PFVSSLPIPA
760 770 780 790 800
ETSPISNSSV NERMVHQQRK SPSGSEEANS PQKEEPSIPT KPLGESLVSH
810 820 830 840 850
PKPLSTIPEP INMSSAMVPE ALPPEGLHSQ TLSQEPCNAH VEMEKLYASS
860 870 880 890 900
IPELPSSEMT KVKNHSVLQR PEKKGLSAPL EVPVFSEETE TKGIELPPAK
910 920 930 940 950
LQDKQYAPSV DKATFLEGSR NKIHKQSSTL NRLETSHTSK VSEPSKSPDG
960 970 980 990 1000
IRNDNRESEI SKRKTVEHSF GICKEKRARI EDDQSARSLA SSSPPEKEQP
1010 1020 1030 1040 1050
PREEPRVPPL KIQLSKIGPP FIIKSQPVSK AESRASTSTS VSSGRNTGAR
1060 1070 1080 1090 1100
TLADIKARAQ QARAQREAAA AAAVAAAASI VSGAMGSPGE GGKARTLAHI
1110 1120 1130 1140 1150
KEQTKAKLFA KHQSRAHLFQ TSKETRLPSV STKEDSLNME ASPTPETKME
1160 1170 1180 1190 1200
GSTGVIIINP NCRSPSSKPT HIREITTVLQ QPLNPPQIPE TATDLSVHSS
1210 1220 1230 1240 1250
DDNIPVSHLT EKIVSSTSSE NSSVPILHNK SPINPIPMSV CSTAMSGAIK
1260 1270 1280 1290 1300
EHPFVSPVDK SSVLMSVDSA NSTISACNIS MLKSIQGSDA PCIALVPKCI
1310 1320 1330 1340 1350
NRTPIPAAPE GTGQSNSMDG KALLVPSSKA ANVISNQYTS VPAPTIASNL
1360 1370 1380 1390 1400
PNHLCTSSVL IPPTGINNRF VSEKIAMPGS EEQAAVSIGA TMRTALSCGD
1410 1420 1430 1440 1450
SVAVTDSLVP RSPIAMFAGN MLTANSYNCP PKLSGENLDN NSGPLNRTDN
1460 1470 1480 1490 1500
SEKPQQPAGG FVPATINRSI PCKVIVDHST TLTSNLSLTV SIESGDSSLD
1510 1520 1530 1540 1550
SQTRSVRTDV SIQPVACPQV SVISRPEQAT SEGLDHGSVF IAAPTAKQDC
1560 1570 1580 1590 1600
KTLQATCTSL RELPLTLPDK LNEVTVPTHG FAEQARNSST FKKETDTACS
1610 1620 1630 1640 1650
NQYNPGNRIC WSEDPMRNTA PPVVSHSSSS KQKEHPEQTG LKAVKTEHVS
1660 1670 1680 1690 1700
YAHVSDLHPR NLITNVSLPV KPEPHEVDKG FRMDTEDFPG PERPPPVTEV
1710 1720 1730 1740 1750
TSSASVQPTQ TMKPSTTSPV EEAISLAPDT LKRIPSASSS SCRLSSVEAN
1760 1770 1780 1790 1800
NPLVTQLLQG NLPLEKVLPQ PRLGAKLEIN RLPLPLQTTS VGKTGLERNM
1810 1820 1830 1840 1850
VEMPSSSPNP DGKGYLAGTL APVQMRKREN HPKKRAARTV GDHAQVKCEP
1860 1870 1880 1890 1900
GKMVMEPDVK AVPCVISPSM SQLGHNQPFK QERLNKPSMA NRIMPSPEVK
1910 1920 1930 1940 1950
QQKRLLPACS FQPSLFHVNK NEGFHADTGT SHRQQFYQMP MAARGPLPTP
1960 1970 1980 1990 2000
ALLQNSPKTP VGCNAFAFNR HLEQKALGDV NLPTAPHQLR LANMLSPNMP
2010 2020 2030 2040 2050
IKEGEDGGGT THTMPSKAVV HAPLPPPPPP PPPPPPPLAL PPPPPPPPPL
2060 2070 2080 2090 2100
PPPLPTVEVP SDQKQPPVNM ETTKRLSWPQ STGICSNIKS EPLSFEESLS
2110 2120 2130 2140 2150
SSCELGMKQV PYDQNEVKEQ LKAFALKNAD FSSYLLSEPQ KPFTQLAAQK
2160 2170 2180 2190 2200
LPVPQQQPLC GSYPTIHFGS TNFKRAASAI EKSIGILGSG SNPATSTGLT
2210 2220 2230 2240 2250
GQNTQMPVQN FADNSNADEL ELKCSCRLKA MIVCKGCGAF CHDDCIGPSK

