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UniProtKB - Q8C341 (SUCO_MOUSE)
Protein
SUN domain-containing ossification factor
Gene
Suco
Organism
Mus musculus (Mouse)
Status
Functioni
Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation.
1 PublicationGO - Biological processi
- ossification Source: UniProtKB-KW
- positive regulation of collagen biosynthetic process Source: UniProtKB
- positive regulation of osteoblast differentiation Source: UniProtKB
- regulation of bone remodeling Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Osteogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: SUN domain-containing ossification factorAlternative name(s): Membrane protein CH1 Protein osteopotentia SUN-like protein 1 |
Gene namesi | Name:Suco Synonyms:Opt |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2138346, Suco |
VEuPathDBi | HostDB:ENSMUSG00000040297 |
Subcellular locationi
Endoplasmic reticulum
- Rough endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Endoplasmic reticulum
- rough endoplasmic reticulum Source: UniProtKB
- rough endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1007 – 1027 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
Most mice die neonatally from respiratory distress (50% on a mixed C57BL6/CD1 background and 100% on an inbred C57BL6/129Ola background). Surviving mice fail to thrive and show significantly reduced body weight, skeletal deformities and spontaneous fractures. More than 80% die by postnatal day 10, and none survives to weaning.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000302718 | 20 – 1250 | SUN domain-containing ossification factorAdd BLAST | 1231 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 235 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 523 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 924 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 951 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1077 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1.By similarity
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8C341 |
jPOSTi | Q8C341 |
MaxQBi | Q8C341 |
PaxDbi | Q8C341 |
PRIDEi | Q8C341 |
ProteomicsDBi | 257371 [Q8C341-1] 257372 [Q8C341-2] |
PTM databases
GlyConnecti | 2743, 6 N-Linked glycans (3 sites) |
GlyGeni | Q8C341, 6 sites, 6 N-linked glycans (3 sites) |
iPTMneti | Q8C341 |
PhosphoSitePlusi | Q8C341 |
Expressioni
Tissue specificityi
Present in chondrocytes, osteoblasts, osteoclasts and osteocytes (at protein level).1 Publication
Developmental stagei
Expressed at 9.5 dpc and 13.5 dpc.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000040297, Expressed in epithelium of lens and 279 other tissues |
Genevisiblei | Q8C341, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 230529, 1 interactor |
STRINGi | 10090.ENSMUSP00000044815 |
Miscellaneous databases
RNActi | Q8C341, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 283 – 452 | SUNPROSITE-ProRule annotationAdd BLAST | 170 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 55 – 75 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 116 – 302 | DisorderedSequence analysisAdd BLAST | 187 | |
Regioni | 527 – 547 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 581 – 602 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 742 – 769 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1148 – 1168 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 905 – 1005 | Sequence analysisAdd BLAST | 101 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 119 – 142 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 203 – 224 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 228 – 263 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 265 – 286 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 287 – 302 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 584 – 602 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 742 – 766 | Polar residuesSequence analysisAdd BLAST | 25 |
Keywords - Domaini
Coiled coil, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1396, Eukaryota |
GeneTreei | ENSGT00390000013502 |
HOGENOMi | CLU_006401_0_0_1 |
InParanoidi | Q8C341 |
OMAi | MNHTVDA |
TreeFami | TF105817 |
Family and domain databases
InterProi | View protein in InterPro IPR008979, Galactose-bd-like_sf IPR045120, Suco/Slp1-like IPR012919, SUN_dom |
PANTHERi | PTHR12953, PTHR12953, 1 hit |
Pfami | View protein in Pfam PF07738, Sad1_UNC, 1 hit |
SUPFAMi | SSF49785, SSF49785, 1 hit |
PROSITEi | View protein in PROSITE PS51469, SUN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8C341-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKYRRALAL VSCLSLCSLV WLPSWHVCCK ESSSASTSYY SQDDNCAIGS
60 70 80 90 100
EDTQFQKKNE REEPSNAELS GKSNSYLTIS PEGNKIKDDY TVDVQDLETT
110 120 130 140 150
