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Protein

Tetratricopeptide repeat protein 21A

Gene

Ttc21a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • intraciliary retrograde transport Source: GO_Central
  • protein localization to cilium Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 21A
Short name:
TPR repeat protein 21A
Alternative name(s):
Tetratricopeptide repeat-containing hedgehog modulator 2
Gene namesi
Name:Ttc21a
Synonyms:Thm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1921302 Ttc21a

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919161 – 1314Tetratricopeptide repeat protein 21AAdd BLAST1314

Proteomic databases

PaxDbiQ8C0S4
PRIDEiQ8C0S4

PTM databases

iPTMnetiQ8C0S4
PhosphoSitePlusiQ8C0S4

Expressioni

Gene expression databases

BgeeiENSMUSG00000032514 Expressed in 29 organ(s), highest expression level in testis
CleanExiMM_TTC21A
GenevisibleiQ8C0S4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035100

Structurei

3D structure databases

ProteinModelPortaliQ8C0S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati110 – 143TPR 1Add BLAST34
Repeati214 – 247TPR 2Add BLAST34
Repeati326 – 359TPR 3Add BLAST34
Repeati494 – 527TPR 4Add BLAST34
Repeati529 – 561TPR 5Add BLAST33
Repeati565 – 598TPR 6Add BLAST34
Repeati616 – 649TPR 7Add BLAST34
Repeati721 – 754TPR 8Add BLAST34
Repeati755 – 788TPR 9Add BLAST34
Repeati790 – 821TPR 10Add BLAST32
Repeati831 – 863TPR 11Add BLAST33
Repeati883 – 916TPR 12Add BLAST34
Repeati918 – 950TPR 13Add BLAST33
Repeati951 – 984TPR 14Add BLAST34
Repeati986 – 1018TPR 15Add BLAST33
Repeati1022 – 1055TPR 16Add BLAST34
Repeati1195 – 1228TPR 17Add BLAST34
Repeati1230 – 1262TPR 18Add BLAST33
Repeati1264 – 1297TPR 19Add BLAST34

Sequence similaritiesi

Belongs to the TTC21 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEX1 Eukaryota
ENOG410XV69 LUCA
GeneTreeiENSGT00390000005979
HOGENOMiHOG000004809
HOVERGENiHBG108607
InParanoidiQ8C0S4
OMAiQVPKART
OrthoDBiEOG091G00TY
PhylomeDBiQ8C0S4
TreeFamiTF314664

Family and domain databases

Gene3Di1.25.40.10, 5 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 14 hits
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 11 hits
PS50293 TPR_REGION, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C0S4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSDDSSLMA SIIYYSQEKY FHHVLQAANV GLERYSSDPA LQFFRAYGIL
60 70 80 90 100
GEDHIHDAIS ELEGIQSHPD TSLCAVIALL SAHKSCDTID IEAVQELESS
110 120 130 140 150
LKEIRRSASS TALYYASLFL WFMGHHDKAR EYVDHMLKVS SGSKEGYVLK
160 170 180 190 200
GWVDLTSSKP HVVKKSIKYL EQGTQDTKDV LGLMGKATYF MTQQNFSGAL
210 220 230 240 250
EVANQVTLAC SNFLPALVLK MKLFLARQDW DQTIETGQRI LEKDENNIDA
260 270 280 290 300
WQILAVHELV KEGNTDRAAD RVRNLIKALE TGEPHNPNLH LKKILVISRL
310 320 330 340 350
CGRHQVVHRL VSGFLERIFM ATPSCALVAT ELGYLFILHQ QVKEACLWYK
360 370 380 390 400
EAMKLEENRL AALAGSIWCQ ILQGQLEEAA HQLEFLKEVQ QSLGKSELLV
410 420 430 440 450
FLQALVAAKK QRLEQEATAL LKEAVEVHFS SMQGLALSPE YFEKLDPLFL
460 470 480 490 500
VCIAKEYLHF CPKQPRSPGQ LVSPLLKQVA MILSPVVKVA PAMMEPLYVT
510 520 530 540 550
AQVKFLSGEL ENAQSTLQRC LELDPTFVDA HLLMSQIYLA QGNFAMCSHC
560 570 580 590 600
LELGVSHNFQ VRDHPLYHFI KARALNKTGD YAEAIKTLKM IIKVPTSKAE
610 620 630 640 650
EGRKSQSPSV RPSERASILL ELVEALRLNG ELHEATKIMQ DAINEFSGTP
660 670 680 690 700
EEMRITVANV DLALSKGNVD LALNMLRGIT PKQPCYTEAK EKMASIYLHT
710 720 730 740 750
RKDVRLYIGC YVELCEHLPG PHSSLLLGDA FMNIQEPEKA LEVYDEAYRK
760 770 780 790 800
NPHDASLVSR IGQAYVKTHQ YAKAINYYEA AQKISGQDFL CCELAELLLK
810 820 830 840 850
LKKYHKAEKV LKQALERDSG VKDIPSMINE VKCLLLLAKV YKSHKKEEVM
860 870 880 890 900
ETLNLALDLQ SRILKRVPLE QSEMIPFQNQ LAASICIQIG EHHLAEKDYD
910 920 930 940 950
SALKSYKDAL AYSPTDSKVV LELAHLYLLL GQLDLCEQRC APLLEMEQTH
960 970 980 990 1000
ERAAVMLADL MFRRQNYETA INLYHQVLEK APDNFLVLNK LVDLLRRSGK
1010 1020 1030 1040 1050
LEEAPAFFEL AKKVSSRVPL EPGFNYCQGI YFWHIGQPNE ALRFLNKARK
1060 1070 1080 1090 1100
DSTWGQLATC YMVQICLNPD NEIVGGEAFE SLVGDSNSAS RKESQQHGVR
1110 1120 1130 1140 1150
TAEKLLREFY PHSESGQTQL RLLQNLCLLA TREKANVEVA LGAFIEMAQA
1160 1170 1180 1190 1200
EKDSIPALLA MAQAYILLKQ VPKARTQLKR LAKVPWTVDE AEDLEKSWLL
1210 1220 1230 1240 1250
LADIYCQGGK FDLALELLRR CLQYNKSCCR AYEYMGFIME KEQSYKDAAT
1260 1270 1280 1290 1300
NYELAWKYSH QANPAIGFKL AFNYLKDKKF VDAIEVCHSV LTEHPKYPKI
1310
REEILEKAQG SLRP
Length:1,314
Mass (Da):148,617
Last modified:June 26, 2007 - v2
Checksum:iA1790B1DA679883B
GO
Isoform 2 (identifier: Q8C0S4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1227-1233: SCCRAYE → AKLTSLG
     1234-1314: Missing.

