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UniProtKB - Q8C1C1 (SAPL1_MOUSE)
Protein
Proactivator polypeptide-like 1
Gene
Psapl1
Organism
Mus musculus (Mouse)
Status
Functioni
May activate the lysosomal degradation of sphingolipids.
By similarityGO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: GO_Central
- epithelial cell differentiation involved in prostate gland development Source: GO_Central
- prostate gland growth Source: GO_Central
- regulation of lipid metabolic process Source: GO_Central
- sphingolipid metabolic process Source: UniProtKB-KW
Keywordsi
Biological process | Lipid metabolism, Sphingolipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Proactivator polypeptide-like 1Cleaved into the following 5 chains: |
Gene namesi | Name:Psapl1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924193, Psapl1 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular space Source: GO_Central
Lysosome
- lysosome Source: InterPro
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
PropeptideiPRO_0000280315 | 18 – 59 | By similarityAdd BLAST | 42 | |
ChainiPRO_0000280316 | 61 – 144 | Saposin A-likeBy similarityAdd BLAST | 84 | |
PropeptideiPRO_0000280317 | 146 – 183 | By similarityAdd BLAST | 38 | |
ChainiPRO_0000280318 | 184 – 260 | Saposin B-Val-likeBy similarityAdd BLAST | 77 | |
ChainiPRO_0000280319 | 184 – 259 | Saposin B-likeBy similarityAdd BLAST | 76 | |
PropeptideiPRO_0000280320 | 261 – 290 | By similarityAdd BLAST | 30 | |
ChainiPRO_0000280321 | 291 – 370 | Saposin C-likeBy similarityAdd BLAST | 80 | |
PropeptideiPRO_0000280322 | 371 – 392 | By similarityAdd BLAST | 22 | |
ChainiPRO_0000280323 | 393 – 474 | Saposin D-likeBy similarityAdd BLAST | 82 | |
PropeptideiPRO_0000280324 | 475 – 522 | By similarityAdd BLAST | 48 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 64 ↔ 140 | PROSITE-ProRule annotation | ||
Disulfide bondi | 67 ↔ 134 | PROSITE-ProRule annotation | ||
Disulfide bondi | 95 ↔ 107 | PROSITE-ProRule annotation | ||
Disulfide bondi | 187 ↔ 257 | PROSITE-ProRule annotation | ||
Disulfide bondi | 190 ↔ 251 | PROSITE-ProRule annotation | ||
Glycosylationi | 204 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 216 ↔ 227 | PROSITE-ProRule annotation | ||
Disulfide bondi | 295 ↔ 367 | PROSITE-ProRule annotation | ||
Disulfide bondi | 298 ↔ 361 | PROSITE-ProRule annotation | ||
Glycosylationi | 312 | N-linked (GlcNAc...) (high mannose) asparaginePROSITE-ProRule annotation1 Publication | 1 | |
Disulfide bondi | 326 ↔ 337 | PROSITE-ProRule annotation | ||
Disulfide bondi | 397 ↔ 470 | PROSITE-ProRule annotation | ||
Disulfide bondi | 400 ↔ 464 | PROSITE-ProRule annotation | ||
Disulfide bondi | 428 ↔ 439 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-4003 |
MaxQBi | Q8C1C1 |
PaxDbi | Q8C1C1 |
PeptideAtlasi | Q8C1C1 |
PRIDEi | Q8C1C1 |
ProteomicsDBi | 256834 |
PTM databases
GlyGeni | Q8C1C1, 2 sites |
iPTMneti | Q8C1C1 |
PhosphoSitePlusi | Q8C1C1 |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000100594 |
Miscellaneous databases
RNActi | Q8C1C1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 59 | Saposin A-type 1PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 60 – 144 | Saposin B-type 1PROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 183 – 261 | Saposin B-type 2PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 291 – 371 | Saposin B-type 3PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 393 – 474 | Saposin B-type 4PROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 476 – 516 | Saposin A-type 2PROSITE-ProRule annotationAdd BLAST | 41 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG1340, Eukaryota |
InParanoidi | Q8C1C1 |
OrthoDBi | 865505at2759 |
PhylomeDBi | Q8C1C1 |
TreeFami | TF316942 |
Family and domain databases
InterProi | View protein in InterPro IPR003119, SAP_A IPR007856, SapB_1 IPR008138, SapB_2 IPR008373, Saposin IPR011001, Saposin-like IPR021165, Saposin_chordata IPR008139, SaposinB_dom |
