Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Septin-11

Gene

Sept11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103GTP; via amide nitrogenBy similarity1
Binding sitei238GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei253GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 55GTPBy similarity8
Nucleotide bindingi184 – 192GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • protein-containing complex scaffold activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-11
Gene namesi
Name:Sept11
Synonyms:D5Ertd606e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1277214 Sept11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001735432 – 431Septin-11Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8C1B7
PeptideAtlasiQ8C1B7
PRIDEiQ8C1B7

PTM databases

iPTMnetiQ8C1B7
PhosphoSitePlusiQ8C1B7
SwissPalmiQ8C1B7

Expressioni

Gene expression databases

BgeeiENSMUSG00000058013 Expressed in 274 organ(s), highest expression level in gonadal ridge
CleanExiMM_SEPT11
ExpressionAtlasiQ8C1B7 baseline and differential
GenevisibleiQ8C1B7 MM

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT7, SEPT9 and SEPT12. Forms homooligomers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206563, 17 interactors
IntActiQ8C1B7, 18 interactors
MINTiQ8C1B7
STRINGi10090.ENSMUSP00000074293

Structurei

3D structure databases

ProteinModelPortaliQ8C1B7
SMRiQ8C1B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 304Septin-type GPROSITE-ProRule annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 55G1 motifPROSITE-ProRule annotation8
Regioni100 – 103G3 motifPROSITE-ProRule annotation4
Regioni183 – 186G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili320 – 413Sequence analysisAdd BLAST94

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ8C1B7
KOiK16939
OrthoDBiEOG091G0IKM
PhylomeDBiQ8C1B7
TreeFamiTF101080

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C1B7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAVGRPSN EELRNLSLSG HVGFDSLPDQ LVNKSTSQGF CFNILCVGET
60 70 80 90 100
GIGKSTLMDT LFNTKFESDP ATHNEPGVRL KARSYELQES NVRLKLTIVD
110 120 130 140 150
TVGFGDQINK DDSYKPIVEY IDAQFEAYLQ EELKIKRSLF NYHDTRIHAC
160 170 180 190 200
LYFIAPTGHS LKSLDLVTMK KLDSKVNIIP IIAKADTIAK NELHKFKSKI
210 220 230 240 250
MSELVSNGVQ IYQFPTDEET VAEINATMSV HLPFAVVGST EEVKIGNKMA
260 270 280 290 300
KARQYPWGVV QVENENHCDF VKLREMLIRV NMEDLREQTH TRHYELYRRC
310 320 330 340 350
KLEEMGFKDT DPDSKPFSLQ ETYEAKRNEF LGELQKKEEE MRQMFVMRVK
360 370 380 390 400
EKEAELKEAE KELHEKFDLL KRTHQEEKKK VEDKKKELEE EVSNFQKKKA
410 420 430
AAQLLQSQAQ QSGAQQTKKD KDKKNPWLCT E
Note: No experimental confirmation available.
Length:431
Mass (Da):49,695
Last modified:January 23, 2007 - v4
Checksum:iCC838B791729B511
GO
Isoform 2 (identifier: Q8C1B7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     426-431: PWLCTE → ASFA

Show »
Length:429
Mass (Da):49,341
Checksum:iC817F1F30511DED8
GO
Isoform 3 (identifier: Q8C1B7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     426-431: Missing.

