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Protein

Dedicator of cytokinesis protein 8

Gene

Dock8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (PubMed:22461490, PubMed:25713392). Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dock8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921396 Dock8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile (PubMed:22461490). The number of CD4+ and CD8+ T-cells are reduced by 50 percent in the spleen and peripheral lymph nodes (PubMed:22461490). The number of marginal zone B cells in the spleen are also reduced (PubMed:22461490). In response to an immune challenge, impaired migration of epidermal dendritic cells to the draining lymph nodes resulting in a failure to prime CD4+ T-cells characterized by a lack of CD4+ T-cell proliferation in lymph nodes and a lack of antigen-specific IgG antibody production (PubMed:25713392, PubMed:22461490).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1827S → P in an experimental autoimmune encephalomyelitis (EAE) disease model, 50 percent of animals have no EAE symptoms. In the remaining animals, EAE is less severe with a reduction in the demyelination of the spinal cord and in the number of CD4(+) T-cells infiltrating the central nervous system. In addition, CD4(+) T-cell proliferation and apoptosis are increased. Reduced CD4(+) T-cell transmigration towards chemokine CXCL12 and CCL5. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899981 – 2100Dedicator of cytokinesis protein 8Add BLAST2100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei905PhosphoserineCombined sources1
Modified residuei937PhosphoserineBy similarity1
Modified residuei1146PhosphoserineBy similarity1
Modified residuei1244PhosphoserineCombined sources1
Modified residuei2088PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In response to chemokine CXCL12/SDF-1-alpha stimulation, phosphorylated by PRKCA/PKC-alpha which promotes DOCK8 dissociation from LRCH1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C147

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C147

PeptideAtlas

More...
PeptideAtlasi
Q8C147

PRoteomics IDEntifications database

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PRIDEi
Q8C147

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C147

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8C147

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in T cells (PubMed:28028151). Expressed in bone marrow-derived dendritic cells (PubMed:25713392).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052085 Expressed in 170 organ(s), highest expression level in spleen

CleanEx database of gene expression profiles

More...
CleanExi
MM_DOCK8

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C147 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via DHR-2 domain) with GTPase CDC42; the interaction activates CDC42 by exchanging GDP for GTP (PubMed:22461490). The unphosphorylated form interacts (via DHR-2 domain) with LRCH1 (via LRR repeats); the interaction prevents the association between DOCK8 and CDC42 (PubMed:28028151). Interacts with CCDC88B (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
217953, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8C147

Protein interaction database and analysis system

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IntActi
Q8C147, 5 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000025831

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8C147

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8C147

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini561 – 730DHR-1PROSITE-ProRule annotationAdd BLAST170
Domaini1633 – 2067DHR-2PROSITE-ProRule annotationAdd BLAST435

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHR-2 domain is necessary and sufficient for the GEF activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997 Eukaryota
ENOG410ZJ2S LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155876

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051390

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8C147

KEGG Orthology (KO)