LCVACLVVR
Length:2,259
Mass (Da):243,673
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1968675ABC6704B
GO
Isoform 2 (identifier: Q8C4A5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Show »
Length:2,204
Mass (Da):237,516
Checksum:i59E3615BDB6B9DEE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A668KLS4A0A668KLS4_MOUSE
Putative Polycomb group protein ASX...
Asxl3
2,260Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0317201 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC103351 Genomic DNA No translation available.
AC163208 Genomic DNA No translation available.
AK082659 mRNA Translation: BAC38564.2
AK086668 mRNA Translation: BAC39715.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50234.1 [Q8C4A5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001161249.1, NM_001167777.1 [Q8C4A5-2]
XP_011245170.1, XM_011246868.1 [Q8C4A5-2]
XP_017173342.1, XM_017317853.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000097655; ENSMUSP00000095260; ENSMUSG00000045215 [Q8C4A5-2]
ENSMUST00000120223; ENSMUSP00000112793; ENSMUSG00000045215 [Q8C4A5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
211961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:211961

UCSC genome browser

More...
UCSCi
uc008efm.2, mouse [Q8C4A5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103351 Genomic DNA No translation available.
AC163208 Genomic DNA No translation available.
AK082659 mRNA Translation: BAC38564.2
AK086668 mRNA Translation: BAC39715.1
CCDSiCCDS50234.1 [Q8C4A5-2]
RefSeqiNP_001161249.1, NM_001167777.1 [Q8C4A5-2]
XP_011245170.1, XM_011246868.1 [Q8C4A5-2]
XP_017173342.1, XM_017317853.1

3D structure databases

SMRiQ8C4A5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229278, 2 interactors
STRINGi10090.ENSMUSP00000095260

PTM databases

iPTMnetiQ8C4A5
PhosphoSitePlusiQ8C4A5

Proteomic databases

PaxDbiQ8C4A5
PRIDEiQ8C4A5
ProteomicsDBi281863 [Q8C4A5-1]
281864 [Q8C4A5-2]

Genome annotation databases

EnsembliENSMUST00000097655; ENSMUSP00000095260; ENSMUSG00000045215 [Q8C4A5-2]
ENSMUST00000120223; ENSMUSP00000112793; ENSMUSG00000045215 [Q8C4A5-2]
GeneIDi211961
KEGGimmu:211961
UCSCiuc008efm.2, mouse [Q8C4A5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80816
MGIiMGI:2685175, Asxl3
VEuPathDBiHostDB:ENSMUSG00000045215

Phylogenomic databases

eggNOGiENOG502QWPH, Eukaryota
GeneTreeiENSGT00520000055578
HOGENOMiCLU_001823_0_0_1
InParanoidiQ8C4A5
OrthoDBi53757at2759
TreeFamiTF328464

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
211961, 1 hit in 65 CRISPR screens

Protein Ontology

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PROi
PR:Q8C4A5
RNActiQ8C4A5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000045215, Expressed in superior cervical ganglion and 200 other tissues
GenevisibleiQ8C4A5, MM

Family and domain databases

InterProiView protein in InterPro
IPR026905, ASX-like_PHD
IPR024811, ASX/ASX-like
IPR028020, ASX_DEUBAD_dom
IPR024818, ASXL3
IPR007759, Asxl_HARE-HTH
IPR044867, DEUBAD_dom
PANTHERiPTHR13578, PTHR13578, 1 hit
PTHR13578:SF18, PTHR13578:SF18, 1 hit
PfamiView protein in Pfam
PF13919, ASXH, 1 hit
PF05066, HARE-HTH, 1 hit
PF13922, PHD_3, 1 hit
PROSITEiView protein in PROSITE
PS51916, DEUBAD, 1 hit
PS51913, HTH_HARE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASXL3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C4A5
Secondary accession number(s): Q8C380
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 29, 2021
This is version 119 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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