UniProtKB - Q8C437 (PEX5R_MOUSE)
Protein
PEX5-related protein
Gene
Pex5l
Organism
Mus musculus (Mouse)
Status
Functioni
Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.2 Publications
GO - Molecular functioni
- intracellular cyclic nucleotide activated cation channel activity Source: MGI
- peroxisome matrix targeting signal-1 binding Source: MGI
- peroxisome targeting sequence binding Source: MGI
- Rab GTPase binding Source: MGI
- small GTPase binding Source: MGI
GO - Biological processi
- maintenance of protein location Source: MGI
- positive regulation of corticotropin secretion Source: MGI
- protein import into peroxisome matrix, docking Source: GO_Central
- regulated exocytosis Source: MGI
- regulation of cAMP-mediated signaling Source: UniProtKB
- regulation of membrane potential Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: PEX5-related proteinAlternative name(s): PEX2-related protein PEX5-like protein Peroxin-5-related protein Tetratricopeptide repeat-containing Rab8b-interacting protein Short name: Pex5Rp Short name: TRIP8b |
Gene namesi | Name:Pex5l Synonyms:Pex2, Pex5r, Pxr2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916672, Pex5l |
Subcellular locationi
Other locations
- Cytoplasm By similarity
- Membrane By similarity; Peripheral membrane protein By similarity
Note: Some fraction is membrane associated via its interaction with RAB8B.By similarity
Cytosol
- cytosol Source: MGI
Peroxisome
- peroxisomal membrane Source: GO_Central
Other locations
- cell tip Source: MGI
- cytoplasm Source: MGI
- dendrite Source: MGI
- intracellular cyclic nucleotide activated cation channel complex Source: MGI
- perinuclear region of cytoplasm Source: MGI
- receptor complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106318 | 1 – 567 | PEX5-related proteinAdd BLAST | 567 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Modified residuei | 194 | PhosphoserineBy similarity | 1 | |
Modified residuei | 198 | PhosphoserineBy similarity | 1 | |
Modified residuei | 202 | PhosphoserineCombined sources | 1 | |
Modified residuei | 386 | PhosphoserineCombined sources | 1 | |
Modified residuei | 388 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q8C437 |
PRIDEi | Q8C437 |
PTM databases
iPTMneti | Q8C437 |
PhosphoSitePlusi | Q8C437 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027674, Expressed in retinal neural layer and 152 other tissues |
Genevisiblei | Q8C437, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- Rab GTPase binding Source: MGI
- small GTPase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 208454, 44 interactors |
IntActi | Q8C437, 45 interactors |
STRINGi | 10090.ENSMUSP00000103861 |
Miscellaneous databases
RNActi | Q8C437, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8C437 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 267 – 300 | TPR 1Add BLAST | 34 | |
Repeati | 301 – 334 | TPR 2Add BLAST | 34 | |
Repeati | 336 – 368 | TPR 3Add BLAST | 33 | |
Repeati | 415 – 448 | TPR 4Add BLAST | 34 | |
Repeati | 450 – 482 | TPR 5Add BLAST | 33 | |
Repeati | 484 – 516 | TPR 6Add BLAST | 33 |
Sequence similaritiesi
Belongs to the peroxisomal targeting signal receptor family.Curated
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1125, Eukaryota |
GeneTreei | ENSGT00940000155931 |
HOGENOMi | CLU_013516_1_0_1 |
InParanoidi | Q8C437 |
OMAi | KYKYIAK |
OrthoDBi | 588648at2759 |
PhylomeDBi | Q8C437 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR024112, PEX5-rel IPR024111, PTS1R_family IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR10130, PTHR10130, 1 hit PTHR10130:SF1, PTHR10130:SF1, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 2 hits |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8C437-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYQGHMQLVN EQQESRPLLS PSIDDFLCET KSEAIAKPVT SNTAVLTTGL
60 70 80 90 100
DLLDLSEPVS QPQTKAKKSE PSSKSSSLKK KADGSDLISA DAEQRAQALR
110 120 130 140 150
GPETSSLDLD IQTQLEKWDD VKFHGDRTSK GHLMAERKSC SSRTGSKELL
160 170 180 190 200
WSAEHRSQPE LSTGKSALNS ESASELELVA PAQARLTKEH RWGSALLSRN
