UniProtKB - Q8C2M0 (Q8C2M0_MOUSE)
Protein
Submitted name:
Cathepsin W
Gene
Ctsw
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Cathepsin WImported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1338045, Ctsw |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015020115 | 22 – 371 | Sequence analysisAdd BLAST | 350 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000024910, Expressed in blood and 86 other tissues |
ExpressionAtlasi | Q8C2M0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 97 | Inhibitor_I29InterPro annotationAdd BLAST | 58 | |
Domaini | 126 – 357 | Pept_C1InterPro annotationAdd BLAST | 232 |
Sequence similaritiesi
Belongs to the peptidase C1 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_012184_4_1_1 |
OMAi | TCGITKY |
OrthoDBi | 1264766at2759 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR033158, Cathepsin_W IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
PANTHERi | PTHR12411:SF101, PTHR12411:SF101, 1 hit |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8C2M0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLTAHLSYF LVLLLAGQGL SDSLLTKDAG PRPLELKEVF KLFQIRFNRS
60 70 80 90 100
YWNPAEYTRR LSIFAHNLAQ AQRLQQEDLG TAEFGETPFS DLTEEEFGQL
110 120 130 140 150
YGQERSPERT PNMTKKVESN TWGESVPRTC DWRKAKNIIS SVKNQGSCKC
160 170 180 190 200
CWAMAAADNI QALWRIKHQQ FVDVSVQELL DCERCGNGCN GGFVWDAYLT
210 220 230 240 250
VLNNSGLASE KDYPFQGDRK PHRCLAKKYK KVAWIQDFTM LSNNEQAIAH
260 270 280 290 300
YLAVHGPITV TINMKLLQHY QKGVIKATPS SCDPRQVDHS VLLVGFGKEK
310 320 330 340 350
EGMQTGTVLS HSRKRRHSSP YWILKNSWGA HWGEKGYFRL YRGNNTCGVT
360 370
KYPFTAQVDS PVKKARTSCP P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY499549 Genomic DNA Translation: AAS48498.1 AK088375 mRNA Translation: BAC40314.1 |
RefSeqi | NP_034115.2, NM_009985.5 |
Genome annotation databases
GeneIDi | 13041 |
KEGGi | mmu:13041 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY499549 Genomic DNA Translation: AAS48498.1 AK088375 mRNA Translation: BAC40314.1 |
RefSeqi | NP_034115.2, NM_009985.5 |
3D structure databases
SMRi | Q8C2M0 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 4281, 100 antibodies |
DNASUi | 13041 |
Genome annotation databases
GeneIDi | 13041 |
KEGGi | mmu:13041 |
Organism-specific databases
CTDi | 1521 |
MGIi | MGI:1338045, Ctsw |
Phylogenomic databases
HOGENOMi | CLU_012184_4_1_1 |
OMAi | TCGITKY |
OrthoDBi | 1264766at2759 |
Miscellaneous databases
BioGRID-ORCSi | 13041, 0 hits in 17 CRISPR screens |
ChiTaRSi | Ctsw, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024910, Expressed in blood and 86 other tissues |
ExpressionAtlasi | Q8C2M0, baseline and differential |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR033158, Cathepsin_W IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
PANTHERi | PTHR12411:SF101, PTHR12411:SF101, 1 hit |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8C2M0_MOUSE | |
Accessioni | Q8C2M0Primary (citable) accession number: Q8C2M0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |