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Protein

Putative Polycomb group protein ASXL3

Gene

Asxl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2221 – 2258PHD-type; atypicalAdd BLAST38

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • DNA binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • peroxisome proliferator activated receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Polycomb group protein ASXL3
Alternative name(s):
Additional sex combs-like protein 3
Gene namesi
Name:Asxl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2685175 Asxl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206711 – 2259Putative Polycomb group protein ASXL3Add BLAST2259

Proteomic databases

PaxDbiQ8C4A5
PRIDEiQ8C4A5

PTM databases

iPTMnetiQ8C4A5
PhosphoSitePlusiQ8C4A5

Expressioni

Gene expression databases

BgeeiENSMUSG00000045215 Expressed in 168 organ(s), highest expression level in rostral migratory stream
CleanExiMM_ASXL3
GenevisibleiQ8C4A5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095260

Structurei

3D structure databases

SMRiQ8C4A5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi609 – 759Ser-richAdd BLAST151
Compositional biasi1049 – 1078Ala-richAdd BLAST30
Compositional biasi2023 – 2067Pro-richAdd BLAST45

Sequence similaritiesi

Belongs to the Asx family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2221 – 2258PHD-type; atypicalAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIF3 Eukaryota
ENOG4111F3G LUCA
GeneTreeiENSGT00520000055578
HOGENOMiHOG000034113
HOVERGENiHBG100451
InParanoidiQ8C4A5
KOiK11471
OMAiDKGFRMD
OrthoDBiEOG091G0C66
TreeFamiTF328464

