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Entry version 123 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Ankyrin repeat and MYND domain-containing protein 1

Gene

Ankmy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi845Zinc 1PROSITE-ProRule annotation1
Metal bindingi848Zinc 1PROSITE-ProRule annotation1
Metal bindingi859Zinc 2PROSITE-ProRule annotation1
Metal bindingi862Zinc 2PROSITE-ProRule annotation1
Metal bindingi868Zinc 1PROSITE-ProRule annotation1
Metal bindingi872Zinc 1PROSITE-ProRule annotation1
Metal bindingi881Zinc 2PROSITE-ProRule annotation1
Metal bindingi885Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri845 – 885MYND-typePROSITE-ProRule annotationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and MYND domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankmy1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045261, Ankmy1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003200651 – 906Ankyrin repeat and MYND domain-containing protein 1Add BLAST906

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8C0W1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C0W1

PRoteomics IDEntifications database

More...
PRIDEi
Q8C0W1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
281993

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C0W1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C0W1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000108622

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C0W1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati16 – 38MORN 1Add BLAST23
Repeati39 – 59MORN 2Add BLAST21
Repeati61 – 83MORN 3Add BLAST23
Repeati282 – 311ANK 1Add BLAST30
Repeati479 – 508ANK 2Add BLAST30
Repeati511 – 540ANK 3Add BLAST30
Repeati547 – 579ANK 4Add BLAST33
Repeati623 – 657ANK 5Add BLAST35
Repeati660 – 689ANK 6Add BLAST30
Repeati701 – 732ANK 7Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni391 – 411DisorderedSequence analysisAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri845 – 885MYND-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQJP, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C0W1

Database of Orthologous Groups

More...
OrthoDBi
323321at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR003409, MORN
IPR002893, Znf_MYND

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF02493, MORN, 2 hits
PF01753, zf-MYND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 5 hits
SM00698, MORN, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 2 hits
PS50088, ANK_REPEAT, 3 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8C0W1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLGYGEFSW PTGEAYHGQF YRDHFHGLGT YTWPDGSSFT GTFYLSQREG
60 70 80 90 100
YGTMHTKTML FQGLYKEDQR FGPGIETYPD GSQDVGLWFR EYLLKLCTRV
110 120 130 140 150
PSGFSLVNYP EFLAFLTKSR RRLDLSDEKV ELGLSEEQDP FFYDYKQYLL
160 170 180 190 200
NDELKLPPEM HVYSTDNSHL PMTDSLRQEL DDHIFMNEIP PFIEDEEPWL
210 220 230 240 250
ITNETPLLVK IQKQTYKFRN KDAHTSWNIP AILEGNRSRF GPSGPKEQIS
260 270 280 290 300
KKMIMKAEEG DYNWIFGILR DNLACADVAD SKGYTVLAAA AMHSHLDIVN
310 320 330 340 350
LLLDFGADVN KRSDEGITPL SMCFLQYYPC KSFHPNIAER TLLQESPKSL
360 370 380 390 400
VTPKISFLLA DANIDYLYDV GMPIAGGDEL KTSSLDDSLA SMQTPESSNM
410 420 430 440 450
LHKEEVSPVK TVSTDVEKES EGAAENVDAS TLYSVDTNFE STKCLRNYTI
460 470 480 490 500
NVSRDIMEKS AQAYSSLPQH PCFPYKGTVR KMAQSMVERR NRWMTITLLL
510 520 530 540 550
RRGADPNLCQ VPMQALFLAV KAGDVEGVRL LLMSGAQTDI QFPPQLQSLT
560 570 580 590 600
PLHIAVSLPG EEGVKITELL LHVITNVDAK AADEDYVYKG GKADLLPSSL
610 620 630 640 650
KLNNEPGPPK SFYSTHTFIP EEGGRTALHV ACEREDNKKC ARDIVRLLLS
660 670 680 690 700
HRANPNVLWS GHSPLSLAIA SGNDLVVKEL LSQGADPNLP LTKGLGTALC
710 720 730 740 750
VVCDLVYEQQ RSVENKIALI DRLISYGADV LNPVTLVQGD RTAVGTAVDY
760 770 780 790 800
GYFKFFQDRK IAHCPFHALM PAEREVFMAR KRLLEYLGLQ LRLAVLSKES
810 820 830 840 850
RLDTKALYLS KRAELAPCHR LKKKGSSSVR TQSSEKQSIP FYKFCYQCGR
860 870 880 890 900
SIGVRLSPCP RCYGILTCSK YCKTKAWIEF HKKDCNDIMA MIPHLEGSAW

RVAESP
Length:906
Mass (Da):101,999
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i436AE985B3E3E5A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUG3E9PUG3_MOUSE
Ankyrin repeat and MYND domain-cont...
Ankmy1
1,001Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM06A0A1D5RM06_MOUSE
Ankyrin repeat and MYND domain-cont...
Ankmy1
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CYY3E0CYY3_MOUSE
Ankyrin repeat and MYND domain-cont...
Ankmy1
1,002Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti813Missing in AAI20888 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK029700 mRNA Translation: BAC26572.1
BC120887 mRNA Translation: AAI20888.1
BC120888 mRNA Translation: AAI20889.1

NCBI Reference Sequences

More...
RefSeqi
NP_766438.2, NM_172850.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
241158

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:241158

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029700 mRNA Translation: BAC26572.1
BC120887 mRNA Translation: AAI20888.1
BC120888 mRNA Translation: AAI20889.1
RefSeqiNP_766438.2, NM_172850.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108622

PTM databases

iPTMnetiQ8C0W1
PhosphoSitePlusiQ8C0W1

Proteomic databases

MaxQBiQ8C0W1
PaxDbiQ8C0W1
PRIDEiQ8C0W1
ProteomicsDBi281993

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
241158

Genome annotation databases

GeneIDi241158
KEGGimmu:241158

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51281
MGIiMGI:3045261, Ankmy1

Phylogenomic databases

eggNOGiENOG502QQJP, Eukaryota
InParanoidiQ8C0W1
OrthoDBi323321at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
241158, 1 hit in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8C0W1
RNActiQ8C0W1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR003409, MORN
IPR002893, Znf_MYND
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF02493, MORN, 2 hits
PF01753, zf-MYND, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SM00698, MORN, 2 hits
SUPFAMiSSF48403, SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 2 hits
PS50088, ANK_REPEAT, 3 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANMY1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C0W1
Secondary accession number(s): Q0IJ76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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