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Protein

Sperm motility kinase Z

Gene

Gm4922

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in sperm motility, especially in the regulation of flagellar function.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57ATPPROSITE-ProRule annotation1
Active sitei146Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm motility kinase Z (EC:2.7.11.1)
Gene namesi
Name:Gm4922
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3644318 Gm4922

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078771 – 497Sperm motility kinase ZAdd BLAST497

Proteomic databases

PaxDbiQ8C0N0
PRIDEiQ8C0N0

Expressioni

Gene expression databases

BgeeiENSMUSG00000044624 Expressed in 6 organ(s), highest expression level in testis
CleanExiMM_EG237300

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055273

Structurei

3D structure databases

ProteinModelPortaliQ8C0N0
SMRiQ8C0N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 275Protein kinasePROSITE-ProRule annotationAdd BLAST248
Domaini292 – 332UBAAdd BLAST41

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00910000144203
HOGENOMiHOG000154351
HOVERGENiHBG108494
InParanoidiQ8C0N0
OMAiKFDETMA
OrthoDBiEOG091G09I6
PhylomeDBiQ8C0N0
TreeFamiTF338820

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C0N0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSDSEDESS ELSTVLSMFE EKEFTRQYTV LKTLSQHGTT EVRLCSHHLT
60 70 80 90 100
GVTVAVKALK YQRWWEPKVS EVEIMKMLSH PNIVSLLQVI ETEQNIYLIM
110 120 130 140 150
EVAQGTQLHN RVQEARCLKE DEARSIFVQL LSAIGYCHGE GVVHRDLKPD
160 170 180 190 200
NVIVDEHGNV KIVDFGLGAR FMPGQKLERL CGAFQFIPPE IFLGLPYDGP
210 220 230 240 250
KVDIWALGVL LYYMVTGIFP FVGSTLSEIS KEVLQGRYEI PYNLSKDLRS
260 270 280 290 300
MIGLLLATNA RQRPTAQDLL SHPWLQEGEK TITFHSNGDT SFPDPDIMAA
310 320 330 340 350
MKNIGFHVQD IRESLKHRKF DETMATYNLL RAEACQDDGN YVQTKLMNPG
360 370 380 390 400
MPPFPSVTDS GAFSLPPRRR ASEPSFKVLV SSTEEHQLRQ TGGTNAPFPP
410 420 430 440 450
KKTPTMGRSQ KQKRAMTAPC ICLLRNTYID TEDSSFCTSS QAEKTSSDPE
460 470 480 490
KSETSTSCPL TPRGWRKWKK RIVACIQTLC CCTLPQKKCP RSVHPQK
Length:497
Mass (Da):56,083
Last modified:March 1, 2003 - v1
Checksum:iE87CD61E4F040310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030207 mRNA Translation: BAC26842.1
BC125502 mRNA Translation: AAI25503.1
BC125506 mRNA Translation: AAI25507.1
CCDSiCCDS48509.1
RefSeqiNP_808374.1, NM_177706.4
XP_017169423.1, XM_017313934.1
UniGeneiMm.444821

Genome annotation databases

EnsembliENSMUST00000055107; ENSMUSP00000055273; ENSMUSG00000044624
ENSMUST00000216654; ENSMUSP00000149756; ENSMUSG00000044624
GeneIDi237300
KEGGimmu:237300
UCSCiuc007emq.1 mouse

Entry informationi

Entry nameiSMKZ_MOUSE
AccessioniPrimary (citable) accession number: Q8C0N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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