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Protein

Zinc fingers and homeoboxes protein 3

Gene

Zhx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri77 – 100C2H2-type 1Sequence analysisAdd BLAST24
Zinc fingeri109 – 132C2H2-type 2Sequence analysisAdd BLAST24
DNA bindingi300 – 359Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi489 – 548Homeobox 2PROSITE-ProRule annotationAdd BLAST60
DNA bindingi607 – 666Homeobox 3PROSITE-ProRule annotationAdd BLAST60
DNA bindingi759 – 818Homeobox 4PROSITE-ProRule annotationAdd BLAST60
DNA bindingi830 – 889Homeobox 5PROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc fingers and homeoboxes protein 3
Alternative name(s):
Triple homeobox protein 1
Zinc finger and homeodomain protein 3
Gene namesi
Name:Zhx3
Synonyms:Kiaa0395, Tix1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2444772 Zhx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493961 – 951Zinc fingers and homeoboxes protein 3Add BLAST951

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei599PhosphoserineBy similarity1
Modified residuei703PhosphoserineCombined sources1
Modified residuei718PhosphoserineBy similarity1
Modified residuei922PhosphoserineBy similarity1
Modified residuei941PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C0Q2
PaxDbiQ8C0Q2
PRIDEiQ8C0Q2

PTM databases

iPTMnetiQ8C0Q2
PhosphoSitePlusiQ8C0Q2

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000035877 Expressed in 248 organ(s), highest expression level in secondary oocyte
CleanExiMM_ZHX3
ExpressionAtlasiQ8C0Q2 baseline and differential
GenevisibleiQ8C0Q2 MM

Interactioni

Subunit structurei

Homodimer (via homeobox domain). Also forms heterodimers with ZHX1 and ZHX2. Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8C0Q2, 1 interactor
MINTiQ8C0Q2

Structurei

3D structure databases

ProteinModelPortaliQ8C0Q2
SMRiQ8C0Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 107Required for nuclear localizationBy similarityAdd BLAST107
Regioni238 – 483Required for homodimerization and interaction with NFYABy similarityAdd BLAST246
Regioni299 – 497Required for repressor activityBy similarityAdd BLAST199
Regioni492 – 550Required for nuclear localizationBy similarityAdd BLAST59

Sequence similaritiesi

Belongs to the ZHX family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri77 – 100C2H2-type 1Sequence analysisAdd BLAST24
Zinc fingeri109 – 132C2H2-type 2Sequence analysisAdd BLAST24

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHET Eukaryota
ENOG410Z8A2 LUCA
GeneTreeiENSGT00530000063149
HOGENOMiHOG000013231
HOVERGENiHBG007920
InParanoidiQ8C0Q2
OMAiKGSRAMM
OrthoDBiEOG091G02WT
PhylomeDBiQ8C0Q2
TreeFamiTF333363

Family and domain databases

CDDicd00086 homeodomain, 5 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR024578 Homez_homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00046 Homeobox, 3 hits
PF11569 Homez, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 4 hits
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF46689 SSF46689, 5 hits
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8C0Q2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKRKSTTP CMIPVKTVVL PGASTEPQPV ESLPEGPQQD LPSEAPDASS
60 70 80 90 100
EAAPNPSSTD GSALANGHRS TLDGYVYCCK ECEFRSQDVT HFIGHMNSEH
110 120 130 140 150
TDFNKDPTFV CTGCSFLAKN PEGLSLHNAK CHSGEASFLW NVTKPDNHVV
160 170 180 190 200
VEQSVPDSAS SSVLAGESTT EGTEIIITKT PIMKIMKGKA EAKKIHMLKE
210 220 230 240 250
NAPNQPGSEA LPKPLAGERE VKEGDHTFIN GAAPGSQASA KSTKPPPAAN
260 270 280 290 300
GPLIGTVPVL PAGIAQFLSL QQQPPVHAQH HTHQPLPTSK TLPKVMIPLS
310 320 330 340 350
SIPTYNAAMD SNSFLKNSFH KFPYPTKAEL CYLTVVTKYP EEQLKIWFTA
360 370 380 390 400
QRLKQGISWS PEEIEDARKK MFNTVIQSVP QPTITVLNTP LVASAGNVQH
410 420 430 440 450
LIQATLPGHA VGQPEGTAGG LLVTQPLMAN GLQASSSSLP LTTASVPKPT
460 470 480 490 500
VAPINTVCSN SASAVKVVNA AQSLLTACPS ITSQAFLDAN IYKNKKSHEQ
510 520 530 540 550
LSALKGSFCR NQFPGQSEVE HLTKVTGLST REVRKWFSDR RYHCRNLKGS
560 570 580 590 600
RAMMPGEHGS VLIDSVPEVP FPLASKVPEV TCIPTATSLV SHPATKRQSW
610 620 630 640 650
HQTPDFTPTK YKERAPEQLR VLENSFAQNP LPPEEELDRL RSETKMTRRE
660 670 680 690 700
IDGWFSERRK KVNTEETKKA DGHMPKEEEE GAEQEGRDEE LANELRVPGE
710 720 730 740 750
NGSPEMFLSH ALAERKVSPI KINLKNLRVT EASGKSEFPG MGVCEPEEDG
760 770 780 790 800
LNKLVEQPPS KVSYKKTAQQ RHLLRQLFVQ TQWPSNQDYD SIMAQTGLPR
810 820 830 840 850
PEVVRWFGDS RYALKNGQLK WYEDYKRGNF PPGLLVIAPG NRELLQDYYM
860 870 880 890 900
THKMLCEEDL QTLCDKTQMS AQQVKQWFAE KMGEETRAVA DISSEDQGPR
910 920 930 940 950
NGEPVAVHKV LGDAYSELSE NSESWEPSAP EASSEPFDTS SPQSGRQLEA

