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UniProtKB - Q8C351 (LAYN_MOUSE)
Protein
Layilin
Gene
Layn
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for hyaluronate.
By similarityGO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- hyaluronic acid binding Source: HGNC-UCL
Keywordsi
Ligand | Lectin |
Names & Taxonomyi
Protein namesi | Recommended name: Layilin |
Gene namesi | Name:Layn |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685357, Layn |
VEuPathDBi | HostDB:ENSMUSG00000060594 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Note: Colocalizes with TLN1 at the membrane ruffles.By similarity
Other locations
- cell surface Source: HGNC-UCL
- integral component of membrane Source: UniProtKB-KW
- ruffle Source: HGNC-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 235 | ExtracellularSequence analysisAdd BLAST | 211 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 381 | CytoplasmicSequence analysisAdd BLAST | 125 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000262509 | 25 – 381 | LayilinAdd BLAST | 357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 71 ↔ 184 | PROSITE-ProRule annotation | ||
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 150 ↔ 176 | PROSITE-ProRule annotation | ||
Modified residuei | 286 | PhosphoserineCombined sources | 1 | |
Modified residuei | 299 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q8C351 |
MaxQBi | Q8C351 |
PaxDbi | Q8C351 |
PeptideAtlasi | Q8C351 |
PRIDEi | Q8C351 |
ProteomicsDBi | 264843 [Q8C351-1] 264844 [Q8C351-2] |
PTM databases
GlyGeni | Q8C351, 1 site |
iPTMneti | Q8C351 |
PhosphoSitePlusi | Q8C351 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000060594, Expressed in aortic valve and 149 other tissues |
ExpressionAtlasi | Q8C351, baseline and differential |
Genevisiblei | Q8C351, MM |
Interactioni
Subunit structurei
Interacts with TLN1 (By similarity).
Interacts with NF2 and RDX.
By similarity1 PublicationProtein-protein interaction databases
ELMi | Q8C351 |
STRINGi | 10090.ENSMUSP00000096379 |
Miscellaneous databases
RNActi | Q8C351, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q8C351 |
SMRi | Q8C351 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8C351 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 185 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 141 | |
Repeati | 340 – 344 | 1-1 | 5 | |
Repeati | 350 – 354 | 1-2 | 5 | |
Repeati | 356 – 359 | 2-1 | 4 | |
Repeati | 371 – 375 | 1-3 | 5 | |
Repeati | 377 – 380 | 2-2 | 4 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 330 – 374 | Interaction with NF21 PublicationAdd BLAST | 45 | |
Regioni | 337 – 381 | Interaction with TLN1By similarityAdd BLAST | 45 | |
Regioni | 340 – 375 | 3 X 5 AA repeats of E-S-G-X-VAdd BLAST | 36 | |
Regioni | 356 – 380 | 2 X 4 AA repeats of N-X-I-YAdd BLAST | 25 |
Domaini
The C-terminal domain interacts with the N-terminal domain of RDX.
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00390000001844 |
HOGENOMi | CLU_045492_1_1_1 |
InParanoidi | Q8C351 |
OMAi | VHSGEAT |
OrthoDBi | 1005951at2759 |
PhylomeDBi | Q8C351 |
TreeFami | TF330715 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
IDEALi | IID50232 |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8C351-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQPGAALQAM LLAVLLAKPR DSKGRLLSAS DLDPRGGQLV CRGGTRRPCY
60 70 80 90 100
KVIYFHDAFQ RLNFEEAKET CMEDGGQLVS IETEDEQRLI EKFIENLLAS
110 120 130 140 150
DGDFWIGLKR LEEKQSNNTA CQDLYAWTDG STSQFRNWYV DEPSCGSEVC
160 170 180 190 200
VVMYHQPSAP PGIGGSYMFQ WNDDRCNMKN NFICKYHDDK PSTTPSIWPG
210 220 230 240 250
GEATEPATPL LPEETQKEDT KETFKERREA ALNLAYILIP SIPLFLLLVV
260 270 280 290 300
TSAVCWVWIC RRKREQTDPS TKEQHTIWPT PRQENSPNLD VYNVIRKQSE
310 320 330 340 350
ADLAEPRPDL KNISFRVCSG EAMPDDMSCD YENIAVNPSE SGFVTLASME
360 370 380
SGFVTNDIYE FSPDRMGRSK ESGWVENEIY Y
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA4QPF5 | A4QPF5_MOUSE | Layilin | Layn | 320 | Annotation score: | ||
A0A1L1SS94 | A0A1L1SS94_MOUSE | Layilin | Layn | 122 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021782 | 136 – 137 | RN → SG in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_021783 | 138 – 381 | Missing in isoform 2. 1 PublicationAdd BLAST | 244 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK086930 mRNA Translation: BAC39765.2 AK165695 mRNA Translation: BAE38343.1 AC119831 Genomic DNA No translation available. |
CCDSi | CCDS52791.1 [Q8C351-1] |
RefSeqi | NP_001028706.1, NM_001033534.1 [Q8C351-1] |
Genome annotation databases
Ensembli | ENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594 [Q8C351-1] |
GeneIDi | 244864 |
KEGGi | mmu:244864 |
UCSCi | uc012gtc.1, mouse [Q8C351-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK086930 mRNA Translation: BAC39765.2 AK165695 mRNA Translation: BAE38343.1 AC119831 Genomic DNA No translation available. |
CCDSi | CCDS52791.1 [Q8C351-1] |
RefSeqi | NP_001028706.1, NM_001033534.1 [Q8C351-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K00 | NMR | - | B | 367-381 | [»] | |
AlphaFoldDBi | Q8C351 | |||||
SMRi | Q8C351 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ELMi | Q8C351 |
STRINGi | 10090.ENSMUSP00000096379 |
PTM databases
GlyGeni | Q8C351, 1 site |
iPTMneti | Q8C351 |
PhosphoSitePlusi | Q8C351 |
Proteomic databases
jPOSTi | Q8C351 |
MaxQBi | Q8C351 |
PaxDbi | Q8C351 |
PeptideAtlasi | Q8C351 |
PRIDEi | Q8C351 |
ProteomicsDBi | 264843 [Q8C351-1] 264844 [Q8C351-2] |
Protocols and materials databases
Antibodypediai | 32045, 371 antibodies from 27 providers |
Genome annotation databases
Ensembli | ENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594 [Q8C351-1] |
GeneIDi | 244864 |
KEGGi | mmu:244864 |
UCSCi | uc012gtc.1, mouse [Q8C351-1] |
Organism-specific databases
CTDi | 143903 |
MGIi | MGI:2685357, Layn |
VEuPathDBi | HostDB:ENSMUSG00000060594 |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00390000001844 |
HOGENOMi | CLU_045492_1_1_1 |
InParanoidi | Q8C351 |
OMAi | VHSGEAT |
OrthoDBi | 1005951at2759 |
PhylomeDBi | Q8C351 |
TreeFami | TF330715 |
Miscellaneous databases
BioGRID-ORCSi | 244864, 0 hits in 72 CRISPR screens |
ChiTaRSi | Layn, mouse |
EvolutionaryTracei | Q8C351 |
PROi | PR:Q8C351 |
RNActi | Q8C351, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000060594, Expressed in aortic valve and 149 other tissues |
ExpressionAtlasi | Q8C351, baseline and differential |
Genevisiblei | Q8C351, MM |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
IDEALi | IID50232 |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LAYN_MOUSE | |
Accessioni | Q8C351Primary (citable) accession number: Q8C351 Secondary accession number(s): E9QQ23, Q3TMU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references