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Protein

G-protein coupled receptor 157

Gene

Gpr157

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs) (PubMed:27142930). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger (PubMed:27142930).1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • circadian behavior Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
  • radial glial cell differentiation Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 157
Gene namesi
Name:Gpr157
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2442046 Gpr157

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15ExtracellularSequence analysisAdd BLAST15
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 48CytoplasmicSequence analysisAdd BLAST12
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini70 – 87ExtracellularSequence analysisAdd BLAST18
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini109 – 119CytoplasmicSequence analysisAdd BLAST11
Transmembranei120 – 140Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini141 – 166ExtracellularSequence analysisAdd BLAST26
Transmembranei167 – 187Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini188 – 227CytoplasmicSequence analysisAdd BLAST40
Transmembranei228 – 248Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini249 – 259ExtracellularSequence analysisAdd BLAST11
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 330CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000703401 – 330G-protein coupled receptor 157Add BLAST330

Proteomic databases

PaxDbiQ8C206
PRIDEiQ8C206

PTM databases

iPTMnetiQ8C206
PhosphoSitePlusiQ8C206

Expressioni

Tissue specificityi

Expressed in the primary cilia of radial glial progenitors (RGPs) in the developing neocortex (PubMed:27142930).1 Publication

Developmental stagei

Preferential expression during the early to mid stages of corticogenesis. High levels in the early radial glial progenitors from 10 to 17 dpc and gradually decrease thereafter (at protein level) (PubMed:27142930).1 Publication

Gene expression databases

BgeeiENSMUSG00000047875
CleanExiMM_GPR157
ExpressionAtlasiQ8C206 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092020

Structurei

3D structure databases

ProteinModelPortaliQ8C206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi295 – 298Poly-Cys4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGF4 Eukaryota
ENOG410XSF0 LUCA
GeneTreeiENSGT00390000012992
HOGENOMiHOG000070448
HOVERGENiHBG055714
InParanoidiQ8C206
KOiK08467
OMAiQGAANCI
OrthoDBiEOG091G0LK3
PhylomeDBiQ8C206
TreeFamiTF330856

Family and domain databases

InterProiView protein in InterPro
IPR022343 GCR1-cAMP_receptor
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PRINTSiPR02001 GCR1CAMPR
PROSITEiView protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPAPPTEL LPWERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL
60 70 80 90 100
LFLSLADLLS AASYFYGVLQ DFAGTSWDCV LQGALSTFAN TSSFFWTVAI
110 120 130 140 150
ALYLYLSIVR TTRGPSTDHL IWAFHLISWG VPLAITVAAV SLKKIGYDAS
160 170 180 190 200
DVSVGWCWIN LEAEDRVLWM LLTGKLWEML AYILLPLLYL LVRKHINRAH
210 220 230 240 250
QALSEYRPIC EGRQLQRGSS TSTADKKLVL IPLIFICLRV WSTVRFVLTL
260 270 280 290 300
CGSPAVQTPV LVVLHGIGNT FQGGANCIMF VLCTRAVRTR LFSLCCCCPR
310 320 330
PSTQSPPGAP TPPKIGESQE SRRTPEVPST
Length:330
Mass (Da):36,344
Last modified:March 1, 2003 - v1
Checksum:iD2A1F08B4365A2DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296C → W in BAC40879 (PubMed:16141072).Curated1
Sequence conflicti326 – 330EVPST → RSAQHSGWLSSLSVLALPSW FLLQD in BAC40879 (PubMed:16141072).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089544 mRNA Translation: BAC40921.1
AK089429 mRNA Translation: BAC40879.1
CCDSiCCDS38977.1
RefSeqiNP_796340.2, NM_177366.3
UniGeneiMm.219307

Genome annotation databases

EnsembliENSMUST00000094451; ENSMUSP00000092020; ENSMUSG00000047875
GeneIDi269604
KEGGimmu:269604
UCSCiuc008vxj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGP157_MOUSE
AccessioniPrimary (citable) accession number: Q8C206
Secondary accession number(s): Q8C224
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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