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Entry version 114 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Ion channel TACAN

Gene

Tmem120a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ion channel involved in sensing mechanical pain (PubMed:32084332).

Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (PubMed:32084332).

May also be required for efficient adipogenesis (PubMed:26024229).

2 Publications

Miscellaneous

TACAN means movement in Farsi.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ion channel TACAN1 Publication
Alternative name(s):
Transmembrane protein 120A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmem120a1 PublicationImported
Synonyms:Net291 Publication, Tacan1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2686991, Tmem120a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 135Cytoplasmic1 PublicationAdd BLAST135
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei136 – 156Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini157 – 162Extracellular1 Publication6
Transmembranei163 – 183Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini184 – 190Cytoplasmic1 Publication7
Transmembranei191 – 211Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini212 – 222Extracellular1 PublicationAdd BLAST11
Transmembranei223 – 240Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini241 – 273Cytoplasmic1 PublicationAdd BLAST33
Transmembranei274 – 294Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini295 – 305Extracellular1 PublicationAdd BLAST11
Transmembranei306 – 326Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini327 – 343Cytoplasmic1 PublicationAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality (PubMed:32084332). Conditional knockout in nociceptors decreases the mechanosensitivity of nociceptors and reduces behavioral responses to painful mechanical stimuli but not to thermal or touch stimuli (PubMed:32084332).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003093401 – 343Ion channel TACANAdd BLAST343

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C1E7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8C1E7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8C1E7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C1E7

PeptideAtlas

More...
PeptideAtlasi
Q8C1E7

PRoteomics IDEntifications database

More...
PRIDEi
Q8C1E7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
263211

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8C1E7, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C1E7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C1E7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8C1E7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with higher expression in the heart, kidneys, colon and sensory neurons of the dorsal root ganglia (PubMed:32084332). Expressed in nociceptors (PubMed:32084332). Highly expressed in white adipose tissue (at protein level) (PubMed:26024229). Highly expressed in brown adipose tissue and expressed at low levels in liver (PubMed:26024229).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during adipocyte differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039886, Expressed in white adipose tissue and 236 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C1E7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer and heterooligomer with TMEM120B.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229606, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000045252

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C1E7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C1E7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4758, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007848

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_048749_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C1E7

Identification of Orthologs from Complete Genome Data

More...
OMAi
SYCLYQS

Database of Orthologous Groups

More...
OrthoDBi
916768at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C1E7

TreeFam database of animal gene trees

More...
TreeFami
TF313552

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012926, TACAN/TMEM120B

The PANTHER Classification System

More...
PANTHERi
PTHR21433, PTHR21433, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07851, TMPIT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C1E7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSPPPDPLG DCLRNWEDLQ QDFQGIQETH RLYRLKLEEL TKLQANCTNS
60 70 80 90 100
ITRQKKRLQE LALVLKKCRP SLPSESMEAA QELENQMKER QGLFFDMEAY
110 120 130 140 150
LPKKNGLYLS LVLGNVNVTL LSKQAKFAYK DEYEKFKLYL TIILIVISFT
160 170 180 190 200
CRFLLNSRVT DAAFNFLLVW YYCTLTIRES ILINNGSRIK GWWVFHHYVS
210 220 230 240 250
TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY QSGCLYRLRA
260 270 280 290 300
LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP
310 320 330 340
ECKEWQVLMC GFPFLLLFLG NFFTTLRVVH QKFHSQQHGN KKD
Length:343
Mass (Da):40,751
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AC1BE2A31E0A6C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0U3D3Z0U3_MOUSE
Ion channel TACAN
Tmem120a
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK028119 mRNA Translation: BAC25759.1
AK050367 mRNA Translation: BAC34212.1
BC046757 mRNA Translation: AAH46757.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19744.1

NCBI Reference Sequences

More...
RefSeqi
NP_766129.1, NM_172541.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
215210

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:215210

UCSC genome browser

More...
UCSCi
uc008zyu.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028119 mRNA Translation: BAC25759.1
AK050367 mRNA Translation: BAC34212.1
BC046757 mRNA Translation: AAH46757.1
CCDSiCCDS19744.1
RefSeqiNP_766129.1, NM_172541.2

3D structure databases

SMRiQ8C1E7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229606, 1 interactor
STRINGi10090.ENSMUSP00000045252

PTM databases

GlyGeniQ8C1E7, 1 site
iPTMnetiQ8C1E7
PhosphoSitePlusiQ8C1E7
SwissPalmiQ8C1E7

Proteomic databases

EPDiQ8C1E7
jPOSTiQ8C1E7
MaxQBiQ8C1E7
PaxDbiQ8C1E7
PeptideAtlasiQ8C1E7
PRIDEiQ8C1E7
ProteomicsDBi263211

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29220, 29 antibodies

Genome annotation databases

EnsembliENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886
GeneIDi215210
KEGGimmu:215210
UCSCiuc008zyu.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83862
MGIiMGI:2686991, Tmem120a

Phylogenomic databases

eggNOGiKOG4758, Eukaryota
GeneTreeiENSGT00390000007848
HOGENOMiCLU_048749_1_1_1
InParanoidiQ8C1E7
OMAiSYCLYQS
OrthoDBi916768at2759
PhylomeDBiQ8C1E7
TreeFamiTF313552

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
215210, 0 hits in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8C1E7
RNActiQ8C1E7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039886, Expressed in white adipose tissue and 236 other tissues
GenevisibleiQ8C1E7, MM

Family and domain databases

InterProiView protein in InterPro
IPR012926, TACAN/TMEM120B
PANTHERiPTHR21433, PTHR21433, 1 hit
PfamiView protein in Pfam
PF07851, TMPIT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTACAN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C1E7
Secondary accession number(s): Q8BWP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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