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Entry version 107 (17 Jun 2020)
Sequence version 3 (20 Apr 2010)
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Protein

Terminal nucleotidyltransferase 5B

Gene

Tent5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal nucleotidyltransferase 5BCurated (EC:2.7.7.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tent5bBy similarity
Synonyms:Fam46bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2140500 Tent5b

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002599321 – 427Terminal nucleotidyltransferase 5BAdd BLAST427

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C152

PRoteomics IDEntifications database

More...
PRIDEi
Q8C152

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C152

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8C152

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000046694 Expressed in secondary oocyte and 76 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C152 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8C152, 1 interactor

Molecular INTeraction database

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MINTi
Q8C152

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000056015

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C152 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TENT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3852 Eukaryota
ENOG410XTG4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160747

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008115_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C152

KEGG Orthology (KO)

More...
KOi
K23033

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTWLPCS

Database of Orthologous Groups

More...
OrthoDBi
612201at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C152

TreeFam database of animal gene trees

More...
TreeFami
TF315239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012937 TET5

The PANTHER Classification System

More...
PANTHERi
PTHR12974 PTHR12974, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07984 NTP_transf_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01153 DUF1693, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8C152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPSESGAES LEQPAAQVGT GAASAVATAG AAGGGPDPEA SSASLGRHQS
60 70 80 90 100
RLSWPQVKRL DALLKEPIPI HGRGNFPTLS VQPQQIVQVV RSSLEEHGLR
110 120 130 140 150
VHSVRLHGSA ASHVLHPESG LGYKDLDLVF QMDLRSEVSF QLTKAVVLAC
160 170 180 190 200
LLDFLPAGVS RAKITPLTLK EAYVQKLVKV CTDLDRWSLI SLSNKSGKNV
210 220 230 240 250
ELKFVDSVRR QFEFSIDSFQ IILDSLLLFG QCSSTPMSEA FHPTVTGESL
260 270 280 290 300
YGDFAEALEH LQHRVIATRS PEEIRGGGLL KYCHLLVRGF RPRPSTDVRA
310 320 330 340 350
LQRYMCSRFF IDFPDLVEQR RILERYLEAH FGGAEAARRY ACLVTLHQVV
360 370 380 390 400
NESTVCLMSH ERRQTLDLIA MLALQALAEQ GPAAMAALAW RRPGSDGVVP
410 420
ATVNYYVTPM QPLLPRAHSY PTWLPCN
Length:427
Mass (Da):46,998
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD4406CD3E66F9BD
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH38001 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138V → A in AAH38001 (PubMed:15489334).Curated1
Sequence conflicti290F → L in BAE36752 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK028944 mRNA Translation: BAC26207.1
AK135706 mRNA Translation: BAE22618.1
AK137659 mRNA Translation: BAE23449.1
AK162145 mRNA Translation: BAE36752.1
BC038001 mRNA Translation: AAH38001.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18748.1

NCBI Reference Sequences

More...
RefSeqi
NP_780516.1, NM_175307.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000051676; ENSMUSP00000056015; ENSMUSG00000046694

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100342

UCSC genome browser

More...
UCSCi
uc008vct.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028944 mRNA Translation: BAC26207.1
AK135706 mRNA Translation: BAE22618.1
AK137659 mRNA Translation: BAE23449.1
AK162145 mRNA Translation: BAE36752.1
BC038001 mRNA Translation: AAH38001.1 Different initiation.
CCDSiCCDS18748.1
RefSeqiNP_780516.1, NM_175307.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8C152, 1 interactor
MINTiQ8C152
STRINGi10090.ENSMUSP00000056015

PTM databases

iPTMnetiQ8C152
PhosphoSitePlusiQ8C152

Proteomic databases

PaxDbiQ8C152
PRIDEiQ8C152

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
69553 27 antibodies

Genome annotation databases

EnsembliENSMUST00000051676; ENSMUSP00000056015; ENSMUSG00000046694
GeneIDi100342
KEGGimmu:100342
UCSCiuc008vct.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
115572
MGIiMGI:2140500 Tent5b

Phylogenomic databases

eggNOGiKOG3852 Eukaryota
ENOG410XTG4 LUCA
GeneTreeiENSGT00940000160747
HOGENOMiCLU_008115_2_0_1
InParanoidiQ8C152
KOiK23033
OMAiRTWLPCS
OrthoDBi612201at2759
PhylomeDBiQ8C152
TreeFamiTF315239

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
100342 0 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tent5b mouse

Protein Ontology

More...
PROi
PR:Q8C152
RNActiQ8C152 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046694 Expressed in secondary oocyte and 76 other tissues
GenevisibleiQ8C152 MM

Family and domain databases

InterProiView protein in InterPro
IPR012937 TET5
PANTHERiPTHR12974 PTHR12974, 1 hit
PfamiView protein in Pfam
PF07984 NTP_transf_7, 1 hit
SMARTiView protein in SMART
SM01153 DUF1693, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET5B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C152
Secondary accession number(s): Q3TSC3, Q8CI10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 20, 2010
Last modified: June 17, 2020
This is version 107 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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