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Entry version 124 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Dipeptidase 2

Gene

Dpep2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:12738806). Does not hydrolyze cystinyl-bis-glycine (PubMed:12738806).1 Publication
Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappa-B inflammatory signaling pathway.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+PROSITE-ProRule annotationBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by L-penicillamine.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5 µM for LTD41 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi91Zinc 1; catalyticPROSITE-ProRule annotation1
    Metal bindingi93Zinc 1; catalyticPROSITE-ProRule annotation1
    Metal bindingi190Zinc 1; catalyticPROSITE-ProRule annotation1
    Metal bindingi190Zinc 2; catalyticPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei217SubstratePROSITE-ProRule annotation1
    Metal bindingi263Zinc 2; catalyticPROSITE-ProRule annotation1
    Metal bindingi284Zinc 2; catalyticPROSITE-ProRule annotation1
    Binding sitei295SubstratePROSITE-ProRule annotation1
    Binding sitei353SubstratePROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
    Biological processLipid metabolism
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
    R-MMU-5423646, Aflatoxin activation and detoxification
    R-MMU-9664535, LTC4-CYSLTR mediated IL4 production

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M19.002

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001462

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Dipeptidase 2 (EC:3.4.13.191 Publication)
    Alternative name(s):
    Membrane-bound dipeptidase 21 Publication
    Short name:
    MBD-21 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Dpep2
    Synonyms:Mbd2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2442042, Dpep2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023160532 – 459Dipeptidase 2Add BLAST428
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000231606460 – 478Removed in mature formBy similarityAdd BLAST19

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi140 ↔ 219PROSITE-ProRule annotation
    Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi291 ↔ 323PROSITE-ProRule annotation
    Disulfide bondi428InterchainPROSITE-ProRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi459GPI-anchor amidated serineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    non-CPTAC-3551

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8C255

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8C255

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8C255

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    Q8C255, 2 sites

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8C255

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in heart, lung, testis, spleen and skeletal muscle. Not detected in kidney and brain.1 Publication

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated during CVB3-induced viral myocarditis in the cardiac infiltrating macrophages.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000053687, Expressed in bone marrow macrophage and 50 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8C255, baseline

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer; disulfide-linked.

    PROSITE-ProRule annotation

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000080659

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8C255, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8C255

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG4127, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160211

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_031404_4_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8C255

    KEGG Orthology (KO)

    More...
    KOi
    K01273

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HTMPGTY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1272387at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8C255

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF324523

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01301, rDP_like, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000180, Dipep_AS
    IPR028531, Dpep2/3
    IPR032466, Metal_Hydrolase
    IPR008257, Pept_M19

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10443, PTHR10443, 1 hit
    PTHR10443:SF14, PTHR10443:SF14, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01244, Peptidase_M19, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51556, SSF51556, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00869, RENAL_DIPEPTIDASE_1, 1 hit
    PS51365, RENAL_DIPEPTIDASE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8C255-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSLTGLKGHW VLGHGLSVFL LVLLLLGPSQ PLIWTQTKPG FSGASTTSSI
    60 70 80 90 100
    PRALTKPDIS SIPTTPGNPN FPDLRDRARA LMQEFPLIDG HNDMPLVLRQ
    110 120 130 140 150
    FYQNGLQDAN LRNFTHGQTS LDRLKDGLVG AQFWSAYVPC QTQDRDALRL
    160 170 180 190 200
    TLEQIDLIRR ICASYSELEL VTSVKALNST QKLACLIGVE GGHSLDNSLA
    210 220 230 240 250
    VLRSFYLLGV RYLTLTHTCN TPWAETSSKG VHAFYSSVTG LTSFGEKVVA
    260 270 280 290 300
    EMNRLGMMVD LSHVSDAAAR RALEVSQAPV IFSHSAARAV CPNARNLPDD
    310 320 330 340 350
    LLQLLKKNGG IVMVTFSVGV LPCNPLANVS TVADHFDHIR SVIGSEFIGI
    360 370 380 390 400
    GGDYDGTKQF PQGLEDVSTY PVLIEELLRR GWNEQELQGI LRGNLLRVFR
    410 420 430 440 450
    QVEQVRDKSK WQSPLEDMIP EEQLDSACHS ALRPQKQHPE KNQPETPEYH
    460 470
    ILKFSHSKSS PHIVPSLAIV ATLLGLIV
    Length:478
    Mass (Da):52,664
    Last modified:March 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0790B97009F5D41F
    GO
    Isoform 2 (identifier: Q8C255-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MAWHGETYCL...VPACSALSKM
         176-179: ALNS → VKWIYSG
         334-340: DHFDHIR → EKGQQKHQFTPPRDTHFV

    Show »
    Length:578
    Mass (Da):63,675
    Checksum:i253DC762000875A4
    GO
    Isoform 3 (identifier: Q8C255-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-93: Missing.

    Show »
    Length:385
    Mass (Da):42,667
    Checksum:iD28E45A1A5169543
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2K6EDK8A0A2K6EDK8_MOUSE
    Dipeptidase
    Dpep2
    588Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78A → T in BAE42354 (PubMed:16141072).Curated1
    Sequence conflicti89D → G in BAE42559 (PubMed:16141072).Curated1
    Sequence conflicti99R → G in BAE42559 (PubMed:16141072).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0178521 – 93Missing in isoform 3. 1 PublicationAdd BLAST93
    Alternative sequenceiVSP_0178531M → MAWHGETYCLIGGYRVYGDA PLPTPAKAEQEEKPVPRRAP KRQRVQEESDQDLGCPGAKV PRLKLKHGGKGLSRPSSVPA CSALSKM in isoform 2. 1 Publication1
    Alternative sequenceiVSP_017854176 – 179ALNS → VKWIYSG in isoform 2. 1 Publication4
    Alternative sequenceiVSP_017855334 – 340DHFDHIR → EKGQQKHQFTPPRDTHFV in isoform 2. 1 Publication7

