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Protein

Proactivator polypeptide-like 1

Gene

Psapl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May activate the lysosomal degradation of sphingolipids.By similarity

GO - Biological processi

Keywordsi

Biological processLipid metabolism, Sphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Proactivator polypeptide-like 1
Cleaved into the following 5 chains:
Gene namesi
Name:Psapl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924193 Psapl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000028031518 – 59By similarityAdd BLAST42
ChainiPRO_000028031661 – 144Saposin A-likeBy similarityAdd BLAST84
PropeptideiPRO_0000280317146 – 183By similarityAdd BLAST38
ChainiPRO_0000280318184 – 260Saposin B-Val-likeBy similarityAdd BLAST77
ChainiPRO_0000280319184 – 259Saposin B-likeBy similarityAdd BLAST76
PropeptideiPRO_0000280320261 – 290By similarityAdd BLAST30
ChainiPRO_0000280321291 – 370Saposin C-likeBy similarityAdd BLAST80
PropeptideiPRO_0000280322371 – 392By similarityAdd BLAST22
ChainiPRO_0000280323393 – 474Saposin D-likeBy similarityAdd BLAST82
PropeptideiPRO_0000280324475 – 522By similarityAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 140PROSITE-ProRule annotation
Disulfide bondi67 ↔ 134PROSITE-ProRule annotation
Disulfide bondi95 ↔ 107PROSITE-ProRule annotation
Disulfide bondi187 ↔ 257PROSITE-ProRule annotation
Disulfide bondi190 ↔ 251PROSITE-ProRule annotation
Glycosylationi204N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi216 ↔ 227PROSITE-ProRule annotation
Disulfide bondi295 ↔ 367PROSITE-ProRule annotation
Disulfide bondi298 ↔ 361PROSITE-ProRule annotation
Glycosylationi312N-linked (GlcNAc...) (high mannose) asparaginePROSITE-ProRule annotation1 Publication1
Disulfide bondi326 ↔ 337PROSITE-ProRule annotation
Disulfide bondi397 ↔ 470PROSITE-ProRule annotation
Disulfide bondi400 ↔ 464PROSITE-ProRule annotation
Disulfide bondi428 ↔ 439PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8C1C1
PaxDbiQ8C1C1
PeptideAtlasiQ8C1C1
PRIDEiQ8C1C1

PTM databases

iPTMnetiQ8C1C1
PhosphoSitePlusiQ8C1C1
UniCarbKBiQ8C1C1

Expressioni

Gene expression databases

CleanExiMM_PSAPL1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100594

Structurei

3D structure databases

ProteinModelPortaliQ8C1C1
SMRiQ8C1C1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 59Saposin A-type 1PROSITE-ProRule annotationAdd BLAST41
Domaini60 – 144Saposin B-type 1PROSITE-ProRule annotationAdd BLAST85
Domaini183 – 261Saposin B-type 2PROSITE-ProRule annotationAdd BLAST79
Domaini291 – 371Saposin B-type 3PROSITE-ProRule annotationAdd BLAST81
Domaini393 – 474Saposin B-type 4PROSITE-ProRule annotationAdd BLAST82
Domaini476 – 516Saposin A-type 2PROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1340 Eukaryota
ENOG410XSI5 LUCA
HOGENOMiHOG000049216
HOVERGENiHBG002617
InParanoidiQ8C1C1
KOiK12382
PhylomeDBiQ8C1C1
TreeFamiTF316942

