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Protein

Mediator of RNA polymerase II transcription subunit 19

Gene

Med19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 19
Alternative name(s):
Mediator complex subunit 19
Gene namesi
Name:Med19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914234 Med19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003047671 – 244Mediator of RNA polymerase II transcription subunit 19Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineBy similarity1
Modified residuei226PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C1S0
MaxQBiQ8C1S0
PaxDbiQ8C1S0
PeptideAtlasiQ8C1S0
PRIDEiQ8C1S0

PTM databases

iPTMnetiQ8C1S0
PhosphoSitePlusiQ8C1S0

Expressioni

Gene expression databases

BgeeiENSMUSG00000027080 Expressed in 270 organ(s), highest expression level in cumulus cell
GenevisibleiQ8C1S0 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237911, 2 interactors
ComplexPortaliCPX-3264 Core mediator complex
IntActiQ8C1S0, 11 interactors
MINTiQ8C1S0
STRINGi10090.ENSMUSP00000099705

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 45Pro-richAdd BLAST32
Compositional biasi172 – 222Lys-richAdd BLAST51

Sequence similaritiesi

Belongs to the Mediator complex subunit 19 family.Curated

Phylogenomic databases

eggNOGiKOG4043 Eukaryota
ENOG4111KKA LUCA
GeneTreeiENSGT00390000001774
HOGENOMiHOG000047323
HOVERGENiHBG055317
InParanoidiQ8C1S0
KOiK15137
OMAiNRHSPEH
OrthoDBiEOG091G0U4B
PhylomeDBiQ8C1S0
TreeFamiTF317417

Family and domain databases

InterProiView protein in InterPro
IPR019403 Mediator_Med19_met
PfamiView protein in Pfam
PF10278 Med19, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C1S0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENFTALFGA QTDPPPPPSA LGFGPGKPPP PPPPPPGGGP GAAPPSTATS
60 70 80 90 100
APAGADKSTA GSGPFYLMRE LPGSTELTGS TNLITHYNLE QAYNKFCGKK
110 120 130 140 150
VKEKLSNFLP DLPGMIDLPG SHDNSSLRSL IEKPPILGGS FNPITGTMLS
160 170 180 190 200
GFRLHTGPLP EQCRLMHIQP PKKKNKHKHK QSRTQDPVPP ETPSDSDHKK
210 220 230 240
KKKKKEEDPE RKRKKKEKKK KKNRHSPDHP GMGSSQASSS SSLR
Length:244
Mass (Da):26,263
Last modified:March 1, 2003 - v1
Checksum:i6F38036D801490AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129 – 140SLIEK…ILGGS → HASAHASAHASA in AAH25475 (PubMed:15489334).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005399 mRNA Translation: BAC25114.1
AK160579 mRNA Translation: BAE35886.1
AK168787 mRNA Translation: BAE40621.1
BC025475 mRNA Translation: AAH25475.1
BC044207 mRNA Translation: AAH44207.1
BC082559 mRNA Translation: AAH82559.1
CCDSiCCDS16189.1
RefSeqiNP_080161.1, NM_025885.3
UniGeneiMm.219643

Genome annotation databases

EnsembliENSMUST00000102645; ENSMUSP00000099705; ENSMUSG00000027080
GeneIDi381379
KEGGimmu:381379
UCSCiuc008kiy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005399 mRNA Translation: BAC25114.1
AK160579 mRNA Translation: BAE35886.1
AK168787 mRNA Translation: BAE40621.1
BC025475 mRNA Translation: AAH25475.1
BC044207 mRNA Translation: AAH44207.1
BC082559 mRNA Translation: AAH82559.1
CCDSiCCDS16189.1
RefSeqiNP_080161.1, NM_025885.3
UniGeneiMm.219643

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237911, 2 interactors
ComplexPortaliCPX-3264 Core mediator complex
IntActiQ8C1S0, 11 interactors
MINTiQ8C1S0
STRINGi10090.ENSMUSP00000099705

PTM databases

iPTMnetiQ8C1S0
PhosphoSitePlusiQ8C1S0

Proteomic databases

EPDiQ8C1S0
MaxQBiQ8C1S0
PaxDbiQ8C1S0
PeptideAtlasiQ8C1S0
PRIDEiQ8C1S0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102645; ENSMUSP00000099705; ENSMUSG00000027080
GeneIDi381379
KEGGimmu:381379
UCSCiuc008kiy.2 mouse

Organism-specific databases

CTDi219541
MGIiMGI:1914234 Med19

Phylogenomic databases

eggNOGiKOG4043 Eukaryota
ENOG4111KKA LUCA
GeneTreeiENSGT00390000001774
HOGENOMiHOG000047323
HOVERGENiHBG055317
InParanoidiQ8C1S0
KOiK15137
OMAiNRHSPEH
OrthoDBiEOG091G0U4B
PhylomeDBiQ8C1S0
TreeFamiTF317417

Miscellaneous databases

ChiTaRSiMed19 mouse
PROiPR:Q8C1S0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027080 Expressed in 270 organ(s), highest expression level in cumulus cell
GenevisibleiQ8C1S0 MM

Family and domain databases

InterProiView protein in InterPro
IPR019403 Mediator_Med19_met
PfamiView protein in Pfam
PF10278 Med19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMED19_MOUSE
AccessioniPrimary (citable) accession number: Q8C1S0
Secondary accession number(s): Q80XM2, Q8R3G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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