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Protein

Signal-induced proliferation-associated 1-like protein 1

Gene

Sipa1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 1
Short name:
SIPA1-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sipa1l1
Synonyms:Kiaa0440
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443679 Sipa1l1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567471 – 1782Signal-induced proliferation-associated 1-like protein 1Add BLAST1782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei162PhosphoserineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei255PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei1078PhosphoserineBy similarity1
Modified residuei1087PhosphoserineBy similarity1
Modified residuei1116PhosphoserineBy similarity1
Modified residuei1127PhosphoserineCombined sources1
Modified residuei1149PhosphoserineBy similarity1
Modified residuei1170PhosphoserineBy similarity1
Modified residuei1181PhosphoserineBy similarity1
Modified residuei1234PhosphoserineBy similarity1
Modified residuei1249PhosphoserineBy similarity1
Modified residuei1305Phosphoserine; by PLK2By similarity1
Modified residuei1309Phosphothreonine; by PLK2By similarity1
Modified residuei1328Phosphoserine; by CDK5By similarity1
Modified residuei1345PhosphoserineBy similarity1
Modified residuei1369PhosphoserineBy similarity1
Modified residuei1370PhosphoserineBy similarity1
Modified residuei1391PhosphoserineBy similarity1
Modified residuei1410PhosphoserineCombined sources1
Modified residuei1412PhosphoserineCombined sources1
Modified residuei1507PhosphoserineBy similarity1
Modified residuei1528PhosphoserineCombined sources1
Modified residuei1530PhosphothreonineBy similarity1
Modified residuei1533PhosphoserineBy similarity1
Modified residuei1544PhosphoserineBy similarity1
Modified residuei1547PhosphoserineCombined sources1
Modified residuei1564PhosphoserineCombined sources1
Modified residuei1567PhosphoserineBy similarity1
Modified residuei1580Asymmetric dimethylarginineCombined sources1
Modified residuei1582PhosphoserineCombined sources1
Modified residuei1624PhosphoserineCombined sources1
Modified residuei1626PhosphoserineCombined sources1
Modified residuei1629PhosphoserineCombined sources1
Modified residuei1687PhosphoserineCombined sources1
Modified residuei1690PhosphoserineCombined sources1
Modified residuei1707PhosphoserineCombined sources1
Modified residuei1708PhosphoserineCombined sources1
Modified residuei1712PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.By similarity
Phosphorylated at Ser-1328 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C0T5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C0T5

PeptideAtlas

More...
PeptideAtlasi
Q8C0T5

PRoteomics IDEntifications database

More...
PRIDEi
Q8C0T5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C0T5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C0T5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042700 Expressed in 251 organ(s), highest expression level in striatum

CleanEx database of gene expression profiles

More...
CleanExi
MM_SIPA1L1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C0T5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C0T5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
229945, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8C0T5, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8C0T5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000061014

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8C0T5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C0T5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini599 – 816Rap-GAPPROSITE-ProRule annotationAdd BLAST218
Domaini953 – 1031PDZPROSITE-ProRule annotationAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1713 – 1773Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi93 – 129Ser-richAdd BLAST37
Compositional biasi1114 – 1447Ser-richAdd BLAST334
Compositional biasi1438 – 1447Poly-Ser10

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686 Eukaryota
ENOG410XTIX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154319

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056135

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C0T5

KEGG Orthology (KO)

More...
KOi
K17701

Identification of Orthologs from Complete Genome Data

More...
OMAi
KAMEIDC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G016P

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C0T5

TreeFam database of animal gene trees

More...
TreeFami
TF318626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR030770 SIPA1L1
IPR021818 SIPA1L_C