Family and domain databases

InterProiView protein in InterPro
IPR026905 ASX-like_PHD
IPR024811 ASX/ASX-like
IPR028020 ASXH
IPR024818 ASXL3
IPR007759 HB1/Asxl_HTH
PANTHERiPTHR13578 PTHR13578, 1 hit
PTHR13578:SF18 PTHR13578:SF18, 1 hit
PfamiView protein in Pfam
PF13919 ASXH, 1 hit
PF05066 HARE-HTH, 1 hit
PF13922 PHD_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C4A5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDKRKKKDR TWAEAARLAL EKHPNSPMTA KQILEVIQKE GLKETGTSPL
60 70 80 90 100
ACLNAMLHTN TRVGDGTFFK IPGKSGLYAL RKEESSCPVD GTLDLVVDPD
110 120 130 140 150
LDGAEMAEAS ANGEENRVCT KQVTDEVSST RDCSLTNTAV QSKLVSSFQQ
160 170 180 190 200
HTKKALKQAL RQQQKRRNGV SMMVNKTVPR VVLTPLKVSD EQSDSPSGSE
210 220 230 240 250
SKNGEADSSD KEMKHGQKSP TGKQTSQHLK RLKKSGLGHL KWTKAEDIDI
260 270 280 290 300
ETPGSILVNT NLRALINKHT FASFPQHFQQ YLLLLLPEVD RQMGSDGILR
310 320 330 340 350
LSTSALNNEF FAYAAQGWKQ RLAEGEFTPE MQLRIRQEIE KEKKTEPWKE
360 370 380 390 400
KFFERFYGER SGMSREESIK LTSGPNHEGA EGSSSHGDSG IPGPSAQNAL
410 420 430 440 450
EEQQPKILKS SASLEPDFCT TVCPMLEVPV KDVMTESETE DIFIPEESVI
460 470 480 490 500
QEEVAEEVET SIYECQDEHL KTIPAFSEES ESPATPCEEP QVAAPEDSLE
510 520 530 540 550
SCVVMNDILH TLPHIEVKIV EKLECPQEEM SVVIDQLEIC DSLLPCPSSV
560 570 580 590 600
THILDVEQKE QETTIETSAM ALREGPSSLE SQLPNEGIAV DMELQSDPEE
610 620 630 640 650
QLSENACISE TSFSSESPEG ACASLPSPGG ETQSTSEESC TPASLETTFC
660 670 680 690 700
SEVSSTENTD KYNQRNPTGE SLHASLVSEV SPLATSPEIS EASLMSNLPL
710 720 730 740 750
TSEASPVSNL PLTSEASPMS DLPPTSETSS ESSMPLTSET PFVSSLPIPA
760 770 780 790 800
ETSPISNSSV NERMVHQQRK SPSGSEEANS PQKEEPSIPT KPLGESLVSH
810 820 830 840 850
PKPLSTIPEP INMSSAMVPE ALPPEGLHSQ TLSQEPCNAH VEMEKLYASS
860 870 880 890 900
IPELPSSEMT KVKNHSVLQR PEKKGLSAPL EVPVFSEETE TKGIELPPAK
910 920 930 940 950
LQDKQYAPSV DKATFLEGSR NKIHKQSSTL NRLETSHTSK VSEPSKSPDG
960 970 980 990 1000
IRNDNRESEI SKRKTVEHSF GICKEKRARI EDDQSARSLA SSSPPEKEQP
1010 1020 1030 1040 1050
PREEPRVPPL KIQLSKIGPP FIIKSQPVSK AESRASTSTS VSSGRNTGAR
1060 1070 1080 1090 1100
TLADIKARAQ QARAQREAAA AAAVAAAASI VSGAMGSPGE GGKARTLAHI
1110 1120 1130 1140 1150
KEQTKAKLFA KHQSRAHLFQ TSKETRLPSV STKEDSLNME ASPTPETKME
1160 1170 1180 1190 1200
GSTGVIIINP NCRSPSSKPT HIREITTVLQ QPLNPPQIPE TATDLSVHSS
1210 1220 1230 1240 1250
DDNIPVSHLT EKIVSSTSSE NSSVPILHNK SPINPIPMSV CSTAMSGAIK
1260 1270 1280 1290 1300
EHPFVSPVDK SSVLMSVDSA NSTISACNIS MLKSIQGSDA PCIALVPKCI
1310 1320 1330 1340 1350
NRTPIPAAPE GTGQSNSMDG KALLVPSSKA ANVISNQYTS VPAPTIASNL
1360 1370 1380 1390 1400
PNHLCTSSVL IPPTGINNRF VSEKIAMPGS EEQAAVSIGA TMRTALSCGD
1410 1420 1430 1440 1450
SVAVTDSLVP RSPIAMFAGN MLTANSYNCP PKLSGENLDN NSGPLNRTDN
1460 1470 1480 1490 1500
SEKPQQPAGG FVPATINRSI PCKVIVDHST TLTSNLSLTV SIESGDSSLD
1510 1520 1530 1540 1550
SQTRSVRTDV SIQPVACPQV SVISRPEQAT SEGLDHGSVF IAAPTAKQDC
1560 1570 1580 1590 1600
KTLQATCTSL RELPLTLPDK LNEVTVPTHG FAEQARNSST FKKETDTACS
1610 1620 1630 1640 1650
NQYNPGNRIC WSEDPMRNTA PPVVSHSSSS KQKEHPEQTG LKAVKTEHVS
1660 1670 1680 1690 1700
YAHVSDLHPR NLITNVSLPV KPEPHEVDKG FRMDTEDFPG PERPPPVTEV
1710 1720 1730 1740 1750
TSSASVQPTQ TMKPSTTSPV EEAISLAPDT LKRIPSASSS SCRLSSVEAN
1760 1770 1780 1790 1800
NPLVTQLLQG NLPLEKVLPQ PRLGAKLEIN RLPLPLQTTS VGKTGLERNM
1810 1820 1830 1840 1850
VEMPSSSPNP DGKGYLAGTL APVQMRKREN HPKKRAARTV GDHAQVKCEP
1860 1870 1880 1890 1900
GKMVMEPDVK AVPCVISPSM SQLGHNQPFK QERLNKPSMA NRIMPSPEVK
1910 1920 1930 1940 1950
QQKRLLPACS FQPSLFHVNK NEGFHADTGT SHRQQFYQMP MAARGPLPTP
1960 1970 1980 1990 2000
ALLQNSPKTP VGCNAFAFNR HLEQKALGDV NLPTAPHQLR LANMLSPNMP
2010 2020 2030 2040 2050
IKEGEDGGGT THTMPSKAVV HAPLPPPPPP PPPPPPPLAL PPPPPPPPPL
2060 2070 2080 2090 2100
PPPLPTVEVP SDQKQPPVNM ETTKRLSWPQ STGICSNIKS EPLSFEESLS
2110 2120 2130 2140 2150
SSCELGMKQV PYDQNEVKEQ LKAFALKNAD FSSYLLSEPQ KPFTQLAAQK
2160 2170 2180 2190 2200
LPVPQQQPLC GSYPTIHFGS TNFKRAASAI EKSIGILGSG SNPATSTGLT
2210 2220 2230 2240 2250
GQNTQMPVQN FADNSNADEL ELKCSCRLKA MIVCKGCGAF CHDDCIGPSK

LCVACLVVR
Length:2,259
Mass (Da):243,673
Last modified:February 26, 2008 - v3
Checksum:iD1968675ABC6704B
GO
Isoform 2 (identifier: Q8C4A5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Note: No experimental confirmation available.
Show »
Length:2,204
Mass (Da):237,516
Checksum:i59E3615BDB6B9DEE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317201 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103351 Genomic DNA No translation available.
AC163208 Genomic DNA No translation available.
AK082659 mRNA Translation: BAC38564.2
AK086668 mRNA Translation: BAC39715.1
CCDSiCCDS50234.1 [Q8C4A5-2]
RefSeqiNP_001161249.1, NM_001167777.1 [Q8C4A5-2]
XP_011245170.1, XM_011246868.1 [Q8C4A5-2]
XP_017173342.1, XM_017317853.1 [Q8C4A5-2]
UniGeneiMm.392310

Genome annotation databases

EnsembliENSMUST00000097655; ENSMUSP00000095260; ENSMUSG00000045215 [Q8C4A5-2]
ENSMUST00000120223; ENSMUSP00000112793; ENSMUSG00000045215 [Q8C4A5-2]
GeneIDi211961
KEGGimmu:211961
UCSCiuc008efm.2 mouse [Q8C4A5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103351 Genomic DNA No translation available.
AC163208 Genomic DNA No translation available.
AK082659 mRNA Translation: BAC38564.2
AK086668 mRNA Translation: BAC39715.1
CCDSiCCDS50234.1 [Q8C4A5-2]
RefSeqiNP_001161249.1, NM_001167777.1 [Q8C4A5-2]
XP_011245170.1, XM_011246868.1 [Q8C4A5-2]
XP_017173342.1, XM_017317853.1 [Q8C4A5-2]
UniGeneiMm.392310

3D structure databases

SMRiQ8C4A5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095260

PTM databases

iPTMnetiQ8C4A5
PhosphoSitePlusiQ8C4A5

Proteomic databases

PaxDbiQ8C4A5
PRIDEiQ8C4A5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097655; ENSMUSP00000095260; ENSMUSG00000045215 [Q8C4A5-2]
ENSMUST00000120223; ENSMUSP00000112793; ENSMUSG00000045215 [Q8C4A5-2]
GeneIDi211961
KEGGimmu:211961
UCSCiuc008efm.2 mouse [Q8C4A5-1]

Organism-specific databases

CTDi80816
MGIiMGI:2685175 Asxl3

Phylogenomic databases

eggNOGiENOG410IIF3 Eukaryota
ENOG4111F3G LUCA
GeneTreeiENSGT00520000055578
HOGENOMiHOG000034113
HOVERGENiHBG100451
InParanoidiQ8C4A5
KOiK11471
OMAiDKGFRMD
OrthoDBiEOG091G0C66
TreeFamiTF328464

Miscellaneous databases

PROiPR:Q8C4A5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045215 Expressed in 168 organ(s), highest expression level in rostral migratory stream
CleanExiMM_ASXL3
GenevisibleiQ8C4A5 MM

Family and domain databases

InterProiView protein in InterPro
IPR026905 ASX-like_PHD
IPR024811 ASX/ASX-like
IPR028020 ASXH
IPR024818 ASXL3
IPR007759 HB1/Asxl_HTH
PANTHERiPTHR13578 PTHR13578, 1 hit
PTHR13578:SF18 PTHR13578:SF18, 1 hit
PfamiView protein in Pfam
PF13919 ASXH, 1 hit
PF05066 HARE-HTH, 1 hit
PF13922 PHD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASXL3_MOUSE
AccessioniPrimary (citable) accession number: Q8C4A5
Secondary accession number(s): Q8C380
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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