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Entry version 145 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Glycerophosphocholine phosphodiesterase GPCPD1

Gene

Gpcpd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

No significant reactions when glycerophosphoglycerol, glycerophosphoinositol and glycerophosphoserine are used as substrates.
    1. Vmax=2.0 µmol/min/mg enzyme with glycerophosphocholine as substrate1 Publication
    2. Vmax=0.34 µmol/min/mg enzyme with glycerophosphoethanolamine as substrate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei70SubstrateSequence analysis1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    CBM20, Carbohydrate-Binding Module Family 20

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glycerophosphocholine phosphodiesterase GPCPD1 (EC:3.1.4.2)
    Alternative name(s):
    Glycerophosphodiester phosphodiesterase 5
    Preimplantation protein 4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Gpcpd1
    Synonyms:Gde5, Kiaa1434, Prei4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:104898, Gpcpd1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002519471 – 675Glycerophosphocholine phosphodiesterase GPCPD1Add BLAST675

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei178PhosphoserineBy similarity1
    Modified residuei427PhosphoserineCombined sources1
    Modified residuei611PhosphotyrosineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8C0L9

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8C0L9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8C0L9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8C0L9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8C0L9

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    271434 [Q8C0L9-1]
    271435 [Q8C0L9-2]
    271436 [Q8C0L9-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8C0L9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8C0L9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed with highest levels in skeletal muscle and heart.1 Publication

    <p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Down-regulated in skeletal muscles atrophies, including atrophies linked to aging and denervation.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000027346, Expressed in gastrocnemius and 312 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8C0L9, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8C0L9, MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000105769

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8C0L9, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8C0L9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 115CBM20PROSITE-ProRule annotationAdd BLAST115
    Domaini321 – 621GP-PDEAdd BLAST301

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni88 – 89Substrate bindingSequence analysis2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2421, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00440000033970

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_013007_2_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8C0L9

    Database of Orthologous Groups

    More...
    OrthoDBi
    687958at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8C0L9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314722

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd05814, CBM20_Prei4, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.10, 1 hit
    3.20.20.190, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013784, Carb-bd-like_fold
    IPR034839, CBM20_GPCPD1
    IPR002044, CBM_fam20
    IPR033506, Gde1
    IPR030395, GP_PDE_dom
    IPR013783, Ig-like_fold
    IPR017946, PLC-like_Pdiesterase_TIM-brl

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR22958:SF1, PTHR22958:SF1, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00686, CBM_20, 1 hit
    PF03009, GDPD, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM01065, CBM_2, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49452, SSF49452, 1 hit
    SSF51695, SSF51695, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51166, CBM20, 1 hit
    PS51704, GP_PDE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8C0L9-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTPSQVTFEI RGTLLPGEVF AICGSCDALG NWNPQNAVAL INENETGDSV
    60 70 80 90 100
    LWKAVIALNR GVSVKYRYFR GCFLEPKTIG GPCQVIVHKW ETHLQPRSIT
    110 120 130 140 150
    PLESEIIIDD GQFGIHNGVE TLDSGWLTCQ TEIRLRLHFS EKPPVSISKK
    160 170 180 190 200
    KFKKSRFRVK LTLEGLEEDE DDDDDKVSPT VLHKMSNSLE ISLISDNEFK
    210 220 230 240 250
    CRHSQPECGY GLQPDRWTEY SIQTMEPDNL ELIFDFFEED LSEHVVQGDV
    260 270 280 290 300
    LPGHVGTACL LSSTIAESGR SAGILTLPIM SRNSRKTIGK VRVDFIIIKP
    310 320 330 340 350
    LPGYSCSMQS SFSKYWKPRI PLDVGHRGAG NSTTTAKLAK VQENTIASLR
    360 370 380 390 400
    NAASHGAAFV EFDVHLSKDF VPVVYHDLTC CLTMKRKYEA DPVELFEIPV
    410 420 430 440 450
    KELTFDQLQL LKLSHVTALK TKDRKQSLYE EENFFSENQP FPSLKMVLES
    460 470 480 490 500
    LPENVGFNIE IKWICQHRDG VWDGNLSTYF DMNVFLDIIL KTVLENSGKR
    510 520 530 540 550
    RIVFSSFDAD ICTMVRQKQN KYPILFLTQG KSDIYPELMD LRSRTTPIAM
    560 570 580 590 600
    SFAQFENILG INAHTEDLLR NPSYVQEAKA KGLVIFCWGD DTNDPENRRK
    610 620 630 640 650
    LKEFGVNGLI YDRIYDWMPE QPNIFQVEQL ERLKQELPEL KNCLCPTVSH
    660 670
    FIPSSFCVEP DIHVDANGID SVENA
    Length:675
    Mass (Da):76,579
    Last modified:March 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7ABF9EE48CF39B47
    GO
    Isoform 2 (identifier: Q8C0L9-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-184: Missing.

    Show »
    Length:491
    Mass (Da):55,919
    Checksum:i3B087FDB9B0CD315
    GO
    Isoform 3 (identifier: Q8C0L9-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-445: Missing.

    Show »
    Length:230
    Mass (Da):26,541
    Checksum:i15F29E5FEE611B3A
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A2AMD6A2AMD6_MOUSE
    Glycerophosphocholine phosphodieste...
    Gpcpd1
    188Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B0R058B0R058_MOUSE
    Glycerophosphocholine phosphodieste...
    Gpcpd1
    444Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A2AMD7A2AMD7_MOUSE
    Glycerophosphocholine phosphodieste...
    Gpcpd1
    157Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RHB5D6RHB5_MOUSE
    Glycerophosphocholine phosphodieste...
    Gpcpd1
    117Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RGT7D6RGT7_MOUSE
    Glycerophosphocholine phosphodieste...
    Gpcpd1
    107Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RHS8D6RHS8_MOUSE
    Glycerophosphocholine phosphodieste...
    Gpcpd1
    102Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F6YDB7F6YDB7_MOUSE
    Glycerophosphocholine phosphodieste...
    Gpcpd1
    27Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAB26361 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
    The sequence BAC33775 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence BAC34739 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence BAC65792 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti289G → D in BAE38686 (PubMed:16141072).Curated1
    Sequence conflicti460E → Q in BAC33775 (PubMed:16141072).Curated1
    Sequence conflicti494 – 495LE → SQ in BAC33775 (PubMed:16141072).Curated2
    Sequence conflicti499K → N in BAC33775 (PubMed:16141072).Curated1
    Sequence conflicti559L → S in BAB26361 (PubMed:16141072).Curated1
    Sequence conflicti602K → E in BAB26361 (PubMed:16141072).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0208191 – 445Missing in isoform 3. 1 PublicationAdd BLAST445
    Alternative sequenceiVSP_0208201 – 184Missing in isoform 2. 1 PublicationAdd BLAST184

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK122510 mRNA Translation: BAC65792.1 Different initiation.
    AK009563 mRNA Translation: BAB26361.2 Different initiation.
    AK030645 mRNA Translation: BAC27063.1
    AK049491 mRNA Translation: BAC33775.1 Different initiation.
    AK051728 mRNA Translation: BAC34739.1 Different initiation.
    AK166293 mRNA Translation: BAE38686.1
    AL807386 Genomic DNA No translation available.
    BC033408 mRNA Translation: AAH33408.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS38246.1 [Q8C0L9-1]
    CCDS71151.1 [Q8C0L9-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001277979.1, NM_001291050.1 [Q8C0L9-2]
    NP_001277980.1, NM_001291051.1 [Q8C0L9-2]
    NP_001277981.1, NM_001291052.1 [Q8C0L9-2]
    NP_081372.1, NM_027096.2 [Q8C0L9-2]
    NP_083078.3, NM_028802.3 [Q8C0L9-1]
    XP_011238111.1, XM_011239809.2
    XP_017174784.1, XM_017319295.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000060955; ENSMUSP00000062221; ENSMUSG00000027346 [Q8C0L9-1]
    ENSMUST00000110136; ENSMUSP00000105763; ENSMUSG00000027346 [Q8C0L9-2]
    ENSMUST00000110142; ENSMUSP00000105769; ENSMUSG00000027346 [Q8C0L9-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    74182

