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Protein

Transport and Golgi organization protein 6 homolog

Gene

Tango6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transport and Golgi organization protein 6 homolog
Alternative name(s):
Transmembrane and coiled-coil domain-containing protein 7
Gene namesi
Name:Tango6
Synonyms:Kiaa1746, Tmco7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142786 Tango6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050601 – 1079Transport and Golgi organization protein 6 homologAdd BLAST1079

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei561PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C3S2
PeptideAtlasiQ8C3S2
PRIDEiQ8C3S2

PTM databases

iPTMnetiQ8C3S2
PhosphoSitePlusiQ8C3S2

Expressioni

Gene expression databases

BgeeiENSMUSG00000041949 Expressed in 159 organ(s), highest expression level in ear vesicle
CleanExiMM_TMCO7
ExpressionAtlasiQ8C3S2 baseline and differential
GenevisibleiQ8C3S2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043953

Structurei

3D structure databases

ProteinModelPortaliQ8C3S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati864 – 902HEAT 1Add BLAST39
Repeati937 – 973HEAT 2Add BLAST37

Sequence similaritiesi

Belongs to the Tango6 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4653 Eukaryota
ENOG410XS2I LUCA
GeneTreeiENSGT00390000010938
HOGENOMiHOG000154637
HOVERGENiHBG057050
InParanoidiQ8C3S2
OMAiFTLFCFT
OrthoDBiEOG091G02MW
PhylomeDBiQ8C3S2
TreeFamiTF330876

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019451 Rtp1_C1
IPR019414 Rtp1_C2
IPR039600 TANGO6/Rtp1
PANTHERiPTHR20959 PTHR20959, 1 hit
PfamiView protein in Pfam
PF10363 RTP1_C1, 1 hit
PF10304 RTP1_C2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C3S2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASGPAAAA PSGVLVTCGL EQVLEALKLL LSPGGSGSSS LQNTKHDVLL
60 70 80 90 100
QTLKSNLSAL EAKFLKDAQW KKLKALRDEL ADKAEWPQSS EDITWSFTSQ
110 120 130 140 150
TLLLLLCLKE VLARLVADFN PGKPNPRTPE AAPALSPDTL SVSQQKTFQS
160 170 180 190 200
VLQFVVTLGV CPYLIPGVGV PLRDRTEFGA VVQDVVRLEA APHATRRLYI
210 220 230 240 250
CCRVLLDLAQ HASLGSLIFC RHFGDIAAGL CQLGFCPTKR KPPGPVEEVL
260 270 280 290 300
TEEERTLSRR ALRDILDQVY QPLAVRELLT LQGGPRQPCT DVKTQLRCRA
310 320 330 340 350
QAPAWLRRLC GQLLSERLMR PNGVQAVVRG ILEGAGAGAA GGSDAEATAA
360 370 380 390 400
DWRKCDLIAK ILASCPQQSL SPESYYKDIC PQILDLFHLQ DKLTARQFQR
410 420 430 440 450
VATTTFITLS RERPELAAKY LLQPMLAPLQ RCLSTAEIPE SDMVPGAILV
460 470 480 490 500
TEEELSRCVE DVFKVYVVAN EPVPVLLDSL LPLLRVFFSL YCFTQQSVSH
510 520 530 540 550
IRSLCQEILL WILVKLERKK AIASLKGFSG LDKTVPTLHP QCQFRAATHG
560 570 580 590 600
GIVITAKEAI SDDEDEALYQ KVSSEQSQVE HLGDLLLHCQ QCGLAGDFFI
610 620 630 640 650
FCLKELSHLL EDREAEFTPK PSCYASLLEL EHHQTLLIED QERKLQVLQL
660 670 680 690 700
LAVLCEKMSE QIFTHVTQVV DFVAATLQRA CAGLAHEAES AVGSQTLSMS
710 720 730 740 750
MGLVAVMLGG AVQLKSSDFA VLKQLLPLLE RVSNTYPDPV IQELAADLRI
760 770 780 790 800
TISTHGAFST DAVSTAAQST LNQKDPGQKI EEQRQTSPDI STEGAQKPPR
810 820 830 840 850
TGQGSSGPCT ATSQPPGSIT TQQFREVLLS ACDPEVPTRA AALRTLARWV
860 870 880 890 900
EQREARALEE QKKLLQIFLE NLEHEDSFVY LSAIQGIALL SDVYPEEILV
910 920 930 940 950
DLLAKYDSGK DKHTPETRMK VGEVLMRVVR ALGDMVSKYR EPLIHTFLRG
960 970 980 990 1000
VRDPDAAHRA SSLANLGELC QCLHFLLGPV VHEVTACLIA VAKTDNDVQV
1010 1020 1030 1040 1050
RRAAVHVVVL LLRGLSQKAT EVLSDVLRDL YHLLKHVVRL EPDDVAKLHA
1060 1070
QLALEELDEI MRNFLFPPQK LEKKIVVLP
Length:1,079
Mass (Da):118,732
Last modified:March 1, 2003 - v1
Checksum:iB3C3B425C7DCB3DC
GO
Isoform 2 (identifier: Q8C3S2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-915: IALLSDVYPEEILVDLLAKYDSGKDKHTP → KLTWTKMISCSLRGTATRHNWLFVHLSAP
     916-1079: Missing.

