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Protein

Coronin-2A

Gene

Coro2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2A
Gene namesi
Name:Coro2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1345966 Coro2a

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509291 – 524Coronin-2AAdd BLAST524

Proteomic databases

EPDiQ8C0P5
MaxQBiQ8C0P5
PaxDbiQ8C0P5
PRIDEiQ8C0P5

PTM databases

iPTMnetiQ8C0P5
PhosphoSitePlusiQ8C0P5

Expressioni

Gene expression databases

BgeeiENSMUSG00000028337 Expressed in 247 organ(s), highest expression level in ileum
CleanExiMM_CORO2A
ExpressionAtlasiQ8C0P5 baseline and differential
GenevisibleiQ8C0P5 MM

Interactioni

Subunit structurei

Binds actin. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223484, 1 interactor
DIPiDIP-59203N
IntActiQ8C0P5, 1 interactor
STRINGi10090.ENSMUSP00000030021

Structurei

3D structure databases

ProteinModelPortaliQ8C0P5
SMRiQ8C0P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 120WD 1Add BLAST41
Repeati130 – 170WD 2Add BLAST41
Repeati178 – 217WD 3Add BLAST40
Repeati220 – 263WD 4Add BLAST44
Repeati269 – 308WD 5Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili484 – 523Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ8C0P5
KOiK13887
PhylomeDBiQ8C0P5
TreeFamiTF314280

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027335 CORO2A
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF2 PTHR10856:SF2, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C0P5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWHPQYRSS KFRHVYGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV
60 70 80 90 100
VTECAGGGAF LVIPLHQTGK LDPHYPKVCG HRGNVLDIKW NPFNDFEIAS
110 120 130 140 150
CSEDATIKIW NIPKQLLTRN LTTYRKELIG HARRVGLVEW HPTTANILFS
160 170 180 190 200
AGYDYKVMVW NLDTKDSVIA GPVKTINCHQ DVILSMSFNT NGSLLATTCK
210 220 230 240 250
DRKIRIVDPR LGIVLQEASY KGHRANKVLF LGSLKKLLST GTSRWNNRQM
260 270 280 290 300
ALWDQENLSV PLTEEDLDGS SGVLFPFFDS DTSMLYIVGK GDGNIRYYEV
310 320 330 340 350
SMEKPHLTYL TEYRSYNPQK GIGIMPKRGL DVSSCEIFRF YKLITTKSLI
360 370 380 390 400
EPVSMIVPRR SESYQEDIYP PTAAAQPSLT AHEWLSGMNR GPIMMSLRPG
410 420 430 440 450
SELLDSQTLP PERPLSNSMV QVSPQPLEPM KQPAEDGDQA PFSLLEEKLA
460 470 480 490 500
KWTAEHHLGE KSCLTNGFDV FECSPPKTEN ELLQMFYRQQ EEIRRLRELL
510 520
IQREVQTKQL ELEIKNLRMA LGQL
Length:524
Mass (Da):59,573
Last modified:March 1, 2003 - v1
Checksum:i21F73CFB3B27A5E7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AVH5B1AVH5_MOUSE
Coronin
Coro2a
543Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → R in BAC35761 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030097 mRNA Translation: BAC26782.1
AK054394 mRNA Translation: BAC35761.2
AK152490 mRNA Translation: BAE31261.1
AK153134 mRNA Translation: BAE31746.1
CCDSiCCDS18154.1
RefSeqiNP_001158276.1, NM_001164804.1
NP_849224.2, NM_178893.4
UniGeneiMm.416311
Mm.485361

Genome annotation databases

EnsembliENSMUST00000030021; ENSMUSP00000030021; ENSMUSG00000028337
ENSMUST00000107756; ENSMUSP00000103385; ENSMUSG00000028337
GeneIDi107684
KEGGimmu:107684
UCSCiuc008sua.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030097 mRNA Translation: BAC26782.1
AK054394 mRNA Translation: BAC35761.2
AK152490 mRNA Translation: BAE31261.1
AK153134 mRNA Translation: BAE31746.1
CCDSiCCDS18154.1
RefSeqiNP_001158276.1, NM_001164804.1
NP_849224.2, NM_178893.4
UniGeneiMm.416311
Mm.485361

3D structure databases

ProteinModelPortaliQ8C0P5
SMRiQ8C0P5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223484, 1 interactor
DIPiDIP-59203N
IntActiQ8C0P5, 1 interactor
STRINGi10090.ENSMUSP00000030021

PTM databases

iPTMnetiQ8C0P5
PhosphoSitePlusiQ8C0P5

Proteomic databases

EPDiQ8C0P5
MaxQBiQ8C0P5
PaxDbiQ8C0P5
PRIDEiQ8C0P5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030021; ENSMUSP00000030021; ENSMUSG00000028337
ENSMUST00000107756; ENSMUSP00000103385; ENSMUSG00000028337
GeneIDi107684
KEGGimmu:107684
UCSCiuc008sua.2 mouse

Organism-specific databases

CTDi7464
MGIiMGI:1345966 Coro2a

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ8C0P5
KOiK13887
PhylomeDBiQ8C0P5
TreeFamiTF314280

Miscellaneous databases

ChiTaRSiCoro2a mouse
PROiPR:Q8C0P5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028337 Expressed in 247 organ(s), highest expression level in ileum
CleanExiMM_CORO2A
ExpressionAtlasiQ8C0P5 baseline and differential
GenevisibleiQ8C0P5 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027335 CORO2A
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF2 PTHR10856:SF2, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOR2A_MOUSE
AccessioniPrimary (citable) accession number: Q8C0P5
Secondary accession number(s): Q3U6H8, Q8BW42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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