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UniProtKB - Q8C0I1 (ADAS_MOUSE)
Protein
Alkyldihydroxyacetonephosphate synthase, peroxisomal
Gene
Agps
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.
1 PublicationCatalytic activityi
- a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H+1 PublicationEC:2.5.1.261 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H+ + hexadecanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
FADBy similarity
: ether lipid biosynthesis Pathwayi
This protein is involved in the pathway ether lipid biosynthesis, which is part of Glycerolipid metabolism.View all proteins of this organism that are known to be involved in the pathway ether lipid biosynthesis and in Glycerolipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 406 | Important for enzyme activityBy similarity | 1 | |
Binding sitei | 502 | SubstrateBy similarity | 1 | |
Active sitei | 565 | Proton donor/acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 221 – 227 | FADBy similarity | 7 | |
Nucleotide bindingi | 290 – 296 | FADBy similarity | 7 | |
Nucleotide bindingi | 303 – 306 | FADBy similarity | 4 | |
Nucleotide bindingi | 355 – 361 | FADBy similarity | 7 |
GO - Molecular functioni
- alkylglycerone-phosphate synthase activity Source: UniProtKB
- FAD binding Source: UniProtKB
- oxidoreductase activity Source: InterPro
GO - Biological processi
- ether lipid biosynthetic process Source: UniProtKB
- lipid biosynthetic process Source: MGI
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
BRENDAi | 2.5.1.26, 3474 |
Reactomei | R-MMU-75896, Plasmalogen biosynthesis R-MMU-9033241, Peroxisomal protein import |
UniPathwayi | UPA00781 |
Chemistry databases
SwissLipidsi | SLP:000000608 |
Names & Taxonomyi
Protein namesi | Recommended name: Alkyldihydroxyacetonephosphate synthase, peroxisomal (EC:2.5.1.261 Publication)Short name: Alkyl-DHAP synthase Alternative name(s): Alkylglycerone-phosphate synthase |
Gene namesi | Name:Agps |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443065, Agps |
Subcellular locationi
Peroxisome
- Peroxisome membrane By similarity
- Peroxisome By similarity
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleolus Source: MGI
Peroxisome
- peroxisomal matrix Source: Reactome
- peroxisomal membrane Source: UniProtKB-SubCell
- peroxisome Source: MGI
Keywords - Cellular componenti
Membrane, PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 45 | PeroxisomeBy similarityAdd BLAST | 45 | |
ChainiPRO_0000231676 | 46 – 645 | Alkyldihydroxyacetonephosphate synthase, peroxisomalAdd BLAST | 600 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 52 | PhosphoserineCombined sources | 1 | |
Modified residuei | 57 | PhosphoserineCombined sources | 1 | |
Modified residuei | 61 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 89 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 334 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8C0I1 |
jPOSTi | Q8C0I1 |
MaxQBi | Q8C0I1 |
PaxDbi | Q8C0I1 |
PRIDEi | Q8C0I1 |
ProteomicsDBi | 285675 |
PTM databases
iPTMneti | Q8C0I1 |
PhosphoSitePlusi | Q8C0I1 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 230710, 6 interactors |
IntActi | Q8C0I1, 1 interactor |
STRINGi | 10090.ENSMUSP00000041967 |
Miscellaneous databases
RNActi | Q8C0I1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 189 – 371 | FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 602 – 604 | Important for enzyme activityBy similarity | 3 | |
Regioni | 641 – 645 | Important for enzyme activityBy similarity | 5 |
Sequence similaritiesi
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1233, Eukaryota |
InParanoidi | Q8C0I1 |
