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Entry version 118 (18 Sep 2019)
Sequence version 3 (05 Feb 2008)
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Protein

Calmodulin-regulated spectrin-associated protein 2

Gene

Camsap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also reduces the velocity of microtubule polymerization (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (By similarity). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (By similarity). Through the microtubule cytoskeleton, regulates the autophagosome transport (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 2Curated
Alternative name(s):
Calmodulin-regulated spectrin-associated protein 1-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Camsap2Imported
Synonyms:Camsap1l1, Kiaa10781 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1922434 Camsap2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003168331 – 1461Calmodulin-regulated spectrin-associated protein 2Add BLAST1461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei391PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei401PhosphothreonineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei572PhosphoserineBy similarity1
Modified residuei573PhosphoserineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei647PhosphoserineBy similarity1
Modified residuei652PhosphothreonineCombined sources1
Modified residuei654PhosphoserineCombined sources1
Modified residuei836PhosphoserineCombined sources1
Modified residuei905PhosphoserineBy similarity1
Modified residuei910PhosphoserineBy similarity1
Modified residuei970PhosphothreonineBy similarity1
Modified residuei975PhosphothreonineBy similarity1
Modified residuei977PhosphothreonineBy similarity1
Modified residuei981PhosphoserineBy similarity1
Modified residuei992PhosphoserineBy similarity1
Modified residuei1120PhosphoserineCombined sources1
Modified residuei1285PhosphoserineCombined sources1
Modified residuei1291PhosphoserineCombined sources1
Modified residuei1293PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C1B1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8C1B1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C1B1

PeptideAtlas

More...
PeptideAtlasi
Q8C1B1

PRoteomics IDEntifications database

More...
PRIDEi
Q8C1B1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C1B1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C1B1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8C1B1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041570 Expressed in 247 organ(s), highest expression level in utricle of membranous labyrinth

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C1B1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C1B1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CAMSAP3 (PubMed:23169647).

Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP2-decorated microtubule stretches (By similarity).

Interacts with a complex formed by AKAP9 and PDE4DIP isoform 2/MMG8/SMYLE, which recruits CAMSAP2 to the Golgi (By similarity).

Interacts with MAPRE1/EB1 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Camsap3Q80VC92EBI-8839434,EBI-2125556

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
212510, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-60092N

Protein interaction database and analysis system

More...
IntActi
Q8C1B1, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041920

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C1B1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini211 – 324Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114
Domaini1321 – 1455CKKPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni896 – 1007MBD regionBy similarityAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili730 – 767Sequence analysisAdd BLAST38
Coiled coili861 – 900Sequence analysisAdd BLAST40
Coiled coili1138 – 1210Sequence analysisAdd BLAST73

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CKK domain binds microtubules and specifically recognizes the minus-end of microtubules.PROSITE-ProRule annotationBy similarity
The MBD (microtubule-binding domain) region can recognize some features of the microtubule lattice, which might contribute to the specific decoration of growing microtubule minus-ends by CAMSAP2.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IU7J Eukaryota
ENOG411033G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182975

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C1B1

KEGG Orthology (KO)

