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Entry version 129 (12 Aug 2020)
Sequence version 2 (15 Jan 2008)
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Protein

DIS3-like exonuclease 1

Gene

Dis3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
LigandMagnesium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DIS3-like exonuclease 1 (EC:3.1.13.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dis3l
Synonyms:Kiaa1955
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2143272, Dis3l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Exosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148111 – 1053DIS3-like exonuclease 1Add BLAST1053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei989PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C0S1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C0S1

PeptideAtlas

More...
PeptideAtlasi
Q8C0S1

PRoteomics IDEntifications database

More...
PRIDEi
Q8C0S1

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C0S1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032396, Expressed in spermatocyte and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C0S1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C0S1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229452, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-596, Cytoplasmic exosome complex, Dis3l variant
CPX-601, Cytoplasmic exosome complex, Dis3l-Exosc10 variant

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000113503

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C0S1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C0S1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNR ribonuclease family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2102, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002333_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C0S1

KEGG Orthology (KO)

More...
KOi
K18681

Identification of Orthologs from Complete Genome Data

More...
OMAi
GILQRNW

Database of Orthologous Groups

More...
OrthoDBi
1104619at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C0S1

TreeFam database of animal gene trees

More...
TreeFami
TF105755

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041505, Dis3_CSD2
IPR031192, DIS3L
IPR012340, NA-bd_OB-fold
IPR001900, RNase_II/R
IPR022966, RNase_II/R_CS
IPR033771, Rrp44_CSD1
IPR033770, RRP44_S1

The PANTHER Classification System

More...
PANTHERi
PTHR23355:SF30, PTHR23355:SF30, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17849, OB_Dis3, 1 hit
PF00773, RNB, 1 hit
PF17216, Rrp44_CSD1, 1 hit
PF17215, Rrp44_S1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00955, RNB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249, SSF50249, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01175, RIBONUCLEASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C0S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQKREKVLL LRTFQGRTLR IVREHYLRPS VPCNSPLCPQ PAACRNDGKL
60 70 80 90 100
LAAEVTHYVI PDWKVVQDYL EVLEFPELKG VIFMQTACQA VQHQRGRRQY
110 120 130 140 150
NKLRNLLKDA RHDCVLFANE FQQHCYLPRE KGEAMEKWQT RSIYNSAVWY
160 170 180 190 200
YHHCEDRMPI VMVTEDEEAI QKYGSETEGV FVISFKNYLD NFWPDLKAAH
210 220 230 240 250
DLCDSILQSR RERETESQET HGKEYPEHLP LEVLEAGIKS GRYIQGILNV
260 270 280 290 300
NKHRAQIEAF VRLHGASSKD SGLVSDILIH GSKARNRSIH GDVVVVEMLP
310 320 330 340 350
KSEWKGRTAA LGENDSDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP
360 370 380 390 400
SKEEVQSQGK NAQKILVTPW DYRIPKIRIS TQQAEALQDF RVVVRIDSWE
410 420 430 440 450
ATSVYPNGHF VRVLGRIGDL EGEIATILVE NSISVVPFSE AQMCEMPVNT
460 470 480 490 500
PENPWKVSPK EEQERKDLRT THLVFSIDPK GCEDVDDTLS VRTLNNGNLE
510 520 530 540 550
LGVHIADVTH FVAPNSYIDV EARTRATTYY LADRRYDMLP SILSADLCSL
560 570 580 590 600
LGGVDRYAVS VMWELDKTSY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN
610 620 630 640 650
FSIVDDIPEL KALDKQSQQA KLEELVWAIG KLTDIARHIR AKRDRCGALE
660 670 680 690 700
LEGVEVRVQL DDKKNIRDLI PKQPLEVHET VAECMILANH WVAKKIWESF
710 720 730 740 750
PHQALLRQHP PPHQEFFSEL RECAKAKGFF IDTRSNKTLA DSLDSANDPK
760 770 780 790 800
DPLVNKLLRS MATQAMSNAL YFSTGSCAEE EFHHYGLALD KYTHFTSPIR
810 820 830 840 850
RYSDIVVHRL LMAAISKDKK MEIKENLFSN KNLEELCRHI NNRNRAAQRS
860 870 880 890 900
QKQSTELFQC MYFKDRDAET EERCIADGVI YSIRTNGVLV FIPRFGIKGA
910 920 930 940 950
AYLKNKDSLV ISCGPEGSSE WKPGSLQRSQ NKIISTTAGG QSVTFHLFDH
960 970 980 990 1000
VTVRISVQAS RCHSDTIRLE IVSNKPYMIP NTELCHQSSL LKSELVKEVT
1010 1020 1030 1040 1050
RSVEEAQLAQ EVKGKVIQEE HQEYCQTKGR SLYTLLEEIR DLALLDVSDS

