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Entry version 165 (08 May 2019)
Sequence version 2 (16 May 2003)
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Protein

Histone deacetylase 7

Gene

Hdac7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3 (By similarity).By similarity1 Publication

Miscellaneous

Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. EC:3.5.1.98

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi520ZincBy similarity1
Metal bindingi522ZincBy similarity1
Metal bindingi528ZincBy similarity1
Metal bindingi605ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei657By similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei830Contributes to catalysisBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-350054 Notch-HLH transcription pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone deacetylase 7 (EC:3.5.1.98)
Short name:
HD7
Alternative name(s):
Histone deacetylase 7A
Short name:
HD7a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hdac7
Synonyms:Hdac7a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891835 Hdac7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi178S → A: Strong reduction of CaMK1-dependent nuclear export. Reduces interaction with YWHAE. 1 Publication1
Mutagenesisi344S → A: Strong reduction of CaMK1-dependent nuclear export. Reduces interaction with YWHAE. 1 Publication1
Mutagenesisi479S → A: Strong reduction of CaMK1-dependent nuclear export. Reduces interaction with YWHAE. 1 Publication1
Mutagenesisi657H → A: Abolishes deacetylase activity, but not the interaction with HDAC2 and HDAC3. 2 Publications1
Mutagenesisi692D → A: Disrupts the dot-like nuclear pattern. 1 Publication1
Mutagenesisi694D → A: Disrupts the dot-like nuclear pattern. Abolishes deacetylase activity, but not the interaction with HDAC2 and HDAC3. 1 Publication1
Mutagenesisi717H → A: Abolishes deacetylase activity, but not the interaction with HDAC2 and HDAC3. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3832944

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001147061 – 938Histone deacetylase 7Add BLAST938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphoserineBy similarity1
Modified residuei178Phosphoserine; by MARK2, MARK3 and PKD/PRKD11 Publication1
Modified residuei204Phosphoserine; by PKD/PRKD2By similarity1
Modified residuei344Phosphoserine; by PKD/PRKD11 Publication1
Modified residuei350PhosphoserineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei479Phosphoserine; by PKD/PRKD11 Publication1
Modified residuei480PhosphoserineBy similarity1
Modified residuei582PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-178 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-178 is a prerequisite for phosphorylation at Ser-204 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8C2B3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C2B3

PRoteomics IDEntifications database

More...
PRIDEi
Q8C2B3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C2B3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C2B3

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q8C2B3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart and lung. Expressed at intermediate level in muscle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022475 Expressed in 231 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C2B3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C2B3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KDM5B (By similarity). Interacts with KAT5 and EDNRA. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with ZMYND15. Interacts with PML (By similarity). Interacts with FOXP3.By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
207862, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8C2B3

Database of interacting proteins

More...
DIPi
DIP-42594N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8C2B3

Protein interaction database and analysis system

More...
IntActi
Q8C2B3, 6 interactors

Molecular INTeraction database

More...
MINTi
Q8C2B3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000085744

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C2B3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 121Interaction with MEF2CAdd BLAST121
Regioni2 – 254Transcription repression 1Add BLAST253
Regioni72 – 172Interaction with MEF2A1 PublicationAdd BLAST101
Regioni241 – 533Transcription repression 2Add BLAST293
Regioni505 – 852Histone deacetylaseAdd BLAST348
Regioni864 – 938Interaction with SIN3AAdd BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi904 – 938Nuclear export signalBy similarityAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi220 – 226Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1343 Eukaryota
COG0123 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232065

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C2B3

KEGG Orthology (KO)

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KOi
K11408

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQQVFLW

Database of Orthologous Groups

More...
OrthoDBi
1484694at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C2B3

TreeFam database of animal gene trees

More...
TreeFami
TF106173

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.800.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR017320 Histone_deAcase_II_euk
IPR023696 Ureohydrolase_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00850 Hist_deacetyl, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037911 HDAC_II_euk, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01270 HDASUPER

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52768 SSF52768, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C2B3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHSPGAGCPA LQPDTPGSQP QPMDLRVGQR PTVEPPPEPA LLTLQHPQRL
60 70 80 90 100
HRHLFLAGLH QQQRSAEPMR LSMDPPMPEL QGGQQEQELR QLLNKDKSKR
110 120 130 140 150
SAVASSVVKQ KLAEVILKKQ QAALERTVHP SSPSIPYRTL EPLDTEGAAR
160 170 180 190 200
SVLSSFLPPV PSLPTEPPEH FPLRKTVSEP NLKLRYKPKK SLERRKNPLL
210 220 230 240 250
RKESAPPSLR RRPAETLGDS SPSSSSTPAS GCSSPNDSEH GPNPALGSEA
260 270 280 290 300
DGDRRTHSTL GPRGPVLGNP HAPLFLHHGL EPEAGGTLPS RLQPILLLDP
310 320 330 340 350
SVSHAPLWTV PGLGPLPFHF AQPLLTTERL SGSGLHRPLN RTRSEPLPPS
360 370 380 390 400
ATASPLLAPL QPRQDRLKPH VQLIKPAISP PQRPAKPSEK PRLRQIPSAE
410 420 430 440 450
DLETDGGGVG PMANDGLEHR ESGRGPPEGR GSISLQQHQQ VPPWEQQHLA
460 470 480 490 500
GRLSQGSPGD SVLIPLAQVG HRPLSRTQSS PAAPVSLLSP EPTCQTQVLN
510 520 530 540 550
SSETPATGLV YDSVMLKHQC SCGDNSKHPE HAGRIQSIWS RLQERGLRSQ
560 570 580 590 600
CECLRGRKAS LEELQSVHSE RHVLLYGTNP LSRLKLDNGK LTGLLAQRTF
610 620 630 640 650
VMLPCGGVGV DTDTIWNELH SSNAARWAAG SVTDLAFKVA SRELKNGFAV
660 670 680 690 700
VRPPGHHADH STAMGFCFFN SVAIACRQLQ QHGKASKILI VDWDVHHGNG
710 720 730 740 750
TQQTFYQDPS VLYISLHRHD DGNFFPGSGA VDEVGTGSGE GFNVNVAWAG
760 770 780 790 800
GLDPPMGDPE YLAAFRIVVM PIAREFAPDL VLVSAGFDAA EGHPAPLGGY
810 820 830 840 850
HVSAKCFGYM TQQLMNLAGG AVVLALEGGH DLTAICDASE ACVAALLGNK
860 870 880 890 900
VDPLSEESWK QKPNLSAIRS LEAVVRVHRK YWGCMQRLAS CPDSWLPRVP
910 920 930
GADAEVEAVT ALASLSVGIL AEDRPSERLV EEEEPMNL
Length:938
Mass (Da):101,287
Last modified:May 16, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D4B455CE6F95483
GO
Isoform 2 (identifier: Q8C2B3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     249-249: E → EALLGQRLRLQETSLAPFALPTVSLLPAITLGLPAPAR
     376-382: Missing.

Show »
Length:946
Mass (Da):102,289
Checksum:i035DE255A4F44F7E
GO
Isoform 3 (identifier: Q8C2B3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     249-249: E → EALLGQRLRLQETSLAPFALPTVSLLPAITLGLPAPAR

Show »
Length:953
Mass (Da):102,980
Checksum:i4D87C0E22274202C
GO
Isoform 4 (identifier: Q8C2B3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-161: Missing.
     249-249: E → EALLGQRLRLQETSLAPFALPTVSLLPAITLGLPAPAR
     376-382: Missing.

Show »
Length:944
Mass (Da):101,910
Checksum:i5DD4D8F2A30A8C16
GO
Isoform 5 (identifier: Q8C2B3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Show »
Length:916
Mass (Da):99,131
Checksum:i1586B7308A24964A
GO
Isoform 6 (identifier: Q8C2B3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-161: Missing.

Show »
Length:914
Mass (Da):98,752
Checksum:i23AD714981D53FC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PXW1E9PXW1_MOUSE
Histone deacetylase
Hdac7
892Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PX62E9PX62_MOUSE
Histone deacetylase
Hdac7
851Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PXW8E9PXW8_MOUSE
Histone deacetylase
Hdac7
868Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PZG4E9PZG4_MOUSE
Histone deacetylase 7
Hdac7
636Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VIB5F6VIB5_MOUSE
Histone deacetylase 7
Hdac7
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RY11F6RY11_MOUSE
Histone deacetylase 7
Hdac7
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169E → G in BAC27161 (PubMed:16141072).Curated1
Sequence conflicti183K → M in BAC29493 (PubMed:16141072).Curated1
Sequence conflicti228P → T in BAC27161 (PubMed:16141072).Curated1
Sequence conflicti487L → M in AAF31419 (PubMed:10640276).Curated1
Sequence conflicti487L → M in BAC40598 (PubMed:16141072).Curated1
Sequence conflicti487L → M in BAC40666 (PubMed:16141072).Curated1
Sequence conflicti645K → R in BAC29493 (PubMed:16141072).Curated1
Sequence conflicti661S → P in BAC40598 (PubMed:16141072).Curated1
Sequence conflicti737G → A in AAF31419 (PubMed:10640276).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0074321 – 22Missing in isoform 2, isoform 3 and isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_007433138 – 161Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_007434249E → EALLGQRLRLQETSLAPFAL PTVSLLPAITLGLPAPAR in isoform 2, isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_007435376 – 382Missing in isoform 2 and isoform 4. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF207749 mRNA Translation: AAF31419.1
AK030863 mRNA Translation: BAC27161.1
AK036586 mRNA Translation: BAC29493.1
AK044287 mRNA Translation: BAC31856.1
AK088828 mRNA Translation: BAC40598.1
AK088945 mRNA Translation: BAC40666.1
BC057332 mRNA Translation: AAH57332.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37188.1 [Q8C2B3-1]
CCDS57004.1 [Q8C2B3-5]
CCDS57005.1 [Q8C2B3-2]
CCDS57006.1 [Q8C2B3-3]
CCDS57007.1 [Q8C2B3-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001191204.1, NM_001204275.1 [Q8C2B3-3]
NP_001191205.1, NM_001204276.1 [Q8C2B3-2]
NP_001191206.1, NM_001204277.1 [Q8C2B3-4]
NP_001191207.1, NM_001204278.1 [Q8C2B3-5]
NP_062518.2, NM_019572.3 [Q8C2B3-1]
XP_006521268.1, XM_006521205.2 [Q8C2B3-3]
XP_006521270.1, XM_006521207.3 [Q8C2B3-3]
XP_006521271.1, XM_006521208.3 [Q8C2B3-3]
XP_006521272.1, XM_006521209.2 [Q8C2B3-3]
XP_006521273.1, XM_006521210.2 [Q8C2B3-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000079838; ENSMUSP00000078766; ENSMUSG00000022475 [Q8C2B3-4]
ENSMUST00000088402; ENSMUSP00000085744; ENSMUSG00000022475 [Q8C2B3-1]
ENSMUST00000116408; ENSMUSP00000112109; ENSMUSG00000022475 [Q8C2B3-5]
ENSMUST00000116409; ENSMUSP00000112110; ENSMUSG00000022475 [Q8C2B3-3]
ENSMUST00000118294; ENSMUSP00000113380; ENSMUSG00000022475 [Q8C2B3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56233