Family and domain databases

InterProiView protein in InterPro
IPR003119 SAP_A
IPR007856 SapB_1
IPR008138 SapB_2
IPR008373 Saposin
IPR011001 Saposin-like
IPR021165 Saposin_chordata
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF02199 SapA, 2 hits
PF05184 SapB_1, 2 hits
PF03489 SapB_2, 2 hits
PIRSFiPIRSF002431 Saposin, 1 hit
PRINTSiPR01797 SAPOSIN
SMARTiView protein in SMART
SM00162 SAPA, 2 hits
SM00741 SapB, 4 hits
SUPFAMiSSF47862 SSF47862, 4 hits
PROSITEiView protein in PROSITE
PS51110 SAP_A, 2 hits
PS50015 SAP_B, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C1C1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCALILWSG LLGAARASPI SVPRECAKGS EVWCQDLQAA AKCRAVRHCQ
60 70 80 90 100
SAVWNKPTVK SLPCSVCQDV AAAAGNGVNP GATESDILTS VMKTCEWLPS
110 120 130 140 150
QESSAKCKWM VNNHSAAVLS MLSGAQETDL ASVCTALTLC EPLQRHLAET
160 170 180 190 200
TSERPLTQED ANEVMAPFLS NGALSFHPSQ MPEGAVCHDC VQLISLLQDA
210 220 230 240 250
LESNLTLAEV TVQNQCQSMG PGLAALCENY IHRQFVPAKQ TLQGLPPQEV
260 270 280 290 300
CRKGGFCERE SAHWLTRVAA VDGVPSLEME MPRTNELQMQ LGLTCDVCLN
310 320 330 340 350
LVQELDKWLV TNSTEALISH TLERVCTVVP EPLVQQCITL VDTYSPELVQ
360 370 380 390 400
LMSKVTPEKV CETIKLCGSK RRARSISRAV ATTPSLPVDE ENQGSFCQGC
410 420 430 440 450
KRLLGMSSQN LDHKSTKRDI LNAFKGGCRI LPLPYVMQCN RFVAEYEPVL
460 470 480 490 500
IESLKFMMNP TDLCKKMGAC HGPKTPLLGT DQCVMGPSFW CKSPEAAEMC
510 520
NALEHCQRLV WKKPVSKINE QP
Length:522
Mass (Da):57,061
Last modified:March 20, 2007 - v2
Checksum:i374F7E914CB9EC7A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1A5A0A0R4J1A5_MOUSE
Proactivator polypeptide-like 1
Psapl1 2310020A21Rik, mCG_56169
525Annotation score:

Sequence cautioni

The sequence BAC25258 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAC25961 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC37363 differs from that shown. Reason: Frameshift at positions 406 and 504.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293L → Q in BAC37363 (PubMed:16141072).Curated1
Sequence conflicti432P → T in BAC37363 (PubMed:16141072).Curated1
Sequence conflicti438Q → H in BAC37363 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009408 mRNA Translation: BAC25258.1 Frameshift.
AK028455 mRNA Translation: BAC25961.1 Different initiation.
AK078699 mRNA Translation: BAC37363.1 Sequence problems.
RefSeqiNP_780458.2, NM_175249.3
UniGeneiMm.44242

Genome annotation databases

GeneIDi76943
KEGGimmu:76943
UCSCiuc008xem.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009408 mRNA Translation: BAC25258.1 Frameshift.
AK028455 mRNA Translation: BAC25961.1 Different initiation.
AK078699 mRNA Translation: BAC37363.1 Sequence problems.
RefSeqiNP_780458.2, NM_175249.3
UniGeneiMm.44242

3D structure databases

ProteinModelPortaliQ8C1C1
SMRiQ8C1C1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100594

PTM databases

iPTMnetiQ8C1C1
PhosphoSitePlusiQ8C1C1
UniCarbKBiQ8C1C1

Proteomic databases

MaxQBiQ8C1C1
PaxDbiQ8C1C1
PeptideAtlasiQ8C1C1
PRIDEiQ8C1C1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76943
KEGGimmu:76943
UCSCiuc008xem.1 mouse

Organism-specific databases

CTDi768239
MGIiMGI:1924193 Psapl1

Phylogenomic databases

eggNOGiKOG1340 Eukaryota
ENOG410XSI5 LUCA
HOGENOMiHOG000049216
HOVERGENiHBG002617
InParanoidiQ8C1C1
KOiK12382
PhylomeDBiQ8C1C1
TreeFamiTF316942

Miscellaneous databases

PROiPR:Q8C1C1
SOURCEiSearch...

Gene expression databases

CleanExiMM_PSAPL1

Family and domain databases

InterProiView protein in InterPro
IPR003119 SAP_A
IPR007856 SapB_1
IPR008138 SapB_2
IPR008373 Saposin
IPR011001 Saposin-like
IPR021165 Saposin_chordata
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF02199 SapA, 2 hits
PF05184 SapB_1, 2 hits
PF03489 SapB_2, 2 hits
PIRSFiPIRSF002431 Saposin, 1 hit
PRINTSiPR01797 SAPOSIN
SMARTiView protein in SMART
SM00162 SAPA, 2 hits
SM00741 SapB, 4 hits
SUPFAMiSSF47862 SSF47862, 4 hits
PROSITEiView protein in PROSITE
PS51110 SAP_A, 2 hits
PS50015 SAP_B, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSAPL1_MOUSE
AccessioniPrimary (citable) accession number: Q8C1C1
Secondary accession number(s): Q8BJV5, Q8C1N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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