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Entry version 144 (16 Jan 2019)
Sequence version 2 (03 May 2011)
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Protein

Serine/threonine-protein kinase greatwall

Gene

Mastl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei61ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei155Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi40 – 48ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2465910 MASTL Facilitates Mitotic Progression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase greatwall (EC:2.7.11.1)
Short name:
GW
Short name:
GWL
Alternative name(s):
Microtubule-associated serine/threonine-protein kinase-like
Short name:
MAST-L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mastl
Synonyms:Gw, Gwl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914371 Mastl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000863161 – 865Serine/threonine-protein kinase greatwallAdd BLAST865

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei206PhosphothreonineBy similarity1
Modified residuei221PhosphothreonineBy similarity1
Modified residuei362PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1
Modified residuei508PhosphothreonineBy similarity1
Modified residuei545PhosphoserineBy similarity1
Modified residuei619PhosphoserineBy similarity1
Modified residuei644PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1
Modified residuei708PhosphothreonineBy similarity1
Modified residuei711PhosphoserineBy similarity1
Modified residuei727Phosphothreonine; by CDK1By similarity1
Modified residuei861PhosphoserineBy similarity1
Modified residuei864PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-727 by CDK1 during M phase activates its kinase activity. Maximum phosphorylation occurs in prometaphase (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C0P0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8C0P0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C0P0

PeptideAtlas

More...
PeptideAtlasi
Q8C0P0

PRoteomics IDEntifications database

More...
PRIDEi
Q8C0P0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C0P0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C0P0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026779 Expressed in 204 organ(s), highest expression level in primary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C0P0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028119

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8C0P0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C0P0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 821Protein kinasePROSITE-ProRule annotationAdd BLAST788
Domaini822 – 865AGC-kinase C-terminalAdd BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUCW Eukaryota
ENOG410ZHM9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157002

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG074267

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8C0P0

KEGG Orthology (KO)

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KOi
K16309

Identification of Orthologs from Complete Genome Data

More...
OMAi
WDNLQNQ

Database of Orthologous Groups

More...
OrthoDBi
878671at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313149

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05610 STKc_MASTL, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR037638 MASTL_STKc
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8C0P0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESASASEEN EGGAAIEECV SRIPVPRPPS IEEFTIVKPI SRGAFGKVYL
60 70 80 90 100
GQKGGKLYAV KVVKKADMIN KNMTHQVQAE RDALALSKSP FVVHLYYSLQ
110 120 130 140 150
SASNIYLIME YLIGGDVKSL LHIYGYFDEE MAIKYISEVA LALDYLHRHG
160 170 180 190 200
IIHRDLKPDN MLISNEGHIK LTDFGLSKVT LNRDINMMDI LTTPSMSKPK
210 220 230 240 250
QDYSRTPGQV LSLISSLGFF TPVGEKDQDS ANMFSAPKSA AQLSRGFICP
260 270 280 290 300
MSVDQKEPTS YSSKLLKSCF ETLSSNPEIP VKCLTSNLLQ CRKRLGTSST
310 320 330 340 350
SSQSHTFVSS VESECHSNPK WERDCQSTES SGCAMSWNAV EMLYAKSTSA
360 370 380 390 400
IKTKTELELA LSPIHDSSAI PAAGSNQVTL PRKCFREISW EARDPDNENM
410 420 430 440 450
TIDKGQSGFC QSSQRSVNSS ATSEEHLGKR NYKRNFHLVD SSPCQEIMQS
460 470 480 490 500
KKNCTEYEAN KERQGCRANQ STGLTTEVQN LKLSGCESQQ LDYANKENIV
510 520 530 540 550
TYLTDRQTPE KLHIPTIAKN LMSELDEDCE LSSKKDCLSS NSVCSDEDRA
560 570 580 590 600
LKTTCVDSDS SFPGVSMMES SLEIQALEPD KSIRDYSFEE PNTEDLFVLP
610 620 630 640 650
KCQENSLPQD DCHACIQDSS QVSAHPSKAP KALTSKINVV AFRSFNSHIN
660 670 680 690 700
ASTNSEPSKI SITSLDAMDI SCDYSGSYPM AVSPTEKGRH YTSHQTPNQV
710 720 730 740 750
KLGTSYRTPK SVRRGAAPVD DGRILGTPDY LAPELLLGTA HGPAVDWWAL
760 770 780 790 800
GVCLFEFLTG IPPFNDETPQ QVFQNILKRD IPWPEGEEKL SDNAQSAMDM
810 820 830 840 850
LLTIDDSKRA GMRELKQHPL FSEVDWENLQ HQTMPFVPQP DDETDTSYFE
860
ARNNAQHLTI SGFSL
Length:865
Mass (Da):95,975
Last modified:May 3, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59C228B1E1D5CDC4
GO
Isoform 2 (identifier: Q8C0P0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-348: STESSGCAMSWNAVEMLYAKST → VSSKYSSLKLIYTRNQ
     349-865: Missing.