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KOi
K21852

Identification of Orthologs from Complete Genome Data

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OMAi
QYVHNMD

Database of Orthologous Groups

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OrthoDBi
EOG091G0067

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8C147

TreeFam database of animal gene trees

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TreeFami
TF313629

Family and domain databases

Conserved Domains Database

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CDDi
cd08696 C2_Dock-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037808 C2_Dock-C
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C147-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATLPSAERR AFALKINRYS SSEIRKQFTL PPNLGQYHRH SISTSGFPSL
60 70 80 90 100
QLPQLYEPVE PVDFEGLVMT HLNSLDAELA QELGDLTDDD LHVAFTPKEC
110 120 130 140 150
RTLQHSLPEE GVELDPHVRD CVQTYIREWL IVNRKNQGSS EFCSFKKTGS
160 170 180 190 200
RRDFQKTLQK QTFESETLEC SEPDTQTGPR HPLNVLCDVS GKGPLTSCDF
210 220 230 240 250
DLRSLQPDER LENLLQLVSA EDFEKEKEEA RKTNRPAELF ALYPPVDEED
260 270 280 290 300
AVEIRPVPEC PKEHLGNRIL VKVLTLKFEI EIEPLFASIA LYDVKERKKI
310 320 330 340 350
SENFHCDLNS DQFKGFLRAH TPSIDPSSQA RSAVFSVTYP SSDIYLVVKI
360 370 380 390 400
EKVLQQGEIA DCAEPYMIIK ESDGGKSKEK VEKLKLQAES FCQRLGKYRM
410 420 430 440 450
PFAWAPISLA SFFNISTLER ESTDVEPGVG RNSVGEKRSL SQSRRPSERT
460 470 480 490 500
LSLEENGVGS NFKATTLATN IFFKQEGDRL SDEDLFKFLA DYKRSSSLQR
510 520 530 540 550
RVKSIPGSLR LEISPAPDVM NCCLTPEMLP VKPFPENRTR PHKEILEFPI
560 570 580 590 600
REVYVPHTVY RNLLYVYPQR LNFASKLASA RNITIKIQFM CGEDPSNAMP
610 620 630 640 650
VIFGKSSGPE FLQEVYTAIT YHNKSPDFYE EVKIKLPAKL TVNHHLLFTF
660 670 680 690 700
YHISCQQKQG ASGESLLGYS WLPILLNERL QTGSYCLPVA LEKLPPNYSI
710 720 730 740 750
HSAEKVPLQN PPIKWAEGHK GVFNIEVQAV SSVHTQDNHL EKFFTLCHSL
760 770 780 790 800
ESQVSFPIRV LDQKITESTL EHELKLSIIC LNSSRLEPLV LFLHLVLDKL
810 820 830 840 850
FQLSVQPMVI AGQTANFSQF AFESVVAIAN SLHNSKDLRK DQHGRNCLLA
860 870 880 890 900
SYVHYVFRLP ELHRDTSKSG GPTTVVPDPR YHTYGRTSAA AVSSKLMQAR
910 920 930 940 950
VMSSSNPDLT GSHCAADEEV KNIMSSKIAD RNCSRMSYYC SGNSDAPGST
960 970 980 990 1000
AAPRPVSKKH FHEELALQMV VSTGVVRETV FKYAWFFFEL LVKSMAQYVH
1010 1020 1030 1040 1050
NLDKRDSFRR TRFSDRFKDD ITTIVNVVTS EIAALLVKPQ KESEQAEKIN
1060 1070 1080 1090 1100
ISLAFFLYDL LSIMDRGFVF NLIKHYCSQL SAKLNILPTL ISMRLEFLRI
1110 1120 1130 1140 1150
LCSHEHYLNL NLLFMNTDTA PASPCPSISS QNSSSCSSFQ DQKIASMFDL
1160 1170 1180 1190 1200
TPEYRQQHFL TGLLFTELAV ALDAEGDGIS RVQRKAVSAI HSLLCSHDLD
1210 1220 1230 1240 1250
PRCRKPEVKV KIAALYLPLV GIILDALPQL YDFTDARSGR SRASGSYEEQ
1260 1270 1280 1290 1300
DVANGINQNV ALAIAGNHFN LKTSGAMLSS LPYKQYNMLN ADTTRHLMIC
1310 1320 1330 1340 1350
FLWIMKNADQ SLIRKWIADL PSMQLNRILD LLFICVSCFE YKGKQSSDKV
1360 1370 1380 1390 1400
SNQVLQKSRD VKAKLEEALL RGEGARGEMM RRRIPGTDRF PGINENLRWR
1410 1420 1430 1440 1450
KEQTQWRQAN EKLDKTKAEL DQEALISGNL ATEANLIILD MQENIIQASS
1460 1470 1480 1490 1500
ALDCKDSLLG GVLRVLVNSL SCDQSTTYLT HCFATLRALI AKFGDLLFEE
1510 1520 1530 1540 1550
EMEQCADLCQ RVLHHCSSSM DVTRSQACAT LYLLMRFSFG ATSNFARVKM
1560 1570 1580 1590 1600
QVTMALASLV GKAPDFNEEH LRRSLRTILA YSEEDTAMQT TPFPMQVEEL
1610 1620 1630 1640 1650
LCNLNSILYD TVKMREFQED PEMLMDLMYR IAKSYQASPD LRLTWLQNMA
1660 1670 1680 1690 1700
EKHTKKKCFT EAAMCLVHAA ALVAEYLSML EDHSYLPVGS VSFQNISSNV
1710 1720 1730 1740 1750
LEESAVSDDT LSPDEDGVCS GRYFTESGLV GLLEQAAELF STGGLYETVN
1760 1770 1780 1790 1800
EVYKLVIPIL EAHRDFRKLT STHDKLQKAF DNIINKDHKR MFGTYFRVGF
1810 1820 1830 1840 1850
YGSRFGDLDE QEFVYKEPAI TKLPEISHRL EGFYGQCFGA EFVEVIKDST
1860 1870 1880 1890 1900
PVDKTKLDPN KAYIQITFVE PYFDEYEMKD RVTYFEKNFN LRRFMYTTPF
1910 1920 1930 1940 1950
TLEGRPRGEL HEQHRRNTVL TTMHAFPYIK TRIRVSQKEE FVLTPIEVAI
1960 1970 1980 1990 2000
EDMKKKTLQL AVATHQEPPD AKMLQMVLQG SVGATVNQGP LEVAQVFLAE
2010 2020 2030 2040 2050
IPADPKLYRH HNKLRLCFKE FIMRCGEAVE KNRRLITAEQ REYQQELKKN
2060 2070 2080 2090 2100
YNKLRDSLRP MIERKIPELY KPIFRVDSQK RDSFHRSSFR KCETQLSQGS
Length:2,100
Mass (Da):238,978
Last modified:August 21, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE867E04339CC6009
GO
Isoform 2 (identifier: Q8C147-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.
     1042-1044: ESE → VAV
     1045-2100: Missing.

