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Entry version 128 (16 Oct 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Pleckstrin homology domain-containing family H member 2

Gene

Plekhh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family H member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plekhh2
Synonyms:Kiaa2028
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2146813 Plekhh2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003071221 – 1491Pleckstrin homology domain-containing family H member 2Add BLAST1491

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C115

PRoteomics IDEntifications database

More...
PRIDEi
Q8C115

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C115

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C115

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the kidney and testis. Expressed in the kidney exclusively by glomerular podocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040852 Expressed in 137 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C115 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

Interacts with TGFB1I1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8C115, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039628

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini702 – 796PH 1PROSITE-ProRule annotationAdd BLAST95
Domaini810 – 918PH 2PROSITE-ProRule annotationAdd BLAST109
Domaini954 – 1109MyTH4PROSITE-ProRule annotationAdd BLAST156
Domaini1120 – 1449FERMPROSITE-ProRule annotationAdd BLAST330

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili19 – 177Sequence analysisAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi396 – 399Poly-Ser4
Compositional biasi404 – 442Pro-richAdd BLAST39
Compositional biasi612 – 665Ser-richAdd BLAST54

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0248 Eukaryota
ENOG410XPCT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046075

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C115

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTPCGSE

TreeFam database of animal gene trees

More...
TreeFami
TF312866

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373 FERM_M, 1 hit
PF00784 MyTH4, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM00139 MyTH4, 1 hit
SM00233 PH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit
PS51016 MYTH4, 1 hit
PS50003 PH_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C115-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEPSEPEGL IDWKERCVAL EAQLMKFRVQ ASKIRELLAD KMQQLERQVI
60 70 80 90 100
DAERQAEKAF QEVQVMEEKL KAANIQTSES ETRLYKKCQD LESVMQEKDD
110 120 130 140 150
IIQNLALRLE EQKQVRIQEA KIIEEKAAKI KEWVTVKLNE LEVENQNLRF
160 170 180 190 200
INQTQTEEIR AIQSKLQELQ EKKISCVSSP KTSEGQRNLT FGCFLSRAKS
210 220 230 240 250
PPCVVRCEEV SKMASNEPEI TEGRCVEEME IAEKPADNQV QENSRSQRKL
260 270 280 290 300
HETSCSSEQN QKTRASFAMD GGTSQNSGVP VSDWSSDEDD GSKGRSKSRC
310 320 330 340 350
TSTLSSHTSE EGGQCGRLGS EAYLTASDDS SSIFEEETFD GNRPEQKKLC
360 370 380 390 400
SWQQKAPWKA QGNLAKGRSQ SGVKEQDSSS DELNKKFHSQ RLDYTSSSSE
410 420 430 440 450
ANTPSPILTP ALTPRYPNSL PGKGGAPLVP PPFQPPPKLR VPNVFSISVA
460 470 480 490 500
LTKRHLSQPQ LCSDRMFGTN RNAISMIRPL RPQETDLDVV DGDGAEAVNR
510 520 530 540 550
MDTGCDDGLF SYDSQDPPPC ADDQENSEAP KKAPCNKPPT PPLHRFPSWE
560 570 580 590 600
SRIYAVAKSG IRVSEAFNME HANKNSADIL SYSAASLYTS LIYKNMTTPV
610 620 630 640 650
YTTLKGKATQ ISSSPFLDDS SGSDEEDSSR SSSRLSESDA RSRSGPSSPR
660 670 680 690 700
AMKRGVSDSS AASESDYAIP PDAYPIDAEC SQPEQKLLKT CLASCDNGKN
710 720 730 740 750
EPLEKSGYLL KMSVRVKTWK RRWFVLKGGE LLYYKSPSDV IRKPQGHIEL
760 770 780 790 800
SASCSILRGD NKQTVQLATE KHTYYLTADS PNILEEWIKV LQSVLRVQAA
810 820 830 840 850
NPLCLQPEGK PAVKGLLTKV KHGYSKRVWC MLVGKVLYYF RNQEDKFPLG
860 870 880 890 900
QLKLWEAKVE EVDRSCDSDE DYETRGCYLL STHYTIIVHP KDQGPTYLLI
910 920 930 940 950
GSKHEKEAWL YHLTVAAGSN NINVGSEFEQ LVCKLLNIEG EPSSQIWRHP
960 970 980 990 1000
MLCHSKEGIL SPLTTLPSEA LQTEAIKLFK TCQLFINAAV DSPAIDYHIS
1010 1020 1030 1040 1050
LAQSALQVCL THPELQNEIC CQLIKQTRRR QLQNQPGPLQ GWQLLALCVG
1060 1070 1080 1090 1100
LFLPHHPFLW LLQLHLQRNA DSRTEFGKYA IYCQRCVERT QQNGDREARP
1110 1120 1130 1140 1150
SRMEILSTLL RNPYHHSRPF SIPVHFMNGL YQVVGFDAST TVEEFLNTLN
1160 1170 1180 1190 1200
QDTGMRKPAQ SGFALFTDDP SGRDLEHCLQ GNIKICDIIS KWEQASKEQQ
1210 1220 1230 1240 1250
PGKCEGSRTV RLTYKNRLYF SVQARGETDR EKTLLLYQTN DQIINGLFPL
1260 1270 1280 1290 1300
NKDLALEMAA LLAQVDIGDF ERPFSTPAGP VTNQCKANQT LKQVIERFYP
1310 1320 1330 1340 1350
KRYREGCSEE QLRQLYQRLS TKWMALRGHS AADCIRIYLT VARKWPFFGA
1360 1370 1380 1390 1400
KLFFAKPIAP SSLGNNCVWL AVHENGLSIL EYTSMRLVTS YMYKGLMTFG
1410 1420 1430 1440 1450
GYQEDFMVVV STQSKDRPTE KLLFAMAKHK ILEITLLIAS YINSFHQQKT
1460 1470 1480 1490
TFHHLSAPAL LSPRTQAPQA RVMGSQPPLS NSRPTKGPTL L
Length:1,491
Mass (Da):167,733
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1466907976E6A58
GO
Isoform 2 (identifier: Q8C115-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     607-640: KATQISSSPFLDDSSGSDEEDSSRSSSRLSESDA → VMSAFLVVRPMVFSRIVRDSTLGILTSIPLFVEL
     641-1491: Missing.