Note: No experimental confirmation available.
Show »
Length:915
Mass (Da):100,401
Checksum:iF5A5EBF730471DD1
GO
Isoform 3 (identifier: Q8C3S2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     886-891: Missing.

Note: No experimental confirmation available.
Show »
Length:1,073
Mass (Da):118,178
Checksum:i39A037AFE7C3E420
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLK1A0A1D5RLK1_MOUSE
Transport and Golgi organization pr...
Tango6
481Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti568L → P in AAH66869 (PubMed:15489334).Curated1
Sequence conflicti568L → P in AAH69838 (PubMed:15489334).Curated1
Sequence conflicti1067P → L in AAH66869 (PubMed:15489334).Curated1
Sequence conflicti1067P → L in AAH69838 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028206886 – 891Missing in isoform 3. 1 Publication6
Alternative sequenceiVSP_028207887 – 915IALLS…DKHTP → KLTWTKMISCSLRGTATRHN WLFVHLSAP in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_028208916 – 1079Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047206 mRNA Translation: BAC32990.1
AK054283 mRNA Translation: BAC35717.1
AK085030 mRNA Translation: BAC39344.1
BC066869 mRNA Translation: AAH66869.1
BC069838 mRNA Translation: AAH69838.1
AK173250 mRNA Translation: BAD32528.1
CCDSiCCDS22639.1 [Q8C3S2-1]
RefSeqiNP_766625.1, NM_173037.1 [Q8C3S2-1]
UniGeneiMm.87151

Genome annotation databases

EnsembliENSMUST00000048359; ENSMUSP00000043953; ENSMUSG00000041949 [Q8C3S2-1]
GeneIDi272538
KEGGimmu:272538
UCSCiuc009ngk.1 mouse [Q8C3S2-2]
uc009ngl.1 mouse [Q8C3S2-1]
uc012gjv.1 mouse [Q8C3S2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047206 mRNA Translation: BAC32990.1
AK054283 mRNA Translation: BAC35717.1
AK085030 mRNA Translation: BAC39344.1
BC066869 mRNA Translation: AAH66869.1
BC069838 mRNA Translation: AAH69838.1
AK173250 mRNA Translation: BAD32528.1
CCDSiCCDS22639.1 [Q8C3S2-1]
RefSeqiNP_766625.1, NM_173037.1 [Q8C3S2-1]
UniGeneiMm.87151

3D structure databases

ProteinModelPortaliQ8C3S2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043953

PTM databases

iPTMnetiQ8C3S2
PhosphoSitePlusiQ8C3S2

Proteomic databases

PaxDbiQ8C3S2
PeptideAtlasiQ8C3S2
PRIDEiQ8C3S2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048359; ENSMUSP00000043953; ENSMUSG00000041949 [Q8C3S2-1]
GeneIDi272538
KEGGimmu:272538
UCSCiuc009ngk.1 mouse [Q8C3S2-2]
uc009ngl.1 mouse [Q8C3S2-1]
uc012gjv.1 mouse [Q8C3S2-3]

Organism-specific databases

CTDi79613
MGIiMGI:2142786 Tango6
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4653 Eukaryota
ENOG410XS2I LUCA
GeneTreeiENSGT00390000010938
HOGENOMiHOG000154637
HOVERGENiHBG057050
InParanoidiQ8C3S2
OMAiFTLFCFT
OrthoDBiEOG091G02MW
PhylomeDBiQ8C3S2
TreeFamiTF330876

Miscellaneous databases

PROiPR:Q8C3S2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041949 Expressed in 159 organ(s), highest expression level in ear vesicle
CleanExiMM_TMCO7
ExpressionAtlasiQ8C3S2 baseline and differential
GenevisibleiQ8C3S2 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019451 Rtp1_C1
IPR019414 Rtp1_C2
IPR039600 TANGO6/Rtp1
PANTHERiPTHR20959 PTHR20959, 1 hit
PfamiView protein in Pfam
PF10363 RTP1_C1, 1 hit
PF10304 RTP1_C2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNG6_MOUSE
AccessioniPrimary (citable) accession number: Q8C3S2
Secondary accession number(s): Q69ZB6
, Q6NXV4, Q8C6M0, Q8C8G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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