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Protein

Dynein intermediate chain 1, axonemal

Gene

Dnai1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the dynein complex of respiratory cilia.By similarity

GO - Molecular functioni

GO - Biological processi

  • cilium movement Source: MGI
  • determination of left/right symmetry Source: MGI
  • epithelial cilium movement Source: MGI
  • flagellated sperm motility Source: MGI
  • heart development Source: MGI
  • insulin receptor signaling pathway Source: CAFA
  • outer dynein arm assembly Source: MGI

Keywordsi

Molecular functionMotor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein intermediate chain 1, axonemal
Alternative name(s):
Axonemal dynein intermediate chain 1
Gene namesi
Name:Dnai1
Synonyms:Dnaic1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916172 Dnaic1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546551 – 701Dynein intermediate chain 1, axonemalAdd BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C0M8
PaxDbiQ8C0M8
PRIDEiQ8C0M8

PTM databases

iPTMnetiQ8C0M8
PhosphoSitePlusiQ8C0M8

Expressioni

Gene expression databases

BgeeiENSMUSG00000061322 Expressed in 83 organ(s), highest expression level in testis
CleanExiMM_DNAIC1
ExpressionAtlasiQ8C0M8 baseline and differential
GenevisibleiQ8C0M8 MM

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with BICD2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100028

Structurei

3D structure databases

ProteinModelPortaliQ8C0M8
SMRiQ8C0M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati382 – 422WD 1Add BLAST41
Repeati431 – 474WD 2Add BLAST44
Repeati539 – 579WD 3Add BLAST41
Repeati581 – 621WD 4Add BLAST41
Repeati629 – 668WD 5Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 177Glu-richAdd BLAST44

Sequence similaritiesi

Belongs to the dynein intermediate chain family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IU35 Eukaryota
ENOG410YQQE LUCA
GeneTreeiENSGT00730000110228
HOGENOMiHOG000231705
HOVERGENiHBG005545
InParanoidiQ8C0M8
KOiK10409
OMAiVWQVKWQ
OrthoDBiEOG091G0CPJ
TreeFamiTF300553

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C0M8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSKQIRKQS ISVTRGARRR DEDSGTDVGE GTDEWSQSKA TVRPPDQLEL
60 70 80 90 100
TDAELKEEFT RILTANNPHA PQNIVRYSFK EGTYKLIGFV NQMAVHFSQV
110 120 130 140 150
GNLIPKDSDE GRRQHYRDEM VAGSQESIKV VTSEAENLEE EEEPKEGEGE
160 170 180 190 200
AEAEAEAGSQ TDIPAAAETT EKVIEEELMA PVQPKERKLT NQFNFSERAS
210 220 230 240 250
QTFNNPLRDR ECQMEPPPRT NFSATANQWE IYDAYVDELE KQEKTKEKEK
260 270 280 290 300
AKTPVAKKTE KMAMRKLTSM ESQSDDITKV TQAAKIVERM VNQNTYDDVA
310 320 330 340 350
QDFKYYEDTA DEYRDQEGTL LPLWKFQNDK AKRLAVTALC WNPKYKDLFA
360 370 380 390 400
VGHGSYDFMK QSRGMLLLYS MKNPSFPEYM FSSESGIMCL DVHVDHPYLV
410 420 430 440 450
VVGYYDGNVA IYNLKKPHSQ PCFRSTSKSG KHTDPVWQVK WQKDDMDHNL
460 470 480 490 500
NFFSVSSDGR IVSWTLVKSE LVHIDIIKLK TEGSTTEIPE GLQLHTVGCG
510 520 530 540 550
TAFDFHKEID YMFLVGTEEG KIYKCSKSYS SQFLDTYDAH NMAVDAVLWN
560 570 580 590 600
PYHTKVFMSC SSDWTVKIWD HTIKTPMFIY DLNSAVGDVA WAPYSSTVFA
610 620 630 640 650
AVTTDGKAHV FDLAVNKYEA ICNQPVVAKK KNKITHVQFN PIHPIIIVGD
660 670 680 690 700
DRGHIICLKL SPNLRKMPKE KKGQEVQKGP AVEIAKLDKL LNLVREVKTK

T
Length:701
Mass (Da):79,758
Last modified:March 1, 2003 - v1
Checksum:i4FC542B80B37931E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BMY8Q8BMY8_MOUSE
Dynein, axonemal, intermediate chai...
Dnaic1
95Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti636H → R in BAC33160 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030213 mRNA Translation: BAC26847.1
AK047808 mRNA Translation: BAC33160.1
CCDSiCCDS18066.1
RefSeqiNP_780347.2, NM_175138.4
UniGeneiMm.79127

Genome annotation databases

EnsembliENSMUST00000102963; ENSMUSP00000100028; ENSMUSG00000061322
GeneIDi68922
KEGGimmu:68922
UCSCiuc008sjc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030213 mRNA Translation: BAC26847.1
AK047808 mRNA Translation: BAC33160.1
CCDSiCCDS18066.1
RefSeqiNP_780347.2, NM_175138.4
UniGeneiMm.79127

3D structure databases

ProteinModelPortaliQ8C0M8
SMRiQ8C0M8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100028

PTM databases

iPTMnetiQ8C0M8
PhosphoSitePlusiQ8C0M8

Proteomic databases

MaxQBiQ8C0M8
PaxDbiQ8C0M8
PRIDEiQ8C0M8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102963; ENSMUSP00000100028; ENSMUSG00000061322
GeneIDi68922
KEGGimmu:68922
UCSCiuc008sjc.2 mouse

Organism-specific databases

CTDi68922
MGIiMGI:1916172 Dnaic1

Phylogenomic databases

eggNOGiENOG410IU35 Eukaryota
ENOG410YQQE LUCA
GeneTreeiENSGT00730000110228
HOGENOMiHOG000231705
HOVERGENiHBG005545
InParanoidiQ8C0M8
KOiK10409
OMAiVWQVKWQ
OrthoDBiEOG091G0CPJ
TreeFamiTF300553

Miscellaneous databases

PROiPR:Q8C0M8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061322 Expressed in 83 organ(s), highest expression level in testis
CleanExiMM_DNAIC1
ExpressionAtlasiQ8C0M8 baseline and differential
GenevisibleiQ8C0M8 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNAI1_MOUSE
AccessioniPrimary (citable) accession number: Q8C0M8
Secondary accession number(s): Q8BKY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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