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UniProtKB - Q8C3X8 (LMF2_MOUSE)
Protein
Lipase maturation factor 2
Gene
Lmf2
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).
By similarityGO - Biological processi
- protein maturation Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-8963889, Assembly of active LPL and LIPC lipase complexes |
Names & Taxonomyi
Protein namesi | Recommended name: Lipase maturation factor 2Alternative name(s): Transmembrane protein 112B Transmembrane protein 153 |
Gene namesi | Name:Lmf2 Synonyms:Tmem112b, Tmem153 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2146015, Lmf2 |
VEuPathDBi | HostDB:ENSMUSG00000022614 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 75 – 95 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 226 – 246 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 259 – 279 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 316 – 336 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 363 – 383 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 636 – 656 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324511 | 1 – 702 | Lipase maturation factor 2Add BLAST | 702 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 488 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8C3X8 |
jPOSTi | Q8C3X8 |
MaxQBi | Q8C3X8 |
PaxDbi | Q8C3X8 |
PeptideAtlasi | Q8C3X8 |
PRIDEi | Q8C3X8 |
ProteomicsDBi | 290049 |
PTM databases
GlyGeni | Q8C3X8, 1 site |
iPTMneti | Q8C3X8 |
PhosphoSitePlusi | Q8C3X8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022614, Expressed in dorsal pancreas and 222 other tissues |
ExpressionAtlasi | Q8C3X8, baseline and differential |
Genevisiblei | Q8C3X8, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 222935, 2 interactors |
STRINGi | 10090.ENSMUSP00000023283 |
Miscellaneous databases
RNActi | Q8C3X8, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 660 – 702 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 663 – 679 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 680 – 694 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the lipase maturation factor family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTN6, Eukaryota |
GeneTreei | ENSGT00530000063702 |
HOGENOMi | CLU_020557_1_0_1 |
InParanoidi | Q8C3X8 |
OMAi | YKPGNVN |
OrthoDBi | 759759at2759 |
PhylomeDBi | Q8C3X8 |
TreeFami | TF314339 |
Family and domain databases
InterProi | View protein in InterPro IPR009613, LMF |
PANTHERi | PTHR14463, PTHR14463, 1 hit |
Pfami | View protein in Pfam PF06762, LMF1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8C3X8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSRVPQQL FLQGVAAVYL FAFASLYTQI PGLYGPEGIL PARRTLRPQG
60 70 80 90 100
KGLWQQLWET PTLLWEAPRL GLDTAQGLDL LTLLGTVLAL GALLLNSLRH
110 120 130 140 150
PFVYLLLWVA YRSAYQVGQV FLYFQWDSLL LETGFLAILV APLRGPSKHK
160 170 180 190 200
ILQGRLAGAL PHEDLPFWLV RWLLFRLMFA SGVVKLTSRC PTWWGLTALT
210 220 230 240 250
YHYETQCLPT PAAWFAHHLP VWLHKLSVVA TFLIEIAVPP LFFAPIRRLR
260 270 280 290 300
LTAFYAQALL QVLIIITGNY NFFNLLTLVL TTALLDDRHL SAEPGLRCHK
310 320 330 340 350
KMPTSWPKAL LTALSLLLEL TVYGLLAYGT VYYFGLEVDW QQHIILSKTT
360 370 380 390 400
FTFHQFSQWL KTVTLPTVWL GTASLAWELL VVLWRWIQVQ GWSRKFSAGI
410 420 430 440 450
QLSVLGTATV ALFLISLVPY SYVEPGTHGR LWTGAHRLFG SVEHLQLANS
460 470 480 490 500
YGLFRRMTGV GGRPEVVLEG SYDGQHWTEI EFMYKPGNVS RPPPFLTPHQ
510 520 530 540 550
PRLDWQMWFA ALGPHTHSPW FTGLVLRLLQ GKEPVIRLVQ SHVANYPFHE
560 570 580 590 600
RPPTYLRAQR YKYWFSKPGD QSRWWHRQWV EEFFPSVSLG DPTLETLLQQ
610 620 630 640 650
FGLKDKSPPR ARSPSNGLAQ TLNWVRTQLS PLEPPILLWG LFGAVVAIRV
660 670 680 690 700
VQTLLAPRPL QSSKQTREEK RKQTSKKDSR AASEQAAANS NSRDSWAPRR
KK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8VKK1 | A0A2R8VKK1_MOUSE | Lipase maturation factor 2 | Lmf2 | 81 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK084606 mRNA Translation: BAC39228.1 AK149916 mRNA Translation: BAE29164.1 AK149934 mRNA Translation: BAE29177.1 AK171488 mRNA Translation: BAE42488.1 BC079532 mRNA Translation: AAH79532.1 |
CCDSi | CCDS27746.1 |
RefSeqi | NP_849250.1, NM_178919.4 |
Genome annotation databases
Ensembli | ENSMUST00000023283; ENSMUSP00000023283; ENSMUSG00000022614 |
GeneIDi | 105847 |
KEGGi | mmu:105847 |
UCSCi | uc007xgd.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK084606 mRNA Translation: BAC39228.1 AK149916 mRNA Translation: BAE29164.1 AK149934 mRNA Translation: BAE29177.1 AK171488 mRNA Translation: BAE42488.1 BC079532 mRNA Translation: AAH79532.1 |
CCDSi | CCDS27746.1 |
RefSeqi | NP_849250.1, NM_178919.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 222935, 2 interactors |
STRINGi | 10090.ENSMUSP00000023283 |
PTM databases
GlyGeni | Q8C3X8, 1 site |
iPTMneti | Q8C3X8 |
PhosphoSitePlusi | Q8C3X8 |
Proteomic databases
EPDi | Q8C3X8 |
jPOSTi | Q8C3X8 |
MaxQBi | Q8C3X8 |
PaxDbi | Q8C3X8 |
PeptideAtlasi | Q8C3X8 |
PRIDEi | Q8C3X8 |
ProteomicsDBi | 290049 |
Protocols and materials databases
Antibodypediai | 28648, 127 antibodies from 21 providers |
Genome annotation databases
Ensembli | ENSMUST00000023283; ENSMUSP00000023283; ENSMUSG00000022614 |
GeneIDi | 105847 |
KEGGi | mmu:105847 |
UCSCi | uc007xgd.2, mouse |
Organism-specific databases
CTDi | 91289 |
MGIi | MGI:2146015, Lmf2 |
VEuPathDBi | HostDB:ENSMUSG00000022614 |
Phylogenomic databases
eggNOGi | ENOG502QTN6, Eukaryota |
GeneTreei | ENSGT00530000063702 |
HOGENOMi | CLU_020557_1_0_1 |
InParanoidi | Q8C3X8 |
OMAi | YKPGNVN |
OrthoDBi | 759759at2759 |
PhylomeDBi | Q8C3X8 |
TreeFami | TF314339 |
Enzyme and pathway databases
Reactomei | R-MMU-8963889, Assembly of active LPL and LIPC lipase complexes |
Miscellaneous databases
BioGRID-ORCSi | 105847, 1 hit in 65 CRISPR screens |
ChiTaRSi | Lmf2, mouse |
PROi | PR:Q8C3X8 |
RNActi | Q8C3X8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022614, Expressed in dorsal pancreas and 222 other tissues |
ExpressionAtlasi | Q8C3X8, baseline and differential |
Genevisiblei | Q8C3X8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR009613, LMF |
PANTHERi | PTHR14463, PTHR14463, 1 hit |
Pfami | View protein in Pfam PF06762, LMF1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LMF2_MOUSE | |
Accessioni | Q8C3X8Primary (citable) accession number: Q8C3X8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families