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:56233

UCSC genome browser

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UCSCi
uc007xle.2 mouse [Q8C2B3-1]
uc007xlf.2 mouse [Q8C2B3-2]
uc007xlg.2 mouse [Q8C2B3-4]
uc007xlh.2 mouse [Q8C2B3-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207749 mRNA Translation: AAF31419.1
AK030863 mRNA Translation: BAC27161.1
AK036586 mRNA Translation: BAC29493.1
AK044287 mRNA Translation: BAC31856.1
AK088828 mRNA Translation: BAC40598.1
AK088945 mRNA Translation: BAC40666.1
BC057332 mRNA Translation: AAH57332.1
CCDSiCCDS37188.1 [Q8C2B3-1]
CCDS57004.1 [Q8C2B3-5]
CCDS57005.1 [Q8C2B3-2]
CCDS57006.1 [Q8C2B3-3]
CCDS57007.1 [Q8C2B3-4]
RefSeqiNP_001191204.1, NM_001204275.1 [Q8C2B3-3]
NP_001191205.1, NM_001204276.1 [Q8C2B3-2]
NP_001191206.1, NM_001204277.1 [Q8C2B3-4]
NP_001191207.1, NM_001204278.1 [Q8C2B3-5]
NP_062518.2, NM_019572.3 [Q8C2B3-1]
XP_006521268.1, XM_006521205.2 [Q8C2B3-3]
XP_006521270.1, XM_006521207.3 [Q8C2B3-3]
XP_006521271.1, XM_006521208.3 [Q8C2B3-3]
XP_006521272.1, XM_006521209.2 [Q8C2B3-3]
XP_006521273.1, XM_006521210.2 [Q8C2B3-3]

3D structure databases

SMRiQ8C2B3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207862, 7 interactors
CORUMiQ8C2B3
DIPiDIP-42594N
ELMiQ8C2B3
IntActiQ8C2B3, 6 interactors
MINTiQ8C2B3
STRINGi10090.ENSMUSP00000085744

Chemistry databases

ChEMBLiCHEMBL3832944

PTM databases

iPTMnetiQ8C2B3
PhosphoSitePlusiQ8C2B3

Proteomic databases

jPOSTiQ8C2B3
PaxDbiQ8C2B3
PRIDEiQ8C2B3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079838; ENSMUSP00000078766; ENSMUSG00000022475 [Q8C2B3-4]
ENSMUST00000088402; ENSMUSP00000085744; ENSMUSG00000022475 [Q8C2B3-1]
ENSMUST00000116408; ENSMUSP00000112109; ENSMUSG00000022475 [Q8C2B3-5]
ENSMUST00000116409; ENSMUSP00000112110; ENSMUSG00000022475 [Q8C2B3-3]
ENSMUST00000118294; ENSMUSP00000113380; ENSMUSG00000022475 [Q8C2B3-2]
GeneIDi56233
KEGGimmu:56233
UCSCiuc007xle.2 mouse [Q8C2B3-1]
uc007xlf.2 mouse [Q8C2B3-2]
uc007xlg.2 mouse [Q8C2B3-4]
uc007xlh.2 mouse [Q8C2B3-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51564
MGIiMGI:1891835 Hdac7

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00940000159065
HOGENOMiHOG000232065
InParanoidiQ8C2B3
KOiK11408
OMAiHQQVFLW
OrthoDBi1484694at2759
PhylomeDBiQ8C2B3
TreeFamiTF106173

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-350054 Notch-HLH transcription pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hdac7 mouse
PMAP-CutDBiQ8C2B3

Protein Ontology

More...
PROi
PR:Q8C2B3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022475 Expressed in 231 organ(s), highest expression level in thymus
ExpressionAtlasiQ8C2B3 baseline and differential
GenevisibleiQ8C2B3 MM

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR017320 Histone_deAcase_II_euk
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDAC7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C2B3
Secondary accession number(s): Q8C2C9
, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 16, 2003
Last modified: May 8, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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