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Protein

Microtubule-associated protein 1S

Gene

Map1s

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis (By similarity). Involved in the formation of microtubule bundles.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: GO_Central
  • actin filament binding Source: HGNC
  • beta-tubulin binding Source: HGNC
  • DNA binding Source: HGNC
  • identical protein binding Source: MGI
  • microtubule binding Source: HGNC
  • tubulin binding Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 1S
Short name:
MAP-1S
Alternative name(s):
BPY2-interacting protein 1
Microtubule-associated protein 8
Cleaved into the following 2 chains:
Gene namesi
Name:Map1s
Synonyms:Bpy2ip1, Map8, Mtap1s
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443304 Map1s

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113821 – 973Microtubule-associated protein 1SAdd BLAST973
ChainiPRO_00003113831 – 742MAP1S heavy chainAdd BLAST742
ChainiPRO_0000311384743 – 973MAP1S light chainAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei462PhosphoserineCombined sources1
Modified residuei586PhosphoserineBy similarity1
Modified residuei591PhosphoserineBy similarity1
Modified residuei593PhosphoserineBy similarity1
Modified residuei660PhosphoserineCombined sources1
Modified residuei684PhosphoserineBy similarity1
Modified residuei724PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C052
MaxQBiQ8C052
PaxDbiQ8C052
PeptideAtlasiQ8C052
PRIDEiQ8C052

PTM databases

iPTMnetiQ8C052
PhosphoSitePlusiQ8C052

Expressioni

Tissue specificityi

Expressed in ventral and dorsal horns of the spinal cord, hippocampus, cerebral cortex, molecular, Purkinje and granular cell layers of the cerebellum and in dorsal root ganglia of the PNS (at protein level). Expressed in brain, testis, heart, lung, kidney and liver.2 Publications

Developmental stagei

Expressed in embryo at 10 dpc onwards (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000019261 Expressed in 244 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_MTAP1S
ExpressionAtlasiQ8C052 baseline and differential
GenevisibleiQ8C052 MM

Interactioni

Subunit structurei

Heterodimer of a heavy and a light chain. Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin. Interacts with ESR1, LRPPRC, RASSF1, microtubules and VCY2. Interacts with WDR47 (via N-terminus of light chain) (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8C052, 3 interactors
MINTiQ8C052
STRINGi10090.ENSMUSP00000019405

Structurei

3D structure databases

ProteinModelPortaliQ8C052
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 716Necessary for the microtubule-organizing center localizationBy similarityAdd BLAST716
Regioni601 – 973Necessary for interaction with RASSF1By similarityAdd BLAST373
Regioni645 – 880Necessary for association with microtubulesAdd BLAST236
Regioni875 – 973Necessary for association with actinAdd BLAST99
Regioni881 – 905Necessary for the mitochondrial aggregation and genome destructionBy similarityAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi560 – 850Pro-richAdd BLAST291

Domaini

Its C-terminal part of the heavy chain interacts with ESR1 (By similarity). The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex.By similarity

Sequence similaritiesi

Belongs to the MAP1 family.Curated

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
GeneTreeiENSGT00550000074593
HOGENOMiHOG000072716
HOVERGENiHBG108117
InParanoidiQ8C052
KOiK10429
OrthoDBiEOG091G12OH
TreeFamiTF350229