Note: No experimental confirmation available.
Show »
Length:640
Mass (Da):71,477
Checksum:i1794F8622563D4BC
GO
Isoform 3 (identifier: Q8C115-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     702-711: Missing.

Note: No experimental confirmation available.
Show »
Length:1,481
Mass (Da):166,604
Checksum:i61750418C12A7710
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21518 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti531K → E in BAC26356 (PubMed:16141072).Curated1
Sequence conflicti917A → V in BAD32615 (PubMed:15368895).Curated1
Sequence conflicti1456S → C in BAC26356 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028576607 – 640KATQI…SESDA → VMSAFLVVRPMVFSRIVRDS TLGILTSIPLFVEL in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_028577641 – 1491Missing in isoform 2. 1 PublicationAdd BLAST851
Alternative sequenceiVSP_028578702 – 711Missing in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK029252 mRNA Translation: BAC26356.1
CH466537 Genomic DNA Translation: EDL38577.1
BC021518 mRNA Translation: AAH21518.1 Different initiation.
BC125583 mRNA Translation: AAI25584.1
BC137804 mRNA Translation: AAI37805.1
AK173337 Transcribed RNA Translation: BAD32615.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28999.1 [Q8C115-1]

NCBI Reference Sequences

More...
RefSeqi
NP_808274.2, NM_177606.4 [Q8C115-1]
XP_006524056.1, XM_006523993.3 [Q8C115-1]
XP_006524057.1, XM_006523994.3
XP_017172870.1, XM_017317381.1 [Q8C115-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047206; ENSMUSP00000039628; ENSMUSG00000040852 [Q8C115-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
213556

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:213556

UCSC genome browser

More...
UCSCi
uc008dsv.1 mouse [Q8C115-2]
uc008dsw.2 mouse [Q8C115-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029252 mRNA Translation: BAC26356.1
CH466537 Genomic DNA Translation: EDL38577.1
BC021518 mRNA Translation: AAH21518.1 Different initiation.
BC125583 mRNA Translation: AAI25584.1
BC137804 mRNA Translation: AAI37805.1
AK173337 Transcribed RNA Translation: BAD32615.1
CCDSiCCDS28999.1 [Q8C115-1]
RefSeqiNP_808274.2, NM_177606.4 [Q8C115-1]
XP_006524056.1, XM_006523993.3 [Q8C115-1]
XP_006524057.1, XM_006523994.3
XP_017172870.1, XM_017317381.1 [Q8C115-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8C115, 2 interactors
STRINGi10090.ENSMUSP00000039628

PTM databases

iPTMnetiQ8C115
PhosphoSitePlusiQ8C115

Proteomic databases

PaxDbiQ8C115
PRIDEiQ8C115

Genome annotation databases

EnsembliENSMUST00000047206; ENSMUSP00000039628; ENSMUSG00000040852 [Q8C115-1]
GeneIDi213556
KEGGimmu:213556
UCSCiuc008dsv.1 mouse [Q8C115-2]
uc008dsw.2 mouse [Q8C115-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
130271
MGIiMGI:2146813 Plekhh2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0248 Eukaryota
ENOG410XPCT LUCA
GeneTreeiENSGT00940000157675
HOGENOMiHOG000046075
InParanoidiQ8C115
OMAiQTPCGSE
TreeFamiTF312866

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Plekhh2 mouse

Protein Ontology

More...
PROi
PR:Q8C115

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040852 Expressed in 137 organ(s), highest expression level in testis
GenevisibleiQ8C115 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 3 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00784 MyTH4, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00139 MyTH4, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS51016 MYTH4, 1 hit
PS50003 PH_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHH2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C115
Secondary accession number(s): B2RQ85
, Q059P2, Q69Z29, Q8VDL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 128 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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