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Protein

Meteorin

Gene

Metrn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.1 Publication

Miscellaneous

Was called meteorin because it can transform glial cells into cells with an elongated trail.

GO - Biological processi

  • glial cell differentiation Source: MGI
  • positive regulation of axonogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Meteorin
Alternative name(s):
Hypoxia/reoxygenation regulatory factor
Gene namesi
Name:Metrn
Synonyms:Hyrac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1917333 Metrn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000002168122 – 291MeteorinAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 491 Publication
Disulfide bondi80 ↔ 1161 Publication
Disulfide bondi169 ↔ 2401 Publication
Disulfide bondi172 ↔ 2641 Publication
Disulfide bondi182 ↔ 2861 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8C1Q4
PRIDEiQ8C1Q4

PTM databases

PhosphoSitePlusiQ8C1Q4

Expressioni

Tissue specificityi

Highly expressed in brain. Expressed in undifferentiated neural progenitors and in astrocyte lineage, particulary in Bergmann glia, a subtype of radial glia, and a few discrete neuronal populations residing in the superior colliculus, the ocular motor nucleus, the raphe and pontine nuclei, and in various thalamic nuclei. Weakly expressed in heart, kidney, skeletal muscle, spleen, testis, gut and lung.2 Publications

Inductioni

By all-trans retinoic acid (ATRA).1 Publication

Gene expression databases

BgeeiENSMUSG00000002274 Expressed in 271 organ(s), highest expression level in retina
CleanExiMM_METRN
ExpressionAtlasiQ8C1Q4 baseline and differential
GenevisibleiQ8C1Q4 MM

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002344

Structurei

3D structure databases

ProteinModelPortaliQ8C1Q4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the meteorin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKV7 Eukaryota
ENOG4111FCI LUCA
GeneTreeiENSGT00390000001390
HOGENOMiHOG000236301
HOVERGENiHBG052461
InParanoidiQ8C1Q4
OMAiGAIEWLY
OrthoDBiEOG091G0FAE
PhylomeDBiQ8C1Q4
TreeFamiTF330918

Family and domain databases

InterProiView protein in InterPro
IPR039229 Meteorin
PANTHERiPTHR28593:SF2 PTHR28593:SF2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C1Q4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLVATLLCAL CCGLLAASAH AGYSEDRCSW RGSGLTQEPG SVGQLTLDCT
60 70 80 90 100
EGAIEWLYPA GALRLTLGGP DPGTRPSIVC LRPERPFAGA QVFAERMTGN
110 120 130 140 150
LELLLAEGPD LAGGRCMRWG PRERRALFLQ ATPHRDISRR VAAFRFELHE
160 170 180 190 200
DQRAEMSPQA QGLGVDGACR PCSDAELLLA ACTSDFVIHG TIHGVAHDTE
210 220 230 240 250
LQESVITVVV ARVIRQTLPL FKEGSSEGQG RASIRTLLRC GVRPGPGSFL
260 270 280 290
FMGWSRFGEA WLGCAPRFQE FSRVYSAALT THLNPCEMAL D
Length:291
Mass (Da):31,469
Last modified:July 19, 2004 - v2
Checksum:i643B933B7D127973
GO
Isoform 2 (identifier: Q8C1Q4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.
     165-166: VD → ML

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):13,797
Checksum:i5B0BB2E0C14D507D
GO

Sequence cautioni

The sequence AAH37181 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0108441 – 164Missing in isoform 2. 1 PublicationAdd BLAST164
Alternative sequenceiVSP_010845165 – 166VD → ML in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ133462 mRNA Translation: AAZ41748.1
BC008695 mRNA Translation: AAH08695.1
BC037181 mRNA Translation: AAH37181.1 Different initiation.
BC062118 mRNA Translation: AAH62118.1
CCDSiCCDS28529.1 [Q8C1Q4-1]
RefSeqiNP_598480.1, NM_133719.2 [Q8C1Q4-1]
UniGeneiMm.41925

Genome annotation databases

EnsembliENSMUST00000002344; ENSMUSP00000002344; ENSMUSG00000002274 [Q8C1Q4-1]
ENSMUST00000165838; ENSMUSP00000127275; ENSMUSG00000002274 [Q8C1Q4-1]
GeneIDi70083
KEGGimmu:70083
UCSCiuc008bbz.1 mouse [Q8C1Q4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ133462 mRNA Translation: AAZ41748.1
BC008695 mRNA Translation: AAH08695.1
BC037181 mRNA Translation: AAH37181.1 Different initiation.
BC062118 mRNA Translation: AAH62118.1
CCDSiCCDS28529.1 [Q8C1Q4-1]
RefSeqiNP_598480.1, NM_133719.2 [Q8C1Q4-1]
UniGeneiMm.41925

3D structure databases

ProteinModelPortaliQ8C1Q4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002344

PTM databases

PhosphoSitePlusiQ8C1Q4

Proteomic databases

PaxDbiQ8C1Q4
PRIDEiQ8C1Q4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002344; ENSMUSP00000002344; ENSMUSG00000002274 [Q8C1Q4-1]
ENSMUST00000165838; ENSMUSP00000127275; ENSMUSG00000002274 [Q8C1Q4-1]
GeneIDi70083
KEGGimmu:70083
UCSCiuc008bbz.1 mouse [Q8C1Q4-1]

Organism-specific databases

CTDi79006
MGIiMGI:1917333 Metrn

Phylogenomic databases

eggNOGiENOG410IKV7 Eukaryota
ENOG4111FCI LUCA
GeneTreeiENSGT00390000001390
HOGENOMiHOG000236301
HOVERGENiHBG052461
InParanoidiQ8C1Q4
OMAiGAIEWLY
OrthoDBiEOG091G0FAE
PhylomeDBiQ8C1Q4
TreeFamiTF330918

Miscellaneous databases

PROiPR:Q8C1Q4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002274 Expressed in 271 organ(s), highest expression level in retina
CleanExiMM_METRN
ExpressionAtlasiQ8C1Q4 baseline and differential
GenevisibleiQ8C1Q4 MM

Family and domain databases

InterProiView protein in InterPro
IPR039229 Meteorin
PANTHERiPTHR28593:SF2 PTHR28593:SF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMETRN_MOUSE
AccessioniPrimary (citable) accession number: Q8C1Q4
Secondary accession number(s): Q45G31
, Q6P6N6, Q8CI64, Q922A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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