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UniProtKB - Q8C341 (SUCO_MOUSE)

Entry version 107 (23 Feb 2022)
Sequence version 3 (11 Sep 2007)
Previous versions | rss
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Protein

SUN domain-containing ossification factor

Gene

Suco

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processOsteogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SUN domain-containing ossification factor
Alternative name(s):
Membrane protein CH1
Protein osteopotentia
SUN-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Suco
Synonyms:Opt
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2138346, Suco

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000040297

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1007 – 1027HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Most mice die neonatally from respiratory distress (50% on a mixed C57BL6/CD1 background and 100% on an inbred C57BL6/129Ola background). Surviving mice fail to thrive and show significantly reduced body weight, skeletal deformities and spontaneous fractures. More than 80% die by postnatal day 10, and none survives to weaning.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030271820 – 1250SUN domain-containing ossification factorAdd BLAST1231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi924N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi951N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1077PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8C341

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8C341

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8C341

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8C341

PRoteomics IDEntifications database

More...PRIDEi		Q8C341

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		257371 [Q8C341-1]
257372 [Q8C341-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2743, 6 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8C341, 6 sites, 6 N-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8C341

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8C341

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in chondrocytes, osteoblasts, osteoclasts and osteocytes (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at 9.5 dpc and 13.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000040297, Expressed in epithelium of lens and 279 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8C341, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		230529, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000044815

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8C341, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8C341

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini283 – 452SUNPROSITE-ProRule annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni55 – 75DisorderedSequence analysisAdd BLAST21
Regioni116 – 302DisorderedSequence analysisAdd BLAST187
Regioni527 – 547DisorderedSequence analysisAdd BLAST21
Regioni581 – 602DisorderedSequence analysisAdd BLAST22
Regioni742 – 769DisorderedSequence analysisAdd BLAST28
Regioni1148 – 1168DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili905 – 1005Sequence analysisAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi119 – 142Polar residuesSequence analysisAdd BLAST24
Compositional biasi203 – 224Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi228 – 263Polar residuesSequence analysisAdd BLAST36
Compositional biasi265 – 286Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi287 – 302Polar residuesSequence analysisAdd BLAST16
Compositional biasi584 – 602Polar residuesSequence analysisAdd BLAST19
Compositional biasi742 – 766Polar residuesSequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1396, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006401_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8C341

Identification of Orthologs from Complete Genome Data

More...OMAi		MNHTVDA

TreeFam database of animal gene trees

More...TreeFami		TF105817

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008979, Galactose-bd-like_sf
IPR045120, Suco/Slp1-like
IPR012919, SUN_dom

The PANTHER Classification System

More...PANTHERi		PTHR12953, PTHR12953, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07738, Sad1_UNC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49785, SSF49785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51469, SUN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C341-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKYRRALAL VSCLSLCSLV WLPSWHVCCK ESSSASTSYY SQDDNCAIGS 
        60         70         80         90        100
EDTQFQKKNE REEPSNAELS GKSNSYLTIS PEGNKIKDDY TVDVQDLETT 
       110        120        130        140        150
KLSLPVVEAL PTVDLHEESS SVVVGSETIE NSSSSSTSER TPVSELDEVE 
       160        170        180        190        200
KSGTLSIAKP GEVEQPEADC DAGEAPDADA PVEQPAFVSP PESLVGQHIE 
       210        220        230        240        250
NVSSSHGKEK VTKSEFESKV SVSEQDGGDP KSALNTSDTL KNESSDYTKP 
       260        270        280        290        300
GETDPTSVTS PKDPEDIPTF DEWKKKVMEV EKEKSQSLHP SSNGGPHATK 
       310        320        330        340        350
KVQKNRNNYA SVECGAKILA ANPEAKSTSA ILIENMDLYM LNPCSTKIWF 
       360        370        380        390        400
VIELCEPIQV KQFDIANYEL FSSTPKDFLV SISDRYPTNK WIKLGTFHGR 
       410        420        430        440        450
DERNVQSFPL DEQMYAKYVK MFIKYIKVEL LSHFGSEHFC PLSLIRVFGT 
       460        470        480        490        500
SMVEEYEEIA DSQYQSERQE LFDEDYDYPL DYNTVEDKSS KNLLGSATNA 
       510        520        530        540        550
ILNMVNIAAN ILGAKTEDLT EGNKSISENA TATTEPKMTE STRVSTPVPS 
       560        570        580        590        600
PEYVIKEVHT HDREPSTSDP PKESPIVQLV QEEEEEASPS TVTLLGSGEQ 
       610        620        630        640        650
EDESSSWFES ETHILCSELT SICCISSFSE YIYKWCSVRI ALYRQRSRTV 
       660        670        680        690        700
SKGKDFVPPQ PSLLLPVESV EVSVPQPPSG DVDSENMERE AETVDLDDLS 
       710        720        730        740        750
SVHQGHLINH TVDTIELEPS YPQTLSQSLL LDVTPEMNSL SKVEGSESVK 
       760        770        780        790        800
SEGGYIPSQL MTQESSVEFD DKTEKKTESF SSAEKLSVIY ETSKVNEVMD 
       810        820        830        840        850
NTVKEDILST EVVTKFPETV VPPPMNTATV PEGESVETKP SIADTLKHTV 
       860        870        880        890        900
TPVMDPSLPE VKEDEQSPED ALLRGLQRTA TDFYAELQNS TDLGYGNGNL 
       910        920        930        940        950
VHGSNQKESV FMRLNNRIKA LEVNMSLSGR YLEELSQRYR KQMEEMQKAF 
       960        970        980        990       1000
NKTIVKLQNT SRIAEEQDQR QTEAIHLLQA QLTNMTQLVS NLSATVAELK 
      1010       1020       1030       1040       1050
REVSDRQSYL VMSLVLCVVL GLMLCMQRCR TTSQFDGDYI SKLPKSNQYP 
      1060       1070       1080       1090       1100
SPKRCFSSYD DMNLKRRTSF PLIRSKSLQF TGKEVDPNDL YIVEPLKFSP 
      1110       1120       1130       1140       1150
EKKKKRCKYK TEKIETIKPA DPLHPIANGD IKGRKPFTNQ RDFSNMGEVY 
      1160       1170       1180       1190       1200
HSSYKGPPSE GSSETSSQSE ESYFCGISAC TSLCNGQTQK TKTEKRALKR 
      1210       1220       1230       1240       1250
RRSKVQDQGK LIKALIQTKS GSLPSLHDII KGNKEITVGA FGVTAVSGHI
Length:1,250
Mass (Da):139,169
Last modified:September 11, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8713115267891629
GO
Isoform 2 (identifier: Q8C341-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-285: S → SLSTG