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:74182

    UCSC genome browser

    More...
    UCSCi
    uc008mmv.2, mouse [Q8C0L9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK122510 mRNA Translation: BAC65792.1 Different initiation.
    AK009563 mRNA Translation: BAB26361.2 Different initiation.
    AK030645 mRNA Translation: BAC27063.1
    AK049491 mRNA Translation: BAC33775.1 Different initiation.
    AK051728 mRNA Translation: BAC34739.1 Different initiation.
    AK166293 mRNA Translation: BAE38686.1
    AL807386 Genomic DNA No translation available.
    BC033408 mRNA Translation: AAH33408.1
    CCDSiCCDS38246.1 [Q8C0L9-1]
    CCDS71151.1 [Q8C0L9-2]
    RefSeqiNP_001277979.1, NM_001291050.1 [Q8C0L9-2]
    NP_001277980.1, NM_001291051.1 [Q8C0L9-2]
    NP_001277981.1, NM_001291052.1 [Q8C0L9-2]
    NP_081372.1, NM_027096.2 [Q8C0L9-2]
    NP_083078.3, NM_028802.3 [Q8C0L9-1]
    XP_011238111.1, XM_011239809.2
    XP_017174784.1, XM_017319295.1

    3D structure databases

    SMRiQ8C0L9
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000105769

    Protein family/group databases

    CAZyiCBM20, Carbohydrate-Binding Module Family 20

    PTM databases

    iPTMnetiQ8C0L9
    PhosphoSitePlusiQ8C0L9

    Proteomic databases

    EPDiQ8C0L9
    jPOSTiQ8C0L9
    PaxDbiQ8C0L9
    PeptideAtlasiQ8C0L9
    PRIDEiQ8C0L9
    ProteomicsDBi271434 [Q8C0L9-1]
    271435 [Q8C0L9-2]
    271436 [Q8C0L9-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    23917, 25 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    74182

    Genome annotation databases

    EnsembliENSMUST00000060955; ENSMUSP00000062221; ENSMUSG00000027346 [Q8C0L9-1]
    ENSMUST00000110136; ENSMUSP00000105763; ENSMUSG00000027346 [Q8C0L9-2]
    ENSMUST00000110142; ENSMUSP00000105769; ENSMUSG00000027346 [Q8C0L9-1]
    GeneIDi74182
    KEGGimmu:74182
    UCSCiuc008mmv.2, mouse [Q8C0L9-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    56261
    MGIiMGI:104898, Gpcpd1

    Rodent Unidentified Gene-Encoded large proteins database

    More...
    Rougei
    Search...

    Phylogenomic databases

    eggNOGiKOG2421, Eukaryota
    GeneTreeiENSGT00440000033970
    HOGENOMiCLU_013007_2_0_1
    InParanoidiQ8C0L9
    OrthoDBi687958at2759
    PhylomeDBiQ8C0L9
    TreeFamiTF314722

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    74182, 0 hits in 52 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Gpcpd1, mouse

    Protein Ontology

    More...
    PROi
    PR:Q8C0L9
    RNActiQ8C0L9, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000027346, Expressed in gastrocnemius and 312 other tissues
    ExpressionAtlasiQ8C0L9, baseline and differential
    GenevisibleiQ8C0L9, MM

    Family and domain databases

    CDDicd05814, CBM20_Prei4, 1 hit
    Gene3Di2.60.40.10, 1 hit
    3.20.20.190, 1 hit
    InterProiView protein in InterPro
    IPR013784, Carb-bd-like_fold
    IPR034839, CBM20_GPCPD1
    IPR002044, CBM_fam20
    IPR033506, Gde1
    IPR030395, GP_PDE_dom
    IPR013783, Ig-like_fold
    IPR017946, PLC-like_Pdiesterase_TIM-brl
    PANTHERiPTHR22958:SF1, PTHR22958:SF1, 1 hit
    PfamiView protein in Pfam
    PF00686, CBM_20, 1 hit
    PF03009, GDPD, 1 hit
    SMARTiView protein in SMART
    SM01065, CBM_2, 1 hit
    SUPFAMiSSF49452, SSF49452, 1 hit
    SSF51695, SSF51695, 1 hit
    PROSITEiView protein in PROSITE
    PS51166, CBM20, 1 hit
    PS51704, GP_PDE, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPCP1_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C0L9
    Secondary accession number(s): A2AMD5
    , Q3TLV6, Q80TD5, Q8BKJ7, Q8BKW7, Q8CFW2, Q9D759
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: March 1, 2003
    Last modified: June 2, 2021
    This is version 145 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
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