UniProtKB - Q8C351 (LAYN_MOUSE)

BLAST

>sp|Q8C351|LAYN_MOUSE Layilin OS=Mus musculus OX=10090 GN=Layn PE=1 SV=4
MQPGAALQAMLLAVLLAKPRDSKGRLLSASDLDPRGGQLVCRGGTRRPCYKVIYFHDAFQ
RLNFEEAKETCMEDGGQLVSIETEDEQRLIEKFIENLLASDGDFWIGLKRLEEKQSNNTA
CQDLYAWTDGSTSQFRNWYVDEPSCGSEVCVVMYHQPSAPPGIGGSYMFQWNDDRCNMKN
NFICKYHDDKPSTTPSIWPGGEATEPATPLLPEETQKEDTKETFKERREAALNLAYILIP
SIPLFLLLVVTSAVCWVWICRRKREQTDPSTKEQHTIWPTPRQENSPNLDVYNVIRKQSE
ADLAEPRPDLKNISFRVCSGEAMPDDMSCDYENIAVNPSESGFVTLASMESGFVTNDIYE
FSPDRMGRSKESGWVENEIYY

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History
Entry version 109 (07 Nov 2018)
Sequence version 4 (27 Jul 2011)
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Protein

Layilin

Gene

Layn

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Receptor for hyaluronate.By similarity

GO - Molecular functionⁱ

carbohydrate binding Source: UniProtKB-KW
hyaluronic acid binding Source: HGNC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Lectin

Ligand

Lectin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Layilin
Gene namesⁱ	Name:Layn
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:2685357 Layn

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 235	ExtracellularSequence analysisAdd BLAST	211
Transmembraneⁱ	236 – 256	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	257 – 381	CytoplasmicSequence analysisAdd BLAST	125

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_0000262509	25 – 381	LayilinAdd BLAST		357

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	71 ↔ 184	PROSITE-ProRule annotation
Glycosylationⁱ	117	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	150 ↔ 176	PROSITE-ProRule annotation
Modified residueⁱ	286	PhosphoserineCombined sources	1
Modified residueⁱ	299	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8C351
PeptideAtlas More...PeptideAtlasⁱ	Q8C351
PRIDEⁱ	Q8C351

PTM databases

iPTMnetⁱ	Q8C351
PhosphoSitePlusⁱ	Q8C351

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000060594 Expressed in 111 organ(s), highest expression level in aortic valve
CleanExⁱ	MM_LAYN
ExpressionAtlasⁱ	Q8C351 baseline and differential
Genevisibleⁱ	Q8C351 MM

Interactionⁱ

Subunit structureⁱ

Interacts with TLN1 (By similarity). Interacts with NF2 and RDX.By similarity1 Publication

Protein-protein interaction databases

ELMⁱ	Q8C351
STRINGⁱ	10090.ENSMUSP00000096379

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	372 – 376	Combined sources		5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8C351
SMRⁱ	Q8C351
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q8C351

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	45 – 185	C-type lectinPROSITE-ProRule annotationAdd BLAST	141
Repeatⁱ	340 – 344	1-1	5
Repeatⁱ	350 – 354	1-2	5
Repeatⁱ	356 – 359	2-1	4
Repeatⁱ	371 – 375	1-3	5
Repeatⁱ	377 – 380	2-2	4

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	330 – 374	Interaction with NF21 PublicationAdd BLAST	45
Regionⁱ	337 – 381	Interaction with TLN1By similarityAdd BLAST	45
Regionⁱ	340 – 375	3 X 5 AA repeats of E-S-G-X-VAdd BLAST	36
Regionⁱ	356 – 380	2 X 4 AA repeats of N-X-I-YAdd BLAST	25

Domainⁱ

The C-terminal domain interacts with the N-terminal domain of RDX.

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IS3Y Eukaryota ENOG410XR2Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001844
HOGENOMⁱ	HOG000294068
HOVERGENⁱ	HBG050945
InParanoidⁱ	Q8C351
KEGG Orthology (KO) More...KOⁱ	K10077
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FDX
TreeFamⁱ	TF330715

Family and domain databases

Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00059 Lectin_C, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8C351-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPGAALQAM LLAVLLAKPR DSKGRLLSAS DLDPRGGQLV CRGGTRRPCY 
        60         70         80         90        100
KVIYFHDAFQ RLNFEEAKET CMEDGGQLVS IETEDEQRLI EKFIENLLAS 
       110        120        130        140        150
DGDFWIGLKR LEEKQSNNTA CQDLYAWTDG STSQFRNWYV DEPSCGSEVC 
       160        170        180        190        200
VVMYHQPSAP PGIGGSYMFQ WNDDRCNMKN NFICKYHDDK PSTTPSIWPG 
       210        220        230        240        250
GEATEPATPL LPEETQKEDT KETFKERREA ALNLAYILIP SIPLFLLLVV 
       260        270        280        290        300
TSAVCWVWIC RRKREQTDPS TKEQHTIWPT PRQENSPNLD VYNVIRKQSE 
       310        320        330        340        350
ADLAEPRPDL KNISFRVCSG EAMPDDMSCD YENIAVNPSE SGFVTLASME 
       360        370        380 
SGFVTNDIYE FSPDRMGRSK ESGWVENEIY Y

Length:381

Mass (Da):43,269

Last modified:July 27, 2011 - v4

Checksum:ⁱCF20C2EE708A5E07

Isoform 2 (identifier: Q8C351-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
136-137: RN → SG
138-381: Missing.

