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Protein

Conserved oligomeric Golgi complex subunit 5

Gene

Cog5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 5
Short name:
COG complex subunit 5
Alternative name(s):
Component of oligomeric Golgi complex 5
Gene namesi
Name:Cog5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2145130 Cog5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201461 – 829Conserved oligomeric Golgi complex subunit 5Add BLAST829

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C0L8
MaxQBiQ8C0L8
PaxDbiQ8C0L8
PeptideAtlasiQ8C0L8
PRIDEiQ8C0L8

PTM databases

iPTMnetiQ8C0L8
PhosphoSitePlusiQ8C0L8

Expressioni

Gene expression databases

BgeeiENSMUSG00000035933 Expressed in 159 organ(s), highest expression level in heart
ExpressionAtlasiQ8C0L8 baseline and differential
GenevisibleiQ8C0L8 MM

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044797

Structurei

3D structure databases

ProteinModelPortaliQ8C0L8
SMRiQ8C0L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG5 family.Curated

Phylogenomic databases

eggNOGiKOG2211 Eukaryota
ENOG410XWH0 LUCA
GeneTreeiENSGT00390000004586
HOGENOMiHOG000170357
HOVERGENiHBG051063
InParanoidiQ8C0L8
KOiK20292
OMAiWSIARYS
OrthoDBiEOG091G048P
TreeFamiTF313139

Family and domain databases

InterProiView protein in InterPro
IPR019465 Cog5
PANTHERiPTHR13228 PTHR13228, 1 hit
PfamiView protein in Pfam
PF10392 COG5, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8C0L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGGDSTISV AGRGASGSAV VAATVQAILQ DDCYSEFLNE DFDVKTYTSQ
60 70 80 90 100
SIHQAVIAEQ LAKLAQGISQ LDKELHLQVV ARHEDLLAQA TGIESLEGVL
110 120 130 140 150
QMMQTRIGAL QGAVDRMKSK IVEPYNKIVA RTAQLARLQV ACDLLRRIIR
160 170 180 190 200
ILYLSKRLQG QLQGGSREIT KAAQSLNELD YLSQGIDLSG IEVIENDLLF
210 220 230 240 250
IARARLEVEN QAKRLLEQGV ETQNPTQVGT ALQVFHNLGT LKETVTSVVD
260 270 280 290 300
GYCAALEDSI NNALDVKVLT QPSQSAVRGG PGRAAMPTPG STAGFRASLW
310 320 330 340 350
TNMEKLMDHI CAACGQVQHL QKVLTKKRDP VSHICFIEEI IKDGQPEILY
360 370 380 390 400
MFWNAVTLAL SSHFHSATNS SMFLKQAFEG EYPKLLRLYN DLWKRLQQSS
410 420 430 440 450
QNTQGTFSPS GTPDLCVDLP HMEDDTQDMF RLKRPDYDPE KALKDSLQPY
460 470 480 490 500
EAAYLSKSLS RLFDPINLVF PPGGRNPPSS DELDGITKTI TSELNVAAVD
510 520 530 540 550
ANLTLAVSKN VAKTIQLYAV KSEQLLSTQG DASQVIGPLT EGQKRNVGVV
560 570 580 590 600
NSLFKLHQSV TKVVASQSSF SATAEQTIMS ALKTIHDLMG NAIQPLLTSV
610 620 630 640 650
ADAIEAIIIT MHQEDFSGAS SSSGKPDVPC SLYMKELQGF IARVMNDYFK
660 670 680 690 700
HFECLDFVFD NTEAIAQRAI ELFIRNASLI RPLGEGGKLR LAADFAQMEL
710 720 730 740 750
AVGPLCRRVS DLGKSYRMLR SFRPLLFQTS EHVADSPAVG DIIPFSIIIQ
760 770 780 790 800
FLFTRAPAEL KSPFQRAEWS HARFSQWLDD HPSEKDRLLL LRGALEAYVQ
810 820
SVRSRDGKEF APVYPIMVQL LQKAMSALQ
Length:829
Mass (Da):91,391
Last modified:July 27, 2011 - v3
Checksum:iE4041125F09250DD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7M6A0A1W2P7M6_MOUSE
Conserved oligomeric Golgi complex ...
Cog5
99Annotation score:
A0A1W2P822A0A1W2P822_MOUSE
Conserved oligomeric Golgi complex ...
Cog5
21Annotation score:

Sequence cautioni

The sequence BAC27065 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190G → R in BAC27065 (PubMed:16141072).Curated1
Sequence conflicti430F → Y in BAC27065 (PubMed:16141072).Curated1
Sequence conflicti655L → M in BAC27065 (PubMed:16141072).Curated1
Sequence conflicti826S → Y in BAC27065 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030656 mRNA Translation: BAC27065.1 Different initiation.
AC119950 Genomic DNA No translation available.
AC125020 Genomic DNA No translation available.
CT010463 Genomic DNA No translation available.
CCDSiCCDS49046.1
RefSeqiNP_001156598.1, NM_001163126.1
XP_011242170.1, XM_011243868.2
UniGeneiMm.173068
Mm.458534

Genome annotation databases

EnsembliENSMUST00000036862; ENSMUSP00000044797; ENSMUSG00000035933
GeneIDi238123
KEGGimmu:238123
UCSCiuc007nhs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030656 mRNA Translation: BAC27065.1 Different initiation.
AC119950 Genomic DNA No translation available.
AC125020 Genomic DNA No translation available.
CT010463 Genomic DNA No translation available.
CCDSiCCDS49046.1
RefSeqiNP_001156598.1, NM_001163126.1
XP_011242170.1, XM_011243868.2
UniGeneiMm.173068
Mm.458534

3D structure databases

ProteinModelPortaliQ8C0L8
SMRiQ8C0L8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044797

PTM databases

iPTMnetiQ8C0L8
PhosphoSitePlusiQ8C0L8

Proteomic databases

EPDiQ8C0L8
MaxQBiQ8C0L8
PaxDbiQ8C0L8
PeptideAtlasiQ8C0L8
PRIDEiQ8C0L8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036862; ENSMUSP00000044797; ENSMUSG00000035933
GeneIDi238123
KEGGimmu:238123
UCSCiuc007nhs.1 mouse

Organism-specific databases

CTDi10466
MGIiMGI:2145130 Cog5

Phylogenomic databases

eggNOGiKOG2211 Eukaryota
ENOG410XWH0 LUCA
GeneTreeiENSGT00390000004586
HOGENOMiHOG000170357
HOVERGENiHBG051063
InParanoidiQ8C0L8
KOiK20292
OMAiWSIARYS
OrthoDBiEOG091G048P
TreeFamiTF313139

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiCog5 mouse
PROiPR:Q8C0L8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035933 Expressed in 159 organ(s), highest expression level in heart
ExpressionAtlasiQ8C0L8 baseline and differential
GenevisibleiQ8C0L8 MM

Family and domain databases

InterProiView protein in InterPro
IPR019465 Cog5
PANTHERiPTHR13228 PTHR13228, 1 hit
PfamiView protein in Pfam
PF10392 COG5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOG5_MOUSE
AccessioniPrimary (citable) accession number: Q8C0L8
Secondary accession number(s): E9QM30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 97 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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