OrthoDBi | 824020at2759 |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.43.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR025650, Alkyl-DHAP_Synthase IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
PANTHERi | PTHR46568, PTHR46568, 1 hit |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8C0I1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEAAAGEAG ASERDPDAGR ARRRLRVLSG HLLGRPQEAP STNECKARRA
60 70 80 90 100
ASAAGASPAA TPAAPESGTI PKKRQEVMKW NGWGYNDSKF LLNKKGQVEL
110 120 130 140 150
TGKRYPLSGL VLPTLRDWIQ NTLGVSLEHK TTSKTSINPS EAPPSIVNED
160 170 180 190 200
FLQELKEARI SYSQEADDRV FRAHGHCLHE IFLLREGMFE RIPDIVVWPT
210 220 230 240 250
CHDDVVKIVN LACKYNLCII PIGGGTSVSY GLMCPADETR TIISLDTSQM
260 270 280 290 300
NRILWVDENN LTAHVEAGIT GQDLERQLKE SGYCTGHEPD SLEFSTVGGW
310 320 330 340 350
ISTRASGMKK NIYGNIEDLV VHMKMVTPRG VIEKSSQGPR MSTGPDIHHF
360 370 380 390 400
IMGSEGTLGV ITEATIKIRP TPEYQKYGSV AFPNFEQGVA CLREIAKQRC
410 420 430 440 450
APASIRLMDN QQFQFGHALK PQVSSIFTSF LDGLKKFYIT KFKGFDPNQI
460 470 480 490 500
SVATLLFEGD REKVLQHEKQ VYDIAAKFGG LAAGEDNGQR GYLLTYVIAY
510 520 530 540 550
IRDLGLEYYV IGESFETSAP WDRVIDLCRN VKERIRRECK ERGVQFAPLS
560 570 580 590 600
TCRVTQTYDA GACIYFYFAF NYRGISDPLT VFEHTEAAAR EEILANGGSL
610 620 630 640
SHHHGVGKIR KQWLKESISD VGFGMLKSVK EYVDPSNIFG NRNLL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AL50 | A2AL50_MOUSE | Alkylglycerone-phosphate synthase | Agps | 671 | Annotation score: | ||
H3BKN2 | H3BKN2_MOUSE | Alkylglycerone-phosphate synthase | Agps | 568 | Annotation score: | ||
A2AL49 | A2AL49_MOUSE | Alkylglycerone-phosphate synthase | Agps | 508 | Annotation score: | ||
H3BIY5 | H3BIY5_MOUSE | Alkylglycerone-phosphate synthase | Agps | 57 | Annotation score: | ||
H3BJ14 | H3BJ14_MOUSE | Alkyldihydroxyacetonephosphate synt... | Agps | 24 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK031049 mRNA Translation: BAC27229.1 BC063086 mRNA Translation: AAH63086.1 |
RefSeqi | NP_766254.2, NM_172666.3 |
Genome annotation databases
GeneIDi | 228061 |
KEGGi | mmu:228061 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK031049 mRNA Translation: BAC27229.1 BC063086 mRNA Translation: AAH63086.1 |
RefSeqi | NP_766254.2, NM_172666.3 |
3D structure databases
SMRi | Q8C0I1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230710, 6 interactors |
IntActi | Q8C0I1, 1 interactor |
STRINGi | 10090.ENSMUSP00000041967 |
Chemistry databases
SwissLipidsi | SLP:000000608 |
PTM databases
iPTMneti | Q8C0I1 |
PhosphoSitePlusi | Q8C0I1 |
Proteomic databases
EPDi | Q8C0I1 |
jPOSTi | Q8C0I1 |
MaxQBi | Q8C0I1 |
PaxDbi | Q8C0I1 |
PRIDEi | Q8C0I1 |
ProteomicsDBi | 285675 |
Protocols and materials databases
DNASUi | 228061 |
Genome annotation databases
GeneIDi | 228061 |
KEGGi | mmu:228061 |
Organism-specific databases
CTDi | 8540 |
MGIi | MGI:2443065, Agps |
Phylogenomic databases
eggNOGi | KOG1233, Eukaryota |
InParanoidi | Q8C0I1 |
OrthoDBi | 824020at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00781 |
BRENDAi | 2.5.1.26, 3474 |
Reactomei | R-MMU-75896, Plasmalogen biosynthesis R-MMU-9033241, Peroxisomal protein import |
Miscellaneous databases
BioGRID-ORCSi | 228061, 5 hits in 67 CRISPR screens |
ChiTaRSi | Agps, mouse |
PROi | PR:Q8C0I1 |
RNActi | Q8C0I1, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.43.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR025650, Alkyl-DHAP_Synthase IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
PANTHERi | PTHR46568, PTHR46568, 1 hit |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAS_MOUSE | |
Accessioni | Q8C0I1Primary (citable) accession number: Q8C0I1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families