« Hide

        10         20         30         40         50
MQPGAALQAM LLAVLLAKPR DSKGRLLSAS DLDPRGGQLV CRGGTRRPCY 
        60         70         80         90        100
KVIYFHDAFQ RLNFEEAKET CMEDGGQLVS IETEDEQRLI EKFIENLLAS 
       110        120        130 
DGDFWIGLKR LEEKQSNNTA CQDLYAWTDG STSQFSG

Show »

Length:137

Mass (Da):15,321

Checksum:ⁱ7D76C154D4D17262

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A4QPF5	A4QPF5_MOUSE	Layilin Layilin (Layn protein)	Layn	320	Annotation score:
A0A1L1SS94	A0A1L1SS94_MOUSE	Layilin Layilin	Layn	122	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021782	136 – 137	RN → SG in isoform 2. 1 Publication		2
Alternative sequenceⁱVSP_021783	138 – 381	Missing in isoform 2. 1 PublicationAdd BLAST		244

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK086930 mRNA Translation: BAC39765.2 AK165695 mRNA Translation: BAE38343.1 AC119831 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS52791.1 [Q8C351-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001028706.1, NM_001033534.1 [Q8C351-1]
UniGeneⁱ	Mm.335152

Genome annotation databases

Ensemblⁱ	ENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594 [Q8C351-1]
GeneIDⁱ	244864
KEGGⁱ	mmu:244864
UCSC genome browser More...UCSCⁱ	uc012gtc.1 mouse [Q8C351-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8C351	Layilin (Fragment)		MOUSE		122	UniRef90_Q8C351
UPI00077DCEE0		PERMB		383
UPI000A316172		MUSCR		383
UPI00067B5B89		MICOH		376
UPI000B4F3E4D		MERUN		374
+3

Protein	Similar proteins		Species	Score	Length	Source
Q8C351	Layilin (Fragment)		MOUSE		122	UniRef50_Q8C351
Layilin		FUKDA		390
Layilin		OTOGA		383
Layilin isoform 2		CALJA		373
Uncharacterized protein		AOTNA		374
+61
Q8C351-2	Uncharacterized protein		RHIRO		112	UniRef50_Q8C351-2
LAYN isoform 2		PONAB		134
Layilin		HUMAN		134
LAYN isoform 2		PANTR		134
Uncharacterized protein (Fragment)		NEOLE		126

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK086930 mRNA Translation: BAC39765.2 AK165695 mRNA Translation: BAE38343.1 AC119831 Genomic DNA No translation available.
CCDSⁱ	CCDS52791.1 [Q8C351-1]
RefSeqⁱ	NP_001028706.1, NM_001033534.1 [Q8C351-1]
UniGeneⁱ	Mm.335152

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2K00	NMR	-	B	367-381	[»]
ProteinModelPortalⁱ	Q8C351
SMRⁱ	Q8C351
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ELMⁱ	Q8C351
STRINGⁱ	10090.ENSMUSP00000096379

PTM databases

iPTMnetⁱ	Q8C351
PhosphoSitePlusⁱ	Q8C351

Proteomic databases

PaxDbⁱ	Q8C351
PeptideAtlasⁱ	Q8C351
PRIDEⁱ	Q8C351

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000098782; ENSMUSP00000096379; ENSMUSG00000060594 [Q8C351-1]
GeneIDⁱ	244864
KEGGⁱ	mmu:244864
UCSCⁱ	uc012gtc.1 mouse [Q8C351-1]

Organism-specific databases

CTDⁱ	143903
MGIⁱ	MGI:2685357 Layn

Phylogenomic databases

eggNOGⁱ	ENOG410IS3Y Eukaryota ENOG410XR2Y LUCA
GeneTreeⁱ	ENSGT00390000001844
HOGENOMⁱ	HOG000294068
HOVERGENⁱ	HBG050945
InParanoidⁱ	Q8C351
KOⁱ	K10077
OrthoDBⁱ	EOG091G0FDX
TreeFamⁱ	TF330715

Miscellaneous databases

EvolutionaryTraceⁱ	Q8C351
Protein Ontology More...PROⁱ	PR:Q8C351
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000060594 Expressed in 111 organ(s), highest expression level in aortic valve
CleanExⁱ	MM_LAYN
ExpressionAtlasⁱ	Q8C351 baseline and differential
Genevisibleⁱ	Q8C351 MM

Family and domain databases

Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold
Pfamⁱ	View protein in Pfam PF00059 Lectin_C, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LAYN_MOUSE
Accessionⁱ	Q8C351Primary (citable) accession number: Q8C351 Secondary accession number(s): E9QQ23, Q3TMU7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 109 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8C351 (LAYN_MOUSE)

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Layilin

Layn

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