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Entry version 140 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Zinc fingers and homeoboxes protein 2

Gene

Zhx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor (PubMed:19515908). Represses the promoter activity of the CDC25C gene stimulated by NFYA (By similarity). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (PubMed:30146259). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (PubMed:19515908).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri78 – 101C2H2-type 1PROSITE-ProRule annotationCuratedAdd BLAST24
Zinc fingeri110 – 133C2H2-type 2PROSITE-ProRule annotationCuratedAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi263 – 324Homeobox 1PROSITE-ProRule annotationCuratedAdd BLAST62
DNA bindingi439 – 501Homeobox 2PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi530 – 591Homeobox 3PROSITE-ProRule annotationCuratedAdd BLAST62
DNA bindingi628 – 690Homeobox 4PROSITE-ProRule annotationCuratedAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc fingers and homeoboxes protein 2
Alternative name(s):
Alpha-fetoprotein regulator 1
Short name:
AFP regulator 1
Regulator of AFP
Zinc finger and homeodomain protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zhx2
Synonyms:Afr1, Raf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2683087 Zhx2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000493921 – 836Zinc fingers and homeoboxes protein 2Add BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki455Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei824PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8C0C0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8C0C0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C0C0

PRoteomics IDEntifications database

More...
PRIDEi
Q8C0C0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C0C0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C0C0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in retina where it localizes to Muller glial cells of the inner nuclear layer (at protein level) (PubMed:30146259). Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis (PubMed:14659886).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Strongly expressed in retina from embryonic stages 14.5 dpc to 17.5 dpc, where it is widely detected in retinal progenitor cells (at protein level) (PubMed:30146259). Expression then gradually declines and stabilizes at a low level by postnatal day 10 (P10) (at protein level) (PubMed:30146259). At P0, expression refines to the inner half of the neuroblastic layer (at protein level) (PubMed:30146259). Expression further refines to the retinal inner nuclear layer from stage P3 onwards (at protein level) (PubMed:30146259). Detected in bipolar OFF-type cells at stage P7 (at protein level) (PubMed:30146259). By stage P10, has only weak expression in bipolar OFF-type cells but strong expression in Muller glial cells (at protein level) (PubMed:30146259). Detected in brain at embryonic stages 12.5 dpc to 15.5 dpc, specifically in the ventricular zone and subventricular zone of the cortex (at protein level) (PubMed:19515908). Probably localizes to neural progenitor cells in the developing cortex (at protein level) (PubMed:19515908).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000071757 Expressed in 202 organ(s), highest expression level in quadriceps femoris

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C0C0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (via homeobox domain 1) (By similarity). Heterodimer with ZHX1 (via homeobox domain 1) (By similarity). Heterodimer with ZHX3 (via homeobox domain 1) (By similarity). Heterodimerization with ZHX1 is not necessary for repressor activity (By similarity).

Interacts (via homeobox domain) with NFYA (via N-terminus) (By similarity).

Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (PubMed:19515908).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Dock1Q8BUR43EBI-646042,EBI-646023

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
239920, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8C0C0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000094164

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8C0C0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 77Interaction with EFNB11 PublicationAdd BLAST51
Regioni195 – 358Required for homodimerizationBy similarityAdd BLAST164
Regioni263 – 497Required for interaction with NFYABy similarityAdd BLAST235
Regioni263 – 446Required for repressor activityBy similarityAdd BLAST184
Regioni317 – 446Required for nuclear localizationBy similarityAdd BLAST130

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZHX family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri78 – 101C2H2-type 1PROSITE-ProRule annotationCuratedAdd BLAST24
Zinc fingeri110 – 133C2H2-type 2PROSITE-ProRule annotationCuratedAdd BLAST24

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHET Eukaryota
ENOG410Z8A2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182893

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013231

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C0C0

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIEATNH

Database of Orthologous Groups

More...
OrthoDBi
518562at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C0C0

