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Protein

RNA-binding protein 14

Gene

Rbm14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1 (By similarity). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity (PubMed:25385835). Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.By similarity1 Publication

GO - Molecular functioni

  • nuclear receptor transcription coactivator activity Source: UniProtKB
  • RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processImmunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8941326 RUNX2 regulates bone development

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 14
Alternative name(s):
RNA-binding motif protein 14
Gene namesi
Name:Rbm14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1929092 Rbm14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817751 – 669RNA-binding protein 14Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki153Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei161PhosphoserineBy similarity1
Modified residuei164N6-acetyllysine; alternateCombined sources1
Cross-linki164Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei206PhosphothreonineCombined sources1
Modified residuei220PhosphoserineBy similarity1
Modified residuei242PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei280PhosphoserineBy similarity1
Modified residuei520PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei527PhosphoserineBy similarity1
Modified residuei562PhosphoserineBy similarity1
Modified residuei572PhosphothreonineBy similarity1
Modified residuei582PhosphoserineBy similarity1
Cross-linki600Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei618PhosphoserineCombined sources1
Modified residuei620PhosphoserineBy similarity1
Modified residuei623PhosphoserineCombined sources1
Modified residuei627PhosphoserineBy similarity1
Modified residuei643PhosphoserineBy similarity1
Modified residuei649PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8C2Q3
PaxDbiQ8C2Q3
PeptideAtlasiQ8C2Q3
PRIDEiQ8C2Q3

PTM databases

iPTMnetiQ8C2Q3
PhosphoSitePlusiQ8C2Q3

Expressioni

Gene expression databases

BgeeiENSMUSG00000006456 Expressed in 299 organ(s), highest expression level in urinary bladder
CleanExiMM_RBM14
ExpressionAtlasiQ8C2Q3 baseline and differential
GenevisibleiQ8C2Q3 MM

Interactioni

Subunit structurei

Interacts with NCOA6, CITED1 and XRCC5/KU86. Interacts with SS18. Interacts with STIL and interferes with its interaction with CENPJ. Interacts with gamma-tubulin. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA.By similarity

Protein-protein interaction databases

BioGridi207870, 7 interactors
DIPiDIP-58946N
IntActiQ8C2Q3, 9 interactors
MINTiQ8C2Q3
STRINGi10090.ENSMUSP00000006625

Structurei

3D structure databases

ProteinModelPortaliQ8C2Q3
SMRiQ8C2Q3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73RRM 1PROSITE-ProRule annotationAdd BLAST73
Domaini79 – 149RRM 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni307 – 354TRBP-interacting domain; interaction with STILBy similarityAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 538Ala-richAdd BLAST315

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IES1 Eukaryota
ENOG4111RA3 LUCA
GeneTreeiENSGT00390000020883
HOGENOMiHOG000065673
HOVERGENiHBG053180
InParanoidiQ8C2Q3
KOiK13189
OrthoDBiEOG091G05UU
PhylomeDBiQ8C2Q3
TreeFamiTF320661

Family and domain databases

CDDicd12608 RRM1_CoAA, 1 hit
cd12609 RRM2_CoAA, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034506 RBM14_RRM1
IPR034507 RBM14_RRM2
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C2Q3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKIFVGNVDG ADTTPEELAA LFAPYGTVMS CAVMKQFAFV HMRENAGAVR
60 70 80 90 100
AIEALHGHEL RPGRALVVEM SRPRPLNTWK IFVGNVSAAC TSQELRSLFE
110 120 130 140 150
RRGRVIECDV VKDYAFVHME KEADAKAAIA QLNGKEVKGK RINVELSTKG
160 170 180 190 200
QKKGPALAIQ SGDKTKKPGA GDTAFPGTGG FSATFDYQQA FGNSTGGFDG
210 220 230 240 250
QARQPTPPFF GRDRSPLRRS PPRASYVAPL TAQPATYRAQ PSVSLGAAYR
260 270 280 290 300
AQPSASLGVG YRTQPMAAQA ASYRAQPSVS LGAPYRGQLA SPSSQSAAAS
310 320 330 340 350
SLGPYGGVQP SASALSTYGG QAAAASSLNS YGAQGSSLAS YGNQPSSYGA
360 370 380 390 400
QAASSYGVRA AASSYNTQGA ASSLGSYGAQ AASYGAQSAA SSLAYGAQAA
410 420 430 440 450
SYSAQPSASY SAQSAPYAAQ QAASYSSQPA AYVAQPATAA AYASQPAAYA
460 470 480 490 500
AQATTPMAGS YGAQPVVQTQ LNSYGAQASI GLSGSYGAQS AAAATGSYGA
510 520 530 540 550
AAAYGAQPSA TLAAPYRTQS SASLAASYAA QQHPQAAASY RGQPGSAYDG
560 570 580 590 600
TGQPSAAYLS MSQGAVANAN STPPPYERTR LSPPRASYDD PYKKAVAMSK
610 620 630 640 650
RYGSDRRLAE LSDYRRLSES QLSFRRSPTK SSLDYRRLPD AHSDYARYSG
660
SYNDYLRAAQ MHSGYQRRM
Length:669
Mass (Da):69,449
Last modified:March 1, 2003 - v1
Checksum:i5B913852B06C87FA
GO
Isoform 2 (identifier: Q8C2Q3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     603-669: GSDRRLAELS...QMHSGYQRRM → CMPPRLSPQLGLRARG