KLSLPVVEAL PTVDLHEESS SVVVGSETIE NSSSSSTSER TPVSELDEVE
160 170 180 190 200
KSGTLSIAKP GEVEQPEADC DAGEAPDADA PVEQPAFVSP PESLVGQHIE
210 220 230 240 250
NVSSSHGKEK VTKSEFESKV SVSEQDGGDP KSALNTSDTL KNESSDYTKP
260 270 280 290 300
GETDPTSVTS PKDPEDIPTF DEWKKKVMEV EKEKSQSLHP SSNGGPHATK
310 320 330 340 350
KVQKNRNNYA SVECGAKILA ANPEAKSTSA ILIENMDLYM LNPCSTKIWF
360 370 380 390 400
VIELCEPIQV KQFDIANYEL FSSTPKDFLV SISDRYPTNK WIKLGTFHGR
410 420 430 440 450
DERNVQSFPL DEQMYAKYVK MFIKYIKVEL LSHFGSEHFC PLSLIRVFGT
460 470 480 490 500
SMVEEYEEIA DSQYQSERQE LFDEDYDYPL DYNTVEDKSS KNLLGSATNA
510 520 530 540 550
ILNMVNIAAN ILGAKTEDLT EGNKSISENA TATTEPKMTE STRVSTPVPS
560 570 580 590 600
PEYVIKEVHT HDREPSTSDP PKESPIVQLV QEEEEEASPS TVTLLGSGEQ
610 620 630 640 650
EDESSSWFES ETHILCSELT SICCISSFSE YIYKWCSVRI ALYRQRSRTV
660 670 680 690 700
SKGKDFVPPQ PSLLLPVESV EVSVPQPPSG DVDSENMERE AETVDLDDLS
710 720 730 740 750
SVHQGHLINH TVDTIELEPS YPQTLSQSLL LDVTPEMNSL SKVEGSESVK
760 770 780 790 800
SEGGYIPSQL MTQESSVEFD DKTEKKTESF SSAEKLSVIY ETSKVNEVMD
810 820 830 840 850
NTVKEDILST EVVTKFPETV VPPPMNTATV PEGESVETKP SIADTLKHTV
860 870 880 890 900
TPVMDPSLPE VKEDEQSPED ALLRGLQRTA TDFYAELQNS TDLGYGNGNL
910 920 930 940 950
VHGSNQKESV FMRLNNRIKA LEVNMSLSGR YLEELSQRYR KQMEEMQKAF
960 970 980 990 1000
NKTIVKLQNT SRIAEEQDQR QTEAIHLLQA QLTNMTQLVS NLSATVAELK
1010 1020 1030 1040 1050
REVSDRQSYL VMSLVLCVVL GLMLCMQRCR TTSQFDGDYI SKLPKSNQYP
1060 1070 1080 1090 1100
SPKRCFSSYD DMNLKRRTSF PLIRSKSLQF TGKEVDPNDL YIVEPLKFSP
1110 1120 1130 1140 1150
EKKKKRCKYK TEKIETIKPA DPLHPIANGD IKGRKPFTNQ RDFSNMGEVY
1160 1170 1180 1190 1200
HSSYKGPPSE GSSETSSQSE ESYFCGISAC TSLCNGQTQK TKTEKRALKR
1210 1220 1230 1240 1250
RRSKVQDQGK LIKALIQTKS GSLPSLHDII KGNKEITVGA FGVTAVSGHI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YX94 | A0A0A6YX94_MOUSE | SUN domain-containing ossification ... | Suco | 179 | Annotation score: | ||
A0A0A6YWN8 | A0A0A6YWN8_MOUSE | SUN domain-containing ossification ... | Suco | 164 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | Y → N in BAE42700 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 299 | T → K in BAC26295 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027924 | 285 | S → SLSTG in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK029097 mRNA Translation: BAC26295.1 AK033720 mRNA Translation: BAE43286.1 AK087029 mRNA Translation: BAC39786.2 AK171856 mRNA Translation: BAE42700.1 AC164414 Genomic DNA No translation available. |
CCDSi | CCDS48415.1 [Q8C341-2] |
RefSeqi | XP_006496823.1, XM_006496760.2 |
Genome annotation databases
Ensembli | ENSMUST00000048377; ENSMUSP00000044815; ENSMUSG00000040297 [Q8C341-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK029097 mRNA Translation: BAC26295.1 AK033720 mRNA Translation: BAE43286.1 AK087029 mRNA Translation: BAC39786.2 AK171856 mRNA Translation: BAE42700.1 AC164414 Genomic DNA No translation available. |
CCDSi | CCDS48415.1 [Q8C341-2] |
RefSeqi | XP_006496823.1, XM_006496760.2 |
3D structure databases
SMRi | Q8C341 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230529, 1 interactor |
STRINGi | 10090.ENSMUSP00000044815 |
PTM databases
GlyConnecti | 2743, 6 N-Linked glycans (3 sites) |
GlyGeni | Q8C341, 6 sites, 6 N-linked glycans (3 sites) |
iPTMneti | Q8C341 |
PhosphoSitePlusi | Q8C341 |
Proteomic databases
EPDi | Q8C341 |
jPOSTi | Q8C341 |
MaxQBi | Q8C341 |
PaxDbi | Q8C341 |
PRIDEi | Q8C341 |
ProteomicsDBi | 257371 [Q8C341-1] 257372 [Q8C341-2] |
Protocols and materials databases
Antibodypediai | 63320, 7 antibodies from 7 providers |
Genome annotation databases
Ensembli | ENSMUST00000048377; ENSMUSP00000044815; ENSMUSG00000040297 [Q8C341-2] |
Organism-specific databases
MGIi | MGI:2138346, Suco |
VEuPathDBi | HostDB:ENSMUSG00000040297 |
Phylogenomic databases
eggNOGi | KOG1396, Eukaryota |
GeneTreei | ENSGT00390000013502 |
HOGENOMi | CLU_006401_0_0_1 |
InParanoidi | Q8C341 |
OMAi | MNHTVDA |
TreeFami | TF105817 |
Miscellaneous databases
BioGRID-ORCSi | 226551, 7 hits in 65 CRISPR screens |
ChiTaRSi | Suco, mouse |
PROi | PR:Q8C341 |
RNActi | Q8C341, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040297, Expressed in epithelium of lens and 279 other tissues |
Genevisiblei | Q8C341, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008979, Galactose-bd-like_sf IPR045120, Suco/Slp1-like IPR012919, SUN_dom |
PANTHERi | PTHR12953, PTHR12953, 1 hit |
Pfami | View protein in Pfam PF07738, Sad1_UNC, 1 hit |
SUPFAMi | SSF49785, SSF49785, 1 hit |
PROSITEi | View protein in PROSITE PS51469, SUN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SUCO_MOUSE | |
Accessioni | Q8C341Primary (citable) accession number: Q8C341 Secondary accession number(s): Q3TAG8, Q3V3T1, Q8CE34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot