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Entry version 144 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Prolyl endopeptidase-like

Gene

Prepl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine peptidase whose precise substrate specificity remains unclear (PubMed:21692504).

Does not cleave peptides after a arginine or lysine residue (By similarity).

Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636).

May play a role in the regulation of synaptic vesicle exocytosis (By similarity).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by 1-isobutyl-3-oxo-3,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei557Charge relay system1 Publication1
Active sitei643Charge relay systemBy similarity1
Active sitei688Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
mouse-Q8C167, S9N_PREPL_Peptidase_S9

MEROPS protease database

More...
MEROPSi
S09.015

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolyl endopeptidase-like (EC:3.4.21.-1 Publication)
Alternative name(s):
Prolylendopeptidase-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prepl
Synonyms:Kiaa0436
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2441932, Prepl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

PREPL-null mice are significantly shorter and lighter than their wild-type littermates and suffer from neonatal hypotonia.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi557S → A: Loss of catalytic activity. No effect on the redistribution of AP-1 from the membrane to the cytoplasm. 2 Publications1

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2870

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148621 – 725Prolyl endopeptidase-likeAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei137PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C167

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C167

PeptideAtlas

More...
PeptideAtlasi
Q8C167

PRoteomics IDEntifications database

More...
PRIDEi
Q8C167

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
289799 [Q8C167-1]
289800 [Q8C167-2]
289801 [Q8C167-3]
289802 [Q8C167-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C167

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C167

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the brain, specifically in neurons of the neocortex, substantia nigra, locus coeruleus, and cerebellum, and a slightly lesser extent in neurons in the hypothalamus and hippocampus (at protein level) (PubMed:23321636, PubMed:23485813). Also expressed in interneurons in the stratum lacunosum moleculare and stratum radiatum (PubMed:23485813).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024127, Expressed in subparaventricular zone and 313 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C167, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C167, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with the AP-1 complex (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229467, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8C167, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8C167

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000130967

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C167, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C167

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S9A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2237, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011290_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C167

Database of Orthologous Groups

More...
OrthoDBi
1124637at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C167

TreeFam database of animal gene trees

More...
TreeFami
TF333309

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR023302, Pept_S9A_N
IPR001375, Peptidase_S9
IPR002470, Peptidase_S9A

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00326, Peptidase_S9, 1 hit
PF02897, Peptidase_S9_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00862, PROLIGOPTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C167-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQTAKFSLR ALKHSIPHLG NCMQKQSYRN VAGPYYSRVR LKKYHLTKCL
60 70 80 90 100
QNKPRIAGLA RNIPSRSFSC KDLLPIKPES EKPISENMDA FEKVRTRLET
110 120 130 140 150
QPQEEYEVVN AEIKHGGFVY YQEGCCLVRS KDEEADSDNY EVLFNLEELK
160 170 180 190 200
LDQPFIDCIR VAPDEKYVAA KIRTEDSETS TLVVVKLSDQ PVMEASFPNV
210 220 230 240 250
SSFEWVKDEE DEDVLFYTFQ RNLRCHDVYR ATFGDNKRNE RFYTEKDPSY
260 270 280 290 300
FVFLYLTKDS RFLTLNIMNK TTSEVWLIDG LSPWDPPVLI QKRIHGMLYY
310 320 330 340 350
VEHRDDELYI LTNVGEPTEF KLMRTAADAP AIMNWDLFFT MKRNTKVVDL
360 370 380 390 400
DMFKDHCVLF LKHSNLLYVN VIGLADDSVR SLKLPPWACG FIMDTNSDPK
410 420 430 440 450
NCPFQLCSPI RPPKYYTYKF AEGKLFEETG HEDPITKTSR VLRIEAKSKD
460 470 480 490 500
GKLVPMTVFH KTDSEDLQRK PLLVHVYGAY GMDLKMNFRP EKRVLVDDGW
510 520 530 540 550
ILAYCHVRGG GELGLQWHAD GRLTKKLNGL ADLVACIKTL HSQGFSQPSL
560 570 580 590 600
TTLSAFSAGG VLVGALCNSK PELLRAVTLE APFLDVLNTM LDTTLPLTLE
610 620 630 640 650
ELEEWGNPSS DEKHKNYIKR YCPCQNIKPQ HYPSVHITAY ENDERVPLKG
660 670 680 690 700
IVNYTEKLKE AVAEHTKGAG EGYQPPNIIL DIQPGGNHVI EDSHKKITTQ
710 720
MKFLYEELGL DSTDAFEALK KYLKF
Length:725
Mass (Da):83,194
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i111579DFA45CE68B
GO
Isoform 2 (identifier: Q8C167-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Show »
Length:638
Mass (Da):73,216
Checksum:i2A06AE66501DD489
GO
Isoform 3 (identifier: Q8C167-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-267: Missing.

Show »
Length:458
Mass (Da):51,947
Checksum:i26D0D1BE0FE43A26
GO
Isoform 4 (identifier: Q8C167-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-261: SYFVFLYLTKDSR → RCQRAALTALQALTIQ
     262-725: Missing.

Show »
Length:264
Mass (Da):30,682
Checksum:i4DCD95EB25D51500
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q4EGY4A0A3Q4EGY4_MOUSE
Prolyl endopeptidase-like
Prepl
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4L354A0A3Q4L354_MOUSE
Prolyl endopeptidase-like
Prepl
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC97952 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0304041 – 267Missing in isoform 3. 1 PublicationAdd BLAST267
Alternative sequenceiVSP_0304051 – 87Missing in isoform 2. 2 PublicationsAdd BLAST87
Alternative sequenceiVSP_030406249 – 261SYFVF…TKDSR → RCQRAALTALQALTIQ in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_030407262 – 725Missing in isoform 4. 1 PublicationAdd BLAST464

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129142 mRNA Translation: BAC97952.1 Different initiation.
AK028877 mRNA Translation: BAC26168.1
AK083070 mRNA Translation: BAC38751.1
AK163108 mRNA Translation: BAE37195.1
BC004612 mRNA Translation: AAH04612.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29005.1 [Q8C167-2]
CCDS50202.1 [Q8C167-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001157094.1, NM_001163622.1 [Q8C167-1]
NP_001157095.1, NM_001163623.1 [Q8C167-2]
NP_001157096.1, NM_001163624.1 [Q8C167-2]
NP_666096.3, NM_145984.3 [Q8C167-2]
XP_006524064.1, XM_006524001.3 [Q8C167-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000072406; ENSMUSP00000072239; ENSMUSG00000024127 [Q8C167-2]
ENSMUST00000171795; ENSMUSP00000130967; ENSMUSG00000024127 [Q8C167-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
213760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:213760

UCSC genome browser

More...
UCSCi
uc008dtm.2, mouse [Q8C167-1]
uc008dtr.2, mouse [Q8C167-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129142 mRNA Translation: BAC97952.1 Different initiation.
AK028877 mRNA Translation: BAC26168.1
AK083070 mRNA Translation: BAC38751.1
AK163108 mRNA Translation: BAE37195.1
BC004612 mRNA Translation: AAH04612.1
CCDSiCCDS29005.1 [Q8C167-2]
CCDS50202.1 [Q8C167-1]
RefSeqiNP_001157094.1, NM_001163622.1 [Q8C167-1]
NP_001157095.1, NM_001163623.1 [Q8C167-2]
NP_001157096.1, NM_001163624.1 [Q8C167-2]
NP_666096.3, NM_145984.3 [Q8C167-2]
XP_006524064.1, XM_006524001.3 [Q8C167-2]

3D structure databases

SMRiQ8C167
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229467, 1 interactor
IntActiQ8C167, 2 interactors
MINTiQ8C167
STRINGi10090.ENSMUSP00000130967

Chemistry databases

GuidetoPHARMACOLOGYi2870

Protein family/group databases

ESTHERimouse-Q8C167, S9N_PREPL_Peptidase_S9
MEROPSiS09.015

PTM databases

iPTMnetiQ8C167
PhosphoSitePlusiQ8C167

Proteomic databases

EPDiQ8C167
PaxDbiQ8C167
PeptideAtlasiQ8C167
PRIDEiQ8C167
ProteomicsDBi289799 [Q8C167-1]
289800 [Q8C167-2]
289801 [Q8C167-3]
289802 [Q8C167-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29901, 120 antibodies

The DNASU plasmid repository

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DNASUi
213760

Genome annotation databases

EnsembliENSMUST00000072406; ENSMUSP00000072239; ENSMUSG00000024127 [Q8C167-2]
ENSMUST00000171795; ENSMUSP00000130967; ENSMUSG00000024127 [Q8C167-1]
GeneIDi213760
KEGGimmu:213760
UCSCiuc008dtm.2, mouse [Q8C167-1]
uc008dtr.2, mouse [Q8C167-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9581
MGIiMGI:2441932, Prepl

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG2237, Eukaryota
GeneTreeiENSGT00530000063426
HOGENOMiCLU_011290_2_1_1
InParanoidiQ8C167
OrthoDBi1124637at2759
PhylomeDBiQ8C167
TreeFamiTF333309

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
213760, 5 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Prepl, mouse

Protein Ontology

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PROi
PR:Q8C167
RNActiQ8C167, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024127, Expressed in subparaventricular zone and 313 other tissues
ExpressionAtlasiQ8C167, baseline and differential
GenevisibleiQ8C167, MM

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR023302, Pept_S9A_N
IPR001375, Peptidase_S9
IPR002470, Peptidase_S9A
PfamiView protein in Pfam
PF00326, Peptidase_S9, 1 hit
PF02897, Peptidase_S9_N, 1 hit
PRINTSiPR00862, PROLIGOPTASE
SUPFAMiSSF53474, SSF53474, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPCEL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C167
Secondary accession number(s): Q3TR35
, Q6ZQB4, Q8BUP5, Q99KJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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