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Protein

Kinesin-like protein KIF2B

Gene

Kif2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement during mitosis. Has microtubule depolymerization activity. Plays a role in chromosome congression.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi303 – 310ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF2B
Gene namesi
Name:Kif2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920720 Kif2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002537171 – 668Kinesin-like protein KIF2BAdd BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125Phosphothreonine; by PLK1By similarity1
Modified residuei204Phosphoserine; by PLK1By similarity1

Post-translational modificationi

Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C0N1
PaxDbiQ8C0N1
PRIDEiQ8C0N1

PTM databases

iPTMnetiQ8C0N1
PhosphoSitePlusiQ8C0N1

Expressioni

Gene expression databases

BgeeiENSMUSG00000046755 Expressed in 9 organ(s), highest expression level in testis
CleanExiMM_KIF2B
ExpressionAtlasiQ8C0N1 baseline and differential
GenevisibleiQ8C0N1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058084

Structurei

3D structure databases

ProteinModelPortaliQ8C0N1
SMRiQ8C0N1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini213 – 543Kinesin motorPROSITE-ProRule annotationAdd BLAST331

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili149 – 177Sequence analysisAdd BLAST29
Coiled coili646 – 667Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0246 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150912
HOGENOMiHOG000231329
HOVERGENiHBG003875
InParanoidiQ8C0N1
KOiK10393
OMAiKVYGTFF
OrthoDBiEOG091G06V3
PhylomeDBiQ8C0N1
TreeFamiTF105222

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C0N1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQFCLPLA PRLSPLKPLK SHFTDFQVGI CVAIQRSDKR IHLAVVTEIN
60 70 80 90 100
RENSWVTVEW VEKGVKKGKK IELETVLLLN PALASLEHQR SRRPLRPVSV
110 120 130 140 150
VPSTAIGDQR TATKWIAMIP HRNETPSGDS QTLMIPSNPC LMKRKKSPCL
160 170 180 190 200
REIEKLQKQR EKRRRLQLEI RARRALDINT GNPNFETMRM IEEYRRRLDS
210 220 230 240 250
SKMSSLEPPE DHRICVCVRK RPLNQRETTM KDLDIITIPS HNVVMVHESK
260 270 280 290 300
QKVDLTRYLE NQTFCFDHAF DDKASNELVY QFTARPLVES IFRKGMATCF
310 320 330 340 350
AYGQTGSGKT HTMGGAFLGK AQDCSKGIYA LVAQDVFLLL KTPAYEKLEL
360 370 380 390 400
KVYGTFFEIY GGKVYDLLNW KKKLQVLEDG NQQVQVVGLQ EQEVSCVEEV
410 420 430 440 450
LNLVELGNSC RTSGQTSVNA HSSRSHAVFQ LILKAGGKLH GKFSLVDLAG
460 470 480 490 500
NERGADTAKA TRKRQLEGAE INKSLLALKE CIRALGKNKS HTPFRASKLT
510 520 530 540 550
QVLRDSFIGQ NSYTCMIATI SPGMTSCENT LNTLRYANRV KELALEARPY
560 570 580 590 600
HHCVSPPGHE VPLMIENDNT NSGKSLQRDE VIQIPTVEKE EEKESDELTS
610 620 630 640 650
KKEPAASWSR SNQWWEAIQE TAEGVNGDVD FCIAQSLSVL EQKIGVLTDI
660
QKKLQSLRED LQKKSQVE
Length:668
Mass (Da):75,469
Last modified:March 1, 2003 - v1
Checksum:i30743B57668E94D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030188 mRNA Translation: BAC26831.1
AL662779 Genomic DNA No translation available.
BC100484 mRNA Translation: AAI00485.1
CCDSiCCDS36281.1
RefSeqiNP_082823.1, NM_028547.2
UniGeneiMm.67677

Genome annotation databases

EnsembliENSMUST00000061019; ENSMUSP00000058084; ENSMUSG00000046755
GeneIDi73470
KEGGimmu:73470
UCSCiuc007kxf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030188 mRNA Translation: BAC26831.1
AL662779 Genomic DNA No translation available.
BC100484 mRNA Translation: AAI00485.1
CCDSiCCDS36281.1
RefSeqiNP_082823.1, NM_028547.2
UniGeneiMm.67677

3D structure databases

ProteinModelPortaliQ8C0N1
SMRiQ8C0N1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058084

PTM databases

iPTMnetiQ8C0N1
PhosphoSitePlusiQ8C0N1

Proteomic databases

MaxQBiQ8C0N1
PaxDbiQ8C0N1
PRIDEiQ8C0N1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061019; ENSMUSP00000058084; ENSMUSG00000046755
GeneIDi73470
KEGGimmu:73470
UCSCiuc007kxf.1 mouse

Organism-specific databases

CTDi84643
MGIiMGI:1920720 Kif2b

Phylogenomic databases

eggNOGiKOG0246 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150912
HOGENOMiHOG000231329
HOVERGENiHBG003875
InParanoidiQ8C0N1
KOiK10393
OMAiKVYGTFF
OrthoDBiEOG091G06V3
PhylomeDBiQ8C0N1
TreeFamiTF105222

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase
R-MMU-983189 Kinesins

Miscellaneous databases

PROiPR:Q8C0N1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046755 Expressed in 9 organ(s), highest expression level in testis
CleanExiMM_KIF2B
ExpressionAtlasiQ8C0N1 baseline and differential
GenevisibleiQ8C0N1 MM

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF2B_MOUSE
AccessioniPrimary (citable) accession number: Q8C0N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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