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Entry version 119 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Vacuolar fusion protein CCZ1 homolog

Gene

Ccz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar fusion protein CCZ1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccz1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2141070, Ccz1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000029617

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895852 – 480Vacuolar fusion protein CCZ1 homologAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei264PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C1Y8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8C1Y8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8C1Y8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C1Y8

PeptideAtlas

More...
PeptideAtlasi
Q8C1Y8

PRoteomics IDEntifications database

More...
PRIDEi
Q8C1Y8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
281430

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C1Y8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C1Y8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8C1Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029617, Expressed in cleaving embryo and 327 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C1Y8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MON1A.

Found in a complex with RMC1, CCZ1 MON1A and MON1B.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231188, 7 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000031621

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C1Y8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C1Y8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCZ1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2622, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037828_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C1Y8

Identification of Orthologs from Complete Genome Data

More...
OMAi
QPEPGYW

Database of Orthologous Groups

More...
OrthoDBi
448107at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C1Y8

TreeFam database of animal gene trees

More...
TreeFami
TF314962

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013176, Ccz1
IPR043987, CCZ1/INTU/HSP4_longin_1
IPR043989, CCZ1/INTU/HSP4_longin_3
IPR043988, CCZ1/INTU_longin_2

The PANTHER Classification System

More...
PANTHERi
PTHR13056, PTHR13056, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19031, Intu_longin_1, 1 hit
PF19032, Intu_longin_2, 1 hit
PF19033, Intu_longin_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C1Y8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAAGPGA WAAQEKQFPP ALLSFFIYNP RFGPREGEEE NKILFYHPNE
60 70 80 90 100
VEKNEKIRNV GLCEAIVQFT RTFSPSKPAK SLHTQKNRQF FNEPEENFWM
110 120 130 140 150
VMVVRNPIIE KQSKDGKAVV EYQEEELLDK VYSSVLQQCY SMYKLFNGTF
160 170 180 190 200
LKAMEDGGVK LLKERLEKFF HRYLQTLHLQ SCDLLDIFGG ISFFPLDKMT
210 220 230 240 250
YLKIQSFINR MEESLSVVKY TAFLYNDQLI WSGLEQDDMR ILYKYLTTSL
260 270 280 290 300
FPRHIEPELA GRDSPVRAEM PGNLQHYGRF LTGPLNLNDP EAKCRFPKIF
310 320 330 340 350
VNTDDTYEEL HLIVYKAMSA AVCFMIDAST PLTLDFCRRL DSIVGPQLTV
360 370 380 390 400
LASDICEQFN INKRISGSEK EPQFKFIYFN HMNLAEKSTI HMRKTPSVSL
410 420 430 440 450
TSVHPDLMKI LGDINSDFTR ADEDEEIIVK AMSDYWVVGK KSDQRELYVI
460 470 480
LSQKNANLIE VNEEVKKLCA TQFNNIFFLD
Length:480
Mass (Da):55,505
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6ABFCE751942389
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK090008 mRNA Translation: BAC41041.1
AK150793 mRNA Translation: BAE29856.1
AK152328 mRNA Translation: BAE31127.1
AK152576 mRNA Translation: BAE31327.1
AK153160 mRNA Translation: BAE31770.1
BC048077 mRNA Translation: AAH48077.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19846.1

NCBI Reference Sequences

More...
RefSeqi
NP_808350.1, NM_177682.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000031621; ENSMUSP00000031621; ENSMUSG00000029617

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
231874

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:231874

UCSC genome browser

More...
UCSCi
uc009ale.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090008 mRNA Translation: BAC41041.1
AK150793 mRNA Translation: BAE29856.1
AK152328 mRNA Translation: BAE31127.1
AK152576 mRNA Translation: BAE31327.1
AK153160 mRNA Translation: BAE31770.1
BC048077 mRNA Translation: AAH48077.1
CCDSiCCDS19846.1
RefSeqiNP_808350.1, NM_177682.3

3D structure databases

SMRiQ8C1Y8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231188, 7 interactors
STRINGi10090.ENSMUSP00000031621

PTM databases

iPTMnetiQ8C1Y8
PhosphoSitePlusiQ8C1Y8
SwissPalmiQ8C1Y8

Proteomic databases

EPDiQ8C1Y8
jPOSTiQ8C1Y8
MaxQBiQ8C1Y8
PaxDbiQ8C1Y8
PeptideAtlasiQ8C1Y8
PRIDEiQ8C1Y8
ProteomicsDBi281430

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
231874

Genome annotation databases

EnsembliENSMUST00000031621; ENSMUSP00000031621; ENSMUSG00000029617
GeneIDi231874
KEGGimmu:231874
UCSCiuc009ale.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51622
MGIiMGI:2141070, Ccz1
VEuPathDBiHostDB:ENSMUSG00000029617

Phylogenomic databases

eggNOGiKOG2622, Eukaryota
GeneTreeiENSGT00390000004713
HOGENOMiCLU_037828_2_0_1
InParanoidiQ8C1Y8
OMAiQPEPGYW
OrthoDBi448107at2759
PhylomeDBiQ8C1Y8
TreeFamiTF314962

Enzyme and pathway databases

ReactomeiR-MMU-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
231874, 6 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ccz1, mouse

Protein Ontology

More...
PROi
PR:Q8C1Y8
RNActiQ8C1Y8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029617, Expressed in cleaving embryo and 327 other tissues
GenevisibleiQ8C1Y8, MM

Family and domain databases

InterProiView protein in InterPro
IPR013176, Ccz1
IPR043987, CCZ1/INTU/HSP4_longin_1
IPR043989, CCZ1/INTU/HSP4_longin_3
IPR043988, CCZ1/INTU_longin_2
PANTHERiPTHR13056, PTHR13056, 1 hit
PfamiView protein in Pfam
PF19031, Intu_longin_1, 1 hit
PF19032, Intu_longin_2, 1 hit
PF19033, Intu_longin_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCZ1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C1Y8
Secondary accession number(s): Q3U891
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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