UniProtKB - Q8C156 (CND2_MOUSE)
Condensin complex subunit 2
Ncaph
Functioni
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
By similarityGO - Molecular functioni
- chromatin binding Source: MGI
GO - Biological processi
- cell division Source: UniProtKB-KW
- female meiosis chromosome separation Source: MGI
- female meiotic nuclear division Source: MGI
- meiotic chromosome condensation Source: MGI
- meiotic chromosome segregation Source: MGI
- mitotic chromosome condensation Source: UniProtKB
- positive regulation of chromosome condensation Source: Ensembl
- positive regulation of chromosome segregation Source: ComplexPortal
- positive regulation of chromosome separation Source: ComplexPortal
Keywordsi
Biological process | Cell cycle, Cell division, DNA condensation, Mitosis |
Enzyme and pathway databases
Reactomei | R-MMU-2514853, Condensation of Prometaphase Chromosomes |
Names & Taxonomyi
Protein namesi | Recommended name: Condensin complex subunit 2Alternative name(s): Barren homolog protein 1 Chromosome-associated protein H Short name: mCAP-H Non-SMC condensin I complex subunit H XCAP-H homolog |
Gene namesi | Name:Ncaph Synonyms:Brrn, Brrn1, Caph |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444777, Ncaph |
VEuPathDBi | HostDB:ENSMUSG00000034906 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity).By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- condensed nuclear chromosome Source: ComplexPortal
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- chromosome Source: MGI
- condensin complex Source: MGI
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000095039 | 1 – 731 | Condensin complex subunit 2Add BLAST | 731 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphoserineBy similarity | 1 | |
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 43 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 46 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 67 | PhosphoserineBy similarity | 1 | |
Modified residuei | 75 | PhosphoserineBy similarity | 1 | |
Modified residuei | 78 | PhosphoserineBy similarity | 1 | |
Modified residuei | 83 | PhosphoserineBy similarity | 1 | |
Modified residuei | 91 | PhosphoserineBy similarity | 1 | |
Modified residuei | 182 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 195 | PhosphoserineBy similarity | 1 | |
Modified residuei | 227 | PhosphoserineBy similarity | 1 | |
Modified residuei | 425 | PhosphoserineBy similarity | 1 | |
Cross-linki | 481 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 489 | PhosphoserineBy similarity | 1 | |
Modified residuei | 587 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 627 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8C156 |
jPOSTi | Q8C156 |
MaxQBi | Q8C156 |
PaxDbi | Q8C156 |
PeptideAtlasi | Q8C156 |
PRIDEi | Q8C156 |
ProteomicsDBi | 283397 |
PTM databases
iPTMneti | Q8C156 |
PhosphoSitePlusi | Q8C156 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034906, Expressed in vestibular organ and 228 other tissues |
ExpressionAtlasi | Q8C156, baseline and differential |
Genevisiblei | Q8C156, MM |
Interactioni
Subunit structurei
Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
By similarityProtein-protein interaction databases
BioGRIDi | 229619, 32 interactors |
ComplexPortali | CPX-980, Condensin I complex |
IntActi | Q8C156, 20 interactors |
MINTi | Q8C156 |
STRINGi | 10090.ENSMUSP00000106017 |
Miscellaneous databases
RNActi | Q8C156, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 178 – 214 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 652 – 673 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 19 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2328, Eukaryota |
GeneTreei | ENSGT00390000004149 |
HOGENOMi | CLU_010510_1_0_1 |
InParanoidi | Q8C156 |
OMAi | EPQMRVY |
OrthoDBi | 702078at2759 |
PhylomeDBi | Q8C156 |
TreeFami | TF105678 |
Family and domain databases
InterProi | View protein in InterPro IPR022816, Condensin_barren_su2 |
PANTHERi | PTHR13108, PTHR13108, 1 hit |
Pfami | View protein in Pfam PF05786, Cnd2, 1 hit |