Pfami | View protein in Pfam PF02199, SapA, 2 hits PF05184, SapB_1, 1 hit PF03489, SapB_2, 2 hits |
PIRSFi | PIRSF002431, Saposin, 1 hit |
PRINTSi | PR01797, SAPOSIN |
SMARTi | View protein in SMART SM00162, SAPA, 2 hits SM00741, SapB, 4 hits |
SUPFAMi | SSF47862, SSF47862, 4 hits |
PROSITEi | View protein in PROSITE PS51110, SAP_A, 2 hits PS50015, SAP_B, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8C1C1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLCALILWSG LLGAARASPI SVPRECAKGS EVWCQDLQAA AKCRAVRHCQ
60 70 80 90 100
SAVWNKPTVK SLPCSVCQDV AAAAGNGVNP GATESDILTS VMKTCEWLPS
110 120 130 140 150
QESSAKCKWM VNNHSAAVLS MLSGAQETDL ASVCTALTLC EPLQRHLAET
160 170 180 190 200
TSERPLTQED ANEVMAPFLS NGALSFHPSQ MPEGAVCHDC VQLISLLQDA
210 220 230 240 250
LESNLTLAEV TVQNQCQSMG PGLAALCENY IHRQFVPAKQ TLQGLPPQEV
260 270 280 290 300
CRKGGFCERE SAHWLTRVAA VDGVPSLEME MPRTNELQMQ LGLTCDVCLN
310 320 330 340 350
LVQELDKWLV TNSTEALISH TLERVCTVVP EPLVQQCITL VDTYSPELVQ
360 370 380 390 400
LMSKVTPEKV CETIKLCGSK RRARSISRAV ATTPSLPVDE ENQGSFCQGC
410 420 430 440 450
KRLLGMSSQN LDHKSTKRDI LNAFKGGCRI LPLPYVMQCN RFVAEYEPVL
460 470 480 490 500
IESLKFMMNP TDLCKKMGAC HGPKTPLLGT DQCVMGPSFW CKSPEAAEMC
510 520
NALEHCQRLV WKKPVSKINE QP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J1A5 | A0A0R4J1A5_MOUSE | Proactivator polypeptide-like 1 | Psapl1 | 525 | Annotation score: |
Sequence cautioni
The sequence BAC25258 differs from that shown. Reason: Frameshift.Curated
The sequence BAC25961 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC37363 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 293 | L → Q in BAC37363 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 432 | P → T in BAC37363 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 438 | Q → H in BAC37363 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK009408 mRNA Translation: BAC25258.1 Frameshift. AK028455 mRNA Translation: BAC25961.1 Different initiation. AK078699 mRNA Translation: BAC37363.1 Sequence problems. |
RefSeqi | NP_780458.2, NM_175249.3 |
Genome annotation databases
GeneIDi | 76943 |
KEGGi | mmu:76943 |
UCSCi | uc008xem.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK009408 mRNA Translation: BAC25258.1 Frameshift. AK028455 mRNA Translation: BAC25961.1 Different initiation. AK078699 mRNA Translation: BAC37363.1 Sequence problems. |
RefSeqi | NP_780458.2, NM_175249.3 |
3D structure databases
SMRi | Q8C1C1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000100594 |
PTM databases
GlyGeni | Q8C1C1, 2 sites |
iPTMneti | Q8C1C1 |
PhosphoSitePlusi | Q8C1C1 |
Proteomic databases
CPTACi | non-CPTAC-4003 |
MaxQBi | Q8C1C1 |
PaxDbi | Q8C1C1 |
PeptideAtlasi | Q8C1C1 |
PRIDEi | Q8C1C1 |
ProteomicsDBi | 256834 |
Protocols and materials databases
DNASUi | 76943 |
Genome annotation databases
GeneIDi | 76943 |
KEGGi | mmu:76943 |
UCSCi | uc008xem.1, mouse |
Organism-specific databases
CTDi | 768239 |
MGIi | MGI:1924193, Psapl1 |
Phylogenomic databases
eggNOGi | KOG1340, Eukaryota |
InParanoidi | Q8C1C1 |
OrthoDBi | 865505at2759 |
PhylomeDBi | Q8C1C1 |
TreeFami | TF316942 |
Miscellaneous databases
BioGRID-ORCSi | 76943, 1 hit in 64 CRISPR screens |
ChiTaRSi | Psapl1, mouse |
PROi | PR:Q8C1C1 |
RNActi | Q8C1C1, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR003119, SAP_A IPR007856, SapB_1 IPR008138, SapB_2 IPR008373, Saposin IPR011001, Saposin-like IPR021165, Saposin_chordata IPR008139, SaposinB_dom |
Pfami | View protein in Pfam PF02199, SapA, 2 hits PF05184, SapB_1, 1 hit PF03489, SapB_2, 2 hits |
PIRSFi | PIRSF002431, Saposin, 1 hit |
PRINTSi | PR01797, SAPOSIN |
SMARTi | View protein in SMART SM00162, SAPA, 2 hits SM00741, SapB, 4 hits |
SUPFAMi | SSF47862, SSF47862, 4 hits |
PROSITEi | View protein in PROSITE PS51110, SAP_A, 2 hits PS50015, SAP_B, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SAPL1_MOUSE | |
Accessioni | Q8C1C1Primary (citable) accession number: Q8C1C1 Secondary accession number(s): Q8BJV5, Q8C1N0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot