Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FERM domain-containing protein 6

Gene

Frmd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actomyosin structure organization Source: GO_Central
  • apical constriction Source: MGI
  • cellular protein localization Source: MGI
  • regulation of actin filament-based process Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 6
Gene namesi
Name:Frmd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2442579 Frmd6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194491 – 622FERM domain-containing protein 6Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei522PhosphoserineCombined sources1
Modified residuei523PhosphothreonineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei542PhosphoserineBy similarity1
Modified residuei544PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C0V9
PeptideAtlasiQ8C0V9
PRIDEiQ8C0V9

PTM databases

iPTMnetiQ8C0V9
PhosphoSitePlusiQ8C0V9

Expressioni

Gene expression databases

BgeeiENSMUSG00000048285 Expressed in 259 organ(s), highest expression level in ear
CleanExiMM_FRMD6
GenevisibleiQ8C0V9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052202

Structurei

3D structure databases

ProteinModelPortaliQ8C0V9
SMRiQ8C0V9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 328FERMPROSITE-ProRule annotationAdd BLAST313

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 133Poly-Tyr4
Compositional biasi506 – 512Poly-Ser7

Phylogenomic databases

eggNOGiKOG4371 Eukaryota
ENOG410XSKD LUCA
GeneTreeiENSGT00920000148995
HOGENOMiHOG000294082
HOVERGENiHBG081539
InParanoidiQ8C0V9
KOiK16822
OMAiAQQCVNI
OrthoDBiEOG091G0443
PhylomeDBiQ8C0V9
TreeFamiTF319780

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C0V9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKLTFHNNK AMQDRRRVCI FLPNDKSVSI IINVKILCHQ LLVQVCDLLR
60 70 80 90 100
LKDSHLFGLS VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI
110 120 130 140 150
DQFGPPMIIH FRVQYYVENG KLISDRIARY YYYWHLRKQV LHSQCVLREE
160 170 180 190 200
AYFLLAAFAL QADLGNFKRK LHHGDYFEPE AYFPAWVVSK RGKDYILKHI
210 220 230 240 250
PNMHKDQFAL TASEAYLKYI KEAVRLDDVA IHYYRLYKDK REAEGSLTLG
260 270 280 290 300
LTMRGIQIFQ NLEEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
310 320 330 340 350
VYYTGCPTRS RHLLQLLSNS HRLYMNLQPV LRHLRKQEEN EEKKQYRESY
360 370 380 390 400
ISDNLDLDMD PLEKRSRASG SSAGSVKHKR LSRHSTASHS SSHTSGIEAD
410 420 430 440 450
TKPRDPGPED SCSGSAMHRK LKTCSSMTSH GSSHTSGVES GGKDRLEEDS
460 470 480 490 500
QDEEIEMLVD DPRDLEPMPE ESLEVSPEMC IYITEDMLLS RKLNGHSGLI
510 520 530 540 550
VKEIGSSTSS SSETVVRLRG QSTDSLPQTI CRKPKTSTDR HSLSLDDIRL
560 570 580 590 600
YQKDFLRIAG LCQDTAQSYT FGCGHELDES GLYCNSCLAQ QCVNIQDAFP
610 620
VKRASKYFSL DLTHDEVPEF VV
Note: No experimental confirmation available.
Length:622
Mass (Da):71,652
Last modified:August 15, 2003 - v2
Checksum:iEDDC8490CD84305C
GO
Isoform 2 (identifier: Q8C0V9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     23-33: PNDKSVSIIIN → MCRIPRHCCLR
     91-98: Missing.

Note: No experimental confirmation available.
Show »
Length:592
Mass (Da):68,059
Checksum:i6F61019C80FC3416
GO
Isoform 3 (identifier: Q8C0V9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-98: Missing.
     499-571: LIVKEIGSST...CQDTAQSYTF → ELLGQAVACR...FSEASSVGLI
     572-622: Missing.

Note: No experimental confirmation available.
Show »
Length:563
Mass (Da):64,224
Checksum:i1EE158B4D08B7FCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321H → Q in BAC26574 (PubMed:16141072).Curated1
Sequence conflicti431G → S in BAC35785 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0080241 – 22Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_00802523 – 33PNDKSVSIIIN → MCRIPRHCCLR in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_00802691 – 98Missing in isoform 2 and isoform 3. 1 Publication8
Alternative sequenceiVSP_008027499 – 571LIVKE…QSYTF → ELLGQAVACRSPQAGTSKNR TVVGTLNPPGRRATAGGLIP GQVPSVEEMGEGTRVVSMFC SARFSEASSVGLI in isoform 3. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_008028572 – 622Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029709 mRNA Translation: BAC26574.1
AK054457 mRNA Translation: BAC35785.1
BC053929 mRNA Translation: AAH53929.1
CCDSiCCDS25959.1 [Q8C0V9-1]
RefSeqiNP_082403.2, NM_028127.3 [Q8C0V9-1]
XP_006516040.1, XM_006515977.3 [Q8C0V9-1]
UniGeneiMm.2962

Genome annotation databases

EnsembliENSMUST00000057859; ENSMUSP00000052202; ENSMUSG00000048285 [Q8C0V9-1]
GeneIDi319710
KEGGimmu:319710
UCSCiuc007ntv.1 mouse [Q8C0V9-1]
uc007ntw.1 mouse [Q8C0V9-3]
uc007ntx.1 mouse [Q8C0V9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029709 mRNA Translation: BAC26574.1
AK054457 mRNA Translation: BAC35785.1
BC053929 mRNA Translation: AAH53929.1
CCDSiCCDS25959.1 [Q8C0V9-1]
RefSeqiNP_082403.2, NM_028127.3 [Q8C0V9-1]
XP_006516040.1, XM_006515977.3 [Q8C0V9-1]
UniGeneiMm.2962

3D structure databases

ProteinModelPortaliQ8C0V9
SMRiQ8C0V9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052202

PTM databases

iPTMnetiQ8C0V9
PhosphoSitePlusiQ8C0V9

Proteomic databases

PaxDbiQ8C0V9
PeptideAtlasiQ8C0V9
PRIDEiQ8C0V9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057859; ENSMUSP00000052202; ENSMUSG00000048285 [Q8C0V9-1]
GeneIDi319710
KEGGimmu:319710
UCSCiuc007ntv.1 mouse [Q8C0V9-1]
uc007ntw.1 mouse [Q8C0V9-3]
uc007ntx.1 mouse [Q8C0V9-2]

Organism-specific databases

CTDi122786
MGIiMGI:2442579 Frmd6

Phylogenomic databases

eggNOGiKOG4371 Eukaryota
ENOG410XSKD LUCA
GeneTreeiENSGT00920000148995
HOGENOMiHOG000294082
HOVERGENiHBG081539
InParanoidiQ8C0V9
KOiK16822
OMAiAQQCVNI
OrthoDBiEOG091G0443
PhylomeDBiQ8C0V9
TreeFamiTF319780

Miscellaneous databases

PROiPR:Q8C0V9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048285 Expressed in 259 organ(s), highest expression level in ear
CleanExiMM_FRMD6
GenevisibleiQ8C0V9 MM

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRMD6_MOUSE
AccessioniPrimary (citable) accession number: Q8C0V9
Secondary accession number(s): Q8BW34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again