PIRSFi | PIRSF017126, Condensin_H, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MRIPRSETMN SSFLKARGQQ DVLSSPLERV PPASRPGKAP LGTPKTPVLE
60 70 80 90 100
DFPQNDDEKE RMQRRRSRVF DLQFSTDSIH LASPNRNIDV STTISKFTNT
110 120 130 140 150
QITEHYSTCI KLSSENKITT KNAFGLHLID FMSEILKQKD AEPTNFKVAA
160 170 180 190 200
GTLDASTKIY AVRVDAVHAD VYRVLGGLGK DTPPQGEESH SGDGSTLETE
210 220 230 240 250
RTKKPAKPKK KQSCKTIEQN LSNINVSEAD GKCAVDPMFQ KTAASFDECS
260 270 280 290 300
TTGVFLSTLH CQDYRSELLF PSDMQTLSSG EPLELPDLGF VDMTDLEASL
310 320 330 340 350
QQCVEDRPLC PSLAGFQFTK WDSETHNESV SALVDKFKKN DQVFDINAEA
360 370 380 390 400
EDDEEDVPDG PLVEDFVDND EPDLSAAGDH EEFRSWKELC QVQSNQEEVI
410 420 430 440 450
SLEDRDIQVM CSFLSMKPGE YSYFSPRTMK MWAGPDHWRF RPRPKQDATS
460 470 480 490 500
CTEHKKKSAK KDFEINFDDD IDFDAYFQKT KAATILTKST LENQNWKATT
510 520 530 540 550
LPTDFHYETD NLIQLHLKPG KRSLKMDQDQ KAKTEHYEEI EDYDYNNPND
560 570 580 590 600
TSNYCPGLQA ADSDYEEADD LFADPVGTLD LESDPKTTQE NGHISPENQG
610 620 630 640 650
VDITTYQELN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTKFSR
660 670 680 690 700
KEADTEANHT ESGQEGAPEE VADEKKLSGL TKDLQTRLPP LMAQNLSIPL
710 720 730
AFACLLHLAN EKNLKLEGTE DLSDVLVMQG D
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BL21 | H3BL21_MOUSE | Condensin complex subunit 2 | Ncaph | 60 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028919 mRNA Translation: BAC26195.1 AK042706 mRNA Translation: BAC31339.1 Sequence problems. BC021499 mRNA Translation: AAH21499.1 Different initiation. BC025060 mRNA Translation: AAH25060.1 Different initiation. |
CCDSi | CCDS16693.2 |
RefSeqi | NP_659067.2, NM_144818.3 |
Genome annotation databases
Ensembli | ENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906 |
GeneIDi | 215387 |
KEGGi | mmu:215387 |
UCSCi | uc008met.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028919 mRNA Translation: BAC26195.1 AK042706 mRNA Translation: BAC31339.1 Sequence problems. BC021499 mRNA Translation: AAH21499.1 Different initiation. BC025060 mRNA Translation: AAH25060.1 Different initiation. |
CCDSi | CCDS16693.2 |
RefSeqi | NP_659067.2, NM_144818.3 |
3D structure databases
SMRi | Q8C156 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229619, 32 interactors |
ComplexPortali | CPX-980, Condensin I complex |
IntActi | Q8C156, 20 interactors |
MINTi | Q8C156 |
STRINGi | 10090.ENSMUSP00000106017 |
PTM databases
iPTMneti | Q8C156 |
PhosphoSitePlusi | Q8C156 |
Proteomic databases
EPDi | Q8C156 |
jPOSTi | Q8C156 |
MaxQBi | Q8C156 |
PaxDbi | Q8C156 |
PeptideAtlasi | Q8C156 |
PRIDEi | Q8C156 |
ProteomicsDBi | 283397 |
Protocols and materials databases
Antibodypediai | 1231, 343 antibodies from 38 providers |
DNASUi | 215387 |
Genome annotation databases
Ensembli | ENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906 |
GeneIDi | 215387 |
KEGGi | mmu:215387 |
UCSCi | uc008met.2, mouse |
Organism-specific databases
CTDi | 23397 |
MGIi | MGI:2444777, Ncaph |
VEuPathDBi | HostDB:ENSMUSG00000034906 |
Phylogenomic databases
eggNOGi | KOG2328, Eukaryota |
GeneTreei | ENSGT00390000004149 |
HOGENOMi | CLU_010510_1_0_1 |
InParanoidi | Q8C156 |
OMAi | EPQMRVY |
OrthoDBi | 702078at2759 |
PhylomeDBi | Q8C156 |
TreeFami | TF105678 |
Enzyme and pathway databases
Reactomei | R-MMU-2514853, Condensation of Prometaphase Chromosomes |
Miscellaneous databases
BioGRID-ORCSi | 215387, 17 hits in 67 CRISPR screens |
ChiTaRSi | Ncaph, mouse |
PROi | PR:Q8C156 |
RNActi | Q8C156, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034906, Expressed in vestibular organ and 228 other tissues |
ExpressionAtlasi | Q8C156, baseline and differential |
Genevisiblei | Q8C156, MM |
Family and domain databases
InterProi | View protein in InterPro IPR022816, Condensin_barren_su2 |
PANTHERi | PTHR13108, PTHR13108, 1 hit |
Pfami | View protein in Pfam PF05786, Cnd2, 1 hit |
PIRSFi | PIRSF017126, Condensin_H, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CND2_MOUSE | |
Accessioni | Q8C156Primary (citable) accession number: Q8C156 Secondary accession number(s): Q8BY01, Q8VDM9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families