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Protein

Aquaporin-6

Gene

Aqp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.By similarity

GO - Molecular functioni

  • nitrate transmembrane transporter activity Source: MGI
  • water channel activity Source: MGI

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-6
Short name:
AQP-6
Gene namesi
Name:Aqp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1341204 Aqp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 45HelicalSequence analysisAdd BLAST18
Topological domaini46 – 51ExtracellularSequence analysis6
Transmembranei52 – 70HelicalSequence analysisAdd BLAST19
Topological domaini71 – 96CytoplasmicSequence analysisAdd BLAST26
Transmembranei97 – 118HelicalSequence analysisAdd BLAST22
Topological domaini119 – 138ExtracellularSequence analysisAdd BLAST20
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 165CytoplasmicSequence analysis6
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Topological domaini186 – 211ExtracellularSequence analysisAdd BLAST26
Transmembranei212 – 233HelicalSequence analysisAdd BLAST22
Topological domaini234 – 293CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639561 – 293Aquaporin-6Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8C4A0
PRIDEiQ8C4A0

PTM databases

PhosphoSitePlusiQ8C4A0

Expressioni

Gene expression databases

BgeeiENSMUSG00000043144 Expressed in 126 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_AQP6
ExpressionAtlasiQ8C4A0 baseline and differential
GenevisibleiQ8C4A0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023754

Structurei

3D structure databases

ProteinModelPortaliQ8C4A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi79 – 81NPA 13
Motifi193 – 195NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG000312
InParanoidiQ8C4A0
KOiK09868
OMAiVHWVFWV
OrthoDBiEOG091G166T
PhylomeDBiQ8C4A0
TreeFamiTF312940

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023254 Aquaporin_6
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PTHR19139:SF113 PTHR19139:SF113, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02018 AQUAPORIN6
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C4A0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGLCSRAY LLVGGLWTAI SKALFAEFLA TGLYVFFGVG SVLPWPVALP
60 70 80 90 100
SVLQIAITFN LATATAVQIS WKTSGAHANP AVTLAYLVGS HISLPRAMAY
110 120 130 140 150
IAAQLAGATA GAALLYGVTP GGIRETLGVN VVHNSTSTGQ AVAVELVLTL
160 170 180 190 200
QLVLCVFASM DGRQTLASPA AMIGTSVALG HLIGIYFTGC SMNPARSFGP
210 220 230 240 250
AVIVGKFAVH WIFWVGPLTG AVLASLIYNF ILFPDTKTVA QRLAILVGTT
260 270 280 290
KVEKVVDLEP QKKESQTNSE DTECLTSPCE EAVRSFSFTL GLC
Length:293
Mass (Da):30,709
Last modified:March 1, 2003 - v1
Checksum:iA48282992451ECEE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14BV5Q14BV5_MOUSE
Aqp6 protein
Aqp6 AQP6, mCG_20140
276Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082699 mRNA Translation: BAC38576.1
CCDSiCCDS27824.1
RefSeqiNP_780296.1, NM_175087.4
UniGeneiMm.202309

Genome annotation databases

EnsembliENSMUST00000023754; ENSMUSP00000023754; ENSMUSG00000043144
GeneIDi11831
KEGGimmu:11831
UCSCiuc007xpw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082699 mRNA Translation: BAC38576.1
CCDSiCCDS27824.1
RefSeqiNP_780296.1, NM_175087.4
UniGeneiMm.202309

3D structure databases

ProteinModelPortaliQ8C4A0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023754

PTM databases

PhosphoSitePlusiQ8C4A0

Proteomic databases

PaxDbiQ8C4A0
PRIDEiQ8C4A0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023754; ENSMUSP00000023754; ENSMUSG00000043144
GeneIDi11831
KEGGimmu:11831
UCSCiuc007xpw.1 mouse

Organism-specific databases

CTDi363
MGIiMGI:1341204 Aqp6

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG000312
InParanoidiQ8C4A0
KOiK09868
OMAiVHWVFWV
OrthoDBiEOG091G166T
PhylomeDBiQ8C4A0
TreeFamiTF312940

Miscellaneous databases

PROiPR:Q8C4A0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043144 Expressed in 126 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_AQP6
ExpressionAtlasiQ8C4A0 baseline and differential
GenevisibleiQ8C4A0 MM

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023254 Aquaporin_6
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PTHR19139:SF113 PTHR19139:SF113, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02018 AQUAPORIN6
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAQP6_MOUSE
AccessioniPrimary (citable) accession number: Q8C4A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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