More...
KOi
K17493

Identification of Orthologs from Complete Genome Data

More...
OMAi
VDPEKQW

Database of Orthologous Groups

More...
OrthoDBi
741937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C1B1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21595 PTHR21595, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01051 CAMSAP_CKK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C1B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDAADPREM RRTFIVPAIK PFDHYDFSRA KIACNLAWLV AKAFGTENVP
60 70 80 90 100
EELGDPFYTD QYDQEHIKPP VVNLLLSAEL YCRAGSLILK SDAAKPLLGH
110 120 130 140 150
DAVIQALAQK GLYVTDQEKL VTERDLHKKP IQMSAHLAMI DTLMMAYTVE
160 170 180 190 200
MISIEKVIAC AQQYSAFFQA TDLPYDIEDA VMYWMNKVNE HLKDIMEQEQ
210 220 230 240 250
KSKEHHPAEA PGGQKARYRK EQTLLKQLPC IPLVENLLKD GTDGCALAAL
260 270 280 290 300
IHFYCPAVVR LEDICLKETM SLADSLYNLQ LIQEFCQEYL NHCCHFSLED
310 320 330 340 350
MLYAASSIKS NYLVFMAELF WWFEVVKPSF VQPRVVRPQG AEPAKDVPSV
360 370 380 390 400
PVLNAAKRNI RDSSSSSDFS SRYTRPQTHS SASGGIRRSS SMSYVDGFIG
410 420 430 440 450
TWPKEKRTSV HGVSFDISFD KEDSAQSSTP NRGIIRSVSN EGLTLNNSRA
460 470 480 490 500
SKHIRKNLSF KPVNGEEEES IEEELHVDPH GDLQSPMPLN TNELNSNEST
510 520 530 540 550
HYKLPNGALQ NRVLLDEFGN QIETPSIEEA LQIIHDTERP PHTPRPDQIA
560 570 580 590 600
NGFFLHGQDL SILNSNIKLN QSSPDNLTDT KGALSPITDT TEVDTGIHVP
610 620 630 640 650
SEDIPETMDE DSSLRDYTVS LDSDMDDASK LLQDYDLRAS NPREALSPCP
660 670 680 690 700
STISTKSQPG SSASSSSGVK MTSFAEQKFR KLNHTDGKSS GSSSQKTTPE
710 720 730 740 750
GSELNIPHVV SWAQIPEEAG VAPGRDTTQL LASEMVHLRM RLEEKRRAIE
760 770 780 790 800
AQKKKMEAAF TKQRQKMGRT AFLTVVKKKG EGISPLREEA AGAEDEKVYT
810 820 830 840 850
DRAKERESQK MDGQRSKSLA DIKESMETPP GRWLKSPTTP VDPERQWNLT
860 870 880 890 900
SPSEETLNEG EILEYTKSIE KLNSSLHFLQ QEMQRLSLQQ EMLMQMREQQ
910 920 930 940 950
AWVISPPQPS PQKQIRDFKP RQAGLSSAAA PFSSDSPRPT HPSPQSSTRK
960 970 980 990 1000
SASFSVKNQR TPRPNELKIT PLNRTLTPPR SVDSLPRLRR FSPSQVPIQT
1010 1020 1030 1040 1050
RSFVCFGDDG EPQKEPKQKE EIKKEPSECK GTLGPCDHNP GEKEIKPVES
1060 1070 1080 1090 1100
TVSEVLSQPI TETVCVTPNE DQLSQPTEPP PKPVFPPTAP KNVNLIEVSL
1110 1120 1130 1140 1150
SDLKPPEKAD VSVEKLDGES DKEQFDDDQK VCCGFFFKDD QKAENDMAMK
1160 1170 1180 1190 1200
RAALLEKRLR REKETQLRKQ QLEAEMEHKK EETRRKTEEE RQKKEDERAR
1210 1220 1230 1240 1250
REFIRQEYMR RKQLKLMEDM DTVIKPRPQA AKQKKQRPKS IHRDHIESPK
1260 1270 1280 1290 1300
TPIKGPPVSS LSLASLNTGD SESVHSGKRT PRSESVEGFL SPSRCGSRNG
1310 1320 1330 1340 1350
EKDWENASTT SSVASGTEYT GPKLYKEPSA KSNKHIIQNA LAHCCLAGKV
1360 1370 1380 1390 1400
NEGQKKKILE EMEKSDANNF LILFRDSGCQ FRSLYTYCPE TEEINKLTGI
1410 1420 1430 1440 1450
GPKSITKKMI EGLYKYNSDR KQFSHIPAKT LSASVDAITI HSHLWQTKRP
1460
VTPKKLLPTK A
Length:1,461
Mass (Da):164,333
Last modified:February 5, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24308DADC498788A
GO
Isoform 2 (identifier: Q8C1B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1257-1257: P → PGSRISRVFS

Note: No experimental confirmation available.
Show »
Length:1,470
Mass (Da):165,323
Checksum:iF056D5FAB0D69AFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YY67A0A0A6YY67_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap2
1,472Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX08H7BX08_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap2
1,478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXV8A0A0A6YXV8_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap2
814Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30A → T in AAI45259 (PubMed:15489334).Curated1
Sequence conflicti802R → Q in AAI45259 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0308071257P → PGSRISRVFS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC145258 mRNA Translation: AAI45259.1
AK028542 mRNA Translation: BAC25999.2
AK081975 mRNA Translation: BAC38384.1
AK122436 mRNA Translation: BAC65718.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS83597.1 [Q8C1B1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001334039.1, NM_001347110.1 [Q8C1B1-1]
XP_006529897.1, XM_006529834.2 [Q8C1B1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000192001; ENSMUSP00000142166; ENSMUSG00000041570 [Q8C1B1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67886

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:67886

UCSC genome browser

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UCSCi
uc007cur.2 mouse [Q8C1B1-1]
uc011wsz.1 mouse [Q8C1B1-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145258 mRNA Translation: AAI45259.1
AK028542 mRNA Translation: BAC25999.2
AK081975 mRNA Translation: BAC38384.1
AK122436 mRNA Translation: BAC65718.1
CCDSiCCDS83597.1 [Q8C1B1-1]
RefSeqiNP_001334039.1, NM_001347110.1 [Q8C1B1-1]
XP_006529897.1, XM_006529834.2 [Q8C1B1-2]

3D structure databases

SMRiQ8C1B1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi212510, 2 interactors
DIPiDIP-60092N
IntActiQ8C1B1, 3 interactors
STRINGi10090.ENSMUSP00000041920

PTM databases

iPTMnetiQ8C1B1
PhosphoSitePlusiQ8C1B1
SwissPalmiQ8C1B1

Proteomic databases

EPDiQ8C1B1
jPOSTiQ8C1B1
PaxDbiQ8C1B1
PeptideAtlasiQ8C1B1
PRIDEiQ8C1B1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000192001; ENSMUSP00000142166; ENSMUSG00000041570 [Q8C1B1-1]
GeneIDi67886
KEGGimmu:67886
UCSCiuc007cur.2 mouse [Q8C1B1-1]
uc011wsz.1 mouse [Q8C1B1-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23271
MGIiMGI:1922434 Camsap2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410IU7J Eukaryota
ENOG411033G LUCA
GeneTreeiENSGT00950000182975
InParanoidiQ8C1B1
KOiK17493
OMAiVDPEKQW
OrthoDBi741937at2759
PhylomeDBiQ8C1B1

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8C1B1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000041570 Expressed in 247 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiQ8C1B1 baseline and differential
GenevisibleiQ8C1B1 MM

Family and domain databases

Gene3Di3.10.20.360, 1 hit
InterProiView protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf
PANTHERiPTHR21595 PTHR21595, 1 hit
PfamiView protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit
SMARTiView protein in SMART
SM01051 CAMSAP_CKK, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAMP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C1B1
Secondary accession number(s): B7ZNI4, Q80TK8, Q8C4J5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 18, 2019
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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