Note: No experimental confirmation available.
Show »
Length:618
Mass (Da):63,248
Checksum:i3EFB7B4E3775D541
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QPA9J3QPA9_MOUSE
RNA-binding protein 4
Rbm4
227Annotation score:
F6TBN8F6TBN8_MOUSE
RNA-binding protein 4
Rbm4
172Annotation score:
Q5CZX8Q5CZX8_MOUSE
MCG8382, isoform CRA_b
Rbm4 mCG_8382
143Annotation score:
B0LM42B0LM42_MOUSE
Predicted gene 21992
Gm21992 Rbm14, Rbm4 fusion
336Annotation score:
J3QPT3J3QPT3_MOUSE
RNA-binding protein 14
Rbm14
119Annotation score:
E9QL13E9QL13_MOUSE
MCG8382, isoform CRA_c
Rbm14 mCG_8382
614Annotation score:
F7BGR7F7BGR7_MOUSE
Predicted gene 21992
Gm21992
477Annotation score:
J3QN51J3QN51_MOUSE
MCG8382, isoform CRA_d
Gm21992 mCG_8382
118Annotation score:
J3QQ01J3QQ01_MOUSE
Predicted gene 21992
Gm21992
20Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124D → Y in BAB23678 (PubMed:16141072).Curated1
Sequence conflicti136E → G in BAB23678 (PubMed:16141072).Curated1
Sequence conflicti182S → F in BAB23678 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015080603 – 669GSDRR…YQRRM → CMPPRLSPQLGLRARG in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004928 mRNA Translation: BAB23678.1
AK088201 mRNA Translation: BAC40206.1
AK167503 mRNA Translation: BAE39579.1
BC010294 mRNA Translation: AAH10294.1
CCDSiCCDS29437.1 [Q8C2Q3-1]
RefSeqiNP_063922.2, NM_019869.3 [Q8C2Q3-1]
UniGeneiMm.276338

Genome annotation databases

EnsembliENSMUST00000006625; ENSMUSP00000006625; ENSMUSG00000006456 [Q8C2Q3-1]
GeneIDi56275
KEGGimmu:56275
UCSCiuc008gaz.2 mouse [Q8C2Q3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004928 mRNA Translation: BAB23678.1
AK088201 mRNA Translation: BAC40206.1
AK167503 mRNA Translation: BAE39579.1
BC010294 mRNA Translation: AAH10294.1
CCDSiCCDS29437.1 [Q8C2Q3-1]
RefSeqiNP_063922.2, NM_019869.3 [Q8C2Q3-1]
UniGeneiMm.276338

3D structure databases

ProteinModelPortaliQ8C2Q3
SMRiQ8C2Q3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207870, 7 interactors
DIPiDIP-58946N
IntActiQ8C2Q3, 9 interactors
MINTiQ8C2Q3
STRINGi10090.ENSMUSP00000006625

PTM databases

iPTMnetiQ8C2Q3
PhosphoSitePlusiQ8C2Q3

Proteomic databases

EPDiQ8C2Q3
PaxDbiQ8C2Q3
PeptideAtlasiQ8C2Q3
PRIDEiQ8C2Q3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006625; ENSMUSP00000006625; ENSMUSG00000006456 [Q8C2Q3-1]
GeneIDi56275
KEGGimmu:56275
UCSCiuc008gaz.2 mouse [Q8C2Q3-1]

Organism-specific databases

CTDi10432
MGIiMGI:1929092 Rbm14

Phylogenomic databases

eggNOGiENOG410IES1 Eukaryota
ENOG4111RA3 LUCA
GeneTreeiENSGT00390000020883
HOGENOMiHOG000065673
HOVERGENiHBG053180
InParanoidiQ8C2Q3
KOiK13189
OrthoDBiEOG091G05UU
PhylomeDBiQ8C2Q3
TreeFamiTF320661

Enzyme and pathway databases

ReactomeiR-MMU-8941326 RUNX2 regulates bone development

Miscellaneous databases

ChiTaRSiRbm14 mouse
PROiPR:Q8C2Q3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006456 Expressed in 299 organ(s), highest expression level in urinary bladder
CleanExiMM_RBM14
ExpressionAtlasiQ8C2Q3 baseline and differential
GenevisibleiQ8C2Q3 MM

Family and domain databases

CDDicd12608 RRM1_CoAA, 1 hit
cd12609 RRM2_CoAA, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034506 RBM14_RRM1
IPR034507 RBM14_RRM2
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRBM14_MOUSE
AccessioniPrimary (citable) accession number: Q8C2Q3
Secondary accession number(s): Q3TJB6, Q91Z21, Q9DBI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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