Ncaph

Functionⁱ

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.By similarity

GO - Molecular functionⁱ

chromatin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA topoisomerase (ATP-hydrolyzing) activator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA topoisomerase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
female meiosis chromosome separation
Source: MGI
Inferred from genetic interactionⁱ
- 25961503
female meiotic nuclear division
Source: MGI
Inferred from mutant phenotypeⁱ
- 25961503
meiotic chromosome condensation
Source: MGI
Inferred from mutant phenotypeⁱ
- 21795393
meiotic chromosome segregation
Source: MGI
Inferred from mutant phenotypeⁱ
- 21795393
mitotic chromosome condensation Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, DNA condensation, Mitosis

Biological process

Cell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2514853 Condensation of Prometaphase Chromosomes

Reactomeⁱ

R-MMU-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Condensin complex subunit 2 Alternative name(s): Barren homolog protein 1 Chromosome-associated protein H Short name: mCAP-H Non-SMC condensin I complex subunit H XCAP-H homolog
Gene namesⁱ	Name:Ncaph Synonyms:Brrn, Brrn1, Caph
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:2444777 Ncaph

Keywords - Cellular componentⁱ

Chromosome, Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000095039	1 – 731	Condensin complex subunit 2Add BLAST		731

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	12	PhosphoserineBy similarity	1
Modified residueⁱ	25	PhosphoserineCombined sources	1
Modified residueⁱ	43	PhosphothreonineCombined sources	1
Modified residueⁱ	46	PhosphothreonineBy similarity	1
Modified residueⁱ	67	PhosphoserineBy similarity	1
Modified residueⁱ	75	PhosphoserineBy similarity	1
Modified residueⁱ	78	PhosphoserineBy similarity	1
Modified residueⁱ	83	PhosphoserineBy similarity	1
Modified residueⁱ	91	PhosphoserineBy similarity	1
Modified residueⁱ	182	PhosphothreonineCombined sources	1
Modified residueⁱ	195	PhosphoserineBy similarity	1
Modified residueⁱ	227	PhosphoserineBy similarity	1
Modified residueⁱ	425	PhosphoserineBy similarity	1
Cross-linkⁱ	481	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	489	PhosphoserineBy similarity	1
Modified residueⁱ	587	PhosphothreonineBy similarity	1
Modified residueⁱ	627	N6-acetyllysineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8C156
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8C156
PaxDbⁱ	Q8C156
PeptideAtlas More...PeptideAtlasⁱ	Q8C156
PRIDEⁱ	Q8C156

PTM databases

iPTMnetⁱ	Q8C156
PhosphoSitePlusⁱ	Q8C156

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034906 Expressed in 199 organ(s), highest expression level in vestibular organ
CleanExⁱ	MM_NCAPH
ExpressionAtlasⁱ	Q8C156 baseline and differential
Genevisibleⁱ	Q8C156 MM

Interactionⁱ

Subunit structureⁱ

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.By similarity

GO - Molecular functionⁱ

DNA topoisomerase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	229619, 19 interactors
ComplexPortalⁱ	CPX-980 Condensin I complex
IntActⁱ	Q8C156, 20 interactors
Molecular INTeraction database More...MINTⁱ	Q8C156
STRINGⁱ	10090.ENSMUSP00000106017

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CND2 (condensin subunit 2) family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2328 Eukaryota COG5229 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004149
HOGENOMⁱ	HOG000231887
HOVERGENⁱ	HBG036823
InParanoidⁱ	Q8C156
KEGG Orthology (KO) More...KOⁱ	K06676
OMAⁱ	PFEIDFA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01HE
PhylomeDBⁱ	Q8C156
TreeFamⁱ	TF105678

Family and domain databases

InterProⁱ	View protein in InterPro IPR022816 Condensin_barren_su2
PANTHERⁱ	PTHR13108 PTHR13108, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05786 Cnd2, 1 hit
PIRSFⁱ	PIRSF017126 Condensin_H, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8C156-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRIPRSETMN SSFLKARGQQ DVLSSPLERV PPASRPGKAP LGTPKTPVLE 
        60         70         80         90        100
DFPQNDDEKE RMQRRRSRVF DLQFSTDSIH LASPNRNIDV STTISKFTNT 
       110        120        130        140        150
QITEHYSTCI KLSSENKITT KNAFGLHLID FMSEILKQKD AEPTNFKVAA 
       160        170        180        190        200
GTLDASTKIY AVRVDAVHAD VYRVLGGLGK DTPPQGEESH SGDGSTLETE 
       210        220        230        240        250
RTKKPAKPKK KQSCKTIEQN LSNINVSEAD GKCAVDPMFQ KTAASFDECS 
       260        270        280        290        300
TTGVFLSTLH CQDYRSELLF PSDMQTLSSG EPLELPDLGF VDMTDLEASL 
       310        320        330        340        350
QQCVEDRPLC PSLAGFQFTK WDSETHNESV SALVDKFKKN DQVFDINAEA 
       360        370        380        390        400
EDDEEDVPDG PLVEDFVDND EPDLSAAGDH EEFRSWKELC QVQSNQEEVI 
       410        420        430        440        450
SLEDRDIQVM CSFLSMKPGE YSYFSPRTMK MWAGPDHWRF RPRPKQDATS 
       460        470        480        490        500
CTEHKKKSAK KDFEINFDDD IDFDAYFQKT KAATILTKST LENQNWKATT 
       510        520        530        540        550
LPTDFHYETD NLIQLHLKPG KRSLKMDQDQ KAKTEHYEEI EDYDYNNPND 
       560        570        580        590        600
TSNYCPGLQA ADSDYEEADD LFADPVGTLD LESDPKTTQE NGHISPENQG 
       610        620        630        640        650
VDITTYQELN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTKFSR 
       660        670        680        690        700
KEADTEANHT ESGQEGAPEE VADEKKLSGL TKDLQTRLPP LMAQNLSIPL 
       710        720        730 
AFACLLHLAN EKNLKLEGTE DLSDVLVMQG D