210 220 230 240 250
HSLEEEFERA KAAVESDTEF WDKMQAEWEE MARRNWISEN QEAQNQVTVS
260 270 280 290 300
ASEKGYYFHT ENPFKDWPGA FEEGLKRLKE GDLPVTILFM EAAILQDPGD
310 320 330 340 350
AEAWQFLGIT QAENENEQAA IVALQRCLEL QPNNLKALMA LAVSYTNTSH
360 370 380 390 400
QQDACEALKN WIKQNPKYKY LVKNKKGSPG LTRRMSKSPV DSSVLEGVKE
410 420 430 440 450
LYLEAAHQNG DMIDPDLQTG LGVLFHLSGE FNRAIDAFNA ALTVRPEDYS
460 470 480 490 500
LWNRLGATLA NGDRSEEAVE AYTRALEIQP GFIRSRYNLG ISCINLGAYR
510 520 530 540 550
EAVSNFLTAL SLQRKSRNQQ QVPHPAISGN IWAALRIALS LMDQPELFQA
560
ANLGDLDVLL RAFNLDP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8SLQ1 | F8SLQ1_MOUSE | PEX5-related protein | Pex5l | 650 | Annotation score: | ||
F8SLP9 | F8SLP9_MOUSE | PEX5-related protein | Pex5l | 567 | Annotation score: | ||
D3YYH0 | D3YYH0_MOUSE | PEX5-related protein | Pex5l | 591 | Annotation score: | ||
F8SLQ3 | F8SLQ3_MOUSE | PEX5-related protein | Pex5l | 615 | Annotation score: |
Sequence cautioni
The sequence BAC38781 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | P → T (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 564 | N → K in BAB24376 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010437 | 1 – 223 | Missing in isoform 4. 1 PublicationAdd BLAST | 223 | |
Alternative sequenceiVSP_010439 | 1 – 6 | MYQGHM → MSDSEMDGRTHIPSLLNALL SRNRVMQMSYLKSKEQGYGK LSSDEDLEIIVDQK in isoform 3. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032591 mRNA Translation: BAA92877.1 AK006035 mRNA Translation: BAB24376.1 AK083141 mRNA Translation: BAC38781.1 Different initiation. |
CCDSi | CCDS17302.1 [Q8C437-3] CCDS50888.1 [Q8C437-4] CCDS50889.1 [Q8C437-1] |
RefSeqi | NP_001156988.1, NM_001163516.3 NP_001156989.1, NM_001163517.3 [Q8C437-4] |
Genome annotation databases
Ensembli | ENSMUST00000108221; ENSMUSP00000103856; ENSMUSG00000027674 [Q8C437-4] |
GeneIDi | 58869 |
KEGGi | mmu:58869 |
UCSCi | uc008owt.3, mouse [Q8C437-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032591 mRNA Translation: BAA92877.1 AK006035 mRNA Translation: BAB24376.1 AK083141 mRNA Translation: BAC38781.1 Different initiation. |
CCDSi | CCDS17302.1 [Q8C437-3] CCDS50888.1 [Q8C437-4] CCDS50889.1 [Q8C437-1] |
RefSeqi | NP_001156988.1, NM_001163516.3 NP_001156989.1, NM_001163517.3 [Q8C437-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4EQF | X-ray | 3.00 | A | 206-567 | [»] | |
SMRi | Q8C437 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 208454, 44 interactors |
IntActi | Q8C437, 45 interactors |
STRINGi | 10090.ENSMUSP00000103861 |
PTM databases
iPTMneti | Q8C437 |
PhosphoSitePlusi | Q8C437 |
Proteomic databases
PaxDbi | Q8C437 |
PRIDEi | Q8C437 |
Protocols and materials databases
ABCDi | Q8C437, 4 sequenced antibodies |
Antibodypediai | 54548, 43 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000108221; ENSMUSP00000103856; ENSMUSG00000027674 [Q8C437-4] |
GeneIDi | 58869 |
KEGGi | mmu:58869 |
UCSCi | uc008owt.3, mouse [Q8C437-1] |
Organism-specific databases
CTDi | 51555 |
MGIi | MGI:1916672, Pex5l |
Phylogenomic databases
eggNOGi | KOG1125, Eukaryota |
GeneTreei | ENSGT00940000155931 |
HOGENOMi | CLU_013516_1_0_1 |
InParanoidi | Q8C437 |
OMAi | KYKYIAK |
OrthoDBi | 588648at2759 |
PhylomeDBi | Q8C437 |
Miscellaneous databases
BioGRID-ORCSi | 58869, 0 hits in 17 CRISPR screens |
ChiTaRSi | Pex5l, mouse |
PROi | PR:Q8C437 |
RNActi | Q8C437, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027674, Expressed in retinal neural layer and 152 other tissues |
Genevisiblei | Q8C437, MM |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR024112, PEX5-rel IPR024111, PTS1R_family IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR10130, PTHR10130, 1 hit PTHR10130:SF1, PTHR10130:SF1, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 2 hits |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PEX5R_MOUSE | |
Accessioni | Q8C437Primary (citable) accession number: Q8C437 Secondary accession number(s): Q8CA31, Q9DAA1, Q9JMB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | May 24, 2004 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families