CAM
Length:1,053
Mass (Da):120,284
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA60616AB9A904722
GO
Isoform 2 (identifier: Q8C0S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:970
Mass (Da):110,655
Checksum:i8C72AC2ABE9EBC10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUD6D3YUD6_MOUSE
DIS3-like exonuclease 1
Dis3l
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH56939 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD32588 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0303701 – 83Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173310 mRNA Translation: BAD32588.1 Different initiation.
AK029974 mRNA Translation: BAC26710.1
BC056939 mRNA Translation: AAH56939.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23280.1 [Q8C0S1-2]
CCDS52832.1 [Q8C0S1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001001295.2, NM_001001295.2 [Q8C0S1-1]
NP_001171255.1, NM_001177784.1 [Q8C0S1-2]
NP_766107.1, NM_172519.3 [Q8C0S1-2]
XP_006511045.1, XM_006510982.3 [Q8C0S1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000068367; ENSMUSP00000063830; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000113890; ENSMUSP00000109522; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000120760; ENSMUSP00000113503; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000168844; ENSMUSP00000129772; ENSMUSG00000032396 [Q8C0S1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
213550

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:213550

UCSC genome browser

More...
UCSCi
uc009qbu.2, mouse [Q8C0S1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173310 mRNA Translation: BAD32588.1 Different initiation.
AK029974 mRNA Translation: BAC26710.1
BC056939 mRNA Translation: AAH56939.1 Different initiation.
CCDSiCCDS23280.1 [Q8C0S1-2]
CCDS52832.1 [Q8C0S1-1]
RefSeqiNP_001001295.2, NM_001001295.2 [Q8C0S1-1]
NP_001171255.1, NM_001177784.1 [Q8C0S1-2]
NP_766107.1, NM_172519.3 [Q8C0S1-2]
XP_006511045.1, XM_006510982.3 [Q8C0S1-2]

3D structure databases

SMRiQ8C0S1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229452, 1 interactor
ComplexPortaliCPX-596, Cytoplasmic exosome complex, Dis3l variant
CPX-601, Cytoplasmic exosome complex, Dis3l-Exosc10 variant
STRINGi10090.ENSMUSP00000113503

PTM databases

PhosphoSitePlusiQ8C0S1

Proteomic databases

EPDiQ8C0S1
PaxDbiQ8C0S1
PeptideAtlasiQ8C0S1
PRIDEiQ8C0S1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26111, 126 antibodies

Genome annotation databases

EnsembliENSMUST00000068367; ENSMUSP00000063830; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000113890; ENSMUSP00000109522; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000120760; ENSMUSP00000113503; ENSMUSG00000032396 [Q8C0S1-2]
ENSMUST00000168844; ENSMUSP00000129772; ENSMUSG00000032396 [Q8C0S1-1]
GeneIDi213550
KEGGimmu:213550
UCSCiuc009qbu.2, mouse [Q8C0S1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
115752
MGIiMGI:2143272, Dis3l

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2102, Eukaryota
GeneTreeiENSGT00530000063106
HOGENOMiCLU_002333_5_0_1
InParanoidiQ8C0S1
KOiK18681
OMAiGILQRNW
OrthoDBi1104619at2759
PhylomeDBiQ8C0S1
TreeFamiTF105755

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
213550, 4 hits in 18 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8C0S1
RNActiQ8C0S1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032396, Expressed in spermatocyte and 224 other tissues
ExpressionAtlasiQ8C0S1, baseline and differential
GenevisibleiQ8C0S1, MM

Family and domain databases

InterProiView protein in InterPro
IPR041505, Dis3_CSD2
IPR031192, DIS3L
IPR012340, NA-bd_OB-fold
IPR001900, RNase_II/R
IPR022966, RNase_II/R_CS
IPR033771, Rrp44_CSD1
IPR033770, RRP44_S1
PANTHERiPTHR23355:SF30, PTHR23355:SF30, 1 hit
PfamiView protein in Pfam
PF17849, OB_Dis3, 1 hit
PF00773, RNB, 1 hit
PF17216, Rrp44_CSD1, 1 hit
PF17215, Rrp44_S1, 1 hit
SMARTiView protein in SMART
SM00955, RNB, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
PROSITEiView protein in PROSITE
PS01175, RIBONUCLEASE_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDI3L1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C0S1
Secondary accession number(s): Q69Z56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: August 12, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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