Show »
Length:425
Mass (Da):48,965
Checksum:iA511DED8DD2E0767
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YUL3A0A0J9YUL3_MOUSE
Septin 11, isoform CRA_b
Sept11 mCG_8719
432Annotation score:
A0A0J9YTY0A0A0J9YTY0_MOUSE
Septin-11
Sept11
425Annotation score:
A0A0J9YVA6A0A0J9YVA6_MOUSE
Septin-11
Sept11
204Annotation score:
A0A0J9YUV6A0A0J9YUV6_MOUSE
Septin-11
Sept11
97Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171K → N in BAC25969 (PubMed:16141072).Curated1
Sequence conflicti418K → T in BAE42414 (PubMed:16141072).Curated1
Sequence conflicti425N → K in BAE42414 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011041426 – 431PWLCTE → ASFA in isoform 2. 2 Publications6
Alternative sequenceiVSP_011042426 – 431Missing in isoform 3. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028475 mRNA Translation: BAC25969.1
AK166517 mRNA Translation: BAE38822.1
AK170945 mRNA Translation: BAE42133.1
AK171368 mRNA Translation: BAE42414.1
BC031456 mRNA Translation: AAH31456.1
BC062206 mRNA Translation: AAH62206.1
BC064466 mRNA Translation: AAH64466.1
CCDSiCCDS51549.1 [Q8C1B7-2]
CCDS80331.1 [Q8C1B7-1]
CCDS80332.1 [Q8C1B7-3]
RefSeqiNP_001009818.1, NM_001009818.2 [Q8C1B7-2]
NP_001297598.1, NM_001310669.1 [Q8C1B7-1]
NP_001297600.1, NM_001310671.1 [Q8C1B7-3]
UniGeneiMm.394184
Mm.428571

Genome annotation databases

EnsembliENSMUST00000074733; ENSMUSP00000074293; ENSMUSG00000058013 [Q8C1B7-2]
ENSMUST00000201421; ENSMUSP00000143928; ENSMUSG00000058013 [Q8C1B7-1]
ENSMUST00000202308; ENSMUSP00000144136; ENSMUSG00000058013 [Q8C1B7-3]
GeneIDi52398
KEGGimmu:52398
UCSCiuc008ydx.1 mouse [Q8C1B7-1]
uc008ydy.1 mouse [Q8C1B7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028475 mRNA Translation: BAC25969.1
AK166517 mRNA Translation: BAE38822.1
AK170945 mRNA Translation: BAE42133.1
AK171368 mRNA Translation: BAE42414.1
BC031456 mRNA Translation: AAH31456.1
BC062206 mRNA Translation: AAH62206.1
BC064466 mRNA Translation: AAH64466.1
CCDSiCCDS51549.1 [Q8C1B7-2]
CCDS80331.1 [Q8C1B7-1]
CCDS80332.1 [Q8C1B7-3]
RefSeqiNP_001009818.1, NM_001009818.2 [Q8C1B7-2]
NP_001297598.1, NM_001310669.1 [Q8C1B7-1]
NP_001297600.1, NM_001310671.1 [Q8C1B7-3]
UniGeneiMm.394184
Mm.428571

3D structure databases

ProteinModelPortaliQ8C1B7
SMRiQ8C1B7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206563, 17 interactors
IntActiQ8C1B7, 18 interactors
MINTiQ8C1B7
STRINGi10090.ENSMUSP00000074293

PTM databases

iPTMnetiQ8C1B7
PhosphoSitePlusiQ8C1B7
SwissPalmiQ8C1B7

Proteomic databases

PaxDbiQ8C1B7
PeptideAtlasiQ8C1B7
PRIDEiQ8C1B7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074733; ENSMUSP00000074293; ENSMUSG00000058013 [Q8C1B7-2]
ENSMUST00000201421; ENSMUSP00000143928; ENSMUSG00000058013 [Q8C1B7-1]
ENSMUST00000202308; ENSMUSP00000144136; ENSMUSG00000058013 [Q8C1B7-3]
GeneIDi52398
KEGGimmu:52398
UCSCiuc008ydx.1 mouse [Q8C1B7-1]
uc008ydy.1 mouse [Q8C1B7-2]

Organism-specific databases

CTDi55752
MGIiMGI:1277214 Sept11

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ8C1B7
KOiK16939
OrthoDBiEOG091G0IKM
PhylomeDBiQ8C1B7
TreeFamiTF101080

Miscellaneous databases

ChiTaRSiSept11 mouse
PROiPR:Q8C1B7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058013 Expressed in 274 organ(s), highest expression level in gonadal ridge
CleanExiMM_SEPT11
ExpressionAtlasiQ8C1B7 baseline and differential
GenevisibleiQ8C1B7 MM

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEP11_MOUSE
AccessioniPrimary (citable) accession number: Q8C1B7
Secondary accession number(s): Q3TBA0
, Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 137 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again