Note: No experimental confirmation available.
Show »
Length:1,233
Mass (Da):139,024
Checksum:iEA158DC2D3174C14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16S → N in BAB29674 (PubMed:16141072).Curated1
Sequence conflicti208L → M in BAC26695 (PubMed:16141072).Curated1
Sequence conflicti650P → L in AAY78492 (Ref. 1) Curated1
Sequence conflicti650P → L in AAI33700 (PubMed:15489334).Curated1
Sequence conflicti1037Q → K in BAE21602 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0263041227 – 1233SCCRAYE → AKLTSLG in isoform 2. 1 Publication7
Alternative sequenceiVSP_0263051234 – 1314Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ011665 mRNA Translation: AAY78492.1
AK015017 mRNA Translation: BAB29674.1
AK029952 mRNA Translation: BAC26695.1
AK133304 mRNA Translation: BAE21602.1
BC133699 mRNA Translation: AAI33700.1
CCDSiCCDS40805.1 [Q8C0S4-1]
RefSeqiNP_083011.2, NM_028735.3 [Q8C0S4-1]
UniGeneiMm.189573

Genome annotation databases

EnsembliENSMUST00000035100; ENSMUSP00000035100; ENSMUSG00000032514 [Q8C0S4-1]
GeneIDi74052
KEGGimmu:74052
UCSCiuc009sbs.1 mouse [Q8C0S4-2]
uc009sbt.1 mouse [Q8C0S4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ011665 mRNA Translation: AAY78492.1
AK015017 mRNA Translation: BAB29674.1
AK029952 mRNA Translation: BAC26695.1
AK133304 mRNA Translation: BAE21602.1
BC133699 mRNA Translation: AAI33700.1
CCDSiCCDS40805.1 [Q8C0S4-1]
RefSeqiNP_083011.2, NM_028735.3 [Q8C0S4-1]
UniGeneiMm.189573

3D structure databases

ProteinModelPortaliQ8C0S4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035100

PTM databases

iPTMnetiQ8C0S4
PhosphoSitePlusiQ8C0S4

Proteomic databases

PaxDbiQ8C0S4
PRIDEiQ8C0S4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035100; ENSMUSP00000035100; ENSMUSG00000032514 [Q8C0S4-1]
GeneIDi74052
KEGGimmu:74052
UCSCiuc009sbs.1 mouse [Q8C0S4-2]
uc009sbt.1 mouse [Q8C0S4-1]

Organism-specific databases

CTDi199223
MGIiMGI:1921302 Ttc21a

Phylogenomic databases

eggNOGiENOG410IEX1 Eukaryota
ENOG410XV69 LUCA
GeneTreeiENSGT00390000005979
HOGENOMiHOG000004809
HOVERGENiHBG108607
InParanoidiQ8C0S4
OMAiQVPKART
OrthoDBiEOG091G00TY
PhylomeDBiQ8C0S4
TreeFamiTF314664

Miscellaneous databases

PROiPR:Q8C0S4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032514 Expressed in 29 organ(s), highest expression level in testis
CleanExiMM_TTC21A
GenevisibleiQ8C0S4 MM

Family and domain databases

Gene3Di1.25.40.10, 5 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 14 hits
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 11 hits
PS50293 TPR_REGION, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTT21A_MOUSE
AccessioniPrimary (citable) accession number: Q8C0S4
Secondary accession number(s): Q0HA37, Q3V0A2, Q9D5Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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