The PANTHER Classification System

More...
PANTHERi
PTHR15711:SF10 PTHR15711:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C0T5-1) [UniParc]FASTAAdd to basket
Also known as: E6TP1 alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSLKRSQTE RPVTADRASV VSTDGAPKVH TDDFYMRRFR SQNGSLGSSV
60 70 80 90 100
MAAVGPPRSE GPHHITSTPG VPKMGVRARI ADWPPRKENV KESSRSSQEI
110 120 130 140 150
ETSSCLESLS SKGSPVSQGS SVSLNSNDSA MLKSIQNTLK NKTGPAESMD
160 170 180 190 200
SRFLMPEAYP SSPRKALRRI RQRSNSDITI SELDVDSFDE CISPTYKSGP
210 220 230 240 250
SLHREYGSTS SIDKQGTSGD SFFDLLKGYK DDRSDRGPTP TKLSDFLITG
260 270 280 290 300
GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR
310 320 330 340 350
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR
360 370 380 390 400
HNVIKRRNTT TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLGM
410 420 430 440 450
DQGDDKSNEL VMSCPYFRNE IGGEGERKIS LSKSNSGSFS GCESTSFESA
460 470 480 490 500
LSSHCTNAGV AVLEVPKESL MLHLDRVKRY TVEHVDLGAY YYRKFFYQKE
510 520 530 540 550
HWNYFGADEN LGPVAVSIRR EKPEDMKENG SPYNYRIIFR TSELMTLRGS
560 570 580 590 600
VLEDAIPSTA KHSTARGLPL KEVLEHVIPE LNVQCLRLAF NTPKVTEQLM
610 620 630 640 650
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR
660 670 680 690 700
LKGFEKYRAQ LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL
710 720 730 740 750
LRKRHIGNDI VTIVFQEPGA QPFSPKNIRS HFQHVFVIVR AHNPCTESVC
760 770 780 790 800
YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF RDFLLAKVIN AENAAHKSEK
810 820 830 840 850
FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK KKEKSKPYPG
860 870 880 890 900
AELSSMGAIV WAVRAKDYNK AMEFDCLLGI SSEFIVLIEQ ETKSVAFNCS
910 920 930 940 950
CRDVIGWTSS DTSLKIFYER GECVSVESFI SGEDIKEIVR RLQFVSKGCE
960 970 980 990 1000
SVEMTLRRNG LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV
1010 1020 1030 1040 1050
AVATLSHEQM IDLLRTSVTV KVVIIPPHDD CTPRRSCSET YRMPVMEYQM
1060 1070 1080 1090 1100
NEGISYEFKF PFRNNNKWQR NASKGAHSPQ VPSQLQSPMT SRLNAGKGDG
1110 1120 1130 1140 1150
KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA LARSQCRNSP
1160 1170 1180 1190 1200
SNLSSSSETG SGGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDISGSGKS
1210 1220 1230 1240 1250
TPSWQRSEDS LADQMEPTCH LPAVSKVLPA FRESPSGRLM RQDPVVHLSP
1260 1270 1280 1290 1300
NKQGHSDSHY SSHSSSNTLS SNASSAHSDE KWYDGDRTES DLNSYNYLQG
1310 1320 1330 1340 1350
TSADSGIDTA SYGPSHGSTA SLGASTSSPR SGPGKEKVAP LWHSSSEVLS
1360 1370 1380 1390 1400
LADRTLETEG HGMDRKAESS LSLDIHSKSQ GGSSPLSREN STFSINDAAS
1410 1420 1430 1440 1450
HTSTMSSRHS ASPVVFSSAR SSPKEELHPT ASSQLAPSFS SSSSSSSGPR
1460 1470 1480 1490 1500
TFYPRQGATS KYLIGWKKPE GTINSVGFMD TRKRHQSDGN EIAHTRLRAS
1510 1520 1530 1540 1550
TRDLQASPKP TSKSTIEEDL KKLIDLESPT PESQKNFKFH ALSSPQSPFP
1560 1570 1580 1590 1600
TTPTSRRALH RTLSDESIYS SQREHFFTSR ASLLDQALPN DVLFSSTYPS
1610 1620 1630 1640 1650
LPKSLPLRRP SYTLGMKSLH GEFSASDSSL TDIQETRRQP IPDPGLMPLP
1660 1670 1680 1690 1700
DAASDLDWSN LVDAAKAYEV QRASFFAASD ENHRPLSAAS NSDQLEEQAL
1710 1720 1730 1740 1750
VQMKSYSSKD PSPTLASKVD QLEGMLKMLR EDLKKEKEDK AQLQAEVEHL
1760 1770 1780
REDNLRLQEE SQNASDKLKK FTEWVFNTID MS
Length:1,782
Mass (Da):197,031
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5BBD8CD69A481FC
GO
Isoform 2 (identifier: Q8C0T5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1736-1751: EKEDKAQLQAEVEHLR → VNALRKRRQGPAAGGS
     1752-1782: Missing.