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR027322 MAP1S
IPR036866 RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR13843 PTHR13843, 2 hits
PTHR13843:SF11 PTHR13843:SF11, 2 hits
SUPFAMiSSF56281 SSF56281, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8C052-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVMAAPEA VEAPSSLLLL VVGGECGCPG LLAYVMEELE RGVRSWEDVD
60 70 80 90 100
PAVCSLDEQL KAFVSRHSAT FSSIVKGQRS LHHRGETLET LVLLNPSDKS
110 120 130 140 150
LCDELRNLLM DPAPHKLLVL AGPCLEETGE LLLQTGGFSA HHFLQVLGDK
160 170 180 190 200
EVQDALASAP AAPALTVSCP TFGDWALLGP VPGLQLRLNP PAQLPASEGL
210 220 230 240 250
RAFLEYVAES LEPPSPFELL EPPAAGGFLR LARPCCYVFP GGLGDAAFFA
260 270 280 290 300
VNGFTVLVNG GSNPKSSFWK LVRHLDRVDA VLVTHAGADS LPGLNSLLRR
310 320 330 340 350
KLAEREAAAG PQGQHEERLR RLLSPALGVV FLNAREAASR LRGGEDEAVC
360 370 380 390 400
ARSLLRSLGI APLPLQRGPQ PSCPTVLFEK LGVGRLELFV LHPPPGDPAA
410 420 430 440 450
PACALLVWQP AAPGDKVVRV LFPGRTPPAR LLDGLQRLQH LPCLRRPVVT
460 470 480 490 500
THDLEAPSRA NSQDSLASRD SARKEPVRGT VGSIANRSTV RREPALATRD
510 520 530 540 550
QKKDTRSGPT QPTARDTRRS GPGVVNTKPR VSQNGPRAPV LAAPLTAPVA
560 570 580 590 600
ECPGEAENIL ESERPPAPSP TLSPAQSPPP TAPGNSPERL SLSPLRPEPA
610 620 630 640 650
PDASPSATTP TLTTPSLPAE LGSPHSTEVD ESLSVSFEQV LPAGDPGLSL
660 670 680 690 700
PLRLARRSTS PHDVDLCLVS PCEFSHRKPP PPASPGSSDS SARSQERPPE
710 720 730 740 750
TPPTSVSESL PTLSDSDPVP VADSDDDAGS ESAARDPPPT PRVPPPLPDV
760 770 780 790 800
PGICMVDPEA LPPRARQPLN TTNPSRSRKA PARPSSASAT PRAATVAAKT
810 820 830 840 850
KGPAGDRNRP LSARSEPADR PGRVPLTRKP SVPKTVPKMA SATRLSSGPS
860 870 880 890 900
GRPAPLAAGS PVYLDLAYLP GGGAGHLDQN FFLRVRALCY VISGQGQRQE
910 920 930 940 950
EGLRAVLDAL LAGKRQWDLD LQVTLIPTFD SAVMHRWYEE THAQHQALGI
960 970
RVLGSGSLVS MQDEAFPACK VEF
Length:973
Mass (Da):102,939
Last modified:July 27, 2011 - v2
Checksum:i3DD3E1A43F70E8DD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLY6A0A1D5RLY6_MOUSE
Microtubule-associated protein 1S
Map1s
864Annotation score:
A0A1D5RMF1A0A1D5RMF1_MOUSE
Microtubule-associated protein 1S
Map1s
133Annotation score:
A0A1D5RML0A0A1D5RML0_MOUSE
Microtubule-associated protein 1S
Map1s
79Annotation score:
A0A1D5RMG7A0A1D5RMG7_MOUSE
Microtubule-associated protein 1S
Map1s
239Annotation score:

Sequence cautioni

The sequence AAH52828 differs from that shown. Contaminating sequence. At the N-terminus.Curated
The sequence AAH52828 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti475E → G in AAH52828 (PubMed:15489334).Curated1
Sequence conflicti680P → T in ABD47683 (PubMed:16297881).Curated1
Sequence conflicti680P → T in BAC27800 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ387862 mRNA Translation: ABD47683.1
AK032300 mRNA Translation: BAC27800.1
AK162124 mRNA Translation: BAE36739.1
AC019302 Genomic DNA No translation available.
BC052828 mRNA Translation: AAH52828.1 Different initiation.
CCDSiCCDS22387.1
RefSeqiNP_766601.2, NM_173013.3
UniGeneiMm.248559

Genome annotation databases

EnsembliENSMUST00000019405; ENSMUSP00000019405; ENSMUSG00000019261
GeneIDi270058
KEGGimmu:270058
UCSCiuc009mcd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ387862 mRNA Translation: ABD47683.1
AK032300 mRNA Translation: BAC27800.1
AK162124 mRNA Translation: BAE36739.1
AC019302 Genomic DNA No translation available.
BC052828 mRNA Translation: AAH52828.1 Different initiation.
CCDSiCCDS22387.1
RefSeqiNP_766601.2, NM_173013.3
UniGeneiMm.248559

3D structure databases

ProteinModelPortaliQ8C052
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C052, 3 interactors
MINTiQ8C052
STRINGi10090.ENSMUSP00000019405

PTM databases

iPTMnetiQ8C052
PhosphoSitePlusiQ8C052

Proteomic databases

EPDiQ8C052
MaxQBiQ8C052
PaxDbiQ8C052
PeptideAtlasiQ8C052
PRIDEiQ8C052

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019405; ENSMUSP00000019405; ENSMUSG00000019261
GeneIDi270058
KEGGimmu:270058
UCSCiuc009mcd.2 mouse

Organism-specific databases

CTDi55201
MGIiMGI:2443304 Map1s

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
GeneTreeiENSGT00550000074593
HOGENOMiHOG000072716
HOVERGENiHBG108117
InParanoidiQ8C052
KOiK10429
OrthoDBiEOG091G12OH
TreeFamiTF350229

Miscellaneous databases

ChiTaRSiMap1s mouse
PROiPR:Q8C052
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019261 Expressed in 244 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_MTAP1S
ExpressionAtlasiQ8C052 baseline and differential
GenevisibleiQ8C052 MM

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR027322 MAP1S
IPR036866 RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR13843 PTHR13843, 2 hits
PTHR13843:SF11 PTHR13843:SF11, 2 hits
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAP1S_MOUSE
AccessioniPrimary (citable) accession number: Q8C052
Secondary accession number(s): E9QKR8, Q3TSD6, Q7TMW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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