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Protein

Phosphatidylinositol-glycan biosynthesis class W protein

Gene

Pigw

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the transport of GPI-anchored proteins to the plasma membrane. Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins.By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

  • glucosaminyl-phosphotidylinositol O-acyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayi
UPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol-glycan biosynthesis class W proteinCurated (EC:2.3.-.-By similarity)
Short name:
PIG-WCurated
Gene namesi
Name:PigwImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917575 Pigw

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21LumenalSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002462831 – 503Phosphatidylinositol-glycan biosynthesis class W proteinAdd BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei415PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8C398
PRIDEiQ8C398

PTM databases

PhosphoSitePlusiQ8C398

Expressioni

Gene expression databases

BgeeiENSMUSG00000045140 Expressed in 21 organ(s), highest expression level in liver
ExpressionAtlasiQ8C398 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064547

Structurei

3D structure databases

ProteinModelPortaliQ8C398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGW family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0411 Eukaryota
COG5062 LUCA
GeneTreeiENSGT00390000013520
HOGENOMiHOG000204712
HOVERGENiHBG079452
InParanoidiQ8C398
KOiK05283
OMAiVPCSWKL
OrthoDBiEOG091G07LB
PhylomeDBiQ8C398
TreeFamiTF314687

Family and domain databases

InterProiView protein in InterPro
IPR009447 PIGW/GWT1
PANTHERiPTHR20661 PTHR20661, 1 hit
PfamiView protein in Pfam
PF06423 GWT1, 1 hit
PIRSFiPIRSF017321 GWT1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C398-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKQLKEAF VRNLSGTSVL EVTQGLCFPA FCILCRGLWI IFSQHVCSFS
60 70 80 90 100
NTWSTRFLMD FVVLIVPLVI TLTVLSSFIL LENLTVIVWG AWLLYQIYHR
110 120 130 140 150
RTCYAKVPVQ KVFANFLKIS LESEYNPAIT CYRVINSVFT AIAILAVDFP
160 170 180 190 200
LFPRRFAKTE LYGTGAMDFG VGGFIFGAAM VCPEVRRKSI EESRFNYLRK
210 220 230 240 250
SLYSVWPLVF LGMGRLVIIK SIGYQEHSTE YGIHWNFFFT IIVVRLVTSL
260 270 280 290 300
LLIIFPLNKS WIVAVSITVV YQLALDYTPL KRILLYGTDG SGTRVGFLNA
310 320 330 340 350
NREGIISTLG YVTIHMAGVQ TGLYVLKGRA QVRDWIKATC WVFSVAVGFF
360 370 380 390 400
ISLHIVQVNI EAVSRRMANL AFCLWVVASS LMLLSCLLLS GIILSFAQFL
410 420 430 440 450
IKGSLVPCSW KLIQSPTTHK NHSESLILEA EKNQPSLCLI TALNRNQLFF
460 470 480 490 500
FLLSNITTGL INLTMDTLHT GALWTLVVLS IYMFTNCLVI YVLDLQGKTI

KFW
Length:503
Mass (Da):56,841
Last modified:March 1, 2003 - v1
Checksum:i3814E3D18680BACF
GO

Sequence cautioni

The sequence BAC38199 differs from that shown. Reason: Frameshift at position 453.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011762 mRNA Translation: BAB27826.3
AK081337 mRNA Translation: BAC38199.1 Frameshift.
AK086537 mRNA Translation: BAC39687.1
AL645623 Genomic DNA No translation available.
CCDSiCCDS36263.1
RefSeqiNP_001071104.1, NM_001077636.1
NP_081664.2, NM_027388.2
XP_006534222.1, XM_006534159.2
UniGeneiMm.390414

Genome annotation databases

EnsembliENSMUST00000067058; ENSMUSP00000064547; ENSMUSG00000045140
ENSMUST00000108080; ENSMUSP00000103715; ENSMUSG00000045140
GeneIDi70325
KEGGimmu:70325
UCSCiuc007kqy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011762 mRNA Translation: BAB27826.3
AK081337 mRNA Translation: BAC38199.1 Frameshift.
AK086537 mRNA Translation: BAC39687.1
AL645623 Genomic DNA No translation available.
CCDSiCCDS36263.1
RefSeqiNP_001071104.1, NM_001077636.1
NP_081664.2, NM_027388.2
XP_006534222.1, XM_006534159.2
UniGeneiMm.390414

3D structure databases

ProteinModelPortaliQ8C398
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064547

PTM databases

PhosphoSitePlusiQ8C398

Proteomic databases

PaxDbiQ8C398
PRIDEiQ8C398

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067058; ENSMUSP00000064547; ENSMUSG00000045140
ENSMUST00000108080; ENSMUSP00000103715; ENSMUSG00000045140
GeneIDi70325
KEGGimmu:70325
UCSCiuc007kqy.1 mouse

Organism-specific databases

CTDi284098
MGIiMGI:1917575 Pigw

Phylogenomic databases

eggNOGiKOG0411 Eukaryota
COG5062 LUCA
GeneTreeiENSGT00390000013520
HOGENOMiHOG000204712
HOVERGENiHBG079452
InParanoidiQ8C398
KOiK05283
OMAiVPCSWKL
OrthoDBiEOG091G07LB
PhylomeDBiQ8C398
TreeFamiTF314687

Enzyme and pathway databases

UniPathwayi
UPA00196

ReactomeiR-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)

Miscellaneous databases

PROiPR:Q8C398
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045140 Expressed in 21 organ(s), highest expression level in liver
ExpressionAtlasiQ8C398 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009447 PIGW/GWT1
PANTHERiPTHR20661 PTHR20661, 1 hit
PfamiView protein in Pfam
PF06423 GWT1, 1 hit
PIRSFiPIRSF017321 GWT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIGW_MOUSE
AccessioniPrimary (citable) accession number: Q8C398
Secondary accession number(s): Q8C4S0, Q9CSX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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