Show »
Length:1,254
Mass (Da):139,527
Checksum:i52330ED0DCE0F0F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YX94A0A0A6YX94_MOUSE
SUN domain-containing ossification ...
Suco
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWN8A0A0A6YWN8_MOUSE
SUN domain-containing ossification ...
Suco
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4Y → N in BAE42700 (PubMed:16141072).Curated1
Sequence conflicti299T → K in BAC26295 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027924285S → SLSTG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK029097 mRNA Translation: BAC26295.1
AK033720 mRNA Translation: BAE43286.1
AK087029 mRNA Translation: BAC39786.2
AK171856 mRNA Translation: BAE42700.1
AC164414 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48415.1 [Q8C341-2]

NCBI Reference Sequences

More...RefSeqi		XP_006496823.1, XM_006496760.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000048377; ENSMUSP00000044815; ENSMUSG00000040297 [Q8C341-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029097 mRNA Translation: BAC26295.1
AK033720 mRNA Translation: BAE43286.1
AK087029 mRNA Translation: BAC39786.2
AK171856 mRNA Translation: BAE42700.1
AC164414 Genomic DNA No translation available.
CCDSiCCDS48415.1 [Q8C341-2]
RefSeqiXP_006496823.1, XM_006496760.2

3D structure databases

SMRiQ8C341
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230529, 1 interactor
STRINGi10090.ENSMUSP00000044815

PTM databases

GlyConnecti2743, 6 N-Linked glycans (3 sites)
GlyGeniQ8C341, 6 sites, 6 N-linked glycans (3 sites)
iPTMnetiQ8C341
PhosphoSitePlusiQ8C341

Proteomic databases

EPDiQ8C341
jPOSTiQ8C341
MaxQBiQ8C341
PaxDbiQ8C341
PRIDEiQ8C341
ProteomicsDBi257371 [Q8C341-1]
257372 [Q8C341-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		63320, 7 antibodies from 7 providers

Genome annotation databases

EnsembliENSMUST00000048377; ENSMUSP00000044815; ENSMUSG00000040297 [Q8C341-2]

Organism-specific databases

MGIiMGI:2138346, Suco
VEuPathDBiHostDB:ENSMUSG00000040297

Phylogenomic databases

eggNOGiKOG1396, Eukaryota
GeneTreeiENSGT00390000013502
HOGENOMiCLU_006401_0_0_1
InParanoidiQ8C341
OMAiMNHTVDA
TreeFamiTF105817

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		226551, 7 hits in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Suco, mouse

Protein Ontology

More...PROi		PR:Q8C341
RNActiQ8C341, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000040297, Expressed in epithelium of lens and 279 other tissues
GenevisibleiQ8C341, MM

Family and domain databases

InterProiView protein in InterPro
IPR008979, Galactose-bd-like_sf
IPR045120, Suco/Slp1-like
IPR012919, SUN_dom
PANTHERiPTHR12953, PTHR12953, 1 hit
PfamiView protein in Pfam
PF07738, Sad1_UNC, 1 hit
SUPFAMiSSF49785, SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS51469, SUN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUCO_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C341
Secondary accession number(s): Q3TAG8, Q3V3T1, Q8CE34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: February 23, 2022
This is version 107 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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