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Protein

Transcription initiation factor TFIID subunit 2

Gene

Taf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter (By similarity).By similarity

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • sequence-specific DNA binding Source: GO_Central
  • transcription regulatory region DNA binding Source: MGI

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Protein family/group databases

MEROPSiM01.972

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 2
Alternative name(s):
TBP-associated factor 150 kDa
Transcription initiation factor TFIID 150 kDa subunit
Short name:
TAF(II)150
Short name:
TAFII-150
Short name:
TAFII150
Gene namesi
Name:Taf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2443028 Taf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524251 – 1104Transcription initiation factor TFIID subunit 2Add BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1090PhosphoserineBy similarity1
Modified residuei1093PhosphoserineBy similarity1
Modified residuei1099PhosphoserineBy similarity1
Modified residuei1101PhosphoserineBy similarity1
Modified residuei1103PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C176
MaxQBiQ8C176
PaxDbiQ8C176
PeptideAtlasiQ8C176
PRIDEiQ8C176

PTM databases

iPTMnetiQ8C176
PhosphoSitePlusiQ8C176

Interactioni

Subunit structurei

Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors. Interacts with TAF2C1. Component of the TFTC-HAT complex (By similarity).By similarity

Protein-protein interaction databases

ComplexPortaliCPX-916 TFTC histone acetylation complex
CPX-920 SAGA complex
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ8C176
IntActiQ8C176, 1 interactor
STRINGi10090.ENSMUSP00000043733

Structurei

3D structure databases

ProteinModelPortaliQ8C176
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi590 – 593Poly-Lys4
Compositional biasi1052 – 1077His-richAdd BLAST26
Compositional biasi1061 – 1082Lys-richAdd BLAST22

Sequence similaritiesi

Belongs to the TAF2 family.Curated

Phylogenomic databases

eggNOGiKOG1932 Eukaryota
ENOG410XS52 LUCA
HOVERGENiHBG094022
InParanoidiQ8C176
PhylomeDBiQ8C176

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037813 TAF2
PANTHERiPTHR15137 PTHR15137, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C176-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRKKGDKGF ESPRPYKLTH QVVCINNINF QRKSVVGFVE LTIFPTVANL
60 70 80 90 100
NRIKLNSKQC RIYRVRINDL EAAFIYNDPT LEVCHSESKQ RNLNYFSNAY
110 120 130 140 150
AAAVSAVDPD AGNGELCIKV PSELWKHVDE LKVLKIHINF SLDQPKGGLH
160 170 180 190 200
FVVPSVEGSM AERGAHVFSC GYQNSTRFWF PCVDSYSELC TWKLEFTVDA
210 220 230 240 250
AMVAVSNGDL VETVYTHDMR KKTFHYMLTI PTAASNISLA IGPFEILVDP
260 270 280 290 300
YMHEVTHFCL PQLLPLLKHT TSYIHEVFEF YEEILTCRYP YSCFKTVFID
310 320 330 340 350
EAYVEVAAYA SMSIFSTNLL HSAMIIDETP LTRRCLAQAL AQQFFGCFIS
360 370 380 390 400
RMSWSDEWVL KGISGYIYGL WMKKTFGVNE YHHWIKEELD KIVAYELKTG
410 420 430 440 450
GVLLHPIFGG GKEKDNPASH LHFSIKHPHT LSWEYYTMFQ CKAHLVMRLI
460 470 480 490 500
ENRISMEFML QVFNKLLSLA STASSQKFQS HMWSQMLVST YGFLKSISNV
510 520 530 540 550
SGKDIQPLIK QWLDQSGVVK FYGSFAFNRK RNVLELEIKQ DYTSPGTQKY
560 570 580 590 600
VGPLKVTVQE LDGSFNHTLQ IEENSLKHDI PCHSKSRRNK KKKIPLMNGE
610 620 630 640 650
EVDMDLSAME ADSPLLWIRI DPDMSVLRKV EFEQADFMWQ YELRYERDVV
660 670 680 690 700
AQQESILALE KFPTPASRLA LTDILEQEQC FYRVRMSACF CLAKIANSMV
710 720 730 740 750
STWTGPPAMK SLFTRMFCCK TCPNIVKTNN FMSFQSYFLQ KTMPVAMALL
760 770 780 790 800
RDVHNLCPKE VLTFILDLIK YNDNRKNKFS DNYYRAEMID ALANSVTPAV
810 820 830 840 850
SVNNEVRTLD NLNPDVRLIL EEITRFLNME KLLPSYRHTI TVSCLRAIRV
860 870 880 890 900
LQKNGHVPSD ASLFKSYAEY GHFVDIRIAA LEAVVDYTKV DRSYEELQWL
910 920 930 940 950
LNMIQTDPVP YVRHKILNML TKNPPFTKNM ESPLCNEALV DQLWKLMNSG
960 970 980 990 1000
TAHDWRLRCG AVDLYFTLFG LSRPSCLPLP ELGLVLNLKE KKAVLNPTII
1010 1020 1030 1040 1050
PEAGVGNQFS SSQDEEEVDM DTVHDSQAFI SHHLNMLERP STPGLSKYRP
1060 1070 1080 1090 1100
HHHHHHHEHK KKKKKHKHKH KHKHKHDSKD KDREPFAFSS PASGRSVRSP

SLSD
Length:1,104
Mass (Da):126,997
Last modified:October 17, 2006 - v2
Checksum:iA557FFDF19E9A0F0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9EJX5B9EJX5_MOUSE
TAF2 RNA polymerase II, TATA box bi...
Taf2
1,198Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137950 Genomic DNA No translation available.
AK028828 mRNA Translation: BAC26141.1
AK051126 mRNA Translation: BAC34531.1
UniGeneiMm.380957

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137950 Genomic DNA No translation available.
AK028828 mRNA Translation: BAC26141.1
AK051126 mRNA Translation: BAC34531.1
UniGeneiMm.380957

3D structure databases

ProteinModelPortaliQ8C176
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-916 TFTC histone acetylation complex
CPX-920 SAGA complex
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ8C176
IntActiQ8C176, 1 interactor
STRINGi10090.ENSMUSP00000043733

Protein family/group databases

MEROPSiM01.972

PTM databases

iPTMnetiQ8C176
PhosphoSitePlusiQ8C176

Proteomic databases

EPDiQ8C176
MaxQBiQ8C176
PaxDbiQ8C176
PeptideAtlasiQ8C176
PRIDEiQ8C176

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2443028 Taf2

Phylogenomic databases

eggNOGiKOG1932 Eukaryota
ENOG410XS52 LUCA
HOVERGENiHBG094022
InParanoidiQ8C176
PhylomeDBiQ8C176

Miscellaneous databases

ChiTaRSiTaf2 mouse
PROiPR:Q8C176
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037813 TAF2
PANTHERiPTHR15137 PTHR15137, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAF2_MOUSE
AccessioniPrimary (citable) accession number: Q8C176
Secondary accession number(s): Q8BKQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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