Show »
Length:1,751
Mass (Da):193,047
Checksum:iFFFFD7A29B909C4E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4VBF8Q4VBF8_MOUSE
Signal-induced proliferation-associ...
Sipa1l1
1,713Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJM1A0A1Y7VJM1_MOUSE
Signal-induced proliferation-associ...
Sipa1l1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti855S → N in BAC26660 (PubMed:16141072).Curated1
Sequence conflicti1204W → C in BAC65566 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0109181736 – 1751EKEDK…VEHLR → VNALRKRRQGPAAGGS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0109191752 – 1782Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK029889 mRNA Translation: BAC26660.1
AK032493 mRNA Translation: BAC27896.1
BC058681 mRNA Translation: AAH58681.1
AK122284 mRNA Translation: BAC65566.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26026.1 [Q8C0T5-1]
CCDS49105.1 [Q8C0T5-2]

NCBI Reference Sequences

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RefSeqi
NP_001161455.1, NM_001167983.1 [Q8C0T5-2]
NP_766167.2, NM_172579.3 [Q8C0T5-1]
XP_011242371.1, XM_011244069.2 [Q8C0T5-1]
XP_017170514.1, XM_017315025.1 [Q8C0T5-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.261333

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000053969; ENSMUSP00000061014; ENSMUSG00000042700 [Q8C0T5-1]
ENSMUST00000166429; ENSMUSP00000131030; ENSMUSG00000042700 [Q8C0T5-1]
ENSMUST00000222298; ENSMUSP00000152356; ENSMUSG00000042700 [Q8C0T5-2]
ENSMUST00000222714; ENSMUSP00000152212; ENSMUSG00000042700 [Q8C0T5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
217692

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:217692

UCSC genome browser

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UCSCi
uc007ocu.2 mouse [Q8C0T5-1]
uc007ocw.2 mouse [Q8C0T5-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029889 mRNA Translation: BAC26660.1
AK032493 mRNA Translation: BAC27896.1
BC058681 mRNA Translation: AAH58681.1
AK122284 mRNA Translation: BAC65566.1
CCDSiCCDS26026.1 [Q8C0T5-1]
CCDS49105.1 [Q8C0T5-2]
RefSeqiNP_001161455.1, NM_001167983.1 [Q8C0T5-2]
NP_766167.2, NM_172579.3 [Q8C0T5-1]
XP_011242371.1, XM_011244069.2 [Q8C0T5-1]
XP_017170514.1, XM_017315025.1 [Q8C0T5-1]
UniGeneiMm.261333

3D structure databases

ProteinModelPortaliQ8C0T5
SMRiQ8C0T5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229945, 4 interactors
IntActiQ8C0T5, 3 interactors
MINTiQ8C0T5
STRINGi10090.ENSMUSP00000061014

PTM databases

iPTMnetiQ8C0T5
PhosphoSitePlusiQ8C0T5

Proteomic databases

EPDiQ8C0T5
PaxDbiQ8C0T5
PeptideAtlasiQ8C0T5
PRIDEiQ8C0T5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053969; ENSMUSP00000061014; ENSMUSG00000042700 [Q8C0T5-1]
ENSMUST00000166429; ENSMUSP00000131030; ENSMUSG00000042700 [Q8C0T5-1]
ENSMUST00000222298; ENSMUSP00000152356; ENSMUSG00000042700 [Q8C0T5-2]
ENSMUST00000222714; ENSMUSP00000152212; ENSMUSG00000042700 [Q8C0T5-1]
GeneIDi217692
KEGGimmu:217692
UCSCiuc007ocu.2 mouse [Q8C0T5-1]
uc007ocw.2 mouse [Q8C0T5-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26037
MGIiMGI:2443679 Sipa1l1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00940000155944
HOGENOMiHOG000154319
HOVERGENiHBG056135
InParanoidiQ8C0T5
KOiK17701
OMAiKAMEIDC
OrthoDBiEOG091G016P
PhylomeDBiQ8C0T5
TreeFamiTF318626

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sipa1l1 mouse

Protein Ontology

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PROi
PR:Q8C0T5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042700 Expressed in 251 organ(s), highest expression level in striatum
CleanExiMM_SIPA1L1
ExpressionAtlasiQ8C0T5 baseline and differential
GenevisibleiQ8C0T5 MM

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR030770 SIPA1L1
IPR021818 SIPA1L_C
PANTHERiPTHR15711:SF10 PTHR15711:SF10, 1 hit
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSI1L1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C0T5
Secondary accession number(s): Q6PDI8, Q80U02, Q8C026
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: December 5, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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