Length:731

Mass (Da):82,303

Last modified:March 1, 2003 - v1

Checksum:ⁱ23D2504024C2F0D5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BL21	H3BL21_MOUSE		Condensin complex subunit 2 Condensin complex subunit 2	Ncaph	60	Annotation score:

Sequence cautionⁱ

The sequence AAH21499 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH25060 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC31339 differs from that shown. Reason: Erroneous termination at position 438. Translated as Trp.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028919 mRNA Translation: BAC26195.1 AK042706 mRNA Translation: BAC31339.1 Sequence problems. BC021499 mRNA Translation: AAH21499.1 Different initiation. BC025060 mRNA Translation: AAH25060.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16693.2
NCBI Reference Sequences More...RefSeqⁱ	NP_659067.2, NM_144818.3
UniGeneⁱ	Mm.29786

Genome annotation databases

Ensemblⁱ	ENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906
GeneIDⁱ	215387
KEGGⁱ	mmu:215387
UCSC genome browser More...UCSCⁱ	uc008met.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8C156	MKIAA0074 protein (Fragment)		MOUSE		611	UniRef90_Q8C156
UPI000A319F86		MUSCR		734
UPI000A313746		MUSPA		731
UPI000A316DA1		MUSCR		731

Protein	Similar proteins		Species	Score	Length	Source
Q8C156	Condensin complex subunit 2		HUMAN		741	UniRef50_Q15003
Condensin complex subunit 2		PANPA		745
Condensin complex subunit 2		NOMLE		745
Condensin complex subunit 2		GORGO		745
Condensin complex subunit 2		PANTR		745
+221

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028919 mRNA Translation: BAC26195.1 AK042706 mRNA Translation: BAC31339.1 Sequence problems. BC021499 mRNA Translation: AAH21499.1 Different initiation. BC025060 mRNA Translation: AAH25060.1 Different initiation.
CCDSⁱ	CCDS16693.2
RefSeqⁱ	NP_659067.2, NM_144818.3
UniGeneⁱ	Mm.29786

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229619, 19 interactors
ComplexPortalⁱ	CPX-980 Condensin I complex
IntActⁱ	Q8C156, 20 interactors
MINTⁱ	Q8C156
STRINGⁱ	10090.ENSMUSP00000106017

PTM databases

iPTMnetⁱ	Q8C156
PhosphoSitePlusⁱ	Q8C156

Proteomic databases

EPDⁱ	Q8C156
MaxQBⁱ	Q8C156
PaxDbⁱ	Q8C156
PeptideAtlasⁱ	Q8C156
PRIDEⁱ	Q8C156

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000110387; ENSMUSP00000106017; ENSMUSG00000034906
GeneIDⁱ	215387
KEGGⁱ	mmu:215387
UCSCⁱ	uc008met.2 mouse

Organism-specific databases

CTDⁱ	23397
MGIⁱ	MGI:2444777 Ncaph

Phylogenomic databases

eggNOGⁱ	KOG2328 Eukaryota COG5229 LUCA
GeneTreeⁱ	ENSGT00390000004149
HOGENOMⁱ	HOG000231887
HOVERGENⁱ	HBG036823
InParanoidⁱ	Q8C156
KOⁱ	K06676
OMAⁱ	PFEIDFA
OrthoDBⁱ	EOG091G01HE
PhylomeDBⁱ	Q8C156
TreeFamⁱ	TF105678

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2514853 Condensation of Prometaphase Chromosomes

Reactomeⁱ

R-MMU-2514853 Condensation of Prometaphase Chromosomes

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8C156
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034906 Expressed in 199 organ(s), highest expression level in vestibular organ
CleanExⁱ	MM_NCAPH
ExpressionAtlasⁱ	Q8C156 baseline and differential
Genevisibleⁱ	Q8C156 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR022816 Condensin_barren_su2
PANTHERⁱ	PTHR13108 PTHR13108, 1 hit
Pfamⁱ	View protein in Pfam PF05786 Cnd2, 1 hit
PIRSFⁱ	PIRSF017126 Condensin_H, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CND2_MOUSE
Accessionⁱ	Q8C156Primary (citable) accession number: Q8C156 Secondary accession number(s): Q8BY01, Q8VDM9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8C156 (CND2_MOUSE)

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Condensin complex subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