D
Length:951
Mass (Da):104,343
Last modified:February 16, 2004 - v2
Checksum:iC6625D6FB139E3DE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BIX6H3BIX6_MOUSE
Zinc fingers and homeoboxes protein...
Zhx3
114Annotation score:
F6V503F6V503_MOUSE
Zinc fingers and homeoboxes protein...
Zhx3
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti763S → N in BAC26763 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099527 mRNA Translation: BAC87711.2
AB099703 Genomic DNA Translation: BAC87741.2
AK030057 mRNA Translation: BAC26763.1
BC058111 mRNA Translation: AAH58111.1
AK122271 mRNA Translation: BAC65553.1
CCDSiCCDS16997.1
RefSeqiNP_796237.2, NM_177263.3
UniGeneiMm.436734
Mm.489808

Genome annotation databases

EnsembliENSMUST00000103111; ENSMUSP00000099400; ENSMUSG00000035877
ENSMUST00000103112; ENSMUSP00000099401; ENSMUSG00000035877
ENSMUST00000109460; ENSMUSP00000105086; ENSMUSG00000035877
GeneIDi320799
KEGGimmu:320799
UCSCiuc008nre.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099527 mRNA Translation: BAC87711.2
AB099703 Genomic DNA Translation: BAC87741.2
AK030057 mRNA Translation: BAC26763.1
BC058111 mRNA Translation: AAH58111.1
AK122271 mRNA Translation: BAC65553.1
CCDSiCCDS16997.1
RefSeqiNP_796237.2, NM_177263.3
UniGeneiMm.436734
Mm.489808

3D structure databases

ProteinModelPortaliQ8C0Q2
SMRiQ8C0Q2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C0Q2, 1 interactor
MINTiQ8C0Q2

PTM databases

iPTMnetiQ8C0Q2
PhosphoSitePlusiQ8C0Q2

Proteomic databases

MaxQBiQ8C0Q2
PaxDbiQ8C0Q2
PRIDEiQ8C0Q2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103111; ENSMUSP00000099400; ENSMUSG00000035877
ENSMUST00000103112; ENSMUSP00000099401; ENSMUSG00000035877
ENSMUST00000109460; ENSMUSP00000105086; ENSMUSG00000035877
GeneIDi320799
KEGGimmu:320799
UCSCiuc008nre.1 mouse

Organism-specific databases

CTDi23051
MGIiMGI:2444772 Zhx3
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IHET Eukaryota
ENOG410Z8A2 LUCA
GeneTreeiENSGT00530000063149
HOGENOMiHOG000013231
HOVERGENiHBG007920
InParanoidiQ8C0Q2
OMAiKGSRAMM
OrthoDBiEOG091G02WT
PhylomeDBiQ8C0Q2
TreeFamiTF333363

Miscellaneous databases

PROiPR:Q8C0Q2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035877 Expressed in 248 organ(s), highest expression level in secondary oocyte
CleanExiMM_ZHX3
ExpressionAtlasiQ8C0Q2 baseline and differential
GenevisibleiQ8C0Q2 MM

Family and domain databases

CDDicd00086 homeodomain, 5 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR024578 Homez_homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00046 Homeobox, 3 hits
PF11569 Homez, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 4 hits
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF46689 SSF46689, 5 hits
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZHX3_MOUSE
AccessioniPrimary (citable) accession number: Q8C0Q2
Secondary accession number(s): Q80U14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: February 16, 2004
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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