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Protein

Transmembrane protein 120A

Gene

Tmem120a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for efficient adipogenesis (PubMed:26024229).1 Publication

GO - Biological processi

  • fat cell differentiation Source: UniProtKB
  • protein heterooligomerization Source: UniProtKB
  • protein homooligomerization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120A
Alternative name(s):
Transmembrane protein induced by tumor necrosis factor alpha
Gene namesi
Name:Tmem120a
Synonyms:Net291 Publication, Tmpit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2686991 Tmem120a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 135ExtracellularSequence analysisAdd BLAST135
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 162CytoplasmicSequence analysis6
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 190ExtracellularSequence analysis7
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 273CytoplasmicSequence analysisAdd BLAST62
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305ExtracellularSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 343CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093401 – 343Transmembrane protein 120AAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8C1E7
MaxQBiQ8C1E7
PaxDbiQ8C1E7
PeptideAtlasiQ8C1E7
PRIDEiQ8C1E7

PTM databases

iPTMnetiQ8C1E7
PhosphoSitePlusiQ8C1E7
SwissPalmiQ8C1E7

Expressioni

Tissue specificityi

Highly expressed in white adipose tissue (at protein level). Highly expressed in brown adipose tissue and expressed at low levels in liver.1 Publication

Inductioni

Up-regulated during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000039886 Expressed in 211 organ(s), highest expression level in epididymal fat pad
CleanExiMM_TMEM120A
ExpressionAtlasiQ8C1E7 baseline and differential
GenevisibleiQ8C1E7 MM

Interactioni

Subunit structurei

Homooligomer and heterooligomer with TMEM120B.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045252

Structurei

3D structure databases

SMRiQ8C1E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4758 Eukaryota
ENOG410XT6G LUCA
GeneTreeiENSGT00390000007848
HOGENOMiHOG000267032
HOVERGENiHBG108532
InParanoidiQ8C1E7
OMAiQAYNAWT
OrthoDBiEOG091G0BVA
PhylomeDBiQ8C1E7
TreeFamiTF313552

Family and domain databases

InterProiView protein in InterPro
IPR012926 TMPIT
PANTHERiPTHR21433 PTHR21433, 1 hit
PfamiView protein in Pfam
PF07851 TMPIT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C1E7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSPPPDPLG DCLRNWEDLQ QDFQGIQETH RLYRLKLEEL TKLQANCTNS
60 70 80 90 100
ITRQKKRLQE LALVLKKCRP SLPSESMEAA QELENQMKER QGLFFDMEAY
110 120 130 140 150
LPKKNGLYLS LVLGNVNVTL LSKQAKFAYK DEYEKFKLYL TIILIVISFT
160 170 180 190 200
CRFLLNSRVT DAAFNFLLVW YYCTLTIRES ILINNGSRIK GWWVFHHYVS
210 220 230 240 250
TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY QSGCLYRLRA
260 270 280 290 300
LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP
310 320 330 340
ECKEWQVLMC GFPFLLLFLG NFFTTLRVVH QKFHSQQHGN KKD
Length:343
Mass (Da):40,751
Last modified:March 1, 2003 - v1
Checksum:i7AC1BE2A31E0A6C1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0U3D3Z0U3_MOUSE
Transmembrane protein 120A
Tmem120a
92Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028119 mRNA Translation: BAC25759.1
AK050367 mRNA Translation: BAC34212.1
BC046757 mRNA Translation: AAH46757.1
CCDSiCCDS19744.1
RefSeqiNP_766129.1, NM_172541.2
UniGeneiMm.11688

Genome annotation databases

EnsembliENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886
GeneIDi215210
KEGGimmu:215210
UCSCiuc008zyu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028119 mRNA Translation: BAC25759.1
AK050367 mRNA Translation: BAC34212.1
BC046757 mRNA Translation: AAH46757.1
CCDSiCCDS19744.1
RefSeqiNP_766129.1, NM_172541.2
UniGeneiMm.11688

3D structure databases

SMRiQ8C1E7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045252

PTM databases

iPTMnetiQ8C1E7
PhosphoSitePlusiQ8C1E7
SwissPalmiQ8C1E7

Proteomic databases

EPDiQ8C1E7
MaxQBiQ8C1E7
PaxDbiQ8C1E7
PeptideAtlasiQ8C1E7
PRIDEiQ8C1E7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043378; ENSMUSP00000045252; ENSMUSG00000039886
GeneIDi215210
KEGGimmu:215210
UCSCiuc008zyu.1 mouse

Organism-specific databases

CTDi83862
MGIiMGI:2686991 Tmem120a

Phylogenomic databases

eggNOGiKOG4758 Eukaryota
ENOG410XT6G LUCA
GeneTreeiENSGT00390000007848
HOGENOMiHOG000267032
HOVERGENiHBG108532
InParanoidiQ8C1E7
OMAiQAYNAWT
OrthoDBiEOG091G0BVA
PhylomeDBiQ8C1E7
TreeFamiTF313552

Miscellaneous databases

PROiPR:Q8C1E7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039886 Expressed in 211 organ(s), highest expression level in epididymal fat pad
CleanExiMM_TMEM120A
ExpressionAtlasiQ8C1E7 baseline and differential
GenevisibleiQ8C1E7 MM

Family and domain databases

InterProiView protein in InterPro
IPR012926 TMPIT
PANTHERiPTHR21433 PTHR21433, 1 hit
PfamiView protein in Pfam
PF07851 TMPIT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT120A_MOUSE
AccessioniPrimary (citable) accession number: Q8C1E7
Secondary accession number(s): Q8BWP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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