Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Layilin

Gene

Layn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for hyaluronate.By similarity

GO - Molecular functioni

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Layilin
Gene namesi
Name:Layn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2685357 Layn

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 235ExtracellularSequence analysisAdd BLAST211
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 381CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000026250925 – 381LayilinAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 184PROSITE-ProRule annotation
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 176PROSITE-ProRule annotation
Modified residuei286PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8C351
PeptideAtlasiQ8C351
PRIDEiQ8C351

PTM databases

iPTMnetiQ8C351
PhosphoSitePlusiQ8C351

Expressioni

Gene expression databases

BgeeiENSMUSG00000060594 Expressed in 111 organ(s), highest expression level in aortic valve
CleanExiMM_LAYN
ExpressionAtlasiQ8C351 baseline and differential
GenevisibleiQ8C351 MM

Interactioni

Subunit structurei

Interacts with TLN1 (By similarity). Interacts with NF2 and RDX.By similarity1 Publication

Protein-protein interaction databases

ELMiQ8C351
STRINGi10090.ENSMUSP00000096379

Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8C351
SMRiQ8C351
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8C351

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 185C-type lectinPROSITE-ProRule annotationAdd BLAST141
Repeati340 – 3441-15
Repeati350 – 3541-25
Repeati356 – 3592-14
Repeati371 – 3751-35
Repeati377 – 3802-24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni330 – 374Interaction with NF21 PublicationAdd BLAST45
Regioni337 – 381Interaction with TLN1By similarityAdd BLAST45
Regioni340 – 3753 X 5 AA repeats of E-S-G-X-VAdd BLAST36
Regioni356 – 3802 X 4 AA repeats of N-X-I-YAdd BLAST25

Domaini

The C-terminal domain interacts with the N-terminal domain of RDX.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3Y Eukaryota
ENOG410XR2Y LUCA
GeneTreeiENSGT00390000001844
HOGENOMiHOG000294068
HOVERGENiHBG050945
InParanoidiQ8C351
KOiK10077
OrthoDBiEOG091G0FDX
TreeFamiTF330715

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C351-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPGAALQAM LLAVLLAKPR DSKGRLLSAS DLDPRGGQLV CRGGTRRPCY
60 70 80 90 100
KVIYFHDAFQ RLNFEEAKET CMEDGGQLVS IETEDEQRLI EKFIENLLAS
110 120 130 140 150
DGDFWIGLKR LEEKQSNNTA CQDLYAWTDG STSQFRNWYV DEPSCGSEVC
160 170 180 190 200
VVMYHQPSAP PGIGGSYMFQ WNDDRCNMKN NFICKYHDDK PSTTPSIWPG
210 220 230 240 250
GEATEPATPL LPEETQKEDT KETFKERREA ALNLAYILIP SIPLFLLLVV
260 270 280 290 300
TSAVCWVWIC RRKREQTDPS TKEQHTIWPT PRQENSPNLD VYNVIRKQSE
310 320 330 340 350
ADLAEPRPDL KNISFRVCSG EAMPDDMSCD YENIAVNPSE SGFVTLASME
360 370 380
SGFVTNDIYE FSPDRMGRSK ESGWVENEIY Y
Length:381
Mass (Da):43,269
Last modified:July 27, 2011 - v4
Checksum:iCF20C2EE708A5E07
GO
Isoform 2 (identifier: Q8C351-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-137: RN → SG
     138-381: Missing.

Show »
Length:137
Mass (Da):15,321
Checksum:i7D76C154D4D17262
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4QPF5A4QPF5_MOUSE
Layilin
Layn
320Annotation score:
A0A1L1SS94A0A1L1SS94_MOUSE
Layilin
Layn
122Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021782136 – 137RN → SG in isoform 2. 1 Publication2
Alternative sequenceiVSP_021783138 – 381Missing in isoform 2. 1 PublicationAdd BLAST244

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK086930 mRNA Translation: BAC39765.2
AK165695 mRNA Translation: BAE38343.1
AC119831 Genomic DNA No translation available.
CCDSiCCDS52791.1 [Q8C351-1]
RefSeqiNP_001028706.1, NM_001033534.1 [Q8C351-1]
UniGeneiMm.335152

Genome annotation databases

EnsembliENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594 [Q8C351-1]
GeneIDi244864
KEGGimmu:244864
UCSCiuc012gtc.1 mouse [Q8C351-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK086930 mRNA Translation: BAC39765.2
AK165695 mRNA Translation: BAE38343.1
AC119831 Genomic DNA No translation available.
CCDSiCCDS52791.1 [Q8C351-1]
RefSeqiNP_001028706.1, NM_001033534.1 [Q8C351-1]
UniGeneiMm.335152

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K00NMR-B367-381[»]
ProteinModelPortaliQ8C351
SMRiQ8C351
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiQ8C351
STRINGi10090.ENSMUSP00000096379

PTM databases

iPTMnetiQ8C351
PhosphoSitePlusiQ8C351

Proteomic databases

PaxDbiQ8C351
PeptideAtlasiQ8C351
PRIDEiQ8C351

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594 [Q8C351-1]
GeneIDi244864
KEGGimmu:244864
UCSCiuc012gtc.1 mouse [Q8C351-1]

Organism-specific databases

CTDi143903
MGIiMGI:2685357 Layn

Phylogenomic databases

eggNOGiENOG410IS3Y Eukaryota
ENOG410XR2Y LUCA
GeneTreeiENSGT00390000001844
HOGENOMiHOG000294068
HOVERGENiHBG050945
InParanoidiQ8C351
KOiK10077
OrthoDBiEOG091G0FDX
TreeFamiTF330715

Miscellaneous databases

EvolutionaryTraceiQ8C351
PROiPR:Q8C351
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060594 Expressed in 111 organ(s), highest expression level in aortic valve
CleanExiMM_LAYN
ExpressionAtlasiQ8C351 baseline and differential
GenevisibleiQ8C351 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAYN_MOUSE
AccessioniPrimary (citable) accession number: Q8C351
Secondary accession number(s): E9QQ23, Q3TMU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 109 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again