Note: No experimental confirmation available.
Show »
Length:678
Mass (Da):76,556
Checksum:i56753BFF16C1FB5F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH30316 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB23587 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC26219 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD21430 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1608L → M in BAC26219 (PubMed:16141072).Curated1
Sequence conflicti1616E → K in AAH43470 (PubMed:15489334).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Strain C3H/HeJ mice harbor a point mutation in Dock8 which results in impaired dendritic cell migration. The mutation is not observed in strains CBA/J, C3H/HeOuJ or C3HeB/FeJ.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0273741 – 366Missing in isoform 2. 1 PublicationAdd BLAST366
Alternative sequenceiVSP_0273751042 – 1044ESE → VAV in isoform 2. 1 Publication3
Alternative sequenceiVSP_0273761045 – 2100Missing in isoform 2. 1 PublicationAdd BLAST1056

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC139711 Genomic DNA No translation available.
AC132319 Genomic DNA No translation available.
AK004816 mRNA Translation: BAB23587.1 Different initiation.
AK028968 mRNA Translation: BAC26219.2 Different initiation.
AK038285 mRNA Translation: BAC29959.1
BC029018 mRNA Translation: AAH29018.2
BC030316 mRNA Translation: AAH30316.2 Different initiation.
BC043470 mRNA Translation: AAH43470.1
BC055295 mRNA Translation: AAH55295.1
AK131180 mRNA Translation: BAD21430.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS37943.1 [Q8C147-1]

NCBI Reference Sequences

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RefSeqi
NP_083061.2, NM_028785.3 [Q8C147-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.102485

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000025831; ENSMUSP00000025831; ENSMUSG00000052085 [Q8C147-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
76088

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:76088

UCSC genome browser

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UCSCi
uc008hba.1 mouse [Q8C147-1]
uc008hbc.1 mouse [Q8C147-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139711 Genomic DNA No translation available.
AC132319 Genomic DNA No translation available.
AK004816 mRNA Translation: BAB23587.1 Different initiation.
AK028968 mRNA Translation: BAC26219.2 Different initiation.
AK038285 mRNA Translation: BAC29959.1
BC029018 mRNA Translation: AAH29018.2
BC030316 mRNA Translation: AAH30316.2 Different initiation.
BC043470 mRNA Translation: AAH43470.1
BC055295 mRNA Translation: AAH55295.1
AK131180 mRNA Translation: BAD21430.1 Different initiation.
CCDSiCCDS37943.1 [Q8C147-1]
RefSeqiNP_083061.2, NM_028785.3 [Q8C147-1]
UniGeneiMm.102485

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VHLX-ray2.08A1787-2067[»]
ProteinModelPortaliQ8C147
SMRiQ8C147
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217953, 1 interactor
CORUMiQ8C147
IntActiQ8C147, 5 interactors
STRINGi10090.ENSMUSP00000025831

PTM databases

iPTMnetiQ8C147
PhosphoSitePlusiQ8C147

Proteomic databases

EPDiQ8C147
PaxDbiQ8C147
PeptideAtlasiQ8C147
PRIDEiQ8C147

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025831; ENSMUSP00000025831; ENSMUSG00000052085 [Q8C147-1]
GeneIDi76088
KEGGimmu:76088
UCSCiuc008hba.1 mouse [Q8C147-1]
uc008hbc.1 mouse [Q8C147-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81704
MGIiMGI:1921396 Dock8

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410ZJ2S LUCA
GeneTreeiENSGT00940000155876
HOVERGENiHBG051390
InParanoidiQ8C147
KOiK21852
OMAiQYVHNMD
OrthoDBiEOG091G0067
PhylomeDBiQ8C147
TreeFamiTF313629

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dock8 mouse

Protein Ontology

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PROi
PR:Q8C147

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000052085 Expressed in 170 organ(s), highest expression level in spleen
CleanExiMM_DOCK8
GenevisibleiQ8C147 MM

Family and domain databases

CDDicd08696 C2_Dock-C, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037808 C2_Dock-C
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C147
Secondary accession number(s): Q6KAM7
, Q6PIS0, Q7TMQ5, Q8CAP6, Q8K105, Q9DBQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: August 21, 2007
Last modified: December 5, 2018
This is version 118 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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