TreeFam database of animal gene trees

More...
TreeFami
TF333363

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR041057 ZHX_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 3 hits
PF18387 zf_C2H2_ZHX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 4 hits
SM00355 ZnF_C2H2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 4 hits
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50071 HOMEOBOX_2, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8C0C0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKRKSTTP CMVRTSQVLE QDMLEEADRA KDKGAGMPQS DVTKDSWAAE
60 70 80 90 100
PEHSSKETEV VEVKSMGENL SKKLQGGYEC KYCPYSTQNL NEFTEHVDMQ
110 120 130 140 150
HPNVILNPLY VCAECNFTTK KYDSLSDHNS KFHPGETNFK LKLIKRNNQT
160 170 180 190 200
VLEQSIEATN HVVPITASGP GSSDNDPGVS VGKTPMTKTG KLKADAKKVP
210 220 230 240 250
KKPDEAAPEN HMEGTARLVT DTAEILARLG SVELLQDSLG HVMPSVQLPP
260 270 280 290 300
NINLVPKVPV PLNTTKYNSA LDTNATMINS FNKFPYPTQA ELSWLTAASK
310 320 330 340 350
HPEEHIRIWF ATQRLKHGIS WSPEEVEEAR KKMFNGTIQS VPPTITVLPA
360 370 380 390 400
QLTPTKVSQP ILQTALPCQI LGQPSLVLTQ VTSGSTTVSC SPITLAVAGV
410 420 430 440 450
TNHGQKRPLV TPQAAPEPKR PHIAQVPEPP PKVANTPLTP ASDRKKTKLQ
460 470 480 490 500
IAHLKASFLQ SQFPDDAEVY RLIEVTGLAR SEIKKWFSDH RYRCQRGIVH
510 520 530 540 550
ITSESLAKDQ MAITGTRHGR TYHVYPDFAP QKFKEKSQGQ LKTLEDSFLK
560 570 580 590 600
SSFPTQAEVE RLRVETKLSR REIDSWFSER RKLRDSMEQA VLDSMGSGKK
610 620 630 640 650
GSDAVAPNGA LSRLDQLSGA QLAGSLPSPS SAIVQNQEQV HLLRSTFART
660 670 680 690 700
QWPTPQEYDQ LAAKTGLVRT EIVRWFKENR CLLKTGTLSW LEQYQRHHMS
710 720 730 740 750
DDRGRDAVSR KVAKQVAESP KNGSEAAHQY AKDPKALSEE DSEKLVPRMK
760 770 780 790 800
VGGDPTKDCL AGKPSEATSD RSEGSRDGQG SEENEESGIV DFVEVTVGEE
810 820 830
DAISEKWGSW SRRVAEGTVE RADSDSDSTP AEAGQA
Length:836
Mass (Da):92,259
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC28AF20925D62054
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70L → P in BAC87710 (PubMed:14659886).Curated1
Sequence conflicti70L → P in BAC87712 (PubMed:14659886).Curated1
Sequence conflicti699M → L in BAC87710 (PubMed:14659886).Curated1
Sequence conflicti699M → L in BAC87712 (PubMed:14659886).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB099526 mRNA Translation: BAC87710.1
AB099704 Genomic DNA Translation: BAC87712.1
AK031782 mRNA Translation: BAC27546.1
BC059178 mRNA Translation: AAH59178.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27483.1

NCBI Reference Sequences

More...
RefSeqi
NP_955520.1, NM_199449.2
XP_011243990.1, XM_011245688.2
XP_011243991.1, XM_011245689.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000096430; ENSMUSP00000094164; ENSMUSG00000071757

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
387609

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:387609

UCSC genome browser

More...
UCSCi
uc007vsp.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099526 mRNA Translation: BAC87710.1
AB099704 Genomic DNA Translation: BAC87712.1
AK031782 mRNA Translation: BAC27546.1
BC059178 mRNA Translation: AAH59178.1
CCDSiCCDS27483.1
RefSeqiNP_955520.1, NM_199449.2
XP_011243990.1, XM_011245688.2
XP_011243991.1, XM_011245689.2

3D structure databases

SMRiQ8C0C0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi239920, 2 interactors
IntActiQ8C0C0, 1 interactor
STRINGi10090.ENSMUSP00000094164

PTM databases

iPTMnetiQ8C0C0
PhosphoSitePlusiQ8C0C0

Proteomic databases

EPDiQ8C0C0
MaxQBiQ8C0C0
PaxDbiQ8C0C0
PRIDEiQ8C0C0

Genome annotation databases

EnsembliENSMUST00000096430; ENSMUSP00000094164; ENSMUSG00000071757
GeneIDi387609
KEGGimmu:387609
UCSCiuc007vsp.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22882
MGIiMGI:2683087 Zhx2

Phylogenomic databases

eggNOGiENOG410IHET Eukaryota
ENOG410Z8A2 LUCA
GeneTreeiENSGT00950000182893
HOGENOMiHOG000013231
InParanoidiQ8C0C0
OMAiSIEATNH
OrthoDBi518562at2759
PhylomeDBiQ8C0C0
TreeFamiTF333363

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zhx2 mouse

Protein Ontology

More...
PROi
PR:Q8C0C0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000071757 Expressed in 202 organ(s), highest expression level in quadriceps femoris
GenevisibleiQ8C0C0 MM

Family and domain databases

CDDicd00086 homeodomain, 4 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR041057 ZHX_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00046 Homeodomain, 3 hits
PF18387 zf_C2H2_ZHX, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 4 hits
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF46689 SSF46689, 4 hits
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZHX2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C0C0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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