Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein TGIF2

Gene

Tgif2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi16 – 79Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • nodal signaling pathway Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • regulation of gastrulation Source: MGI
  • retina development in camera-type eye Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF2
Alternative name(s):
5'-TG-3'-interacting factor 2
TGF-beta-induced transcription factor 2
Short name:
TGFB-induced factor 2
Gene namesi
Name:Tgif2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915299 Tgif2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493221 – 237Homeobox protein TGIF2Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei182PhosphothreonineBy similarity1
Modified residuei186PhosphothreonineBy similarity1

Post-translational modificationi

The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C0Y1
PaxDbiQ8C0Y1
PRIDEiQ8C0Y1

PTM databases

PhosphoSitePlusiQ8C0Y1

Expressioni

Gene expression databases

BgeeiENSMUSG00000062175 Expressed in 270 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_TGIF2
ExpressionAtlasiQ8C0Y1 baseline and differential
GenevisibleiQ8C0Y1 MM

Interactioni

Subunit structurei

Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096745

Structurei

3D structure databases

ProteinModelPortaliQ8C0Y1
SMRiQ8C0Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 237Repressive functionAdd BLAST135

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000232039
HOVERGENiHBG001143
InParanoidiQ8C0Y1
KOiK19553
OMAiMCSMPLH
OrthoDBiEOG091G0N1F
PhylomeDBiQ8C0Y1
TreeFamiTF318093

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8C0Y1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSDLGEDE GLLSLTGKRK RRGNLPKESV KILRDWLYLH RYNAYPSEQE
60 70 80 90 100
KLSLSGQTNL SVLQICNWFI NARRRLLPDM LRKDGKDPNQ FTISRRGGKA
110 120 130 140 150
SDVALPRGSS PSLLAVSVPA PTNMLSLSVC SMPLHSGQGE KPAAPFPQVE
160 170 180 190 200
LESPKALVTP ASTLTLLTRA EAGSPTGGLF NTPPPTPPEQ DKDDFSSFQL
210 220 230
LVEVALQRAA EMELQKQQEP APPLLHTPLP FVSENAK
Length:237
Mass (Da):25,933
Last modified:March 1, 2003 - v1
Checksum:iDB22FC96FD45DC59
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TZS1Q3TZS1_MOUSE
Homeobox protein TGIF2
Tgif2
198Annotation score:
H3BJF0H3BJF0_MOUSE
Homeobox protein TGIF2
Tgif2
68Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029490 mRNA Translation: BAC26473.1
CCDSiCCDS16969.1
RefSeqiNP_001278053.1, NM_001291124.1
NP_775572.1, NM_173396.3
XP_006499414.1, XM_006499351.3
XP_006499415.1, XM_006499352.3
XP_006499416.1, XM_006499353.3
XP_006499417.1, XM_006499354.3
UniGeneiMm.315625
Mm.368316
Mm.488917

Genome annotation databases

EnsembliENSMUST00000081335; ENSMUSP00000096745; ENSMUSG00000062175
GeneIDi228839
KEGGimmu:228839
UCSCiuc008nny.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029490 mRNA Translation: BAC26473.1
CCDSiCCDS16969.1
RefSeqiNP_001278053.1, NM_001291124.1
NP_775572.1, NM_173396.3
XP_006499414.1, XM_006499351.3
XP_006499415.1, XM_006499352.3
XP_006499416.1, XM_006499353.3
XP_006499417.1, XM_006499354.3
UniGeneiMm.315625
Mm.368316
Mm.488917

3D structure databases

ProteinModelPortaliQ8C0Y1
SMRiQ8C0Y1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096745

PTM databases

PhosphoSitePlusiQ8C0Y1

Proteomic databases

MaxQBiQ8C0Y1
PaxDbiQ8C0Y1
PRIDEiQ8C0Y1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081335; ENSMUSP00000096745; ENSMUSG00000062175
GeneIDi228839
KEGGimmu:228839
UCSCiuc008nny.2 mouse

Organism-specific databases

CTDi60436
MGIiMGI:1915299 Tgif2

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000232039
HOVERGENiHBG001143
InParanoidiQ8C0Y1
KOiK19553
OMAiMCSMPLH
OrthoDBiEOG091G0N1F
PhylomeDBiQ8C0Y1
TreeFamiTF318093

Enzyme and pathway databases

ReactomeiR-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Miscellaneous databases

PROiPR:Q8C0Y1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062175 Expressed in 270 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_TGIF2
ExpressionAtlasiQ8C0Y1 baseline and differential
GenevisibleiQ8C0Y1 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTGIF2_MOUSE
AccessioniPrimary (citable) accession number: Q8C0Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again