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Protein

Thioredoxin-related transmembrane protein 4

Gene

Tmx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-related transmembrane protein 4
Alternative name(s):
Thioredoxin domain-containing protein 13
Gene namesi
Name:Tmx4
Synonyms:D2Bwg1356e, Kiaa1162, Txndc13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:106558 Tmx4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003419221 – 335Thioredoxin-related transmembrane protein 4Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 63Redox-activePROSITE-ProRule annotation
Modified residuei247PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ8C0L0
MaxQBiQ8C0L0
PaxDbiQ8C0L0
PeptideAtlasiQ8C0L0
PRIDEiQ8C0L0

PTM databases

iPTMnetiQ8C0L0
PhosphoSitePlusiQ8C0L0
SwissPalmiQ8C0L0

Expressioni

Gene expression databases

BgeeiENSMUSG00000034723 Expressed in 241 organ(s), highest expression level in cerebellum
CleanExiMM_TXNDC13
ExpressionAtlasiQ8C0L0 baseline and differential
GenevisibleiQ8C0L0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045154

Structurei

3D structure databases

ProteinModelPortaliQ8C0L0
SMRiQ8C0L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 133ThioredoxinPROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi220 – 288Glu-richAdd BLAST69

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0913 Eukaryota
ENOG4111H66 LUCA
GeneTreeiENSGT00390000011580
HOGENOMiHOG000045750
InParanoidiQ8C0L0
OMAiQHADKGP
OrthoDBiEOG091G0MRE
PhylomeDBiQ8C0L0
TreeFamiTF106376

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8C0L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGGFCVPVL LAAWLAAAAA EGLEQAALPA EESRVQPMTA SNWTLVMEGE
60 70 80 90 100
WMLKFYAPWC PSCQQTDSEW ETFAKNGETL QISVGKVDVI QEPGLSGRFF
110 120 130 140 150
VTTLPAFFHA KDGIFRRYRG PGIYEDLQNY ILEKKWQSVE PLTGWKSPAS
160 170 180 190 200
LTMSGMAGLF SISGKIWHLH NYFTVTLGIP AWCSYVFFVI ATLVFGLFMG
210 220 230 240 250
LILVVISECF CVPLPRASSE RCEQEQSTGE AQGAEQLQDA EEEKDDSNEE
260 270 280 290 300
ENKDSLVDDE EEKEDIGDED EGEEDEEEDN LAGIMAEERS DTNERAVVKE
310 320 330
GSVSPKEDGA HPADTQDVVE DALRQRKSQN ANKGS
Length:335
Mass (Da):37,131
Last modified:May 10, 2005 - v2
Checksum:i526E4E6F894737D2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ARI0A2ARI0_MOUSE
Thioredoxin-related transmembrane p...
Tmx4
183Annotation score:
A2ARI1A2ARI1_MOUSE
Thioredoxin-related transmembrane p...
Tmx4
166Annotation score:

Sequence cautioni

The sequence AAH50918 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98111 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22G → S in BAC27085 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030696 mRNA Translation: BAC27085.1
AK129301 mRNA Translation: BAC98111.1 Different initiation.
AK147465 mRNA Translation: BAE27931.1
BC050918 mRNA Translation: AAH50918.1 Different initiation.
CCDSiCCDS16784.1
RefSeqiNP_083424.1, NM_029148.1
UniGeneiMm.264096

Genome annotation databases

EnsembliENSMUST00000038228; ENSMUSP00000045154; ENSMUSG00000034723
GeneIDi52837
KEGGimmu:52837
UCSCiuc008mnt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030696 mRNA Translation: BAC27085.1
AK129301 mRNA Translation: BAC98111.1 Different initiation.
AK147465 mRNA Translation: BAE27931.1
BC050918 mRNA Translation: AAH50918.1 Different initiation.
CCDSiCCDS16784.1
RefSeqiNP_083424.1, NM_029148.1
UniGeneiMm.264096

3D structure databases

ProteinModelPortaliQ8C0L0
SMRiQ8C0L0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045154

PTM databases

iPTMnetiQ8C0L0
PhosphoSitePlusiQ8C0L0
SwissPalmiQ8C0L0

Proteomic databases

EPDiQ8C0L0
MaxQBiQ8C0L0
PaxDbiQ8C0L0
PeptideAtlasiQ8C0L0
PRIDEiQ8C0L0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038228; ENSMUSP00000045154; ENSMUSG00000034723
GeneIDi52837
KEGGimmu:52837
UCSCiuc008mnt.2 mouse

Organism-specific databases

CTDi56255
MGIiMGI:106558 Tmx4
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0913 Eukaryota
ENOG4111H66 LUCA
GeneTreeiENSGT00390000011580
HOGENOMiHOG000045750
InParanoidiQ8C0L0
OMAiQHADKGP
OrthoDBiEOG091G0MRE
PhylomeDBiQ8C0L0
TreeFamiTF106376

Miscellaneous databases

PROiPR:Q8C0L0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034723 Expressed in 241 organ(s), highest expression level in cerebellum
CleanExiMM_TXNDC13
ExpressionAtlasiQ8C0L0 baseline and differential
GenevisibleiQ8C0L0 MM

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMX4_MOUSE
AccessioniPrimary (citable) accession number: Q8C0L0
Secondary accession number(s): Q3UHC6, Q6ZPW7, Q80X49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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