Show »
Length:342
Mass (Da):38,030
Checksum:i897F8D0E323D1FEE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH86483 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB24595 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC37239 differs from that shown. Reason: Erroneous termination at positions 12 and 56. Translated as Gly, Lys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37V → E in BAC37239 (PubMed:16141072).Curated1
Sequence conflicti62V → G in BAC37239 (PubMed:16141072).Curated1
Sequence conflicti69I → V in BAC26804 (PubMed:16141072).Curated1
Sequence conflicti79A → S in BAC37239 (PubMed:16141072).Curated1
Sequence conflicti104N → I in BAC37239 (PubMed:16141072).Curated1
Sequence conflicti118K → Q in BAC37239 (PubMed:16141072).Curated1
Sequence conflicti222P → S in AAI03780 (PubMed:15489334).Curated1
Sequence conflicti247F → L in BAB24595 (PubMed:16141072).Curated1
Sequence conflicti314E → G in AAI03780 (PubMed:15489334).Curated1
Sequence conflicti323R → T in BAC37239 (PubMed:16141072).Curated1
Sequence conflicti376N → D in BAB28343 (PubMed:16141072).Curated1
Sequence conflicti455T → S in AAI03780 (PubMed:15489334).Curated1
Sequence conflicti529C → R in AAH66834 (PubMed:19468303).Curated1
Sequence conflicti529C → R in AAH86483 (PubMed:19468303).Curated1
Sequence conflicti672C → Y in AAH66834 (PubMed:19468303).Curated1
Sequence conflicti672C → Y in AAH86483 (PubMed:19468303).Curated1
Sequence conflicti699Q → R in AAI03780 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014576327 – 348STESS…YAKST → VSSKYSSLKLIYTRNQ in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_014577349 – 865Missing in isoform 2. 1 PublicationAdd BLAST517

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK006448 mRNA Translation: BAB24595.1 Different initiation.
AK012597 mRNA Translation: BAB28343.2
AK030140 mRNA Translation: BAC26804.1
AK078365 mRNA Translation: BAC37239.1 Sequence problems.
AL845257 Genomic DNA Translation: CAM19537.1
CH466542 Genomic DNA Translation: EDL08150.1
BC066834 mRNA Translation: AAH66834.1
BC086483 mRNA Translation: AAH86483.1 Different initiation.
BC103779 mRNA Translation: AAI03780.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15727.1 [Q8C0P0-1]

NCBI Reference Sequences

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RefSeqi
NP_080255.3, NM_025979.4 [Q8C0P0-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.253721

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028119; ENSMUSP00000028119; ENSMUSG00000026779 [Q8C0P0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67121

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67121

UCSC genome browser

More...
UCSCi
uc008iob.2 mouse [Q8C0P0-1]
uc008ioc.1 mouse [Q8C0P0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006448 mRNA Translation: BAB24595.1 Different initiation.
AK012597 mRNA Translation: BAB28343.2
AK030140 mRNA Translation: BAC26804.1
AK078365 mRNA Translation: BAC37239.1 Sequence problems.
AL845257 Genomic DNA Translation: CAM19537.1
CH466542 Genomic DNA Translation: EDL08150.1
BC066834 mRNA Translation: AAH66834.1
BC086483 mRNA Translation: AAH86483.1 Different initiation.
BC103779 mRNA Translation: AAI03780.1
CCDSiCCDS15727.1 [Q8C0P0-1]
RefSeqiNP_080255.3, NM_025979.4 [Q8C0P0-1]
UniGeneiMm.253721

3D structure databases

ProteinModelPortaliQ8C0P0
SMRiQ8C0P0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028119

PTM databases

iPTMnetiQ8C0P0
PhosphoSitePlusiQ8C0P0

Proteomic databases

EPDiQ8C0P0
jPOSTiQ8C0P0
PaxDbiQ8C0P0
PeptideAtlasiQ8C0P0
PRIDEiQ8C0P0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028119; ENSMUSP00000028119; ENSMUSG00000026779 [Q8C0P0-1]
GeneIDi67121
KEGGimmu:67121
UCSCiuc008iob.2 mouse [Q8C0P0-1]
uc008ioc.1 mouse [Q8C0P0-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84930
MGIiMGI:1914371 Mastl

Phylogenomic databases

eggNOGiENOG410IUCW Eukaryota
ENOG410ZHM9 LUCA
GeneTreeiENSGT00940000157002
HOVERGENiHBG074267
InParanoidiQ8C0P0
KOiK16309
OMAiWDNLQNQ
OrthoDBi878671at2759
TreeFamiTF313149

Enzyme and pathway databases

ReactomeiR-MMU-2465910 MASTL Facilitates Mitotic Progression

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lrp6 mouse

Protein Ontology

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PROi
PR:Q8C0P0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000026779 Expressed in 204 organ(s), highest expression level in primary oocyte
GenevisibleiQ8C0P0 MM

Family and domain databases

CDDicd05610 STKc_MASTL, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR037638 MASTL_STKc
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGWL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C0P0
Secondary accession number(s): A2AQY2
, Q3MIA9, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 3, 2011
Last modified: January 16, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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