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UniProtKB - Q8C3U9 (Q8C3U9_MOUSE)
Protein
Submitted name:
Zinc finger and BTB domain-containing 37
Gene
Zbtb37
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger and BTB domain-containing 37 |
Gene namesi | Name:Zbtb37Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444467, Zbtb37 |
VEuPathDBi | HostDB:ENSMUSG00000043467 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000043467, Expressed in zygote and 141 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 98 | BTBInterPro annotationAdd BLAST | 65 | |
Domaini | 375 – 402 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 403 – 430 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 431 – 459 | C2H2-typeInterPro annotationAdd BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 141 – 174 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 190 – 209 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 283 – 339 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 459 – 504 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 141 – 156 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 157 – 174 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 283 – 321 | Polar residuesSequence analysisAdd BLAST | 39 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159554 |
HOGENOMi | CLU_029118_0_0_1 |
OMAi | TERMEDW |
OrthoDBi | 1318335at2759 |
TreeFami | TF331184 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8C3U9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMEKSGNIQ LEIPDFSNSV LSHLNQLRMQ GRLCDIVVNV QGQAFRAHKV
60 70 80 90 100
VLAASSPYFR DHMSLNEMST VSISVIKNPT VFEQLLSFCY TGRICLQLAD
110 120 130 140 150
IISYLTAASF LQMQHIIDKC TQILEGIHFK INVAEVEAEL SQTRTKHQER
160 170 180 190 200
PPESHRATPN LNRSLSPRHN ASKGNWRGQV SAVLDIRELS PPEEPTSPQI
210 220 230 240 250
IEQSSDAEGR EPILRINRAG QWYVETGLAD QGARSGDEVR VLGAVHIKTE
260 270 280 290 300
NLEEWLGPEN QPSGEDGSSA EEVTAMVIDT TGHGSIGQES YTLGSSGAKV
310 320 330 340 350
ARPTSSEVDR FSPSGSVVSM TERHRARSES PGRMDEPKQL SSQVEESAMM
360 370 380 390 400
GVSAYVEYLR EQEVSERWFR YNPRLTCIYC AKSFNQKGSL DRHMRLHMGI
410 420 430 440 450
TPFVCRMCGK KYTRKDQLEY HIRKHTGNKP FHCHVCGKSF PFQAILNQHF
460 470 480 490 500
RKNHPGCIPL EGPHSISPET TVTSRQAEEG SPSHEEIVAP GESAQGSVST
TGPD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF7ALN1 | F7ALN1_MOUSE | Zinc finger and BTB domain-containi... | Zbtb37 | 310 | Annotation score: | ||
H3BJ23 | H3BJ23_MOUSE | Zinc finger and BTB domain-containi... | Zbtb37 | 98 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK084871 mRNA Translation: BAC39299.1 AK166242 mRNA Translation: BAE38656.1 |
RefSeqi | NP_775600.1, NM_173424.3 XP_006496901.1, XM_006496838.2 XP_011237113.1, XM_011238811.1 XP_011237114.1, XM_011238812.1 XP_011237115.1, XM_011238813.1 XP_011237116.1, XM_011238814.2 XP_011237117.1, XM_011238815.1 XP_011237118.1, XM_011238816.2 XP_011237119.1, XM_011238817.2 XP_011237120.1, XM_011238818.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK084871 mRNA Translation: BAC39299.1 AK166242 mRNA Translation: BAE38656.1 |
RefSeqi | NP_775600.1, NM_173424.3 XP_006496901.1, XM_006496838.2 XP_011237113.1, XM_011238811.1 XP_011237114.1, XM_011238812.1 XP_011237115.1, XM_011238813.1 XP_011237116.1, XM_011238814.2 XP_011237117.1, XM_011238815.1 XP_011237118.1, XM_011238816.2 XP_011237119.1, XM_011238817.2 XP_011237120.1, XM_011238818.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000125253 |
Proteomic databases
ProteomicsDBi | 329011 |
Protocols and materials databases
Antibodypediai | 20565, 70 antibodies from 19 providers |
DNASUi | 240869 |
Genome annotation databases
Organism-specific databases
CTDi | 84614 |
MGIi | MGI:2444467, Zbtb37 |
VEuPathDBi | HostDB:ENSMUSG00000043467 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159554 |
HOGENOMi | CLU_029118_0_0_1 |
OMAi | TERMEDW |
OrthoDBi | 1318335at2759 |
TreeFami | TF331184 |
Miscellaneous databases
BioGRID-ORCSi | 240869, 2 hits in 72 CRISPR screens |
ChiTaRSi | Zbtb37, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000043467, Expressed in zygote and 141 other tissues |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8C3U9_MOUSE | |
Accessioni | Q8C3U9Primary (citable) accession number: Q8C3U9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |