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Protein

Protein YIPF4

Gene

Yipf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maintenance of the Golgi structure.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF4
Alternative name(s):
YIP1 family member 4
Gene namesi
Name:Yipf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1915114 Yipf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 115CytoplasmicBy similarityAdd BLAST115
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 140LumenalCurated4
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 168CytoplasmicCurated7
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 197LumenalCurated8
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 225CytoplasmicCurated7
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426331 – 246Protein YIPF4Add BLAST246

Proteomic databases

PaxDbiQ8C407
PeptideAtlasiQ8C407
PRIDEiQ8C407
TopDownProteomicsiQ8C407-1 [Q8C407-1]

PTM databases

iPTMnetiQ8C407
PhosphoSitePlusiQ8C407

Expressioni

Gene expression databases

BgeeiENSMUSG00000024072 Expressed in 288 organ(s), highest expression level in seminal vesicle
CleanExiMM_YIPF4
GenevisibleiQ8C407 MM

Interactioni

Subunit structurei

Interacts with YIPF3 and YIPF5.By similarity

Protein-protein interaction databases

BioGridi212491, 2 interactors
IntActiQ8C407, 2 interactors
STRINGi10090.ENSMUSP00000024873

Structurei

3D structure databases

ProteinModelPortaliQ8C407
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQ6V Eukaryota
ENOG4111EZE LUCA
GeneTreeiENSGT00730000111152
HOGENOMiHOG000285931
HOVERGENiHBG056534
InParanoidiQ8C407
OMAiQFSPTNG
OrthoDBiEOG091G0J2I
PhylomeDBiQ8C407
TreeFamiTF315055

Family and domain databases

InterProiView protein in InterPro
IPR006977 Yip1
PfamiView protein in Pfam
PF04893 Yip1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C407-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPGPPPAY APANGDFTFV SSADAEDLSG SIAAPDVKLN LGVSGDFIKE
60 70 80 90 100
STATTFLRQR GYGWLLEVED EDPEDNKPLL EELDIDLKDI YYKIRCVLMP
110 120 130 140 150
MPSLGFNRQV VRDNPDFWGP LAVVLFFSMI SLYGQFRVVS WIITIWIFGS
160 170 180 190 200
LTIFLLARVL GGEVAYGQVL GVIGYSLLPL IVIAPILLVV GSFEMVSTLI
210 220 230 240
KLFGVFWAAY SAASLLVGEE FKTKKPLLIY PIFLLYIYFL SLYTGV
Length:246
Mass (Da):27,283
Last modified:March 1, 2003 - v1
Checksum:iCE59292A71ED818F
GO
Isoform 2 (identifier: Q8C407-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MQPPGPPPAYAPANGDFTFVSSADAED → MKKQVDFDID...EKKFQFKDEH

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):32,783
Checksum:iAFB284E0005F6CA6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194571 – 27MQPPG…ADAED → MKKQVDFDIDMEIPGDEPLR PQHLKSRGREIPELKASLDY TVIKFSACRGYILKPCLNKV EKKFQFKDEH in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083301 mRNA Translation: BAC38852.1
AK159227 mRNA Translation: BAE34913.1
AK166347 mRNA Translation: BAE38721.1
BC003936 mRNA Translation: AAH03936.1
CCDSiCCDS28971.1 [Q8C407-1]
RefSeqiNP_080693.2, NM_026417.4 [Q8C407-1]
UniGeneiMm.41891

Genome annotation databases

EnsembliENSMUST00000024873; ENSMUSP00000024873; ENSMUSG00000024072 [Q8C407-1]
GeneIDi67864
KEGGimmu:67864
UCSCiuc008dod.2 mouse [Q8C407-1]
uc012axg.2 mouse [Q8C407-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083301 mRNA Translation: BAC38852.1
AK159227 mRNA Translation: BAE34913.1
AK166347 mRNA Translation: BAE38721.1
BC003936 mRNA Translation: AAH03936.1
CCDSiCCDS28971.1 [Q8C407-1]
RefSeqiNP_080693.2, NM_026417.4 [Q8C407-1]
UniGeneiMm.41891

3D structure databases

ProteinModelPortaliQ8C407
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212491, 2 interactors
IntActiQ8C407, 2 interactors
STRINGi10090.ENSMUSP00000024873

PTM databases

iPTMnetiQ8C407
PhosphoSitePlusiQ8C407

Proteomic databases

PaxDbiQ8C407
PeptideAtlasiQ8C407
PRIDEiQ8C407
TopDownProteomicsiQ8C407-1 [Q8C407-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024873; ENSMUSP00000024873; ENSMUSG00000024072 [Q8C407-1]
GeneIDi67864
KEGGimmu:67864
UCSCiuc008dod.2 mouse [Q8C407-1]
uc012axg.2 mouse [Q8C407-2]

Organism-specific databases

CTDi84272
MGIiMGI:1915114 Yipf4

Phylogenomic databases

eggNOGiENOG410IQ6V Eukaryota
ENOG4111EZE LUCA
GeneTreeiENSGT00730000111152
HOGENOMiHOG000285931
HOVERGENiHBG056534
InParanoidiQ8C407
OMAiQFSPTNG
OrthoDBiEOG091G0J2I
PhylomeDBiQ8C407
TreeFamiTF315055

Miscellaneous databases

PROiPR:Q8C407
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024072 Expressed in 288 organ(s), highest expression level in seminal vesicle
CleanExiMM_YIPF4
GenevisibleiQ8C407 MM

Family and domain databases

InterProiView protein in InterPro
IPR006977 Yip1
PfamiView protein in Pfam
PF04893 Yip1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYIPF4_MOUSE
AccessioniPrimary (citable) accession number: Q8C407
Secondary accession number(s): Q99KZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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