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF488552 mRNA Translation: AAP84986.1
    AK089244 mRNA Translation: BAC40810.1
    AK155417 mRNA Translation: BAE33255.1
    AK170094 mRNA Translation: BAE41559.1
    AK170970 mRNA Translation: BAE42149.1
    AK171044 mRNA Translation: BAE42209.1
    AK171122 mRNA Translation: BAE42264.1
    AK171155 mRNA Translation: BAE42280.1
    AK171196 mRNA Translation: BAE42306.1
    AK171268 mRNA Translation: BAE42354.1
    AK171503 mRNA Translation: BAE42494.1
    AK171606 mRNA Translation: BAE42559.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS22625.1 [Q8C255-2]
    CCDS80925.1 [Q8C255-3]
    CCDS80926.1 [Q8C255-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001288133.1, NM_001301204.1 [Q8C255-1]
    NP_001288134.1, NM_001301205.1 [Q8C255-3]
    NP_795887.2, NM_176913.4 [Q8C255-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000034373; ENSMUSP00000034373; ENSMUSG00000053687 [Q8C255-1]
    ENSMUST00000117555; ENSMUSP00000113877; ENSMUSG00000053687 [Q8C255-3]
    ENSMUST00000227363; ENSMUSP00000154250; ENSMUSG00000115067 [Q8C255-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    319446

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:319446

    UCSC genome browser

    More...
    UCSCi
    uc009nex.2, mouse [Q8C255-3]
    uc009ney.2, mouse [Q8C255-2]
    uc057amr.1, mouse [Q8C255-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF488552 mRNA Translation: AAP84986.1
    AK089244 mRNA Translation: BAC40810.1
    AK155417 mRNA Translation: BAE33255.1
    AK170094 mRNA Translation: BAE41559.1
    AK170970 mRNA Translation: BAE42149.1
    AK171044 mRNA Translation: BAE42209.1
    AK171122 mRNA Translation: BAE42264.1
    AK171155 mRNA Translation: BAE42280.1
    AK171196 mRNA Translation: BAE42306.1
    AK171268 mRNA Translation: BAE42354.1
    AK171503 mRNA Translation: BAE42494.1
    AK171606 mRNA Translation: BAE42559.1
    CCDSiCCDS22625.1 [Q8C255-2]
    CCDS80925.1 [Q8C255-3]
    CCDS80926.1 [Q8C255-1]
    RefSeqiNP_001288133.1, NM_001301204.1 [Q8C255-1]
    NP_001288134.1, NM_001301205.1 [Q8C255-3]
    NP_795887.2, NM_176913.4 [Q8C255-2]

    3D structure databases

    SMRiQ8C255
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000080659

    Chemistry databases

    SwissLipidsiSLP:000001462

    Protein family/group databases

    MEROPSiM19.002

    PTM databases

    GlyGeniQ8C255, 2 sites
    PhosphoSitePlusiQ8C255

    Proteomic databases

    CPTACinon-CPTAC-3551
    PaxDbiQ8C255
    PeptideAtlasiQ8C255
    PRIDEiQ8C255

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    319446

    Genome annotation databases

    EnsembliENSMUST00000034373; ENSMUSP00000034373; ENSMUSG00000053687 [Q8C255-1]
    ENSMUST00000117555; ENSMUSP00000113877; ENSMUSG00000053687 [Q8C255-3]
    ENSMUST00000227363; ENSMUSP00000154250; ENSMUSG00000115067 [Q8C255-2]
    GeneIDi319446
    KEGGimmu:319446
    UCSCiuc009nex.2, mouse [Q8C255-3]
    uc009ney.2, mouse [Q8C255-2]
    uc057amr.1, mouse [Q8C255-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    64174
    MGIiMGI:2442042, Dpep2

    Phylogenomic databases

    eggNOGiKOG4127, Eukaryota
    GeneTreeiENSGT00940000160211
    HOGENOMiCLU_031404_4_1_1
    InParanoidiQ8C255
    KOiK01273
    OMAiHTMPGTY
    OrthoDBi1272387at2759
    PhylomeDBiQ8C255
    TreeFamiTF324523

    Enzyme and pathway databases

    ReactomeiR-MMU-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
    R-MMU-5423646, Aflatoxin activation and detoxification
    R-MMU-9664535, LTC4-CYSLTR mediated IL4 production

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    319446, 0 hits in 22 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Dpep2, mouse

    Protein Ontology

    More...
    PROi
    PR:Q8C255
    RNActiQ8C255, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000053687, Expressed in bone marrow macrophage and 50 other tissues
    ExpressionAtlasiQ8C255, baseline

    Family and domain databases

    CDDicd01301, rDP_like, 1 hit
    InterProiView protein in InterPro
    IPR000180, Dipep_AS
    IPR028531, Dpep2/3
    IPR032466, Metal_Hydrolase
    IPR008257, Pept_M19
    PANTHERiPTHR10443, PTHR10443, 1 hit
    PTHR10443:SF14, PTHR10443:SF14, 1 hit
    PfamiView protein in Pfam
    PF01244, Peptidase_M19, 1 hit
    SUPFAMiSSF51556, SSF51556, 1 hit
    PROSITEiView protein in PROSITE
    PS00869, RENAL_DIPEPTIDASE_1, 1 hit
    PS51365, RENAL_DIPEPTIDASE_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPEP2_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C255
    Secondary accession number(s): Q3TAV9
    , Q3TBF7, Q3TBK3, Q3TBM9, Q7TQ53
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: March 1, 2003
    Last modified: August 12, 2020
    This is version 124 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
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